The novel β-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo

FASEB Journal

Volumn 20, Issue 10, 2006, Pages

  Motzkus, Dirk ^a,b   Schulz Maronde, Sandra ^a   Heitland, Aleksandra ^a   Schulz, Axel ^a   Forssmann, Wolf Georg ^a   Jübner, Martin ^a   Maronde, Erik ^a,c  

^a IPF PHARMACEUTICALS GMBH   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Antimicrobial peptide; LAL assay; Murine sepsis model; RAW264.7; TNF alpha

Indexed keywords

BETA DEFENSIN; DEFB123; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; PEPTIDE FRAGMENT;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DIFFUSION; DILUTION; DRUG BINDING; DRUG EFFECT; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INDUCTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LIMULUS LYSATE TEST; MALE; MINIMUM INHIBITORY CONCENTRATION; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECRETION; SEPSIS; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG ANTAGONISM; MACROPHAGE; METABOLISM; MORTALITY; PHYSIOLOGY; SECRETION; SYNTHESIS;

BACTERIA (MICROORGANISMS); LIMULUS AMOEBOCYTE; MURINAE; NEGIBACTERIA; POSIBACTERIA;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-DEFENSINS; CELL LINE; DRUG ANTAGONISM; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; SEPSIS;

EID: 33845682462     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4970fje     Document Type: Article

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