Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B

Molecular Cancer

Volumn 5, Issue , 2006, Pages

  Chen, Jihong ^a   Ghazawi, Feras M ^a   Bakkar, Wafae ^a   Li, Qiao ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CASPASE 9; HISTONE DEACETYLASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B BETA; VALPROIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BUTYRATES; CASPASE 3; CASPASE 8; CASPASE 9; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSFECTION; TUMOR CELLS, CULTURED; VALPROIC ACID;

EUKARYOTA;

EID: 33846707942     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-5-71     Document Type: Article

References (51)

1. Janknecht R Hunter T Versatile molecular glue. Transcriptional control Curr Biol 1996 6 951-954 10.1016/S0960-9822(02)00636-X 8805328
2. Wong J Li Q Levi BZ Shi YB Wolffe AP Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor EMBO J 1997 16 7130-7145 1170314 9384590 10.1093/emboj/16.23.7130
3. Wolffe AP Histones, nucleosomes and the roles of chromatin structure in transcriptional control Biochem Soc Trans 1997 25 354-358 9191116
4. Li Q Wrange O Accessibility of a glucocorticoid response element in a nucleosome depends on its rotational positioning Mol Cell Biol 1995 15 4375-4384 230677 7623832
5. Li Q Wrange O Translational positioning of a nucleosomal glucocorticoid response element modulates glucocorticoid receptor affinity Genes Dev 1993 7 2471-2482 8253391
6. Li Q Imhof A Collingwood TN Urnov FD Wolffe AP p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption EMBO J 1999 18 5634-5652 1171631 10523307 10.1093/emboj/18.20.5634
7. Li Q Herrler M Landsberger N Kaludov N Ogryzko VV Nakatani Y Wolffe AP Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation- responsive transcription from the Xenopus hsp70 promoter in vivo EMBO J 1998 17 6300-6315 1170955 9799238 10.1093/emboj/17.21.6300
8. Li Q Sachs L Shi YB Wolffe AP Modification of Chromatin Structure by the Thyroid Hormone Receptor Trends Endocrinol Metab 1999 10 157-164 10.1016/ S1043-2760(98)00141-6 10322411
9. Kouzarides T Acetylation: A regulatory modification to rival phosphorylation? EMBO J 2000 19 1176-1179 305658 10716917 10.1093/emboj/ 19.6.1176
10. Jones PA Baylin SB The fundamental role of epigenetic events in cancer Nat Rev Genet 2002 3 415-428 10.1038/nrg962 12042769
11. Johannessen CU Johannessen SI Valproate: Past, present, and future CNS Drug Rev 2003 9 199-216 12847559
12. Louis M Rosato RR Brault L Osbild S Battaglia E Yang XH Grant S Bagrel D The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress Int J Oncol 2004 25 1701-1711 15547708
13. Phiel CJ Zhang F Huang EY Guenther MG Lazar MA Klein PS Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen J Biol Chem 2001 276 36734-36741 10.1074/jbc.M101287200 11473107
14. Riggs MG Whittaker RG Neumann JR Ingram VM n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells Nature 1977 268 462-464 10.1038/268462a0 268489
15. Johnstone RW Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer Nat Rev Drug Discov 2002 1 287-299 10.1038/nrd772 12120280
16. Richon VM Webb Y Merger R Sheppard T Jursic B Ngo L Civoli F Breslow R Rifkind RA Marks PA Second generation hybrid polar compounds are potent inducers of transformed cell differentiation Proc Natl Acad Sci U S A 1996 93 5705-5708 39124 8650156 10.1073/pnas.93.12.5705
17. Marks PA Jiang X Histone deacetylase inhibitors in programmed cell death and cancer therapy Cell Cycle 2005 4 549-551 15738652
18. Luo HR Hattori H Hossain MA Hester L Huang Y Lee-Kwon W Donowitz M Nagata E Snyder SH Akt as a mediator of cell death Proc Natl Acad Sci U S A 2003 100 11712-11717 208823 14504398 10.1073/pnas.1634990100
19. Vivanco I Sawyers CL The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2002 2 489-501 10.1038/nrc839 12094235
20. Testa JR Bellacosa A AKT plays a central role in tumorigenesis Proc Natl Acad Sci U S A 2001 98 10983-10985 58668 11572954 10.1073/pnas.211430998
21. Datta SR Brunet A Greenberg ME Cellular survival: A play in three Akts Genes Dev 1999 13 2905-2927 10.1101/gad.13.22.2905 10579998
22. DeFeo-Jones D Barnett SF Fu S Hancock PJ Haskell KM Leander KR McAvoy E Robinson RG Duggan ME Lindsley CW Zhao Z Huber HE Jones RE Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members Mol Cancer Ther 2005 4 271-279 10.1158/ 1535-7163.MCT-05-0193 15713898
23. Kaneko S Feldman RI Yu L Wu Z Gritsko T Shelley SA Nicosia SV Nobori T Cheng JQ Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter J Biol Chem 2002 277 23230-23235 10.1074/jbc.M201733200 11948187
24. Kandel ES Hay N The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB Exp Cell Res 1999 253 210-229 10.1006/ excr.1999.4690 10579924
25. Nicholson KM Anderson NG The protein kinase B/Akt signalling pathway in human malignancy Cell Signal 2002 14 381-395 10.1016/ S0898-6568(01)00271-6 11882383
26. Brazil DP Hemmings BA Ten years of protein kinase B signalling: A hard Akt to follow Trends Biochem Sci 2001 26 657-664 10.1016/ S0968-0004(01)01958-2 11701324
27. Khwaja A Rodriguez-Viciana P Wennstrom S Warne PH Downward J Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway EMBO J 1997 16 2783-2793 1169887 9184223 10.1093/emboj/16.10.2783
28. Kennedy SG Wagner AJ Conzen SD Jordan J Bellacosa A Tsichlis PN Hay N The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes Dev 1997 11 701-713 9087425
29. Kulik G Klippel A Weber MJ Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt Mol Cell Biol 1997 17 1595-1606 231885 9032287
30. Brunet A Bonni A Zigmond MJ Lin MZ Juo P Hu LS Anderson MJ Arden KC Blenis J Greenberg ME Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 1999 96 857-868 10.1016/ S0092-8674(00)80595-4 10102273
31. Ozes ON Mayo LD Gustin JA Pfeffer SR Pfeffer LM Donner DB NF-kappaB activation by tumour necrosis factor requires the Akt serine- threonine kinase Nature 1999 401 82-85 10.1038/43466 10485710
32. Romashkova JA Makarov SS NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling Nature 1999 401 86-90 10.1038/43474 10485711
33. Kane LP Shapiro VS Stokoe D Weiss A Induction of NF-kappaB by the Akt/ PKB kinase Curr Biol 1999 9 601-604 10.1016/S0960-9822(99)80265-6 10359702
34. Datta SR Dudek H Tao X Masters S Fu H Gotoh Y Greenberg ME Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery Cell 1997 91 231-241 10.1016/S0092-8674(00)80405-5 9346240
35. Zhou H Li XM Meinkoth J Pittman RN Akt regulates cell survival and apoptosis at a postmitochondrial level J Cell Biol 2000 151 483-494 10.1083/jcb.151.3.483 11062251
36. Cardone MH Roy N Stennicke HR Salvesen GS Franke TF Stanbridge E Frisch S Reed JC Regulation of cell death protease caspase-9 by phosphorylation Science 1998 282 1318-1321 10.1126/science.282.5392.1318 9812896
37. Kennedy SG Kandel ES Cross TK Hay N Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria Mol Cell Biol 1999 19 5800-5810 84429 10409766
38. Chen J Halappanavar SS St-Germain JR Tsang BK Li Q Role of Akt/protein kinase B in the activity of transcriptional coactivator p300 Cell Mol Life Sci 2004 61 1675-1683 10.1007/s00018-004-4103-9 15224190
39. Huang WC Chen CC Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity Mol Cell Biol 2005 25 6592-6602 1190347 16024795 10.1128/MCB.25.15.6592-6602.2005
40. Masters JR HeLa cells 50 years on: The good, the bad and the ugly Nat Rev Cancer 2002 2 315-319 10.1038/nrc775 12001993
41. Chen J St-Germain JR Li Q B56 Regulatory Subunit of Protein Phosphatase 2A Mediates Valproic Acid-Induced p300 Degradation Mol Cell Biol 2005 25 525-532 543421 15632055 10.1128/MCB.25.2.525-532.2005
42. Rosato RR Almenara JA Dai Y Grant S Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells Mol Cancer Ther 2003 2 1273-1284 14707268
43. Komata T Kanzawa T Nashimoto T Aoki H Endo S Kon T Takahashi H Kondo S Tanaka R Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells Int J Oncol 2005 26 1345-1352 15809727
44. Rahmani M Reese E Dai Y Bauer C Payne SG Dent P Spiegel S Grant S Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species Cancer Res 2005 65 2422-2432 10.1158/ 0008-5472.CAN-04-2440 15781658
45. Friedl F Kimura I Osato T Ito Y Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology Proc Soc Exp Biol Med 1970 135 543-545 5529598
46. Gui CY Ngo L Xu WS Richon VM Marks PA Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1 Proc Natl Acad Sci U S A 2004 101 1241-1246 337037 14734806 10.1073/pnas.0307708100
47. Nebbioso A Clarke N Voltz E Germain E Ambrosino C Bontempo P Alvarez R Schiavone EM Ferrara F Bresciani F Weisz A de Lera AR Gronemeyer H Altucci L Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells Nat Med 2005 11 77-84 10.1038/ nm1161 15619633
48. Marks PA Miller T Richon VM Histone deacetylases Curr Opin Pharmacol 2003 3 344-351 10.1016/S1471-4892(03)00084-5 12901942
49. Chen CS Weng SC Tseng PH Lin HP Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes J Biol Chem 2005 280 38879-38887 10.1074/ jbc.M505733200 16186112
50. Nimmanapalli R Fuino L Stobaugh C Richon V Bhalla K Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells Blood 2003 101 3236-3239 10.1182/blood-2002-08-2675 12446442
51. Insinga A Monestiroli S Ronzoni S Gelmetti V Marchesi F Viale A Altucci L Nervi C Minucci S Pelicci PG Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway Nat Med 2005 11 71-76 10.1038/nm1160 15619634