Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6500-6505

  Yoon, Jung Hwan ^a   Werneburg, Nathan W ^a   Higuchi, Hajime ^a   Canbay, Ali E ^a   Kaufmann, Scott H ^a   Akgul, Cahit ^b   Edwards, Steven W ^b   Gores, Gregory J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BAY 37 9751; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BILE ACID; CYCLOHEXIMIDE; DACTINOMYCIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; NEUTRALIZING ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN A; PROTEIN BCL 2; PROTEIN INHIBITOR; PROTEIN MCL 1; PROTEIN RAF1; PROTEIN RAF1 INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID METABOLISM; BILE DUCT CARCINOMA; BILIARY TRACT CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; GENE OVEREXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; RECEPTOR BINDING; REGULATORY MECHANISM; RNA STABILITY;

APOPTOSIS; CHOLANGIOCARCINOMA; DEOXYCHOLIC ACID; HUMANS; MAP KINASE SIGNALING SYSTEM; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0037112523     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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