ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line

Journal of Cellular Biochemistry

Volumn 83, Issue 1, 2001, Pages 92-98

  Juretic, Nevenka ^a   Santibáñez, Juan Francisco ^a   Hurtado, Claudia ^a   Martínez, Jorge ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

MAP kinase; Metastases; Osteoblasts; Urokinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; UROKINASE;

ARTICLE; BONE METASTASIS; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOSARCOMA; PRIORITY JOURNAL; PROSTATE CARCINOMA; SIGNAL TRANSDUCTION;

RICKETTSIA SP. PAR;

EID: 0034839130     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.1211     Document Type: Article

References (22)

1. The mitogen-activated protein kinase signal transduction pathway
2. The urokinase receptor is required for human monocyte chemotaxis in vitro
3. Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38α mitogen-activated protein kinase activity
4. Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction
5. Characteristics of prostate-derived growth factors for cells of the osteoblasts phenotype
6. p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation
7. Prostate-derived soluble factors block osteoblast differentiation in culture
8. Matrix deposition by calcifying human osteogenic sarcoma cell line (SaOS-2)
9. Requirements of p38 mitogen-activated protein kinase for neuronal differentiation of PC 12 cells
10. Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation
11. Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility
12. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines
13. Mitogen-activated protein kinase p42mapk and p44mapk are required for fibroblast proliferation
14. Human prostatic cancer cells PC3, elaborate mitogenic activity which selectively stimulates human bone cells
15. An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells
16. Structural requirements for the growth factor activity of amino-terminal domain of urokinase
17. Induction in human osteoblastic cells (SaOS-2) of the early response genes fos, jun and myc by amino terminal fragment (ATF) of urokinase
18. Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine
19. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis
20. Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralization rate in fetal rat osteoblasts in culture
21. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
22. Cardiac muscle cell hypertrophy and apoptosis induced by distinct member of p38 mitogen-activated protein kinase family