Analysis of the ligand binding site of the 5-HT3 receptor using site directed mutagenesis: Importance of glutamate 106

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 637-647

  Boess, F G ^a,c   Steward, L J ^a   Steele, J A ^a   Liu, D ^a   Reid, J ^b   Glencorse, T A ^a,d   Martin, I L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 HT3 receptor; Ligand recognition; Mutagenesis

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 2 METHYLSEROTONIN; 3 (5 METHYL 1H IMIDAZOL 4 YL) 1 (1 METHYL 1H INDOL 3 YL) 1 PROPANONE; ALANINE; ASPARAGINE; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; GRANISETRON; ION CHANNEL; METOCLOPRAMIDE; MUTANT PROTEIN; NICOTINIC RECEPTOR; ONDANSETRON; RADIOLIGAND; RENZAPRIDE; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SELECTIVITY; ELECTROPHYSIOLOGY; EMBRYO; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MEMBRANE CURRENT; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGY; GLUTAMIC ACID; HUMANS; KIDNEY; LIGANDS; MICE; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 0030992581     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00044-0     Document Type: Article

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