Maternal exposure to benzo[a]pyrene alters development of T lymphocytes in offspring

Immunopharmacology and Immunotoxicology

Volumn 21, Issue 2, 1999, Pages 379-396

  Rodriguez, J W ^a   Kirlin, W G ^a   Wirsiy, Y G ^a   Matheravidathu, S ^a   Hodge, T W ^b   Urso, P ^a,c  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c CLARK ATLANTA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNE DEFICIENCY; IMMUNOTOXICITY; MALE; MOUSE; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; SPLEEN CELL; SUPPRESSOR CELL; THYMOCYTE;

EID: 0032890936     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979909052769     Document Type: Article

References (32)

1. Vital Statistics of the United States, 1993, National Center for Health Statistics, Washington, D.C. Public Health Service, 1996.
2. Kosary, C.L., Ries, L.A.G., Miller, B.A., Hankey, B.F, Harras, A., and Edwards, B.K., SEER Cancer Statistics Review, 1973-1993: Tables and Graphs (NIH Pub. 96-2789). Bethesda, M.D., National Cancer Institute, pp. 455-465, 1995.
3. Sandler, D.P., Everson, R.B., Wilcox, A.J., and Browder, J.P., Cancer risk in adulthood from early life exposure to parents' smoking. Am. J. Public Health 75:487-492, 1985.
4. John, E.M., Savitz, D.A. and Sandler, D.P., Prenatal exposure to parent's smoking and childhood cancer. Am. J. Epidemiol. 133:123-132, 1991.
5. Grimmer, G. And Pott, E., Occurrence of PAH, in Environmental carcinogens: polycyclic aromatic hydrocarbons, edited by Grimmer, G., pp. 61-128, CRC Press, Boca Raton, Florida, 1983.
6. Adams, J., O'Mara, K., and Hoffman, D., Toxic and carcinogenic agents in undiluted mainstream smoke, and sidestream smoke of different types of cigarettes. Carcinogenesis 8: 729-731, 1987.
7. Urso, P. and Gengozian, N., Depressed humoral immunity and increased tumor incidence in mice following in utero exposure to benzo[a]pyrene. J. Toxicol. Environ. Health, 6:569-576, 1980.
8. Urso, P. and Gengozian, N., Depressed humoral immunity and increased tumor incidence in mice exposed to benzo[a]pyrene and X-rays before or after birth. J. Toxicol. Environ. Health 10:817-835, 1982.
9. Urso, P. and Gengozian, N., Subnormal expression of cell-mediated and humoral immune responses in progeny disposed toward a high incidence of tumors after in utero exposure to benzo[a]pyrene. J. Toxicol. Environ. Health, 14: 569-584, 1984.
10. Urso, P. and Johnson, R.A., Early changes in T lymphocytes and subsets of mouse progeny defective as adults in controlling growth of a syngeneic tumor after in utero insult with benzo[a]pyrene. Immunopharmacology, 14:1-10, 1987.
11. Urso, P., Zhang, W., and Cobb, J.R., Immunological consequences from exposure to benzo[a]pyrene during pregnancy. Scand. J. Immunol. 36 (Suppl.11): 203-206, 1992.
12. Holladay, S.D. and Smith, B.J., Fetal hematopoietic alterations after maternal exposure to benzo[a]pyrene: a cytometric evaluation. J. Toxicol.Environ. Health, 42(3):259-273, 1994.
13. Lummus, Z.L. and Henningsen, G., Modulation of T-cell ontogeny by transplacental benzo[a]pyrene. Int. J. Immunopharm., 17(4):339-350, 1995.
14. Gelboin, H.V., Benzo[a]pyrene metabolism, activation, and carcinogencsis: role and regulation of mixed-function oxidases and related euzymes. Physiol. Rev. 60: 1107-1166, 1980.
15. Fowlkes, B.J. and Pardoll, D.M., Molecular and cellular events of T-cell development. Adv. Immunol. 44:207-264, 1989.
16. Davila, D.R., Romero, D.L., and Burchiel, S.W., Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by alpha-napthoflavone. Toxicol.Appl. Pharmacol. 139(2):333-341, 1996.
17. Romero, D.L., Mounho, B.J., Lauer, F.T., Born, J.L., and Burchiel, S.W., Depletion of glutathione by benzo[a]pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells. Toxicol. Appl. Pharmacol. 144: 62-69, 1997.
18. Lu, L.J.W, and Wang, M.Y. Modulation of benzo[a]pyrene-induced covalent DNA modifications in adult and fetal mouse tissues by gestation stage. Carcinogenesis, 11(8):1367-1372, 1990.
19. Lu, L.J.W., Anderson, L.M., Jones, A.B., Moskal, T.J., Salazar, J.J., Hokanson, J.A., and Rice, J.M., Persistence, gestation stage-dependent formation and interrelationship of benzo[a]pyrene-induced DNA adducts in mothers, placentae, fetuses of Erythrocebus patas monkeys. Carcinogenesis 14(9):1805-1813, 1993.
20. Hansen, C., Sorensen, L.D., Asmussen, I., and Autrup, H. Transplacental exposure to tobacco smoke in human-adduct formation in placenta and umbilical cord blood vessels. Teratogen. Carcinogen. Mutagen. 12:51-60, 1992.
21. Hansen, C., Asmussen, I., and Autrup, H. Detection of carcinogen-DNA adducts in human fetal tissues by the 32P-postlabeling procedure. Environ. Health Perspect. 99:229-231, 1993.
22. Juchau, M.R., Lee, Q.P., and Fantel, A.G. Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: Implications for embryotoxicity and teratogenesis. Drug Metab. Rev. 24: 195-238, 1992.
23. Joseph, P., Srinivasan, N.S., Byczkowski, J.Z., and Kulkarni, A.P., Bioactivation of benzo[a]pyrene-7,8-dihydrodiol catalyzed by lipoxygenase purified from human term placenta and conceptal tissues. Reprod. Toxicol. 8(4):307313, 1994.
24. Winn, L.M. and Wells, P.G., Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis. Free Radic. Biol. Med. 22(4):607-621, 1997.
25. Havran, W.L. and Allison, J.P., Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335:443-445, 1988.
26. Sanyal, M.K., Li, Y.L., Biggers, W.J., Satish, J., and Barnea, E.R., Augmentation of polynuclear aromatic hydrocarbon metabolism of human placental tissues of first-trimester pregnancy by cigarette smoke exposure. Am. J. Obstet. Gynecol. 168(5): 1587-1597, 1993.
27. Sanyal, M.K., Li, Y.L., and Belanger, K., Metabolism of polynuclear aromatic hydrocarbon in human term placenta influenced by cigarette smoke exposure. Reprod. Toxicol. 8(5): 411-418, 1994.
28. Krieger, J.A., Born, J.L., and Burchiel, S.W., Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 127: 268-274, 1994.
29. Krieger, J.A., Davila, D.R., Lytton, J., Born, J.L., and Burchiel, S.W., Inhibition of sarcoplasmic/endoplasmic reticulum calcium ATPases (SERCA) by polycyclic aromatic hydrocarbons in HPB-ALL human T cells and other tissues. Toxicol. Appl. Pharmacol. 133: 102-108, 1995.
30. Cai, J. And Jones, D.P. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome C Loss. J. Biol. Chem. 8: 11401-11404, 1998.
31. Ventura, S.J., Martin, J.A., Mathews, T.J., and Clarke, S.C. Advance Report of Final Natility Statistics, 1994: Monthly Vital Statistics Report: 44(11S), Hyattsville, M.D., National Center for Health Statistics, pp. 12-13, 1996.
32. U.S. Department of Health and Human Services. Tobacco Use Among U.S. Racial/Ethnic Minority Groups - African Americans, American Indians and Alaska Natives, Asian Americans and Pacific Islanders, and Hispanics: A Report of the Surgeon General. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1998.