Mapping residues in the ligand-binding domain of the 5-HT3 receptor onto d-tubocurarine structure

Molecular Pharmacology

Volumn 70, Issue 2, 2006, Pages 571-578

  Yan, Dong ^a   Meyer, Julia K ^a   White, Michael M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALANINE; AMINO ACID; ASPARAGINE; BINDING PROTEIN; GRANISETRON; PHENYLALANINE; SEROTONIN 3 RECEPTOR; TUBOCURARINE CHLORIDE; TYROSINE;

APLYSIA; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR MODEL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CELL LINE; HUMANS; LIGANDS; MODELS, MOLECULAR; RECEPTORS, SEROTONIN, 5-HT3; STRUCTURE-ACTIVITY RELATIONSHIP; TUBOCURARINE;

EID: 33746256432     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.024075     Document Type: Article

References (49)

1. Barlow R (1982) The ionization of morphine, hydroxyamphetamine and (+)-tubocurarine chloride and a new method for calculating zwitterion constants. Br J Pharmacol 75:503-512.
2. Bernard C and Pelouze J (1850) Recherches sur le curare. 31:533-537.
3. 3A/3B receptors. Neuropharmacology 41:282-284.
4. Brejc K, van Dijk W, Klaassen R, Schuurmans M, van der Oost J, Smit A, and Sixma T (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (Lond) 411:269-276.
5. 3H]granisetron-labelled 5-HT3 receptor in the human forebrain. Neuropharmacology 32:1325-1331.
6. Burley S and Petsko G (1985) Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science (Wash DC) 229:23-28.
7. Carter P, Winter G, Wilkinson A, and Fersht A (1984) The use of double mutants to detect structural changes in the active site of tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell 38:835-840.
8. Celie P, Kasheverov I, Mordvintsev D, Hogg R, van Nierop P, van Elk R, van Rossum-Fikkert S, Zhmak M, Bertrand D, Tsetlin V, et al. (2005) Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant. Nat Struct Mol Biol 12:582-588.
9. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
10. Connolly C and Wafford K (2004) The cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochem Soc Trans 32:529-534.
11. 3B subunit is a major determinant of serotonin receptor function. Nature (Lond) 397:359-363.
12. 3 receptors are membrane ion channels. Nature (Lond) 339:706-709.
13. 3B receptor subunit. J Biol Chem 274:30799-30810.
14. Gao F, Bren N, Litle A, Wang H-L, Hansen S, Talley T, Taylor P, and Sine S (2003) Curariform antagonists bind in different orientations to acetylcholine-binding protein. J Biol Chem 278:23020-23026.
15. Gasteiger J and Marsili M (1980) Iterative partial equalization of orbital electronegativity - a rapid access to atomic charges. Tetrahedron 36:3219-3228.
16. 3 receptors in rodents. J Neurochem 75:240-247.
17. Hansen S, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y (2005) Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO (Eur Mol Biol Organ) J 24:3635-3646.
18. + channel pore through mutant cycles with a peptide inhibitor. Science (Wash DC) 268:307-310.
19. 3A receptor subunits. Mol Pharmacol 55:1037-1043.
20. 3 receptor A subunit. Eur J Pharmacol 245:187-192.
21. Hope A, Peters J, Brown A, Lambert J, and Blackburn T (1996) Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. Br J Pharmacol 118:1237-1245.
22. Jenkinson D (1960) The antagonism between tubocurarine and substances which depolarize the motor end-plate. J Physiol (Lond) 152:309-324.
23. Karnovsky A, Gotow L, McKinley D, Piechan J, Ruble C, Mills C, Schellin K, Slightom J, Fitzgerald L, Benjamin C, et al. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene 319:137-148.
24. 3 receptors. Nature (Lond) 424:321-324.
25. Ku H (1966) Notes on the use of propagation of error formulas. J Res Nat Bur Standards C Eng Instrum 70C:263-273.
26. Lester H, Dibas M, Dahan D, Leite J, and Dougherty D (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-336.
27. 3 receptors in intact N1E-115 neuroblastoma cells. Eur J Pharmacol 189:223-227.
28. 3A receptor models. J Recept Signal Transduct Res 23:255-270.
29. Malany S, Osaka H, Sine S, and Taylor P (2000) Orientation of α-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor. Biochemistry 39:15388-15398.
30. 3 receptors synthesized in rat CNS and peripheral nervous system. J Neurosci 22:6732-6741.
31. Morris G, Goodsell D, RS H, Huey R, Hart W, Belew R, and Olson A (1998) Automated docking using Lamarckian genetic algorithm and an empirical free energy binding free energy function. J Comp Chem 19:1639-1662.
32. 3 receptors of the rat, mouse, and guinea-pig superior cervical ganglion may be different. Br J Pharmacol 102:615-620.
33. Osterberg F, Morris G, Sanner M, Olson A, and Goodsell D (2002) Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock. Prot Struct Func Genet 46:34-40.
34. Papineni R and Pedersen S (1997) Interaction of. d-tubocurarine with the mouse nicotinic acetylcholine receptor: ligand orientation at the binding site. J Biol Chem 272:24891-24898.
35. Pedersen S and Papineni R (1995) Interaction of d-tubocurarine analogs with the Torpedo nicotinic acetylcholine receptor. Methylation and stereoisomerization affect site-selective competitive binding and binding to the noncompetitive site. J Biol Chem 270:31141-31150.
36. 3 receptor-mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci Lett 110:107-112.
37. Pettersen E, Goddard T, Huang C, Couch G, Greenblatt D, Meng E, and Ferrin T (2004) UCSF Chimera: a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.
38. 3 receptor: a model ligand-gated ion channel. Mol Membr Biol 19:11-26.
39. 3 receptor agonist-binding residues using homology modeling. Biophys J 84:2338-2344.
40. Sali A and Blundell T (1993) Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
41. Smit A, Syed N, Schaap D, van Minnen J, Klumperman J, Kits KS, Lodder H, van der Schors R, van Elk R, Sorgedrager B, et al. (2001) A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature (Lond) 411:261-268.
42. 3R receptor binding site using modeling and radioligand binding. J Biol Chem 280:20476-20482.
43. Willcockson I, Hong A, Whisenant R, Edwards J, Wang H, Sarkar H, and Pedersen S (2002) Orientation of d-tubocurarine in the muscle nicotinic acetylcholine receptor-binding site. J Biol Chem 277:42249-42258.
44. 3 receptor. Neuropharmacology 37:251-257.
45. 3 receptor. J Biol Chem 274:5537-5541.
46. 3 receptors. Neuropharmacology 43:367-373.
47. 3 receptor. Mol Pharmacol 68:365-371.
48. 3 receptor channels in dissociated rat superior cervical ganglion neurons. J Physiol (Lond) 448:237-256.
49. Zamyatnin A (1984) Amino acid, peptide, and protein volume in solution. Annu Rev Biophys Bioeng 13:145-165.