Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties

Journal of Leukocyte Biology

Volumn 69, Issue 1, 2001, Pages 98-104

  Getting, Stephen J ^a   Allcock, Graham H ^a   Flower, Roderick ^a   Perretti, Mauro ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

2 MSH; IL I ; Inflammation; KC; MTII

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLIC AMP; GAMMA2 MELANOCYTE STIMULATING HORMONE; INTERLEUKIN 1BETA; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 DEXTRO PHENYLANINE 10 LYSINAMIDE]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GOUT; INFLAMMATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL;

ALPHA-MSH; ANIMALS; GOUT; INFLAMMATION; MALE; MELANOCYTE-STIMULATING HORMONES; MICE; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, CORTICOTROPIN;

ANIMALIA; MURINAE;

EID: 0035157351     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Effect of α-MSH11-13 on fever in rabbits
2. The neuropeptide alpha-melanocyte stimulating hormone inhibits experimental arthritis in rats
3. ACTH revisted: Effective treatment for acute crystal induced synovitis in patients with multiple medical problems
4. POMC gene derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release and inhibit neutrophil migration in acute experimental inflammation
5. Modulation of IL-1, tumour necrosis factor, and C5A-mediated murine neutrophil migration by α-melanocyte stimulating hormone
6. Mechanism underlying the anti-inflammatory actions of central corticotropin-releasing factor
7. α-Melanocyte stimulating hormone inhibits the nuclear transcription factor NF-κB activation by various inflammatory agents
8. Anti-inflammatory actions of the neuro-immunomodulator α-MSH
9. MC3-R as a novel target for anti-inflammatory therapy
10. Melanocortin receptors: Perspectives for novel drugs
11. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
12. Molecular cloning of a novel melanocortin receptor
13. Distribution of cDNA for melanocortin receptor subtypes in human tissues
14. Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene
15. Interaction of dual intracellular signaling pathways activated by the melanocortin 3-receptor
16. Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes
17. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalalmus and limbic system
18. Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
19. Potent and prolonged acting cyclic lactam analogues of α-melanotropin: Design based on molecular dynamics
20. Discovery of a novel superpotent and selective melanocortin 4 receptor antagonist (HS024): Evaluation in vitro and in vivo
21. Alpha-melanocyte stimulating inhibits immunostimulatory actions of interleukin-1
22. α-MSH peptides inhibit acute inflammation induced in mice by rIL-1β. rIL-6, rTNF and endogenous pyrogen but not that caused by LTB4, PAF and IL-8
23. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia
24. Cyclic lactam α-melanotropin analogues of NDP-α-MSH with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
25. Pressor and cardioaccelerator effects of gamma MSH and related peptides
26. 2-MSH and ACTH(1-24)
27. Cardiovascular and renal effect of γ-MSH in spontaneously hypertensive and normotensive Wistar Kyoto rats
28. The haemodynamic effects of γ2-melanocyte-stimulating-hormone and rested melanotropins depend on the arousal potential of the rat
29. Suppression of phagocytosis by adrenocorticotropic hormone in murine peritoneal macrophages
30. Proopiomelanocortin gene expression in a distinct population of rat spleen and lung leukocytes
31. Proopiomelanocortin producing cells of spleen: Increase after transplantation with opiod-peptide producing Ehrlich ascites tumour cells
32. Pro-opiomelanocortin messenger ribonucleic acid and postranslational processing of beta endorphin in spleen macrophages
33. Glucocorticoid and ACTH regulation of rat peritoneal phagocyte chemiluminescence and nitric oxide production in culture
34. α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation
35. ACTH receptor-mediated induction of leukocyte cyclic AMP