Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 178, Issue 3, 2007, Pages 1791-1799

  Ochoa Repáraz, Javier ^a   Riccardi, Carol ^a   Rynda, Agnieszka ^a   Jun, SangMu ^a   Callis, Gayle ^a   Pascual, David W ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BACTERIAL ANTIGEN; COLONIZATION FACTOR ANTIGEN I; INTERLEUKIN 10; MYELIN; SALMONELLA COLONIZATION FACTOR ANTIGEN I VACCINE; SALMONELLOSIS VACCINE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADOLESCENT; ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SWISS JAMES LAMBERT MOUSE; TH2 CELL; VACCINATION;

EID: 33846527540     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.3.1791     Document Type: Article

References (60)

1. Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747.
2. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85: 299-302.
3. Zeine, R., D. Heath, and T. Owens. 1993. Enhanced response to antigen within lymph nodes of SJL/J mice that were protected against experimental allergic encephalomyelitis by T cell vaccination. J. Neuroimmunol. 44: 85-94.
4. Shaw, M. K., C. Kim, H. W. Hao, F. Chen, and H. Y. Tse. 1996. Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor Vβ gene segment usage. J. Neurosci. Res. 45: 690-699.
5. Greer, J. M., R. A. Sobel, A. Sette, S. Southwood, M. B. Lees, and V. K. Kuchroo. 1996. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J. Immunol. 156: 371-379.
6. Encinas, J. A., M. B. Lees, R. A. Sobel, C. Symonowicz, J. M. Greer, C. L. Shovlin, H. L. Weiner, C. E. Seidman, J. G. Seidman, and V. K. Kuchroo. 1996. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J. Immunol. 157: 2186-2192.
7. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1989. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142: 1523-1527.
8. b mice: fine specificity and TCRV β expression of encephalitogenic T cells. Eur. J. Immunol. 25: 1951-1959.
9. Adelmann, M., J. Wood, I. Benzel, P. Fiori, H. Lassmann, J. M. Matthieu, M. V. Gardinier, K. Dornmair, and C. Linington. 1995. The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat. J. Neuroimmunol. 63: 17-27.
10. Linington, C., T. Berger, L. Perry, S. Weerth, D. Hinze-Selch, Y. Zhang, H. C. Lu, H. Lassmann, and H. Wekerle. 1993. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol 23: 1364-1372.
11. Juedes, A. E., P. Hjelmstrom, C. M. Bergman, A. L. Neild, and N. H. Ruddle. 2000. Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J. Immunol. 164: 419-426.
12. Karpus, W. J., and R. M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161: 2667-2671.
13. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
14. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184: 387-396.
15. + T cells. J. Immunol 173: 6526-6531.
16. + regulatory T cells. Arthritis Rheum. 52: 2212-2221.
17. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169: 4712-4716.
18. + regulatory cells within the central nervous system. J. Immunol. 175: 3025-3032.
19. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
20. + T regulatory cells. Nat. Immunol. 4: 337-342.
21. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101: 15434-15439.
22. Yu, P., R. K. Gregg, J. J. Bell, J. S. Ellis, R. Divekar, H. H. Lee, R. Jain, H. Waldner, J. C. Hardaway, M. Collins, et al. 2005. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen. J. Immunol. 174: 6772-6780.
23. + regulatory T cells. Int. Immunol. 16: 249-256.
24. + T cells by regulatory T cells during persistent retroviral infection. Immunity 20: 293-303.
25. + T cell function by friend virus-induced regulatory T cells. J. Immunol. 176: 3342-3349.
26. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3: 253-257.
27. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 184: 349-356.
28. Jun, S., W. Gilmore, G. Callis, A. Rynda, A. Haddad, and D. W. Pascual. 2005. A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine. J. Immunol. 175: 6733-6740.
29. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S.S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80: 707-718.
30. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161: 3299-3306.
31. Young, D. A., L. D. Lowe, S. S. Booth, M. J. Whitters, L. Nicholson, V. K. Kuchroo, and M. Collins. 2000. IL-4, IL-10, IL-13, and TGF-β from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J. Immunol. 164: 3563-3572.
32. Pascual, D. W., D. M. Hone, S. Hall, F. W. van Ginkel, M. Yamamoto, N. Walters, K. Fujihashi, R. J. Powell, S. Wu, J. L. VanCott, et al. 1999. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect. Immun. 67: 6249-6256.
33. St. Louis, J., S. Uniyal, E. Chan, B. Singh, B. M. Chan, and G. H. Strejan. 2001. Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides. J. Neuroimmunol. 115: 79-90.
34. Carson, M. J., J. G. Sutcliffe, and I. L. Campbell. 1999. Microglia stimulate naive T cell differentiation without stimulating T cell proliferation. J. Neurosci. Res. 55: 127-134.
35. Carson, M. J. 2002. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40: 218-231.
36. Juedes, A. E., and N. H. Ruddle. 2001. Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis. J. Immunol. 166: 5168-5175.
37. Ponomarev, E. D., L. P. Shriver, K. Maresz, and B. N. Dittel. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81: 374-389.
38. + T regulatory cells. J. Immunol. 176: 3301-3305.
39. Uyttenhove, C., and J. Van Snick. 2006. Development of an anti-IL17A autovaccine that prevents experimental auto-immune encephalomyelitis. Eur. J. Immunol 36: 2857-2867.
40. Rohn, T. A., G. T. Jennings, M. Hernandez, P. Grest, M. Beck, Y. Zou, M. Kopf, and M. F. Bachmann. 2006. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 36: 2857-2867.
41. Batten, M., J. Li, S. Yi, N. M. Kljavin, D. M. Danilenko, S. Lucas, J. Lee, F. J. de Sauvage, and N. Ghilardi. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7: 929-936.
42. Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role of interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691.
43. Komiyama, Y., S. Nakae, T. Matsuki, A. Nambu, H. Ishgame, S. Kakuta, K. Sudo, and Y. Iwakura. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177: 566-573.
44. Hofstetter, H. H., S. M. Ibrahim, D. Koczan, N. Kruse, A. Weishaupt, K. V. Toyka, and R. Gold. 2005. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237: 123-130.
45. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian, and C. Dong. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6: 1069-1070.
46. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688.
47. Mekala, D. J., R. S. Alli, and T. L. Geiger. 2005. IL-10-dependent suppression of experimental allergic encephalomyelitis by Th2-differentiated, anti-TCR redirected T lymphocytes. J. Immunol 174: 3789-3797.
48. + T lymphocytes. Proc. Natl Acad. Sci. USA 102: 11817-11822.
49. + T cells. Int. Immunol. 18: 495-503.
50. Faria, A. M., and H. L. Weiner. 2005. Oral tolerance. Immunol. Rev. 206: 232-259.
51. + regulatory T cells and TGF-β in oral tolerance. J. Leukocyte Biol. 77: 906-913.
52. + regulatory T cells is antigen-specific and requires IL-10 and TGF-β. J. Immunol. 175: 4283-4291.
53. Neurath, M. F., I. Fuss, B. L. Kelsall, D. H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183: 2605-2616.
54. + regulatory T cells. J. Exp. Med. 201: 1061-1067.
55. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
56. + precursors. J. Immunol. 175: 6107-6116.
57. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99: 3493-3499.
58. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
59. + regulatory T cells. J. Immunol. 172: 5986-5993.
60. Marshall, E. 2006. Violent reaction to monoclonal antibody therapy remains a mystery. Science 311: 1688-1689.