In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 10, 1997, Pages 2108-2112

  Bacchi, Cyrus J ^a   Sanabria, Karen ^a   Spiess, Arthur J ^b   Vargas, Marcus ^a   Marasco Jr , Canio J ^b   Jimenez, Luis M ^a   Goldberg, Burt ^a   Sufrin, Janice R ^b  

^a PACE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' DEOXY 5' (HYDROXYETHYLTHIO)ADENOSINE; 5' METHYLTHIOADENOSINE DERIVATIVE; ADENOSINE DERIVATIVE; ANTITRYPANOSOMAL AGENT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

EID: 0030812873     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.10.2108     Document Type: Article

References (27)

1. Abeles, R. H. 1992. A methionine salvage pathway. Aldrichimica Acta 25: 3-7.
2. Bacchi, C., B. Goldberg, and D. Rattendi. Unpublished data.
3. Bacchi, C. J., J. Garofalo, M. A. Ciminelli, D. Rattendi, B. Goldberg, P. P. McCann, and N. Yarlett. 1993. Resistance to DL-α-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense: role of S-adenosylmethionine. Biochem. Pharmacol. 46:471-481.
4. Bacchi, C. J., H. C. Nathan, T. Livingston, G. Valladares, M. Saric, P. D. Sayer, A. R. Njogu, and A. B. Clarkson, Jr. 1990. Differential susceptibility to DL-α-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense. Antimicrob. Agents Chemother. 34:1183-1188.
5. Bacchi, C. J., and D. Rattendi. Unpublished data.
6. Bacchi, C. J., J. R. Sufrin, H. Nathan, A. J. Spiess, T. Hannan, J. Garofalo, K. Alicea, L. Katz, and N. Yarlett. 1991. 5′-Alkyl-substituted analogs of 5′-methylthioadenosine as trypanocides. Antimicrob. Agents Chemother. 35:1315-1320.
7. Bacchi, C. J., and N. Yarlett. 1995. Polyamine metabolism, p. 119-132. In J. J. Marr and M. Müller (ed.), Biochemistry and molecular biology of parasites. Academic Press, Inc., New York, N.Y.
8. Bacchi, C. J., et al. Unpublished data.
9. Backlund, P. S., Jr., and R. A. Smith. 1981. Methionine synthesis from 5′-methylthioadenosine in rat liver. J. Biol. Chem. 256:1533-1535.
10. Berens, R. L., E. C. Krug, and J. J. Marr. 1995. Purine and pyrimidine metabolism, p. 89-116. In J. J. Marr and M. Müller (ed.), Biochemistry and molecular biology of parasites. Academic Press, Inc., New York, N.Y.
11. Berger, B. J., N. S. Carter, and A. J. Fairlamb. 1995. Characterization of pentamidine-resistant Trypanosoma brucei brucei. Mol. Biochem. Parasitol. 69:289-298.
12. Byers, T. L., T. L. Bush, P. P. McCann, and A. J. Bitonti. 1991. Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine. Biochem. J. 274:527-533.
13. 2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei. J. Biol. Chem. 270:28153-28157.
14. Carter, N. S., and A. H. Fairlamb. 1993. Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature (London) 361:173-176.
15. Goldberg, B., D. Rattendi, N. Yarlett, D. Lloyd, and C. J. Bacchi. 1997. Effects of carboxylmethylation and polyamine synthesis inhibitors on methylation of Trypanosoma brucei cellular proteins and lipids. J. Eukaryot. Microbiol. 44:352-358.
16. Goldberg, B., N. Yarlett, D. Rattendi, D. Lloyd, and C. J. Bacchi. 1997. Rapid methylation of cell proteins and lipids in Trypanosoma brucei. J. Eukaryot. Microbiol. 44:345-351.
17. Goldberg, B., N. Yarlett, J. Sufrin, D. Lloyd, and C. J. Bacchi. 1997. A unique transporter of S-adenosylmethionine in African trypanosomes. FASEB J. 11:256-260.
18. Kuzoe, F. 1993. Current situation of African trypanosomiasis. Acta Trop. 54:153-162.
19. Marton, L. J., and A. E. Pegg. 1995. Polyamines as targets for therapeutic intervention. Annu. Rev. Pharmacol. Toxicol. 35:55-91.
20. Matsuda, A., M. Shinozaki, M. Suzuki, K. Watanabe, and T. Miyasaka. 1986. A convenient method for the selective acylation of guanine nucleosides. Synthesis 1986:385-386.
21. Pegg, A. E. 1988. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 48:759-774.
22. Sufrin, J. R., D. Rattendi, A. J. Spiess, S. Lane, C. J. Marasco, Jr., and C. J. Bacchi. 1996 Anti-trypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives. Antimicrob. Agents Chemother. 40:2567-2572.
23. Sufrin, J. R., A. J. Spiess, D. L. Kramer, P. L. Libby, J. T. Miller, R. J. Bernacki, R. T. Borchardt, Y. Lee, and C. W. Porter. 1991. Targeting 5′-deoxy-5′-(methylthio)adenosine phosphorylase by 5′-haloalkyl analogues of 5′-deoxy-5′-(methylthio)adenosine. J. Med. Chem. 34:2600-2606.
24. Van Nieuwenhove, S. 1992. Advances in sleeping sickness therapy. Ann. Soc. Belg. Med. Trop. 72(Suppl. 1):39-51.
25. World Health Organization. 1995. Tropical disease research. Twelfth Programme report. World Health Organization, Geneva, Switzerland.
26. Yarlett, N., and C. J. Bacchi. 1988. Effect of DL-α-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei. Mol. Biochem.
27. Yarlett, N., J. Garofalo, M. A. Ciminelli, V. Ruggerio, B. Goldberg, J. R. Sufrin, and C. J. Bacchi. 1993. S-Adenosylmethionine synthetase in bloodstream Trypanosoma brucei. Biochim. Biophys. Acta 1181:68-76.