Diagnostic relevance of the determination of lymphocyte subpopulations in environmental medicine

International Journal of Hygiene and Environmental Health

Volumn 210, Issue 2, 2007, Pages 177-198

  Schwenk, M ^a   Sack, U ^b   Esser, C ^c   Klein, R ^d  

^a In Den Kreuzäckern 16   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Chemicals; Environmental health; Flow cytometry; Immunology; Lymphocyte subpopulations; Subsets

Indexed keywords

EID: 33846818558     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2006.10.002     Document Type: Article

References (158)

1. Amicosante M., Sanarico N., Berretta F., Arroyo J., Lombardi G., Lechler R., Colizzi V., and Saltini C. Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. Hum. Immunol. 62 (2001) 686-693
2. Backe E., Lotz G., Tittelbach U., Plitzko S., Gierke E., and Schneider W.B. Immunological biomarkers in salt miners exposed to salt dust, diesel exhaust and nitrogen oxides. Int. Arch. Occup. Environ. Health 77 (2004) 319-327
3. Baines C.J., McKeown-Eyssen G.E., Riley N., Cole D.E., Marshall L., Loescher B., and Jazmaji V. Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures. Occup. Med. (London) 54 (2004) 408-418
4. Basaran N., and Undeger U. Effects of lead on immune parameters in occupationally exposed workers. Am. J. Ind. Med. 38 (2000) 349-354
5. Basaran N., Shubair M., Undeger U., Canpinar H., and Kars A. Alterations in immune parameters in foundry and pottery workers. Toxicology 178 (2002) 81-88
6. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., and Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 (1999) 727-729
7. Becker S., and Soukup J. Coarse (PM(2.5-10)), fine (PM(2.5)), and ultrafine air pollution particles induce/increase immune costimulatory receptors on human blood-derived monocytes but not on alveolar macrophages. J. Toxicol. Environ. Health A 66 (2003) 847-859
8. Bilrha H., Roy R., Moreau B., Belles-Isles M., Dewailly E., and Ayotte P. In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury. Environ. Health Perspect. 111 (2003) 1952-1957
9. Bofill M., Mocroft A., Lipman M., Medina E., Borthwick N.J., Sabin C.A., Timms A., Winter M., Baptista L., Johnson M.A., Lee C.A., Phillips A.N., and Janossy G. Increased numbers of primed activated CD8+CD38+CD45RO+ T cells predict the decline of CD4+ T-cells in HIV-1-infected patients. AIDS 10 (1996) 827-834
10. Bonhomme-Faivre L., Marion S., Forestier F., Santini R., and Auclair H. Effects of electromagnetic fields on the immune systems of occupationally exposed humans and mice. Arch. Environ. Health 58 (2003) 712-717
11. Boscolo P., Di Gioacchino M., Bavazzano P., White P.M., and Sabbioni E. Effects of chromium on lymphocyte subsets and immunoglobulins from normal population and exposed workers. Life Sci. 60 (1997) 1319-1325
12. Boscolo P., Di Gioacchino M., Sabbioni E., Di Giacomo F., Reale M., Volpe A.R., Di Sciascio M.B., Conti P., and Giuliano G. Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment. Life Sci. 67 (2000) 1119-1126
13. Boscolo P., Bergamaschi A., Di Sciascio M., Benvenuti F., Reale M., Di Stefano F., Conti P., and Di Gioacchino M. Effects of low frequency electromagnetic fields on expression of lymphocyte subsets and production of cytokines of men and women employed in a museum. Sci. Total Environ. 270 (2001) 13-20
14. Boscolo P., Di Sciascio M., D'Ostilio S., Del Signore A., Reale M., Conti P., Bavazzano P., Paganelli R., and Di Gioacchino M. Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women. Sci. Total Environ. 273 (2001) 1-10
15. Brando B., Barnett D., Janossy G., Mandy F., Autran B., Rothe G., Scarpati B., D'Avanzo G., D'Hautcourt J.L., Lenkei R., Schmitz G., Kunkl A., Chianese R., Papa S., and Gratama J.W. Cytofluorometric methods for assessing absolute numbers of cell subsets in blood. European Working Group on Clinical Cell Analysis. Cytometry 42 (2000) 327-346
16. Burgisser P., Hammann C., Kaufmann D., Battegay M., and Rutschmann O.T. Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study. Clin. Exp. Immunol. 115 (1999) 458-463
17. Bussa S., Rumi C., Leone G., and Bizzi B. Evaluation of a new whole blood cytometric lymphocyte transformation test for immunological screening. J. Clin. Lab. Immunol. 40 (1993) 39-46
18. Caldwell C.W., Maggi J., Henry L.B., and Taylor H.M. Fluorescence intensity as a quality control parameter in clinical flow cytometry. Am. J. Clin. Pathol. 88 (1987) 447-456
19. Carsetti R., Rosado M.M., and Wardmann H. Peripheral development of B cells in mouse and man. Immunol. Rev. 197 (2004) 179-191
20. Castro A.P., Aguas A.P., Grande N.R., Monteiro E., and Castelo Branco N.A. Increase in CD8+ and CD4+ T lymphocytes in patients with vibroacoustic disease. Aviat. Space Environ. Med. 70 (1999) A141-A144
21. Cavani A. Breaking tolerance to nickel. Toxicology 209 (2005) 119-121
22. Chavance M., Perrot J.Y., and Annesi I. Smoking, CD45R0+ (memory), and CD45RA+ (naive) CD4+ T cells. Am. Rev. Respir. Dis. 148 (1993) 237-240
23. Crosland-Taylor P.J. A device for counting small particles suspended in a fluid through a tube. Nature 171 (1953) 37-38
24. Dasdag S., Sert C., Akdag Z., and Batun S. Effects of extremely low frequency electromagnetic fields on hematologic and immunologic parameters in welders. Arch. Med. Res. 33 (2002) 29-32
25. de Jong J.W., Belt-Gritter B., Koeter G.H., and Postma D.S. Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. Respir. Med. 91 (1997) 67-76
26. Deeks S.G., Kitchen C.M., Liu L., Guo H., Gascon R., Narvaez A.B., Hunt P., Martin J.N., Kahn J.O., Levy J., McGrath M.S., and Hecht F.M. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 104 (2004) 942-947
27. Dunphy C.H. Applications of flow cytometry and immunohistochemistry to diagnostic hematopathology. Arch. Pathol. Lab. Med. 128 (2004) 1004-1022
28. Dyatlov V.A., and Lawrence D.A. Neonatal lead exposure potentiates sickness behavior induced by Listeria monocytogenes infection of mice. Brain Behav. Immun. 16 (2002) 477-492
29. Elewaut D., and Kronenberg M. Molecular biology of NK T cell specificity and development. Semin. Immunol. 12 (2000) 561-568
30. Ernst M., Flesch-Janys D., Morgenstern I., and Manz A. Immune cell functions in industrial workers after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: dissociation of antigenspecific T-cell responses in cultures of diluted whole blood and of isolated peripheral blood mononuclear cells. Environ. Health Perspect. 106 Suppl. 2 (1998) 701-705
31. Farris G.M., Newman L.S., Frome E.L., Barker E., Habbersett R.C., Maier L., Smith H.N., and Marrone B.L. Detection of beryllium sensitivity using a flow cytometric lymphocyte proliferation test: the Immuno-Be-LPT. Toxicology 143 (2000) 125-140
32. Filipic B., Kovacs K., Somogyvari F., Ihan A., Ocsovszky I., Koren S., and Toth S. The effects of medium-strength electric impulses on human blood. Bioelectrochemistry 52 (2000) 29-36
33. Fischbein A., Tsang P., Luo J.C., Roboz J.P., Jiang J.D., and Bekesi J.G. Phenotypic aberrations of CD3+ and CD4+ cells and functional impairments of lymphocytes at low-level occupational exposure to lead. Clin. Immunol. Immunopathol. 66 (1993) 163-168
34. Fontenot A.P., and Kotzin B.L. Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity. Tissue Antigens 62 (2003) 449-458
35. Freedman D.S., Flanders W.D., Barboriak J.J., Malarcher A.M., and Gates L. Cigarette smoking and leukocyte subpopulations in men. Ann. Epidemiol. 6 (1996) 299-306
36. Froom P., Lahat N., Kristal-Boneh E., Cohen C., Lerman Y., and Ribak J. Circulating natural killer cells in retired asbestos cement workers. J. Occup. Environ. Med. 42 (2000) 19-24
37. Giorgi J.V., Liu Z., Hultin L.E., Cumberland W.G., Hennessey K., and Detels R. Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study. J. Acquir. Immune. Defic. Syndr. 6 (1993) 904-912
38. Graham C., Sastre A., Cook M.R., and Gerkovich M.M. All-night exposure to EMF does not alter urinary melatonin, 6-OHMS or immune measures in older men and women. J. Pineal Res. 31 (2001) 109-113
39. Gratama J.W., D'Hautcourt J.L., Mandy F., Rothe G., Barnett D., Janossy G., Papa A., Schmitz G., and Lenkei R. Flow cytometric quantitation of immunofluorescence intensity: problems and perspectives. European Working Group on Clinical Cell Analysis. Cytometry 33 (1998) 166-178
40. Hagmar L., Hallberg T., Leja M., Nilsson A., and Schutz A. High consumption of fatty fish from the Baltic Sea is associated with changes in human lymphocyte subset levels. Toxicol. Lett. 77 (1995) 335-342
41. Harder S.D., Soukup J.M., Ghio A.J., Devlin R.B., and Becker S. Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects. Environ. Health Perspect. 109 Suppl. 4 (2001) 599-604
42. Hirohata S. Inhibition of human B cell activation by gold compounds. Clin. Immunol. Immunopathol. 81 (1996) 175-181
43. Hirohata S., Nakanishi K., Yanagida T., Kawai M., Kikuchi H., and Isshi K. Synergistic inhibition of human B cell activation by gold sodium thiomalate and auranofin. Clin. Immunol. 91 (1999) 226-233
44. Hockertz S., Emmendorffer A., Scherer G., Ruppert T., Daube H., Tricker A.R., and Adlkofer F. Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system. Cell. Biol. Toxicol. 10 (1994) 177-190
45. Hoffkes H.G., and Schmidtke G. [Quality control of flow cytometry by means of fluorescent particles ("beads")]. Infusionsther. Transfusionsmed. 23 (1996) 115-116
46. Holladay S.D., and Smith B.J. Fetal hematopoietic alterations after maternal exposure to benzo[a]pyrene: a cytometric evaluation. J. Toxicol. Environ. Health 42 (1994) 259-273
47. Holsapple M.P. Developmental immunotoxocity testing: a review. Toxicology 185 (2003) 193-203
48. Holsapple M.P., Snyder D.S., Wood S.C., and Morris D.L. A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update. Toxicology 69 (1991) 219-255
49. Holsapple M.P., Paustenbach D.J., Charnley G., West L.J., Luster M.I., Dietert R.R., and Burns-Naas L.A. Symposium summary: children's health risk - what's so special about the developing immune system?. Toxicol. Appl. Pharmacol. 199 (2004) 61-70
50. Hoover D.R., Donnay A., Mitchell C.S., Ziem G., Rose N.R., Sabath D., Yurkow E.J., Nakamura R., Vogt R.F., Waxdal M., and Margolick J.B. Reproducibility of immunological tests used to assess multiple chemical sensitivity syndrome. Clin. Diagn. Lab. Immunol. 10 (2003) 1029-1036
51. Ichinose T.Y., Burch J.B., Noonan C.W., Yost M.G., Keefe T.J., Bachand A., Mandeville R., and Reif J.S. Immune markers and ornithine decarboxylase activity among electric utility workers. J. Occup. Environ. Med. 46 (2004) 104-112
52. Janeway C.A., Travers P., and Walport M. Immunobiology (2004), Garland Publishing, New York, London
53. Kanariou M., Petridou E., Vrachnou E., and Trichopoulos D. Lymphocyte alterations after prolonged sunlight exposure. J. Epidemiol. Biostat. 6 (2001) 463-465
54. Karakaya A., Yucesoy B., Turhan A., Erdem O., Burgaz S., and Karakaya A.E. Investigation of some immunological functions in a group of asphalt workers exposed to polycyclic aromatic hydrocarbons. Toxicology 135 1 (1999) 43-47 (Abstract)
55. Kerkvliet N.I. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int. Immunopharmacol. 2 (2002) 277-291
56. Kimber I. Reduction, refinement and replacement: putting the immune system to work. Altern. Lab. Anim. 30 (2002) 569-577
57. Kuo H.W., and Wu M.L. Effects of chromic acid exposure on immunological parameters among electroplating workers. Int. Arch. Occup. Environ. Health 75 (2002) 186-190
58. Kuo H.W., Hsiao T.Y., and Lai J.S. Immunological effects of long-term lead exposure among Taiwanese workers. Arch. Toxicol. 75 (2001) 569-573
59. Lafuente A., Gonzalez-Carracedol A., and Esquifino A.I. Differential effects of cadmium on blood lymphocyte subsets. Biometals 17 (2004) 451-456
60. Lamy T., and Loughran Jr. T.P. Current concepts: large granular lymphocyte leukemia. Blood Rev. 13 (1999) 230-240
61. Landay A.L., and Muirhead K.A. Procedural guidelines for performing immunophenotyping by flow cytometry. Clin. Immunol. Immunopathol. 52 (1989) 48-60
62. Lenkei R., Gratama J.W., Rothe G., Schmitz G., D'Hautcourt J.L., Arekrans A., Mandy F., and Marti G. Performance of calibration standards for antigen quantitation with flow cytometry. Cytometry 33 (1998) 188-196
63. Leonardi G.S., Houthuijs D., Steerenberg P.A., Fletcher T., Armstrong B., Antova T., Lochman I., Lochmanova A., Rudnai P., Erdei E., Musial J., Jazwiec-Kanyion B., Niciu E.M., Durbaca S., Fabianova E., Koppova K., Lebret E., Brunekreef B., and Van Loveren H. Immune biomarkers in relation to exposure to particulate matter: a cross-sectional survey in 17 cities of Central Europe. Inhal. Toxicol. 12 Suppl. 4 (2000) 1-14
64. Li D., Ong C.N., Ng V., and Tan C. Effect of nickel chloride on mouse T-lymphocyte subsets. Vet. Hum. Toxicol. 40 (1998) 129-131
65. Loftenius A., Sandborgh-Englund G., and Ekstrand J. Acute exposure to mercury from amalgam: no short-time effect on the peripheral blood lymphocytes in healthy individuals. J. Toxicol. Environ. Health A 54 (1998) 547-560
66. Long E.O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17 (1999) 875-904
67. Maino V.C., and Picker L.J. Identification of functional subsets by flow cytometry: intracellular detection of cytokine expression. Cytometry 34 (1998) 207-215
68. Maino V.C., Suni M.A., and Ruitenberg J.J. Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry 20 (1995) 127-133
69. Malavasi F., Funaro A., and Roggero J.J. Human CD38: a glycoprotein in search of a function. Immunol. Today 15 (1994) 95-97
70. Mandy F.F., Nicholson J.K., and McDougal J.S. Guidelines for performing single-platform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention. MMWR Recomm. Rep. 52 (2003) 1-13
71. Matsuoka L.Y., McConnachie P., Wortsman J., and Holick M.F. Immunological responses to ultraviolet light B radiation in Black individuals. Life Sci. 64 (1999) 1563-1569
72. McCarthy D.A., and Macey M.G. Cytometric Analysis of Cell Phenotype and Function (2001), Cambridge University Press, Cambridge
73. Mili F., Flanders W.D., Boring J.R., Annest J.L., and Destefano F. The associations of race, cigarette smoking, and smoking cessation to measures of the immune system in middle-aged men. Clin. Immunol. Immunopathol. 59 (1991) 187-200
74. Milovanova T.N., Popma S.H., Cherian S., Moore J.S., and Rossman M.D. Flow cytometric test for beryllium sensitivity. Cytometry 60B (2004) 23-30
75. Mitteilung der Kommission "Methoden und Qualitätssicherung in der Umweltmedizin" am Robert Koch-Institut (RKI). Grundsätze der Bewertung von umweltmedizinischen Methoden. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 44 (2001) 519-522
76. Mitteilung der Kommission "Methoden und Qualitätssicherung in der Umweltmedizin" am Robert Koch-Institut (RKI). Diagnostische Relevanz des Lymphozytentransformationstestes in der Umweltmedizin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 45 (2002) 745-749
77. Mitteilung der Kommission "Methoden und Qualitätssicherung in der Umweltmedizin" am Robert Koch-Institut (RKI). Bedeutung von Zytokinbestimmungen in der umweltmedizinischen Praxis. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 47 (2004) 73-79
78. Mitteilung der Kommission "Methoden und Qualitätssicherung in der Umweltmedizin" am Robert Koch-Institut (RKI). Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 49 (2006) 468-484
79. Moed H., Boorsma D.M., Stoof T.J., von Blomberg B.M., Bruynzeel D.P., Scheper R.J., Gibbs S., and Rustemeyer T. Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10. Br. J. Dermatol. 151 (2004) 32-41
80. Morris D.L., Jeong H.G., Jordan S.D., Kaminski N.E., and Holsapple M.P. Characterization of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in B6C3F1 and DBA/2 mice following single and repeated exposures. Arch. Toxicol. 72 (1998) 157-168
81. Mosmann T.R., and Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17 (1996) 138-146
82. Moszczynski P., Slowinski S., Rutkowski J., Bem S., and Jakus-Stoga D. Lymphocytes, T and NK cells, in men occupationally exposed to mercury vapours. Int. J. Occup. Med. Environ. Health 8 (1995) 49-56
83. Moszczynski P., Rutowski J., Slowinski S., Bem S., and Jakus-Stoga D. Effects of occupational exposure to mercury vapors on T-cell and NK-cell populations. Arch. Med. Res. 27 (1996) 503-507
84. Moszczynski P., Rutowski J., Slowinski S., and Bem S. Immunological effects of occupational exposure to metallic mercury in the population of T-cells and NK-cells. Analyst 123 (1998) 99-103
85. Nagayama J., Tsuji H., Iida T., Hirakawa H., Matsueda T., Okamura K., Hasegawa M., Sato K., Ma H.Y., Yanagawa T., Igarashi H., Fukushige J., and Watanabe T. Postnatal exposure to chlorinated dioxins and related chemicals on lymphocyte subsets in Japanese breast-fed infants. Chemosphere 37 (1998) 1781-1787
86. Nagayama J., Tsuji H., Iida T., Hirakawa H., Matsueda T., and Ohki M. Effects of contamination level of dioxins and related chemicals on thyroid hormone and immune response systems in patients with "Yusho". Chemosphere 43 (2001) 1005-1010
87. Neubert R., Jacob-Muller U., Stahlmann R., Helge H., and Neubert D. Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. Effects on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Arch. Toxicol. 64 (1990) 345-359
88. Neubert R., Maskow L., Webb J., Jacob-Muller U., Nogueira A.C., Delgado I., Helge H., and Neubert D. Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system. 1. Blood cell receptors in volunteers with moderately increased body burdens. Life Sci. 53 (1993) 1995-2006
89. Nunez R. DNA measurement and cell cycle analysis by flow cytometry. Curr. Issues Mol. Biol. 3 (2001) 67-70
90. Onodera H., Jin Z., Chida S., Suzuki Y., Tago H., and Itoyama Y. Effects of 10-T static magnetic field on human peripheral blood immune cells. Radiat. Res. 159 (2003) 775-779
91. Orange J.S., and Ballas Z.K. Natural killer cells in human health and disease. Clin. Immunol. 118 (2006) 1-10
92. Orfao A., and Ruiz-Arguelles A. General concepts about cell sorting techniques. Clin. Biochem. 29 (1996) 5-9
93. Orfao A., Schmitz G., Brando B., Ruiz-Arguelles A., Basso G., Braylan R., Rothe G., Lacombe F., Lanza F., Papa S., Lucio P., and San Miguel J.F. Clinically useful information provided by the flow cytometric immunophenotyping of hematological malignancies: current status and future directions. Clin. Chem. 45 (1999) 1708-1717
94. Park S.H., Araki S., Nakata A., Kim Y.H., Park J.A., Tanigawa T., Yokoyama K., and Sato H. Effects of occupational metallic mercury vapour exposure on suppressor-inducer (CD4+CD45RA+) T lymphocytes and CD57+CD16+ natural killer cells. Int. Arch. Occup. Environ. Health 73 (2000) 537-542
95. Parry H., Cohen S., Schlarb J.E., Tyrrell D.A., Fisher A., Russell M.A., and Jarvis M.J. Smoking, alcohol consumption, and leukocyte counts. Am. J. Clin. Pathol. 107 (1997) 64-67
96. Paust S., and Cantor H. Regulatory T cells and autoimmune disease. Immunol. Rev. 204 (2005) 195-207
97. Peacock J.S., Colsky A.S., and Pinto V.B. Lectins and antibodies as tools for studying cellular interactions. J. Immunol. Methods 126 (1990) 147-157
98. Pechhold K., Pohl T., and Kabelitz D. Rapid quantification of lymphocyte subsets in heterogeneous cell populations by flow cytometry. Cytometry 16 (1994) 152-159
99. Pedersen B.K., and Abom B. The in vivo effect of triethylphosphine gold (auranofin), sodium aurothiomalate and azathioprine on lymphocyte subsets of patients with rheumatoid arthritis. Allergy 43 (1988) 396-398
100. Petanova J., Fucikova T., and Bencko V. Influence of cadmium and zinc sulphates on the function of human T lymphocytes in vitro. Cent. Eur. J. Public Health 8 (2000) 137-140
101. Peter H.H. Erworbene Immundefekte. In: Thomas L. (Ed). Labor und Diagnose (2000), THBooks Verlagsgesellschaft, Frankfurt/Main 751-759
102. Pinkerton L.E., Biagini R.E., Ward E.M., Hull R.D., Deddens J.A., Boeniger M.F., Schnorr T.M., MacKenzie B.A., and Luster M.I. Immunologic findings among lead-exposed workers. Am. J. Ind. Med. 33 (1998) 400-408
103. Purvis N., and Stelzer G. Multi-platform, multi-site instrumentation and reagent standardization. Cytometry 33 (1998) 156-165
104. Rabinovitch P.S., Kubbies M., Chen Y.C., Schindler D., and Hoehn H. BrdU-Hoechst flow cytometry: a unique tool for quantitative cell cycle analysis. Exp. Cell Res. 174 (1988) 309-318
105. Rivers J.K., Norris P.G., Murphy G.M., Chu A.C., Midgley G., Morris J., Morris R.W., Young A.R., and Hawk J.L. UVA sunbeds: tanning, photoprotection, acute adverse effects and immunological changes. Br. J. Dermatol. 120 (1989) 767-777
106. Robinson J.P. Handbook of Flow Cytometry Methods (1993), Wiley-Liss, New York
107. Rodriguez J.W., Kirlin W.G., Wirsiy Y.G., Matheravidathu S., Hodge T.W., and Urso P. Maternal exposure to benzo[a]pyrene alters development of T lymphocytes in offspring. Immunopharmacol. Immunotoxicol. 21 (1999) 379-396
108. Romagnani S., Kapsenberg M., Radbruch A., and Adorini L. Th1 and Th2 cells. Res. Immunol. 149 (1998) 871-873
109. Rossman M.D. Chronic beryllium disease: a hypersensitivity disorder. Appl. Occup. Environ. Hyg. 16 (2001) 615-618
110. Rudell B., Blomberg A., Helleday R., Ledin M.C., Lundback B., Stjernberg N., Horstedt P., and Sandstrom T. Bronchoalveolar inflammation after exposure to diesel exhaust: comparison between unfiltered and particle trap filtered exhaust. Occup. Environ. Med. 56 (1999) 527-534
111. Sack U., Rothe G., Barlage S., Gruber R., Kabelitz D., Klein T.O., Lun A., Renz H., Ruf A., and Schmitz G. Durchflusszytometrie in der Klinischen Diagnostik. Positionspaper der Arbeitsgruppe Durchflusszytometrie und Quantitative Mikroskopie der Deutschen Gesellschaft für Klinische Chemie und Deutschen Gesellschaft für Laboratoriumsmedizin. J. Lab. Med. 24 (2000) 277-297
112. Salvaggio J.E. Understanding clinical immunological testing in alleged chemically induced environmental illnesses. Regul. Toxicol. Pharmacol. 24 (1996) S16-S27
113. Salvi S., Blomberg A., Rudell B., Kelly F., Sandstrom T., Holgate S.T., and Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159 (1999) 702-709
114. Sarasua S.M., Vogt R.F., Henderson L.O., Jones P.A., and Lybarger J.A. Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure. J. Toxicol. Environ. Health A 60 (2000) 1-15
115. Sata F., Araki S., Tanigawa T., Morita Y., Sakurai S., and Katsuno N. Changes in natural killer cell subpopulations in lead workers. Int. Arch. Occup. Environ. Health 69 (1997) 306-310
116. Sata F., Araki S., Tanigawa T., Morita Y., Sakurai S., Nakata A., and Katsuno N. Changes in T cell subpopulations in lead workers. Environ. Res. 76 (1998) 61-64
117. Sawyer R.T., Parsons C.E., Fontenot A.P., Maier L.A., Gillespie M.M., Gottschall E.B., Silveira L., and Newman L.S. Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DP. Am. J. Respir. Cell. Mol. Biol. 31 (2004) 122-130
118. Schaberg T., Theilacker C., Nitschke O.T., and Lode H. Lymphocyte subsets in peripheral blood and smoking habits. Lung 175 (1997) 387-394
119. Schmidt-Wolf G.D., Negrin R.S., and Schmidt-Wolf I.G. Activated T cells and cytokine induced CD3+CD56+ killer cells. Ann. Hematol. 74 (1997) 51-56
120. Schwartz A., Fernandez-Repollet E., Vogt R., and Gratama J.M. Standardizing flow cytometry: construction of a standardized fluorescence calibration plot using matching spectral calibrators. Cytometry 26 (1996) 22-31
121. Schwartz A., Marti G.E., Poon R., Gratama J.W., and Fernandez-Repollet E. Standardizing flow cytometry: a classification system of fluorescence standards used for flow cytometry. Cytometry 33 (1998) 106-114
122. Selmaoui B., Bogdan A., Auzeby A., Lambrozo J., and Touitou Y. Acute exposure to 50 Hz magnetic field does not affect hematologic or immunologic functions in healthy young men: a circadian study. Bioelectromagnetics 17 (1996) 364-372
123. Serke S., van Lessen A., and Huhn D. Quantitative fluorescence flow cytometry: a comparison of the three techniques for direct and indirect immunofluorescence. Cytometry 33 (1998) 179-187
124. Shevach E.M., McHugh R.S., Piccirillo C.A., and Thornton A.M. Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol. Rev. 182 (2001) 58-67
125. Simon J.C., Krutmann J., Elmets C.A., Bergstresser P.R., and Cruz Jr. P.D. Ultraviolet B-irradiated antigen-presenting cells display altered accessory signaling for T-cell activation: relevance to immune responses initiated in skin. J. Invest. Dermatol. 98 (1992) 66S-69S
126. Simon J.C., Hara H., Denfeld R.W., Denfeld R.W., and Martin S. UVB-irradiated dendritic cells induce nonproliferating, regulatory type T cells. Skin Pharmacol. Appl. Skin Physiol. 15 (2002) 330-334
127. Singh V.K., Mishra K.P., Rani R., Yadav V.S., Awasthi S.K., and Garg S.K. Immunomodulation by lead. Immunol. Res. 28 (2003) 151-166
128. Subra J.F., Renier G., Reboul P., Tollis F., Boivinet R., Schwartz P., and Chevailler A. Lymphopenia in occupational pulmonary silicosis with or without autoimmune disease. Clin. Exp. Immunol. 126 (2001) 540-544
129. Svensson B.G., Hallberg T., Nilsson A., Schutz A., and Hagmar L. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int. Arch. Occup. Environ. Health 65 (1994) 351-358
130. Takahashi K., Sasaki H., Saito T., Hosokawa T., Kurasaki M., and Saito K. Combined effects of working environmental conditions in VDT work. Ergonomics 44 (2001) 562-570
131. Tanigawa T., Araki S., Sata F., Nakata A., and Araki T. Effects of smoking, aromatic amines, and chromates on CD4+ and CD8+ T lymphocytes in male workers. Environ. Res. 78 (1998) 59-63
132. Tanigawa T., Araki S., Nakata A., Sukurai A., and Miki A. Effects of smoking and Japanese cedar pollinosis on lymphocyte subpopulations. Arch. Environ. Health 54 (1999) 119-123
133. Taylor J.M., Fahey J.L., Detels R., and Giorgi J.V. CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use. J. Acquir. Immune. Defic. Syndr. 2 (1989) 114-124
134. ten Tusscher G.W., Steerenberg P.A., Van Loveren H., Vos J.G., dem Borne A.E., Westra M., van der Slikke J.W., Olie K., Pluim H.J., and Koppe J.G. Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure. Environ. Health Perspect. 111 (2003) 1519-1523
135. Terr A.I. Multiple chemical sensitivities. Ann. Intern. Med. 119 (1993) 163-164
136. Teunissen M.B., Sylva-Steenland R.M., and Bos J.D. Effect of low-dose ultraviolet-B radiation on the function of human T lymphocytes in vitro. Clin. Exp. Immunol. 94 (1993) 208-213
137. Tollerud D.J., Clark J.W., Brown L.M., Neuland C.Y., Mann D.L., Pankiw-Trost L.K., Blattner W.A., and Hoover R.N. Association of cigarette smoking with decreased numbers of circulating natural killer cells. Am. Rev. Respir. Dis. 139 (1989) 194-198
138. Tollerud D.J., Clark J.W., Brown L.M., Neuland C.Y., Mann D.L., Pankiw-Trost L.K., Blattner W.A., and Hoover R.N. The effects of cigarette smoking on T cell subsets. A population-based survey of healthy caucasians. Am. Rev. Respir. Dis. 139 (1989) 1446-1451
139. Trinchieri G. Biology of natural killer cells. Adv. Immunol. 47 (1989) 187-376
140. Tryphonas H., Luster M.I., Schiffman G., Dawson L.L., Hodgen M., Germolec D., Hayward S., Bryce F., Loo J.C., and Mandy F. Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatta) monkey. Fundam. Appl. Toxicol. 16 (1991) 773-786
141. Tsuji H. Immune effects of endocrine disruptors. Nippon Rinsho 58 (2000) 2533-2538
142. Tulinska J., Jahnova E., Dusinska M., Kuricova M., Liskova A., Ilavska S., Horvathova M., Wsolova L., Kyrtopoulos S.A., Collins A., Harrington V., and Fuortes L. Immunomodulatory effects of mineral fibres in occupationally exposed workers. Mutat. Res. 553 (2004) 111-124
143. Uhrberg M., Valiante N.M., Young N.T., Lanier L.L., Phillips J.H., and Parham P. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns. J. Immunol. 166 (2001) 3923-3932
144. Vaht M., Kikas U., Reinart A., and Lehtmaa J. Changes in the immune system of female sunbathers due to the effect of natural UV radiation. Int. J. Hyg. Environ. Health 206 (2003) 597-599
145. Valiante N.M., Uhrberg M., Shilling H.G., Weidenbach K., Arnett K.L., D'Andrea A., Phillips J.H., Lanier L.L., and Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 7 (1997) 739-751
146. van Kampen V., Merget R., and Bruning T. Immediate type allergies due to metal-nickel. Pneumologie 57 (2003) 667-670
147. van Larebeke N., Husson B., De Coen W., and Pluygers E. Immunologic and other biological parameters as a function of smoking status and of residence in areas differing in terms of air pollution. Int. J. Environ. Health Res. 13 (2003) 55-69
148. Vimercati L., Santarelli L., Pesola G., Drago I., Lasorsa G., Valentino M., Vacca A., and Soleo L. Monocyte-macrophage system and polymorphonuclear leukocytes in workers exposed to low levels of metallic mercury. Sci. Total Environ. 270 (2001) 157-163
149. Wang Z., Farris G.M., Newman L.S., Shou Y., Maier L.A., Smith H.N., and Marrone B.L. Beryllium sensitivity is linked to HLA-DP genotype. Toxicology 165 (2001) 27-38
150. Weisglas-Kuperus N., Patandin S., Berbers G.A., Sas T.C., Mulder P.G., Sauer P.J., and Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ. Health Perspect. 108 (2000) 1203-1207
151. Werfel T., Boeker M., and Kapp A. Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions. Allergy 52 (1997) 465-469
152. Yawata M., Yawata N., Draghi M., Little A.M., Patheniou F., and Parham P. Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J. Exp. Med. 203 (2006) 633-645
153. Ying C.J., Ye X.L., Xie H., Yan W.S., Zhao W.Y., Xia T., and Yin S.Y. Lymphocyte subsets and sister-chromatid exchanges in the students exposed to formaldehyde vapor. Biomed. Environ. Sci. 12 (1999) 88-94
154. Yssel H., and Groux H. Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases. Int. Arch. Allergy Immunol. 121 (2000) 10-18
155. Yu M.L., Hsin J.W., Hsu C.C., Chan W.C., and Guo Y.L. The immunologic evaluation of the Yucheng children. Chemosphere 37 (1998) 1855-1865
156. Yucesoy B., Turhan A., Ure M., Imir T., and Karakaya A. Simultaneous effects of lead and cadmium on NK cell activity and some phenotypic parameters. Immunopharmacol. Immunotoxicol. 19 (1997) 339-348
157. Yucesoy B., Mirshahidi S., Yucesoy C., and Karakaya A. In vitro effects of various metals on natural killer cell activity in cultured human lymphocytes. Immunopharmacol. Immunotoxicol. 21 (1999) 599-607
158. Zeromski J., Jezewska E., Sikora J., and Kasprzak K.S. The effect of nickel compounds on immunophenotype and natural killer cell function of normal human lymphocytes. Toxicology 97 (1995) 39-48