The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors

Biochemistry

Volumn 46, Issue 5, 2007, Pages 1194-1204

  Zhang, Ran ^a,c   Wen, Xiaofei ^a   Militante, Julius ^a,g   Hester, Brent ^a,b   Rhubottom, Heather E ^c   Sun, Hongwei ^a,d   Leidenheimer, Nancy J ^e   Yan, Dong ^f   White, Michael M ^f   Machu, Tina K ^a,c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b Texas Department of Public Safety   (United States)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^f DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC HUMAN RECEPTORS; CURARE POTENCY; MOUSE RESIDUES; MUTANT RECEPTORS;

AMINO ACIDS; ELECTROPHYSIOLOGY; MICROELECTRODES; MUTAGENESIS; SUBSTITUTION REACTIONS;

PROTEINS;

CURARE; GLUTAMIC ACID; ISOLEUCINE; LYSINE; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; TUBOCURARINE CHLORIDE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; HUMAN; IC 50; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; VOLTAGE CLAMP; XENOPUS;

AMINO ACIDS; ANIMALS; BINDING SITES; ELECTROPHYSIOLOGY; HUMANS; INHIBITORY CONCENTRATION 50; MICE; NEUROMUSCULAR NONDEPOLARIZING AGENTS; OOCYTES; POINT MUTATION; RECEPTORS, SEROTONIN; SPECIES SPECIFICITY; TRANSDUCTION, GENETIC; TUBOCURARINE; XENOPUS;

EID: 33846786975     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0616100     Document Type: Article

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