Therapy insight: Is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?

Nature Clinical Practice Endocrinology and Metabolism

Volumn 3, Issue 2, 2007, Pages 168-179

  De Kloet, E Ronald ^a,b   DeRijk, Roel H ^a   Meijer, Onno C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Brain; Depression; Glucocorticoids; Mineralocorticoids; Stress

Indexed keywords

ANTIDEPRESSANT AGENT; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; ENDOCANNABINOID; FK 506 BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; HYDROCORTISONE; KETOCONAZOLE; METYRAPONE; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; NEUROKININ DERIVATIVE; NEUROPEPTIDE; NEUROTROPHIC FACTOR; SPIRONOLACTONE; VASOPRESSIN ANTAGONIST;

CLINICAL TRIAL; COGNITIVE DEFECT; DEPRESSION; DISEASE PREDISPOSITION; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; FEAR; GENETIC SUSCEPTIBILITY; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; MENTAL DISEASE; NEUROENDOCRINE DISEASE; NONHUMAN; PERSONAL EXPERIENCE; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; UNSPECIFIED SIDE EFFECT;

DEPRESSIVE DISORDER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; VARIATION (GENETICS);

EID: 33846463782     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0403     Document Type: Review

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