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Volumn 5, Issue 4, 2005, Pages 803-807

Detection limits for nanoscale biosensors

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULAR ASSAYS; BIOMOLECULAR SENSORS; DETECTION LIMITS; FEMTOMOLAR (FM) CONCENTRATIONS;

EID: 18144396893     PISSN: 15306984     EISSN: None     Source Type: Journal    
DOI: 10.1021/nl050298x     Document Type: Article
Times cited : (560)

References (35)
  • 13
    • 0030134729 scopus 로고    scopus 로고
    • Zhang, W.; Stone, H. A.; Sherwood, J. D. J. Phys. Chem. 1996, 100, 9462-9464. Note that the stated characteristic flow rate, U, is incorrectly equated to Q/6hw. The correct value is 6 Q/hw.
    • (1996) J. Phys. Chem. , vol.100 , pp. 9462-9464
    • Zhang, W.1    Stone, H.A.2    Sherwood, J.D.3
  • 15
    • 18144395422 scopus 로고    scopus 로고
    • note
    • We focus on biomolecule detection in solution because it is much more challenging than gaseous chemical detection. First, diffusion of molecules in solution is several orders of magnitude slower than through a gas, and consequently mass transport is slower. Second, the desired detection limits for biological species (<0.1 pM) are typically much lower than for gases (1 ppb∼50 pM).
  • 20
    • 18144431715 scopus 로고    scopus 로고
    • note
    • Strictly speaking, the accumulation used here is the average expected accumulation. For a given experiment, the accumulation of a few molecules will be described by Poisson statistics and will display the large relative variances associated with those statistics.
  • 25
    • 18144423999 scopus 로고    scopus 로고
    • note
    • Interestingly, this enhancement may have been overlooked in the explanation of the rings seen when DNA arrays are exposed to a static sample solution. The rings are often attributed to the "coffee stain effect" occurring during spotting, which would result in an uneven distribution of probe DNA.; however, in a static solution, a ring is the expected result.
  • 30
    • 18144402383 scopus 로고    scopus 로고
    • U.S. Patent 6, 676, 904
    • Lee, G. U.; Yanavich, C. U.S. Patent 6, 676, 904, 2004.
    • (2004)
    • Lee, G.U.1    Yanavich, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.