메뉴 건너뛰기




Volumn 47, Issue 1, 2007, Pages 1-14

Genetic insights into the pathobiology of age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; COMPLEMENT FACTOR H; CX3C CHEMOKINE; FIBULIN 5; HLA B ANTIGEN; IMATINIB;

EID: 33846424317     PISSN: 00208167     EISSN: None     Source Type: Journal    
DOI: 10.1097/IIO.0b013e31802bd3e6     Document Type: Review
Times cited : (17)

References (78)
  • 2
    • 0002279574 scopus 로고
    • Peculiar condition of choroiditis occurring in several members of the same family
    • Doyne RW. Peculiar condition of choroiditis occurring in several members of the same family. Trans Ophthalmol Soc UK. 1899;19:71-74.
    • (1899) Trans Ophthalmol Soc UK , vol.19 , pp. 71-74
    • Doyne, R.W.1
  • 3
    • 0015816276 scopus 로고
    • Drusen and disciform macular detachment and degeneration
    • Gass J. Drusen and disciform macular detachment and degeneration. Arch Ophthalmol. 1973;90:206-217.
    • (1973) Arch Ophthalmol , vol.90 , pp. 206-217
    • Gass, J.1
  • 4
    • 0028244159 scopus 로고
    • Heredity and age-related macular degeneration. Observations in monozygotic twins
    • Klein M, Mauldin W, Stoumbos V. Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch Ophthalmol. 1994;112:932-937.
    • (1994) Arch Ophthalmol , vol.112 , pp. 932-937
    • Klein, M.1    Mauldin, W.2    Stoumbos, V.3
  • 5
    • 0032438352 scopus 로고    scopus 로고
    • Genetic risk of age-related maculopathy: Population-based familial aggregation study
    • Klaver CCW, Wolfs RCW, Assink JJM, et al. Genetic risk of age-related maculopathy: population-based familial aggregation study. Arch Ophthalmol. 1998;116:1646-1651.
    • (1998) Arch Ophthalmol , vol.116 , pp. 1646-1651
    • Klaver, C.C.W.1    Wolfs, R.C.W.2    Assink, J.J.M.3
  • 6
    • 0035032662 scopus 로고    scopus 로고
    • Gene therapy restores vision in a canine model of childhood blindness
    • Acland GM, Aguirre GD, Ray J, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genetics. 2001;28:92-95.
    • (2001) Nat Genetics , vol.28 , pp. 92-95
    • Acland, G.M.1    Aguirre, G.D.2    Ray, J.3
  • 7
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 8
    • 0028097367 scopus 로고
    • Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
    • Weber B, Vogt G, Pruett R, et al. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genetics. 1994;8:352-356.
    • (1994) Nat Genetics , vol.8 , pp. 352-356
    • Weber, B.1    Vogt, G.2    Pruett, R.3
  • 9
    • 0028804575 scopus 로고
    • A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration
    • Gorin MB, Jackson KE, Ferrell RE, et al. A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. Ophthalmology. 1995;102:246-255.
    • (1995) Ophthalmology , vol.102 , pp. 246-255
    • Gorin, M.B.1    Jackson, K.E.2    Ferrell, R.E.3
  • 10
    • 0031037951 scopus 로고    scopus 로고
    • A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
    • Allikmets R, Singh N, Sun H, et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genetics. 1997;15:236-246.
    • (1997) Nat Genetics , vol.15 , pp. 236-246
    • Allikmets, R.1    Singh, N.2    Sun, H.3
  • 11
    • 0033027071 scopus 로고    scopus 로고
    • A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy
    • Stone E, Lotery A, Munier F, et al. A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genetics. 1999;22:199-202.
    • (1999) Nat Genetics , vol.22 , pp. 199-202
    • Stone, E.1    Lotery, A.2    Munier, F.3
  • 12
    • 0035168415 scopus 로고    scopus 로고
    • A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
    • Zhang K, Kniazeva M, Han M, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genetics. 2001;27:89-93.
    • (2001) Nat Genetics , vol.27 , pp. 89-93
    • Zhang, K.1    Kniazeva, M.2    Han, M.3
  • 13
    • 0035475141 scopus 로고    scopus 로고
    • Molecular genetics of age-related macular degeneration
    • Stone E, Sheffield V, Hageman G. Molecular genetics of age-related macular degeneration. Hum Mol Genetics. 2001;10:2285-2292.
    • (2001) Hum Mol Genetics , vol.10 , pp. 2285-2292
    • Stone, E.1    Sheffield, V.2    Hageman, G.3
  • 14
    • 0042786559 scopus 로고    scopus 로고
    • Genetics of macular dystrophies and implications for age-related macular degeneration
    • Klaver CC, Allikmets R. Genetics of macular dystrophies and implications for age-related macular degeneration. Dev Ophthalmol. 2003;37:155-169.
    • (2003) Dev Ophthalmol , vol.37 , pp. 155-169
    • Klaver, C.C.1    Allikmets, R.2
  • 15
    • 0033538438 scopus 로고    scopus 로고
    • Insights into the function of rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
    • Weng J, Mata N, Azarian S, et al. Insights into the function of rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell. 1999;98:13-23.
    • (1999) Cell , vol.98 , pp. 13-23
    • Weng, J.1    Mata, N.2    Azarian, S.3
  • 16
    • 0035510172 scopus 로고    scopus 로고
    • Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration
    • Shroyer NF, Lewis RA, Yatsenko AN, et al. Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. Hum Mol Genetics. 2001;10:2671-2678.
    • (2001) Hum Mol Genetics , vol.10 , pp. 2671-2678
    • Shroyer, N.F.1    Lewis, R.A.2    Yatsenko, A.N.3
  • 17
    • 0033859128 scopus 로고    scopus 로고
    • Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium
    • Allikmets R. Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genetics. 2000;67:487-491.
    • (2000) Am J Hum Genetics , vol.67 , pp. 487-491
    • Allikmets, R.1
  • 18
    • 0031795853 scopus 로고    scopus 로고
    • Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration
    • Stone EM, Webster AR, Vandenburgh K, et al. Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration. Nat Genetics. 1998;20:328-329.
    • (1998) Nat Genetics , vol.20 , pp. 328-329
    • Stone, E.M.1    Webster, A.R.2    Vandenburgh, K.3
  • 19
    • 12944255842 scopus 로고    scopus 로고
    • Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration
    • De La Paz M, Guy V, Abou-Donia S, et al. Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration. Ophthalmology. 1999;106:1531-1536.
    • (1999) Ophthalmology , vol.106 , pp. 1531-1536
    • De La Paz, M.1    Guy, V.2    Abou-Donia, S.3
  • 20
    • 0033804333 scopus 로고    scopus 로고
    • A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration
    • Rivera A, White K, Stohr H, et al. A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am J Hum Genetics. 2000;67:800-813.
    • (2000) Am J Hum Genetics , vol.67 , pp. 800-813
    • Rivera, A.1    White, K.2    Stohr, H.3
  • 21
    • 0035650545 scopus 로고    scopus 로고
    • Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene
    • Bernstein PS, Tammur J, Singh N, et al. Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene. Invest Ophthalmol Vis Sci. 2001;42:3331-3336.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 3331-3336
    • Bernstein, P.S.1    Tammur, J.2    Singh, N.3
  • 22
    • 2342532489 scopus 로고    scopus 로고
    • Expression of wild type and mutant ELOVL4 in cell culture: Subcellular localization and cell viability
    • Karan G, Yang Z, Zhang K. Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability. Mol Vis. 2004;10:248-253.
    • (2004) Mol Vis , vol.10 , pp. 248-253
    • Karan, G.1    Yang, Z.2    Zhang, K.3
  • 23
    • 23944475451 scopus 로고    scopus 로고
    • Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy
    • Conley YP, Thalamuthu A, Jakobsdottir J, et al. Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy. Hum Mol Genetics. 2005;14:1991-2002.
    • (2005) Hum Mol Genetics , vol.14 , pp. 1991-2002
    • Conley, Y.P.1    Thalamuthu, A.2    Jakobsdottir, J.3
  • 24
    • 3242719404 scopus 로고    scopus 로고
    • Missense variations in the fibulin 5 gene and age-related macular degeneration
    • Stone E, Braun T, Russell S, et al. Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med. 2004;351:346-353.
    • (2004) N Engl J Med , vol.351 , pp. 346-353
    • Stone, E.1    Braun, T.2    Russell, S.3
  • 25
    • 0348013124 scopus 로고    scopus 로고
    • Analysis of the ARMD1 locus: Evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family
    • Schultz D, Klein M, Humpert A, et al. Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genetics. 2003;12:3315-3323.
    • (2003) Hum Mol Genetics , vol.12 , pp. 3315-3323
    • Schultz, D.1    Klein, M.2    Humpert, A.3
  • 26
    • 18344391007 scopus 로고    scopus 로고
    • Evaluation of the ELOVL4 gene in patients with age-related macular degeneration
    • Ayyagari R, Zhang K, Hutchinson A, et al. Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Ophthalmic Genetics. 2001;22:233-239.
    • (2001) Ophthalmic Genetics , vol.22 , pp. 233-239
    • Ayyagari, R.1    Zhang, K.2    Hutchinson, A.3
  • 27
    • 0030962268 scopus 로고    scopus 로고
    • Exclusion of TIMP3 as a candidate locus in age-related macular degeneration
    • DeLaPaz MA, Pericak-Vance MA, Lennon F, et al. Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1997;38:1060-1065.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 1060-1065
    • DeLaPaz, M.A.1    Pericak-Vance, M.A.2    Lennon, F.3
  • 28
    • 0036915575 scopus 로고    scopus 로고
    • Analysis of the Arg345Trp disease-associated allele of the EFEMP1 gene in individuals with early onset drusen or familial age-related macular degeneration
    • Guymer RH, McNeil R, Cain M, et al. Analysis of the Arg345Trp disease-associated allele of the EFEMP1 gene in individuals with early onset drusen or familial age-related macular degeneration. Clin Exp Ophthalmol. 2002;30:419-423.
    • (2002) Clin Exp Ophthalmol , vol.30 , pp. 419-423
    • Guymer, R.H.1    McNeil, R.2    Cain, M.3
  • 29
  • 30
    • 0032231956 scopus 로고    scopus 로고
    • Genetic association of apolipoprotein E with age-related macular degeneration
    • Klaver CC, Kliffen M, van Duijn CM, et al. Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genetics. 1998;63:200-206.
    • (1998) Am J Hum Genetics , vol.63 , pp. 200-206
    • Klaver, C.C.1    Kliffen, M.2    van Duijn, C.M.3
  • 31
    • 2442711751 scopus 로고    scopus 로고
    • Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center
    • Zareparsi S, Reddick AC, Branham KE, et al. Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Invest Ophthalmol Vis Sci. 2004;45:1306-1310.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 1306-1310
    • Zareparsi, S.1    Reddick, A.C.2    Branham, K.E.3
  • 32
    • 33645792381 scopus 로고    scopus 로고
    • Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)
    • Baird PN, Richardson AJ, Robman LD, et al. Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum Mutat. 2006;27:337-342.
    • (2006) Hum Mutat , vol.27 , pp. 337-342
    • Baird, P.N.1    Richardson, A.J.2    Robman, L.D.3
  • 33
    • 31644431945 scopus 로고    scopus 로고
    • Apolipoprotein E gene and early age-related maculopathy: The Atherosclerosis Risk in Communities Study
    • Wong TY, Shankar A, Klein R, et al. Apolipoprotein E gene and early age-related maculopathy: the Atherosclerosis Risk in Communities Study. Ophthalmology. 2006;113:255-259.
    • (2006) Ophthalmology , vol.113 , pp. 255-259
    • Wong, T.Y.1    Shankar, A.2    Klein, R.3
  • 34
    • 0019995238 scopus 로고
    • Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen
    • Nussenblatt R, Mittal K, Ryan S, et al. Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol. 1982;94:147-158.
    • (1982) Am J Ophthalmol , vol.94 , pp. 147-158
    • Nussenblatt, R.1    Mittal, K.2    Ryan, S.3
  • 35
    • 0025029836 scopus 로고
    • Association of birdshot retinochoroidopathy and HLA-A29 antigen
    • Baarsma GS, Priem HA, Kijlstra A. Association of birdshot retinochoroidopathy and HLA-A29 antigen. Curr Eye Res. 1990;9(suppl):63-68.
    • (1990) Curr Eye Res , vol.9 , Issue.SUPPL. , pp. 63-68
    • Baarsma, G.S.1    Priem, H.A.2    Kijlstra, A.3
  • 36
    • 20444471500 scopus 로고    scopus 로고
    • Association of HLA class I and class II polymorphisms with age-related macular degeneration
    • Goverdhan S, Mullins R, Howell W, et al. Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2005;46:1726-1734.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 1726-1734
    • Goverdhan, S.1    Mullins, R.2    Howell, W.3
  • 37
    • 9444220221 scopus 로고    scopus 로고
    • The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration
    • Tuo J, Smith BC, Bojanowski CM, et al. The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J. 2004;18:1297-1299.
    • (2004) FASEB J , vol.18 , pp. 1297-1299
    • Tuo, J.1    Smith, B.C.2    Bojanowski, C.M.3
  • 38
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein R, Zeiss C, Chew E, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385-389.
    • (2005) Science , vol.308 , pp. 385-389
    • Klein, R.1    Zeiss, C.2    Chew, E.3
  • 39
    • 17244379811 scopus 로고    scopus 로고
    • Complement factor H polymorphism and age-related macular degeneration
    • Edwards A, Ritter R, Abel K, et al. Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308:421-424.
    • (2005) Science , vol.308 , pp. 421-424
    • Edwards, A.1    Ritter, R.2    Abel, K.3
  • 40
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • Haines J, Hauser M, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419-421.
    • (2005) Science , vol.308 , pp. 419-421
    • Haines, J.1    Hauser, M.2    Schmidt, S.3
  • 41
    • 21044453724 scopus 로고    scopus 로고
    • A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    • Hageman G, Anderson D, Johnson L, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005;102:7227-7232.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7227-7232
    • Hageman, G.1    Anderson, D.2    Johnson, L.3
  • 42
    • 27744462212 scopus 로고    scopus 로고
    • Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
    • Rivera A, Fisher SA, Fritsche LG, et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genetics. 2005;14:3227-3236.
    • (2005) Hum Mol Genetics , vol.14 , pp. 3227-3236
    • Rivera, A.1    Fisher, S.A.2    Fritsche, L.G.3
  • 43
    • 32044474231 scopus 로고    scopus 로고
    • CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD
    • Magnusson KP, Duan S, Sigurdsson H, et al. CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med. 2006;3:e5.
    • (2006) PLoS Med , vol.3
    • Magnusson, K.P.1    Duan, S.2    Sigurdsson, H.3
  • 44
    • 33644872864 scopus 로고    scopus 로고
    • Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers
    • Sepp T, Khan JC, Thurlby DA, et al. Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci. 2006;47:536-540.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 536-540
    • Sepp, T.1    Khan, J.C.2    Thurlby, D.A.3
  • 45
    • 29944437979 scopus 로고    scopus 로고
    • Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population
    • Souied EH, Leveziel N, Richard F, et al. Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Mol Vis. 2005;11:1135-1140.
    • (2005) Mol Vis , vol.11 , pp. 1135-1140
    • Souied, E.H.1    Leveziel, N.2    Richard, F.3
  • 46
    • 33644676878 scopus 로고    scopus 로고
    • Complement factor H polymorphisms in Japanese population with age-related macular degeneration
    • Okamoto H, Umeda S, Obazawa M, et al. Complement factor H polymorphisms in Japanese population with age-related macular degeneration. Mol Vis. 2006;12:156-158.
    • (2006) Mol Vis , vol.12 , pp. 156-158
    • Okamoto, H.1    Umeda, S.2    Obazawa, M.3
  • 47
    • 33748357958 scopus 로고    scopus 로고
    • Ethnic variation in AMD-associated complement factor H polymorphism Tyr402His
    • Grassi M, Fingert J, Sheetz T, et al. Ethnic variation in AMD-associated complement factor H polymorphism Tyr402His. Hum Mutat. 2006;27:921-925.
    • (2006) Hum Mutat , vol.27 , pp. 921-925
    • Grassi, M.1    Fingert, J.2    Sheetz, T.3
  • 48
    • 23944478239 scopus 로고    scopus 로고
    • Meta-analysis of genome scans of age-related macular degeneration
    • Fisher SA, Abecasis GR, Yashar BM, et al. Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genetics. 2005;14:2257-2264.
    • (2005) Hum Mol Genetics , vol.14 , pp. 2257-2264
    • Fisher, S.A.1    Abecasis, G.R.2    Yashar, B.M.3
  • 49
    • 23944465880 scopus 로고    scopus 로고
    • Susceptibility genes for age-related maculopathy on chromosome 10q26
    • Jakobsdottir J, Conley YP, Weeks DE, et al. Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genetics. 2005;77:389-407.
    • (2005) Am J Hum Genetics , vol.77 , pp. 389-407
    • Jakobsdottir, J.1    Conley, Y.P.2    Weeks, D.E.3
  • 50
    • 33646070308 scopus 로고    scopus 로고
    • Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration
    • Schmidt S, Hauser MA, Scott WK, et al. Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genetics. 2006;78:852-864.
    • (2006) Am J Hum Genetics , vol.78 , pp. 852-864
    • Schmidt, S.1    Hauser, M.A.2    Scott, W.K.3
  • 51
    • 1842478123 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of age-related macular degeneration
    • Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004;122:598-614.
    • (2004) Arch Ophthalmol , vol.122 , pp. 598-614
    • Zarbin, M.A.1
  • 52
    • 0029950660 scopus 로고    scopus 로고
    • Hydrodynamics of ageing Bruch's membrane: Implications for macular disease
    • Starita C, Hussain A, Pagliarini S, et al. Hydrodynamics of ageing Bruch's membrane: implications for macular disease. Exp Eye Res. 1996;62:565-572.
    • (1996) Exp Eye Res , vol.62 , pp. 565-572
    • Starita, C.1    Hussain, A.2    Pagliarini, S.3
  • 53
    • 0032408085 scopus 로고    scopus 로고
    • Advanced glycation end products in age-related macular degeneration
    • Ishibashi T, Murata T, Hangai M, et al. Advanced glycation end products in age-related macular degeneration. Arch Ophthalmol. 1998;116:1629-1632.
    • (1998) Arch Ophthalmol , vol.116 , pp. 1629-1632
    • Ishibashi, T.1    Murata, T.2    Hangai, M.3
  • 54
    • 0033024626 scopus 로고    scopus 로고
    • Increase in the advanced glycation end product pentosidine in Bruch's membrane with age
    • Handa J, Verzijl N, Matsunaga H, et al. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Invest Ophthalmol Vis Sci. 1999;40:775-779.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 775-779
    • Handa, J.1    Verzijl, N.2    Matsunaga, H.3
  • 55
    • 0035173704 scopus 로고    scopus 로고
    • Accumulation of cholesterol with age in human Bruch's membrane
    • Curcio C, Millican C, Bailey T, et al. Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci. 2001;42:265-274.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 265-274
    • Curcio, C.1    Millican, C.2    Bailey, T.3
  • 56
    • 0034012166 scopus 로고    scopus 로고
    • Ocular drusen contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins R, Anderson D, Russell S, et al. Ocular drusen contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14:835-846.
    • (2000) FASEB J , vol.14 , pp. 835-846
    • Mullins, R.1    Anderson, D.2    Russell, S.3
  • 57
    • 0037332052 scopus 로고    scopus 로고
    • Apolipoprotein B in cholesterol- containing drusen and basal deposits of human eyes with age-related maculopathy
    • Malek G, LI C, Guidry C, et al. Apolipoprotein B in cholesterol- containing drusen and basal deposits of human eyes with age-related maculopathy. Am J Pathol. 2003;162:413-425.
    • (2003) Am J Pathol , vol.162 , pp. 413-425
    • Malek, G.1    LI, C.2    Guidry, C.3
  • 58
    • 0033948684 scopus 로고    scopus 로고
    • Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice
    • Dithmar S, Curcio CA, Le NA, et al. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci. 2000;41:2035-2042.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2035-2042
    • Dithmar, S.1    Curcio, C.A.2    Le, N.A.3
  • 59
    • 23844463473 scopus 로고    scopus 로고
    • Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration
    • Malek G, Johnson LV, Mace BE, et al. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci USA. 2005;102:11900-11905.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11900-11905
    • Malek, G.1    Johnson, L.V.2    Mace, B.E.3
  • 60
    • 0021856681 scopus 로고
    • Pathologic features of senile macular degeneration
    • Green W, McDonnell P, Yeo J. Pathologic features of senile macular degeneration. Ophthalmology. 1985;92:615-627.
    • (1985) Ophthalmology , vol.92 , pp. 615-627
    • Green, W.1    McDonnell, P.2    Yeo, J.3
  • 61
    • 0031050490 scopus 로고    scopus 로고
    • Characteristics of drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration
    • Spraul C, Grossniklaus H. Characteristics of drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration. Arch Ophthalmol. 1997;115:267-273.
    • (1997) Arch Ophthalmol , vol.115 , pp. 267-273
    • Spraul, C.1    Grossniklaus, H.2
  • 62
    • 0344791691 scopus 로고    scopus 로고
    • Basal linear deposit and large drusen are specific for early age-related maculopathy
    • Curcio C, Millican C. Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol. 1999;117:329-339.
    • (1999) Arch Ophthalmol , vol.117 , pp. 329-339
    • Curcio, C.1    Millican, C.2
  • 63
    • 11144230943 scopus 로고    scopus 로고
    • Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to distribution of lesions associated with AMD
    • Chong N, Keonin J, Luthert P, et al. Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to distribution of lesions associated with AMD. Am J Pathol. 2005;166:241-251.
    • (2005) Am J Pathol , vol.166 , pp. 241-251
    • Chong, N.1    Keonin, J.2    Luthert, P.3
  • 64
    • 0037049996 scopus 로고    scopus 로고
    • Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo
    • Yanagisawa H, Davis EC, Starcher BC, et al. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002;415:168-171.
    • (2002) Nature , vol.415 , pp. 168-171
    • Yanagisawa, H.1    Davis, E.C.2    Starcher, B.C.3
  • 65
    • 33744969146 scopus 로고    scopus 로고
    • Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa
    • Lotery AJ, Baas D, Ridley C, et al. Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa. Hum Mutat. 2006;27:568-574.
    • (2006) Hum Mutat , vol.27 , pp. 568-574
    • Lotery, A.J.1    Baas, D.2    Ridley, C.3
  • 66
    • 0034832029 scopus 로고    scopus 로고
    • An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    • Hageman G, Luthert P, Chong N, et al. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705-732.
    • (2001) Prog Retin Eye Res , vol.20 , pp. 705-732
    • Hageman, G.1    Luthert, P.2    Chong, N.3
  • 67
    • 0035077783 scopus 로고    scopus 로고
    • Immunological and aetiological aspects of macular degeneration
    • Penfold P, Madigan M, Gillies M, et al. Immunological and aetiological aspects of macular degeneration. Prog Retinal Eye Res. 2001;20:385-414.
    • (2001) Prog Retinal Eye Res , vol.20 , pp. 385-414
    • Penfold, P.1    Madigan, M.2    Gillies, M.3
  • 68
    • 0036741098 scopus 로고    scopus 로고
    • A role for local inflammation in the formation of drusen in the aging eye
    • Anderson D, Mullins R, Hageman G, et al. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002;134:411-431.
    • (2002) Am J Ophthalmol , vol.134 , pp. 411-431
    • Anderson, D.1    Mullins, R.2    Hageman, G.3
  • 69
    • 0035699547 scopus 로고    scopus 로고
    • Complement activation and inflammatory processes in drusen formation and age related macular degeneration
    • Johnson L, Leitner W, Staples M, et al. Complement activation and inflammatory processes in drusen formation and age related macular degeneration. Exp Eye Res. 2001;73:887-896.
    • (2001) Exp Eye Res , vol.73 , pp. 887-896
    • Johnson, L.1    Leitner, W.2    Staples, M.3
  • 70
    • 10844231850 scopus 로고    scopus 로고
    • Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization
    • Bora P, Sohn J, Cruz J, et al. Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol. 2005;174:491-497.
    • (2005) J Immunol , vol.174 , pp. 491-497
    • Bora, P.1    Sohn, J.2    Cruz, J.3
  • 71
    • 33144488589 scopus 로고    scopus 로고
    • Drusen complement components C3a and C5a promote choroidal neovascularization
    • Nozaki M, Raisler BJ, Sakurai E, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci USA. 2006;103:2328-2333.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2328-2333
    • Nozaki, M.1    Raisler, B.J.2    Sakurai, E.3
  • 73
    • 0022590076 scopus 로고
    • Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium
    • Penfold P, Killingsworth M, Sarks S. Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1986;27:364-371.
    • (1986) Invest Ophthalmol Vis Sci , vol.27 , pp. 364-371
    • Penfold, P.1    Killingsworth, M.2    Sarks, S.3
  • 74
    • 0026048702 scopus 로고
    • Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration
    • Lopez P, Grossniklaus H, Lambert H, et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. 1991;112:647-656.
    • (1991) Am J Ophthalmol , vol.112 , pp. 647-656
    • Lopez, P.1    Grossniklaus, H.2    Lambert, H.3
  • 75
    • 0036978519 scopus 로고    scopus 로고
    • Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization
    • Grossniklaus HE, Ling JX, Wallace TM, et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8:119-126.
    • (2002) Mol Vis , vol.8 , pp. 119-126
    • Grossniklaus, H.E.1    Ling, J.X.2    Wallace, T.M.3
  • 76
    • 21644482231 scopus 로고    scopus 로고
    • Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration
    • Chan CC, Tuo J, Bojanowski CM, et al. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol Histopathol. 2005;20:857-863.
    • (2005) Histol Histopathol , vol.20 , pp. 857-863
    • Chan, C.C.1    Tuo, J.2    Bojanowski, C.M.3
  • 77
    • 20544433415 scopus 로고    scopus 로고
    • Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration
    • Zareparsi S, Buraczynska M, Branham KE, et al. Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genetics. 2005;14:1449-1455.
    • (2005) Hum Mol Genetics , vol.14 , pp. 1449-1455
    • Zareparsi, S.1    Buraczynska, M.2    Branham, K.E.3
  • 78
    • 33645419787 scopus 로고    scopus 로고
    • Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    • Gold B, Merriam JE, Zernant J, et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genetics. 2006;38:458-462.
    • (2006) Nat Genetics , vol.38 , pp. 458-462
    • Gold, B.1    Merriam, J.E.2    Zernant, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.