Beryllium sensitivity is linked to HLA-DP genotype

Toxicology

Volumn 165, Issue 1, 2001, Pages 27-38

  Wang, Zaolin ^a   Farris, Georgia M ^a   Newman, Lee S ^b   Shou, Yulin ^a   Maier, Lisa A ^b   Smith, Hugh N ^a   Marrone, Babetta L ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Beryllium; Chronic beryllium disease; Genetic susceptibility; HLA DP alleles; Immune response; Lymphocyte proliferation test

Indexed keywords

BERYLLIUM; CD4 ANTIGEN; CD8 ANTIGEN; GLUTAMIC ACID; HLA DP ANTIGEN;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BERYLLIOSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA SEQUENCE; EXON; FLOW CYTOMETRY; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PHENOTYPE; PRIORITY JOURNAL; SCREENING TEST; SYMPTOM; T LYMPHOCYTE;

BERYLLIOSIS; CELL DIVISION; CHRONIC DISEASE; DNA; GENOTYPE; HLA-DP ANTIGENS; HUMANS; LYMPHOCYTES; PHENOTYPE; PREDICTIVE VALUE OF TESTS; T-LYMPHOCYTE SUBSETS;

EID: 0035855331     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00410-3     Document Type: Article

References (22)

1. The standard for control of chronic beryllium disease
2. Detection of beryllium sensitivity using a flow cytometric lymphocyte proliferation test: The immuno-Be-LPT
3. Identification of pathogenic T cells in patients with beryllium-induced lung disease
4. Expansions of T-cell subsets expressing particular T-cell receptor variable regions in chronic beryllium disease
5. Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease
6. Statistical methods for the blood beryllium lymphocyte proliferation test
7. Delayed chemical pneumonitis occurring in workers to beryllium compounds
8. Chronic beryllium disease-from the workplace to cellular immunology, molecular immunogenetics, and back
9. Screening blood test identifies subclinical beryllium disease
10. Beryllium disease screening in the ceramics industry. Blood lymphocyte test performance and exposure-disease relations
11. HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease
12. HLA class II region nucleotide sequences
13. Re-examination of the blood lymphocyte transformation test in the diagnosis of chronic beryllium disease
14. To Be2+ or not to Be2+: Immunogenetics and occupational exposure
15. Beryllium disease and sarcoidosis: Clinical and laboratory links
16. Pathologic and immunologic alterations in early stages of beryllium disease. Re-examination of disease definition and natural history
17. HLA-DPB1 glutamate 69: A genetic marker of beryllium disease
18. Proliferative response of bronchoalveolar lymphocytes to beryllium. A test for chronic beryllium disease
19. HLA DPA1-DPB1 linkage disequilibrium in the British caucasoid population
20. Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells
21. Epidemiology of beryllium intoxication
22. Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles