Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33273-33280

  Drummelsmith, Jolyne ^a   Girard, Isabelle ^a   Trudel, Nathalie ^a   Ouellette, Marc ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG DOSAGE; METABOLISM; PROTEINS;

LEISHMANIA INFECTIONS; METABOLITE ANALYSIS; METHOTREXATE; PARASITE;

BIOCHEMISTRY;

FOLIC ACID; FOLIC ACID ANTAGONIST; METHIONINE ADENOSYLTRANSFERASE; METHOTREXATE; PROTOZOAL DNA; S ADENOSYLMETHIONINE;

AMPLICON; ARTICLE; CELL LEVEL; DRUG RESISTANCE; GENE OVEREXPRESSION; GENETIC LINKAGE; GENETIC TRANSFECTION; LEISHMANIA MAJOR; METABOLITE; MICROBIAL GROWTH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; RESISTANCE PHENOTYPE; STRESS; TRYPANOSOMA;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; DRUG RESISTANCE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; HYDROXYPROSTAGLANDIN DEHYDROGENASES; LEISHMANIA MAJOR; METHIONINE ADENOSYLTRANSFERASE; METHOTREXATE; MUTATION; PHOSPHOPYRUVATE HYDRATASE; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; S-ADENOSYLMETHIONINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

LEISHMANIA MAJOR; TRYPANOSOMA;

EID: 4043094169     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405183200     Document Type: Article

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