Label-free immunodetection with CMOS-compatible semiconducting nanowires

Nature

Volumn 445, Issue 7127, 2007, Pages 519-522

  Stern, Eric ^a   Klemic, James F ^a   Routenberg, David A ^a   Wyrembak, Pauline N ^b   Turner Evans, Daniel B ^a   Hamilton, Andrew D ^b   LaVan, David A ^a   Fahmy, Tarek M ^a   Reed, Mark A ^a  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; NANOWIRE;

ANTIBODY; IMMUNE RESPONSE; IMMUNITY; IMMUNOASSAY; MICROORGANISM; MODEL; NANOTECHNOLOGY; PATHOGEN; SEMICONDUCTOR INDUSTRY;

ANTIGEN BINDING; ARTICLE; CELLULAR IMMUNITY; DIAGNOSTIC PROCEDURE; IMMUNODETECTION; INFORMATION SYSTEM; MONITORING; PRIORITY JOURNAL; SEMICONDUCTOR; SENSOR; SIGNAL PROCESSING; TECHNOLOGY;

EID: 33846695595     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05498     Document Type: Article

References (30)

1. Lim, D. V., Simpson, J. M., Kearns, E. A. & Kramer, M. F. Current and developing technologies for monitoring agents of bioterrorism and biowarfare. Clin. Microbiol. Rev. 18, 583-607 (2005).
2. Madou, M. J. & Cubicciotti, R. Scaling issues in chemical and biological sensors. Proc. IEEE 91, 830-838 (2003).
3. Cui, Y., Wei, Q., Park, H. & Lieber, C. M. Nanowire nanosensors for highly sensitivie and selective detection of biological and chemical species. Science 293, 1289-1292 (2001).
4. Wang, W. U., Chen, C., Lin, K.-h., Fang, Y. & Lieber, C. M. Label-free detection of small-molecule-protein interactions by using nanowire nanosensors. Proc. Natl Acad. Sci. USA 102, 3208-3212 (2005).
5. 3 nanowires and carbon nanotubes to low-density lipoprotein chemical gating. Appl. Phys. Lett. 86, 103903 (2005).
6. Zheng, G., Patolsky, F., Cui, Y., Wang, W. U. & Lieber, C. M. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nature Biotechnol. 23, 1294-1301 (2005).
7. Hahm, J.-i. & Lieber, C. M. Direct ultrasensitivie electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 4, 51-54 (2004).
8. Patolsky, F. et al. Electrical detection of single viruses. Proc. Natl Acad. Sci. USA 101, 14017-14022 (2004).
9. Cheng, M. M.-C. et al. Nanotechnologies for biomolecular detection and medical diagnostics. Curr. Opin. Chem. Biol. 10, 11-19 (2006).
10. Li, Z. et al. Sequence-specific label-free DNA sensors based on silicon nanowires. Nano Lett. 4, 245-247 (2004).
11. Chen, R. J. et al. An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. J. Am. Chem. Soc. 126, 1563-1568 (2004).
12. Huang, Y., Duan, X., Wei, Q. & Lieber, C. M. Directed assembly of one-dimensional nanostructures into functional networks. Science 291, 630-633 (2001).
13. Evoy, S. et al. Dielectrophoretic assembly and integration of nanowire devices with functional CMOS operating circuitry. Microelect. Eng. 75, 31-42 (2004).
14. Englander, O., Christensen, D., Kim, J., Lin, L. & Morris, S. J. S. Electric-field assisted growth and self-assembly of intrinsic silicon nanowires. Nano Lett. 5, 705-708 (2005).
15. Elibol, O. H., Morisette, D., Akin, D., Denton, J. P. & Bashir, R. Integrated nanoscale silicon sensors using top-down fabrication. Appl. Phys. Lett. 83, 4613-4615 (2003).
16. Clement, N. et al. Electronic transport properties of single-crystal silicon nanowires fabricated using an atomic force microscope. Physica E 13, 999-1002 (2002).
17. Wang, D., Sheriff, B. A. & Heath, J. R. Silicon p-FETs from ultrahigh density nanowire arrays. Nano Lett. 6, 1096-1100 (2006).
18. Liu, Y., Ishii, K., Tsutsumi, T., Masahara, M. & Suzuki, E. Ideal rectangular cross-section Si-fin channel double-gate MOSFETs fabricated using orientation-dependent wet etching. IEEE Elect. Dev. Lett. 24, 484-486 (2003).
19. Saitoh, M., Murakami, T. & Hiramoto, T. Large Coulomb blockade oscillations at room temperature in ultranarrow wire channel MOSFETs formed by slight oxidation process. IEEE Trans. Nanotech. 2, 241-245 (2003).
20. Tabata, O., Asahi, R., Funabashi, H., Shimaoka, K. & Sugiyama, S. Anisotropic etching of silicon in TMAH solutions. Sensors Actuators A 34, 51-57 (1992).
21. Bunimovich, Y. L. et al. Electrochemically programmed, spatially selective biofunctionalization of silicon wires. Langmuir 20, 10630-10638 (2004).
22. Sze, S. M. Physics of Semiconductor Devices 2nd edn 849 (John Wiley & Sons, New York, 1981).
23. Sun, S. C. & Plummer, J. D. Electron mobility in inversion and accumulation layers on thermally oxidized silicon surfaces. IEEE J. Solid-State Circuits 15, 562-573 (1980).
24. Sheehan, P. E. & Whitman, L. J. Detection limits for nanoscale biosensors. Nano Lett. 5, 803-807 (2005).
25. Laws, G. M. et al. Molecular control of the drain current in a buried channel MOSFET. Phys. Status Solidi B 233, 83-89 (2002).
26. Trautmann, A. Microclusters initiate and sustain T cell signaling. Nature Immunol. 6, 1213-1214 (2005).
27. Beeson, C. et al. Early biochemical signals arise from low affinity TCR-ligand reaction at the cell-cell interface. J. Exp. Med. 184, 777-782 (1996).
28. Strother, T., Hamers, R. J. & Smith, L. M. Covalent attachment of oligodeoxyribonucleotides to amine-modified Si (001) surfaces. Nucleic Acids Res. 28, 3535-3541 (2000).
29. Israelachvili, J. N. Intermolecular and Surface Forces with Applications to Colloidal and Biological Systems Ch. 12 (Academic Press, New York, 1985).
30. Hermanson, G. T. Bioconjugate Techniques Ch. 1-3, 5, 7 8 (Elsevier Science & Technology Books, New York, 1996).