Current concepts: Large granular lymphocyte leukemia

Blood Reviews

Volumn 13, Issue 4, 1999, Pages 230-240

  Lamy, T ^a   Loughran, T P ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; CD3 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DOXORUBICIN; EPITOPE; FAS ANTIGEN; FAS LIGAND; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; INTERLEUKIN 12; INTERLEUKIN 15; METHOTREXATE; PREDNISOLONE; PREDNISONE; PURINE DERIVATIVE; T LYMPHOCYTE RECEPTOR; VINCRISTINE;

ADULT; AGED; ANEMIA; APOPTOSIS; AUTOIMMUNE DISEASE; CANCER REGRESSION; CELL PROLIFERATION; CHILD; CLINICAL FEATURE; CYTOPENIA; DRUG TOXICITY; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOLOGY; LARGE GRANULAR LYMPHOCYTE; LYMPHATIC LEUKEMIA; LYMPHOCYTE CLONE; LYMPHOCYTOSIS; MULTIDRUG RESISTANCE; NATURAL KILLER CELL; NEUTROPENIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT INFECTION; REVIEW; RHEUMATOID ARTHRITIS; SEQUENCE HOMOLOGY; SEROLOGY; SPLENECTOMY; T CELL LEUKEMIA; T LYMPHOCYTE ACTIVATION; VIRUS ENVELOPE;

EID: 0033508739     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1054/blre.1999.0118     Document Type: Review

References (106)

1. Timonen T., Ortaldo J. R., Herberman R. B. Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med. 53:1981;569-582.
2. Lanier L. L., Phillips J. H., Hackett J. Jr, Tutt M., Kumar V. Natural killer cells: definition of a cell type rather than a function. J Immunol. 137:1986;2735-2739.
3. Mc Kenna R. W., Parkin J., Kersey J. H., Gajl-Peczalska K. J., Peterson L., Brunning R. D. Chronic lymphoproliferative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics. Am J Med. 62:1977;588-596.
4. Brouet J. C., Sasportes M., Flandrin G. Chronic lymphocytic leukemia of T cell origin: immunological and clinical evaluation in eleven patients. Lancet. 2:1975;890-893.
5. Dhodapkar M. V., Li C. Y., Lust J. A. Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance? Blood. 84:1994;1620-1627.
6. Semenzato G., Pandolfi F., Chiesesi T. The lymphoproliferative disease of granular lymphocytes. A heterogeneous disorder ranging from indolent to aggressive conditions. Cancer. 60:1987;2971-2978.
7. Oshimi K., Yamada O., Kanako T. Laboratory findings and clinical courses of 33 patients with large granular lymphocyte proliferative disorders. Leukemia. 7:1993;782-788.
8. Loughran T. P., Marshall E., Kadin M. E. Leukemia of large granular lymphocytes: Association with clonal chromosomal abnormalities and auto-immune neutropenia, thrombocytopenia and hemolytic anemia. Ann Intern Med. 102:1985;169-175.
9. Bennet J. M., Catovsky D., Daniel M. T. Proposals for the classification of chronic (mature) B and T lymphoid leukamias: French-American-British (FAB) cooperative group. J Clin Oncol. 42:1989;567-584.
10. Loughran T. P. Jr. Clonal diseases of large granular lymphocytes. Blood. 82:1993;1-4.
11. Harris N. L., Jaffe E. S., Stein H. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood. 84:1994;1361-1392.
12. Lamy T., Bauer F. A., Liu J. H. Pathological role of Fas Ligand in aggressive LGL leukemia. Blood, Abstract 930: 1998.
13. Loughran T. P., Starkebaum G., Kidd P., Neiman P. Clonal proliferation of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum. 31:1988;31-36.
14. Lamy T., Loughran T. P. Jr. Pathogenesis of autoimmune diseases in large granular lymphocyte leukemia. Hematology. 3:1998;17-29.
15. Freimark B., Lanier L., Phillips J. Comparison of T cell receptor gene rearrangements in patients with large granular T cell leukemia and Felty's syndrome. J Immunol. 138:1987;1724-1729.
16. Bowman S. J., Sivakumaran M., Snowden N. The large granular lymphocyte syndrome with rheumatoid arthritis, Immunogenetic evidence for a broader definition of Felty's syndrome. Arthritis Rheum. 37:1994;1326-1330.
17. Starkebaum G., Loughran T. P., Gaur L. K. Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum. 40:1997;624-626.
18. Hingorani R., Monteiro J., Pergolizzi R., Furie R., Chartsah E., Gregersen P. K. CDR3 length restriction of T-cell receptor β chains in CD8+ T-cells of rheumatoid arthritis patients. 1995;American New York of Academic Sciences. p. 179-182.
19. Der Simonian H., Sugita M., Glass D. N. Clonal Vα12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med. 177:1993;1623-1631.
20. Burns C. M., Tsai V., Zvaifler N. J. High percentage of CD8+, Leu7+ cells in rheumatoid arthritis synovial fluid. Arthritis Rheum. 35:1992;865-873.
21. Gonzales-Chambers R., Przepiorka D., Winkelstein A. Lymphocyte subsets associated with T cell receptor β-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia. Arthritis Rheum. 35:1992;516-520.
22. Wallis W. J., Loughran T. P. Jr, Kadin M. E. Polyarthritis and neutropenia associated with circulating large granular lymphocytes. Annals Intern Med. 103:1985;357-362.
23. Kuipers J. G., Jacobs R., Kemper A. TCRI+ large granular lymphocyte proliferation in rheumatoid arthritis. Rheumatology International. 14:1994;163-168.
24. Snowden N., Bhavnani M., Swinson D. R. Large granular T lymphocytes, neutropenia and polyarthropathy: an underdiagnosed syndrome? Q J Med. 78:1991;65-76.
25. Marlton P., Taylor K., Elliott S., McCormack J. Monoclonal large granular lymohocyte proliferation in SLE with HTLV-I seroreactivity. Australian New Zeland Journal of Medicine. 22:1997;54-55.
26. Sampalo L. A., Lopez-Gomez M., Jimenez-Alonso J. Proliferation of large granular lymphocytes in patients with systemic lupus erythematosus. Review of Clin Esp. 195:1995;373-379.
27. Sanchez B. J., Grana G. J., Cadorniga E. Sicca syndrome caused by large granular lymphocytes in rheumatoid arthritis. Med Clin (Barc). 93:1989;741-742.
28. Dhodapkar M. V., Lust J. A., Phyliky R. I. T-cell large granular lymphocytic leukemia and pure red cell aplasia in a patient with type I autoimmune polyendocrinopathy: response to immunosuppressive therapy. Mayo Clinic Proceeding. 69:1994;1085-1088.
29. Molitor J. L., Saint-Louis J., Louvet C., Vachon A., Vincent L., Beaulieu R. Large granular lymphocytic leukemia disclosed by bilateral uveitis: association with celiac disease. Revue de Médecine Interne. 18:1997;237-239.
30. Rodriguez A., Yood R. A., Condon T. J. Recurrent uveitis in a patient with adult onset cyclic neutropenia associated with increased large granular lymphocytes. Br J Ophtalmol. 81:1997;415.
31. Erslev A. J., Soltan A. Pure red-cell aplasia: a review. Blood Rev. 10:1996;20-28.
32. Charles R. J., Sabo K. M., Kidd P. G. The pathophysiology of pure red cell aplasia: implications for therapy. Blood. 87:1996;4831-1838.
33. Lacy M. Q., Kurtin P. J., Tefferi A. Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities. Blood. 87:1996;3000-3006.
34. Levitt L. J., Reyes G. R., Moonka D. K. Human T cell leukemia virus-Iassociated T-suppressor cell inhibition of erythropoiesis in a patient with pure red cell aplasia and chronic T gamma-lyphoproliferative disease. J Clin Invest. 81:1988;538-548.
35. Hoffman R., Kopel S., Hsu S. D. T cell chronic lymphocytic leukemia: presence in bone marrow and peripheral blood of cells that suppress erythropoesis in vitro. Blood. 52:1978;255-260.
36. Hara T., Mizuno Y., Nagata M. Human γδ T-cell receptor-positive cell-mediated inhibition of erythropoeisis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red cell aplasia. Blood. 75:1990;941-950.
37. Means R. J., Krantz S. B. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood. 80:1992;1639-1647.
38. Bassan R., Pronesti M., Buzzetti M. Autoimmunity and B-cell dysfunction in chronic proliferative disorders of large granular lymphocytes/natural killer cells. Cancer. 63:1989;90-95.
39. Loughran T. P. Jr, Starkebaum G. Large granular lymphocyte leukemia: report of 38 cases and review of the literature. Medicine. 66:1987;397-405.
40. Gentile T. C., Wener M. H., Starkebaum G. Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. Leuk Lymphoma. 23:1996;365-370.
41. Linch D. C., Newland A. C., Turnbull A. L. Unusual T cell proliferations and neutropenia in rheumatoid arthritis: comparison with classical Felty's syndrome. Scandinavian J Haematol. 33:1984;342-350.
42. Platanias L., Raefsky E., Youg N. Neutropenia associated with large granular lymphocytes responsive to corticosteroids in vitro and in vivo. European J Haematol. 38:1987;89-94.
43. Thommsen C., Nissen C., Gratwohl A., Tichelli A., Stern A. Agranulocytosis associated with T-gamma-lymphocytosis: no improvement of peripheral blood granulocyte count with human-recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF). British J Haematol. 71:1989;157-160.
44. Dale D. C., Hammond W. P. Cyclic neutropenia. Blood Rev. 2:1988;178-185.
45. Loughran T. P. Jr, Clark E. A., Price T. H. Adult onset cyclic neutropenia is associated with increased large granular lymphocytes. Blood. 68:1986;1082-1087.
46. Loughran T. P. Jr, Hammond W. P. Adult onset cyclic neutropenia is a benign neoplasm associated with clonal proliferation of large granular lymphocyte. J Exper Med. 164:1986;2089-2094.
47. Kouides P. A., Rowe J. M. Large granular lymphocyte leukemia presenting with both amegakaryocytic thrombocytopenic purpura and pure red cell aplasia. Am J Hematol. 49:1995;232-236.
48. Hanada T., Ishida T., Kojima H. 1992 Granular lymphocyte leukemia in association with multiple myeloma. British J Haematol. 80:1992;127-129.
49. Vie H., Chevalier S., Garand R. Clonal expansion of lymphocytes bearing the gamma delta T-cell receptor in a patient with large granular lymphocyte disorder. Blood. 74:1989;285-290.
50. Gorochov G., Debre P., Leblond V., Sadat-Sowti B., Sigaux F., Autran B. Oliglonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor β chain variability after bone marrow transplanation. Blood. 83:1994;587-595.
51. Dolstra H., Preijers F., Van de Wiehl-Van Kemenade E., Schattenberg A., Galama J., De Witte T. Expansion of CD8+ CD57+ T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus infection. British J Haematol. 90:1995;300-307.
52. Gentile T. C., Hadlock K. G., Uner A. H. Large granular lymphocyte leukaemia occurring after renal transplantation. British J Haematol. 101:1998;507-512.
53. Oshimi K., Shinkai Y., Okumura K. Perforin gene expression in granular lymphocyte proliferative disorders. Blood. 75:1990;704-708.
54. Scott C. S., Richards S. J. Classification of large granular lymphocyte (LGL) and NK-associated (Nka) disorders. Blood Rev. 6:1992;220-233.
55. Gentile T. C., Uner A. H., Hutchinson R. E. CD3+ CD56+ aggressive variant of large granular lymphocyte leukemia. Blood. 84:1994;2315-2321.
56. Morley J. K., Batliwalla F. M., Hinorani R., Gregersen P. K. Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset. J Immunol. 154:1995;6182-6190.
57. Posnett D. N., Sinha R., Kabak S., Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to benign monoclonal gammapathy. J Exper Med. 179:1994;609-618.
58. Davey M. P., Starkebaum G., Loughran T. P. Jr. CD3+ leukemic large granular lymphocytes utilize 1995; diverse T-cell receptor Vβ genes. Blood. 85:1995;146-150.
59. Zambello R., Trentin L., Facco M. Analysis of the T cell eceptor in the lymphoproliferative disease of granular lymphocytes: superantigen activation of clonal CD3+ granular lymphocytes. Cancer Res. 55:1995;6140-6145.
60. Kasten-Sportes C., Zaknoen S., Streis R. G., Chan W. C., Winton E. F., Waldmann T. A. T-cell receptor gene rearrangement in T-cell large granular leucocyte leukemia: preferential Vα but diverse Jα usage in one of five patients. Blood. 83:1994;767-775.
61. Hoshino S., Oshimi K., Teramura M. Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in patients with granular lymphocyte proliferative disorders. Blood. 78:1991;3232-3240.
62. Loughran T. P. Jr, Aprile J. A., Ruscetti F. W. Anti-CD3 monoclonal antibody-mediated cytotoxicity occurs through an interleukin-2 independent pathway in CD3+ large granular lymphocytes. Blood. 75:1990;935-940.
63. Persova R., Loughran T. P. Jr. Constitutive expression of Fas ligand in large granular lymphocytes leukaemia. British J Haematol. 97:1997;123-126.
64. Loughran T. P. Jr, Coyle T., Sherman M. P. Detection of human T-cell leukemia/lymphoma virus, Type II in a patient with LGL leukemia. Blood. 80:1992;1116-1119.
65. Loughran T. P. Jr, Sherman M. P., Ruscetti F. W. Prototypical HTLV-I/II infection is rare in LGL leukemia. Leuk Res. 18:1994;423-429.
66. Loughran T. P. Jr, Hadlock K. G., Yang Q. Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3- (NK) lymphoproliferative disease of granular lymphocytes. Blood. 90:1997;1977-1981.
67. Loughran T. P. Jr, Hadlock K. G., Perzova R. Epitope mapping of HTLV envelope seroreactivity in LGL leukemia. British J Haematol. 101:1998;318-324.
68. Gentile T., Loughran T. P. Jr. Interleukin-12 is a costimulatory cytokine for leukemic C. D3+ large granular lymphocytes. Cell Immunol. 66:1995;158-161.
69. Zambello R., Trentin L., Cassatella M. A. IL 12 is involved in the activation of CD3+ granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. British J Haematol. 92:1996;308-314.
70. Zambello R., Facco M., Trentin L. Interleukin-15 triggers the proliferation and cytoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood. 89:1997;20-211.
71. Dhein J., Walczak H., Baumier C. Autocrine T-cell suicide mediated by APO-1 (Fas/CD95). Nature. 373:1995;438-441.
72. Alderson M. R., Tough T. W., Davis-Smith T. Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exper Med. 181:1995;71-77.
73. Ortaldo J. R., Winkler-Pickett R. T., Nagata S. Fas involvement in human NK cell apoptosis: lack of a requirement for CD16-mediated events. J Leuco Biol. 61:1997;209-215.
74. Owen-Schaub L. B., Yonehara S., Crimp W. L. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol. 140:1992;197-205.
75. Nagata S., Goldstein O. The Fas death factor. Science. 267:1995;1449-1456.
76. Nagata, S. 1997, Apoptotis by death factor, Cell, 1997, 88, 355, 365.
77. Watanabe-Fukunaga R., Brannan C. I., Copeland N. G. Generalized lymphoproliferative disease in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 356:1992;314-317.
78. Takahashi T., Tanaka M., Brannan C. I. Generalized lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell. 76:1994;969-976.
79. Steinberg A. D. MRL-lpr/lpr disease: theories meet Fas. Semin Immunol. 6:1994;55-69.
80. Cohen P. L., Eisenbert R. A. The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane. Immunol Today. 13:1992;427-428.
81. Le Deist F., Emile J. F., Rieux-laucat F. Clinical, immunological, and pathological consequences of Fas-deficient conditions. Lancet. 348:1996;719-723.
82. Fisher G. H., Rosenberg F. J., Strauss S. E. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. 81:1995;935-946.
83. Drappa J., Vaishnaw A. K., Sullivan K. E. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med. 335:1996;1643-1649.
84. Sneller M. C., Wang J., Dale J. K. Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocytes apoptosis. Blood. 89:1997;1341-1348.
85. Dianzani U., Bragardo M., DiFranco D. Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation. Blood. 89:1997;2871-2879.
86. Lamy T., Liu J. H., Landowski T. Dysregulation of CD95/CD95 Ligand-apoptotic pathway in CD3+ LGL leukemia. Blood, in press. 1999.
87. Kneitz B., Hermann T., Yonehara S. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. European J Immunol. 25:1995;2572-2577.
88. Tanaka M., Suda T., Haze K. Fas ligand in human serum. Nat Med. 2:1996;317-322.
89. Maciejewski J., Selleri C., Anderson S. Fas antigen expression on CD34+ human marrow cells is induced by interferon γ and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood. 85:1995;3183-3190.
90. Takenaka K., Nagafuji K., Harada M. In vitro expansion of hematopoietic progenitor cells induces functional expression of Fas antigen (CD95). Blood. 88:1996;2871-2877.
91. Iwai K., Miyawaki T., Takizawa T. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood. 84:1994;1201-1208.
92. Pandolfi F., Loughran T. P., Starkebaum G. Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes. A multicenter study. Cancer. 65:1990;341-348.
93. Lamy T., Amiot L., Drenou B. Response to granulocyte-macrophage colony stimulating factor (GM-CSF) but not to G-CSF in a case of agranulocytosis with large granular lymphocyte leukemia. Blood. 84:1994;2164.
94. Gabor E. P., Mishalani S., Lee S. Rapid response to cyclosporine therapy and sustained remission in large granular lymphocyte leukemia. Blood. 87:1995;1199-1200.
95. Sood R., Stewart C. C., Aplan P. D., Murai H. Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. Blood. 91:1998;3372-3378.
96. Loughran T. P., Kidd P. G., Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood. 84:1994;2164-2170.
97. Yamada O., Mizoguchi H., Oshimi K. Cyclophosphamide therapy for pure cell aplasia associated with granular lymphocyte-proliferative disorders. British J Haematol. 97:1997;392-399.
98. Matrai Z., Lelkes G., Milosevits J., Paldine H. P., Pecze K. T-cell large granular lymphocytic leukemia associated with red cell aplasia, successfully treated with cyclophosphamide. Orv Hetil. 138:1997;2075-2080.
99. Gentile T. C., Wener M. H., Starkebaum G., Loughran T. P. Jr. Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. Leuk Lymph. 23:1996;365-370.
100. Takeuchi, M. Tamaoki, A. Soda, R. Takahashi, K. Spontaneous remission of large granular lymphocyte T-cell leukemia. Leukemia,in press.
101. Lamy T., Drenou D., Fardel O. Multidrug resistance analysis in lymphoproliferative disease of large granular lymphocytes. British J Haematol. 100:1998;509-815.
102. Rossof L. J., Genovese J., Coleman M., Dantzker D. R. Primary pulmonary hypertension in a patient with CD8/T-cell large granular lymphocyte. Chest. 112:1997;551-553.
103. Kawa-Ha K., Ishihara S., Ninomiya T. CD3- negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. J Clin Invest. 84:1989;51-55.
104. Tefferi A., Li C. Y., Witzig T. E. Chronic natural killer cell lymphocytosis: a descriptive clinical study. Blood. 84:1994;2721-2725.
105. Zambello R., Trentin L., Ciccone E. Phenotype diversity of natural killer (NK) populations in patients with NK-type lymphoproliferative disease of granular lymphocytes. Blood. 81:1993;2381-2385.
106. Zambello R., Loughran T. P. Jr, Trentin L. Serologic and molecular evidence for a possible pathogenetic role of viral infection in CD3-negative NK-type lymphoproliferative disease of granular lymphocytes. Leukemia. 9:1995;1207-1211.