Increased numbers of primed activated CD8+CD38+CD45RO+ T cells predict the decline of CD4+ T cells in HIV-1-infected patients

AIDS

Volumn 10, Issue 8, 1996, Pages 827-834

  Bofill, Margarita ^a   Mocroft, Amanda ^a   Lipman, Marc ^a   Medina, Eva ^a   Borthwick, Nicola J ^a   Sabin, Caroline A ^a   Timms, Anthony ^a   Winter, Mark ^a   Baptista, Luisa ^a   Johnson, Margaret A ^a   Lee, Christine A ^a   Phillips, Andrew N ^a   Janossy, George ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Activation; CD38; CD4; CD45RO; CD8; Disease progression

Indexed keywords

BETA 2 MICROGLOBULIN; CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN;

ADULT; ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 8944259909     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199607000-00005     Document Type: Article

References (43)

1. Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med 1981, 305:1425-1431.
2. Moss AR, Bacchetti P, Osmond D, et al.: Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort. BMJ 1988, 296:745-750.
3. Fuchs D, Spira TJ, Hausen A, Reibnegger C, Werner ER, Felmayer GW: Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection. Clin Chem 1989, 35:1746-1749.
4. Osmond DH, Shiboski S, Bacchetti P Winger EE, Moss AR: Immune activation markers and AIDS prognosis. AIDS 1991, 5:505-511.
5. Levacher M, Hulstaert F, Tallet S, Ullery S, Pocidalo JJ, Bach BA: The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value. Clin Exp Immunol 1992, 90:376-382.
6. Giorgi JV, Liu Z, Hultin LE, Cumberland WG, Hennessey K, Detels R: Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 1993, 6:904-912.
7. Phillips AN, Sabin CA, Elford J, Bofill M, Lee CA, Janossy G: CD8 lymphocyte counts and serum immunoglobulin A levels early in HIV infection as predictors of CD4 lymphocyte depletion during 8 years of follow-up. AIDS 1993, 7:975-980.
8. Chess Q, Daniels J, North E, Macris NT: Serum immunoglobulin elevations in the acquired immunodeficiency syndrome (AIDS): IgG, IgA, IgM, and IgD. Diagn Immunol 1984, 2:148-153.
9. Bofill M, Gombert W, Borthwick NJ, et al.: Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients. Am J Pathol 1995, 146:1542-1555.
10. Altman A, Coggeshall KM, Mustelin T: Molecular events mediating T cell activation. Adv Immunol 1990, 48:227-360.
11. Alessio M, Roggero S, Funaro A, De Monte LB, Peruzzi L, Geuna M: CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells. J Immunol 1990, 145:878-884.
12. Howard M, Grimaldi JC, Bazan JF, et al.: Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 1993, 262:1056-1059.
13. Akbar AN, Timms A, Janossy G: Cellular events during memory T-cell activation in vitro: the UCHL1 (180,000 MW) determinant is newly synthesized after mitosis. Immunology 1989, 66:213-218.
14. Gerli R, Rambotti P, Cernetti C, et al.: A mature thymocyte-like phenotypic pattern on human cord circulating T-lymphoid cells. J Clin Immunol 1984, 4:461-468.
15. Bofill M, Akbar AN, Salmon M, Robinson M, Burford G, Janossy G: Immature CD45RA(low)RO(low) T cells in the human cord blood. I. Antecedents of CD45RA+ unprimed T cells. J Immunol 1994, 152:5613-5623.
16. Akbar AN, Borthwick N, Salmon M, et al.: The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 1993, 178:427-438.
17. 2-microglobulin by stimulated lymphocytes. J Immunol 1972, 109:407-409.
18. Reddy MM, Lange M, Grieco MH: Elevated soluble CD8 levels in sera of human immunodeficiency virus-infected populations. J Clin Microbiol 1989, 27:257-260.
19. Kloster BE, John PA, Miller LE, et al.: Soluble interleukin 2 receptors are elevated in patients with AIDS or at risk of developing AIDS. Clin Immunol Immunopathol 1987, 45:440-446.
20. Phillips AN, Sabin CA, Elford J, Bofill M, Janossy G, Lee CA: Use of CD4 lymphocyte count to predict long-term survival free of AIDS after HIV infection. BMJ 1994, 309:309-313.
21. Lee CA, Phillips AN, Elford J, Miller EJ, Bofill M, Griffiths PD: The natural history of human immunodeficiency virus infection in a haemophilic cohort. Br J Haematol 1989, 73:228-234.
22. Echaniz P, Arrizabalaga J, Iribarren JA, Cuadrado E: CD8+CD38+ and CD8+DR+ peripheral blood lymphoid subsets of HIV-infected intravenous drug abusers correlate with CD4+ cell counts and proliferation to mitogens. Cell Immunol 1993, 150:72-80.
23. Prince HE, Kleinman S, Czaplicki C, John J, Williams AE: Interrelationships between serologic markers of immune activation and T lymphocyte subsets in HIV infection. J Acquir Immune Defic Syndr 1990, 3:525-530.
24. Bass HZ, Nishanian P, Hardy WD, Mitsuyasu RT, Esmail E, Cumberland W: Immune changes in HIV-1 infection: significant correlations and differences in serum markers and lymphoid phenotypic antigens. Clin Immunol Immunopathol 1992, 64:63-70.
25. SAS Institute, Inc.: SAS Users Guide: Statistics Version 6, 3rd Edn. Cary: SAS Institute; 1990.
26. Mercolino TJ, Connelly MC, Meyer EJ, et al.: Immunologic differentiation of absolute lymphocyte count with an integrated flow cytometric system: a new concept for absolute T cell subset determinations. Cytometry 1995, 21:48-59.
27. Janossy G, Jiang JD, Roboz JP, Bofill M, Bekesi JG: Activated CD45RO,CD8+ T lymphocytes in HIV-1 infection. In Immunodeficiency in HIV Infection and AIDS. Edited by Janossy G, Autran B, Miedema F. Basel: Karger; 1992:195-210.
28. Giorgi JV, Ho HN, Hirji K, et al.: CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. J Infect Dis 1994, 170:775-781.
29. Merkenschlager M, Beverley PC: Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int Immunol 1989, 1:450-459.
30. Pantaleo G, De Maria A, Koenig S, et al.: CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc Natl Acad Sci USA 1990, 87:4818-4822.
31. Landay AL, Mackewicz CE, Levy JA: An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol 1993, 69:106-116.
32. Ho HN, Hultin LE, Mitsuyasu RT, et al.: Circulating HIV-specific CDS+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993, 150:3070-3079.
33. Hoffenbach A, Langlade-Demoyen P, Dadaglio G, et al.: Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol 1989, 142:452-462.
34. Walker BD, Plata F: Cytotoxic T lymphocytes against HIV. AIDS 1990, 4:177-184.
35. Walker CM, Erickson AL, Hsueh FC, Levy JA: Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism. J Virol 1991, 65:5921-5927.
36. Ferbas J, Kaplan AH, Hausner MA, et al.: Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity. J Infect Dis 1995, 172:329-339.
37. Zinkernagel RM, Hengartner H: T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol Today 1994, 15:262-268.
38. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993, 362:359-362.
39. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126.
40. Wei X, Ghosh SK, Taylor ME, et al.: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995, 373:117-122.
41. Banda NK, Bernier J, Kurahara DK, Kurrle R, Haigwood N, Sekaly RP: Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992, 176:1099-1106.
42. Rosenberg ZF, Fauci AS: The immunopathogenesis of HIV infection. Adv Immunol 1989, 47:377-431.
43. Roos MT, de Leeuw NA, Claessen FAP, et al.: Viro-immunological studies in acute HIV-1 infection. AIDS 1994, 8:1533-1538.