Frequent loss of heterozygosity at 6q in pheochromocytoma

Human Pathology

Volumn 37, Issue 6, 2006, Pages 749-754

  Lemeta, Sebsebe ^a,c   Salmenkivi, Kaisa ^a   Pylkkänen, Lea ^c   Sainio, Markku ^c   Saarikoski, Sirkku T ^c   Arola, Johanna ^a   Heikkilä, Päivi ^a   Haglund, Caj ^b   Husgafvel Pursiainen, Kirsti ^c   Böhling, Tom ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

6q loss; loss of heterozygosity; pheochromocytoma; tumor suppressor gene

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CARCINOGENESIS; CHROMOSOME 6Q; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HEMANGIOBLASTOMA; HETEROZYGOSITY LOSS; HUMAN; MALE; MICROSATELLITE MARKER; PHEOCHROMOCYTOMA; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

ADULT; AGED; ALLELES; ALLELIC IMBALANCE; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, PAIR 6; DNA, NEOPLASM; FEMALE; GENE DELETION; GENETIC MARKERS; HEMANGIOBLASTOMA; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PHEOCHROMOCYTOMA; TRANSCRIPTION FACTORS; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEINS;

EID: 33745451159     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2006.02.002     Document Type: Article

References (35)

1. Neumann H.P., Hoegerle S., Manz T., Brenner K., and Iliopoulos O. How many pathways to pheochromocytoma. Semin Nephrol 22 (2002) 89-99
2. Koch A.C., Vortmeyer O.A., Huang C.S., Alesci S., Zhuang Z., and Pacak K. Genetic aspects of pheochromocytoma. Endocr Regul 35 (2001) 43-52
3. Salmenkivi K., Arola J., Voutilainen R., et al. Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. J Clin Endocrinol Metab 86 (2001) 2231-22355
4. McNicol A.M., Young Jr. W.F., Kawashma A., Komminoth P., and Tischler A.S. Benign phaeochromocytoma. In: DeLellis R.A., Lloyd R.V., Heitz P.U., and Eng C. (Eds). WHO classification of tumours: pathology and genetics of tumours of endocrine organs (2004), International Agency for Research on Cancer (IARC), Lyon 151-155
5. Pacak K., Linehan W.M., Eisenhofer G., Walther M.M., and Goldstein D.S. Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma. Ann Intern Med 134 (2001) 315-329
6. Maher E.R., and Eng C. The pressure rises: update on the genetics of phaeochromocytoma. Hum Mol Genet 11 (2002) 2347-2354
7. Neumann H.P., Bausch B., McWhinney S.R., et al. Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med 346 (2002) 1459-1466
8. Brauch H., Hoeppner W., Jahnig H., et al. Sporadic pheochromocytomas are rarely associated with germ line mutations in the vhl tumor suppressor gene or the ret protooncogene. J Clin Endocrinol Metab 82 (1997) 4101-4104
9. Koch .A., Huang S.C., Zhuang Z., et al. Somatic VHL gene deletion and point mutation in MEN 2A-associated pheochromocytoma. Oncogene 21 (2002) 479-482
10. Bender U., Gutsche M., Glasker S., et al. Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas. J Clin Endocrinol Metab 85 (2000) 4568-4574
11. Bar M., Friedman E., Jakobovitz O., et al. Sporadic phaeochromocytomas are rarely associated with germ line mutations in the von Hippel-Lindau and RET genes. Clin Endocrinol 47 (1997) 707-712
12. Aguiar .C., Cox G., Pomeroy S.L., and Dahia P.L. Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas. J Clin Endocrinol Metab 86 (2001) 2890-2894
13. Dannenberg H., Speel E.J., Zhao J., et al. Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas. Am J Pathol 157 (2000) 353-359
14. Lemeta S., Aalto Y., Niemelä M., et al. Recurrent DNA sequence copy losses on chromosomal arm 6q in capillary hemangioblastoma. Cancer Genet Cytogenet 133 (2002) 174-178
15. Sprenger S.H., Gijtenbeek J.M., Wesseling P., et al. Characteristic chromosomal aberrations in sporadic cerebellar hemangioblastomas revealed by comparative genomic hybridization. J Neurooncol 52 (2001) 241-247
16. Lemeta S., Pylkkänen L., Sainio M., et al. Loss of heterozygosity at 6q is frequent and concurrent with 3p loss in sporadic and familial capillary hemangioblastomas. J Neuropathol Exp Neurol 63 (2004) 1072-1079
17. Morita R., Ishikawa J., Tsutsumi M., Hikiji K., Tsukada Y., Kamidono S., et al. Allelotype of renal cell carcinoma. Cancer Res 51 (1991) 820-823
18. Boonstra R., Koning A., Mastik M., van den Berg A., and Poppema S. Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas: frequent loss of chromosome arm 6q. Virchows Arch 443 (2003) 164-169
19. Jensen R.H., Tiirikainen M., You L., et al. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res 23 (2003) 2281-2289
20. Hoglund M., Gisselsson D., Hansen G.B., Sall T., and Mitelman F. Ovarian carcinoma develops through multiple modes of chromosomal evolution. Cancer Res 63 (2003) 3378-3385
21. Gaidano G., Hauptschein R.S., Parsa N.Z., et al. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma. Blood 80 (1992) 1781-1787
22. Yatsuoka T., Sunamura M., Furukawa T., et al. Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. Am J Gastroenterol 95 (2000) 2080-2085
23. Miyakawa A., Ichimura K., Schmidt E.E., Varmeh-Ziaie S., and Collins V.P. Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours. Br J Cancer 82 (2000) 543-549
24. Acevedo C.M., Henriquez M., Emmert-Buck M.R., and Chuaqui R.F. Loss of heterozygosity on chromosome arms 3p and 6q in micro dissected adenocarcinomas of the uterine cervix and adenocarcinoma in situ. Cancer 94 (2002) 793-802
25. Hansen L.L., Jensen L.L., Dimitrakakis C., et al. Allelic imbalance in selected chromosomal regions in ovarian cancer. Cancer Genet Cytogenet 139 (2002) 1-8
26. Healy E., Belgaid C., Takata M., et al. Prognostic significance of allelic losses in primary melanoma. Oncogene 16 (1998) 2213-2218
27. Barghorn A., Speel E.J., Farspour B., et al. Putative tumor suppressor loci at 6q22 and 6q23-24 are involved in the malignant progression of sporadic endocrine pancreatic tumors. Am J Pathol 158 (2001) 1903-1911
28. Zhang Y., Weber-Matthiesen K., Siebert R., Matthiesen P., and Schlegelberger B. Frequent deletions of 6q23-24 in B-cell non-Hodgkin's lymphomas detected by fluorescence in situ hybridization. Genes Chromosomes Cancer 18 (1997) 310-313
29. Bell D.W., Jhanwar S.C., and Testa J.R. Multiple regions of allelic loss from chromosome arm 6q in malignant mesothelioma. Cancer Res 57 (1997) 4057-4062
30. Tibiletti M.G., Bernasconi B., Furlan D., et al. Chromosome 6 abnormalities in ovarian surface epithelial tumors of borderline malignancy suggest a genetic continuum in the progression model of ovarian neoplasms. Clin Cancer Res 7 (2001) 3404-3409
31. Sandhu A.K., Kaur G.P., Reddy D.E., Rane N.S., and Athwal R.S. A gene on 6q14-21 restores senescence to immortal ovarian tumor cells. Oncogene 12 (1996) 247-252
32. Yang X., Li D.M., Chen W., and Xu T. Human homologue of Drosophila lats, LATS1, negatively regulates growth by inducing G2/M arrest or apoptosis. Oncogene 20 (2001) 6516-6523
33. Abdollahi A., Bao R., and Hamilton T.C. LOT 1 is growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein. Oncogene 18 (1999) 6477-6487
34. Varrault A., Ciani E., Apiou F., et al. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci U S A 95 (1998) 8835-8840
35. Varrault A., Bilanges B., Mackay D.J., et al. Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus. J Biol Chem 276 (2001) 18653-18656