A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus

Human Molecular Genetics

Volumn 10, Issue 14, 2001, Pages 1475-1483

  Arima, Takahiro ^a   Drewell, Robert A ^a,e   Arney, Katharine L ^a   Inoue, Jun ^b   Makita, Yoshio ^c   Hata, Akira ^c   Oshimura, Mitsuo ^b   Wake, Norio ^d   Surani, M Azim ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TOTTORI UNIVERSITY   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CHROMOSOME 6Q; CONTROLLED STUDY; CPG ISLAND; DEHYDRATION; DIABETES MELLITUS; DNA METHYLATION; EMBRYO; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HUMAN; HUMAN CELL; HYPOPHYSIS; IN VIVO STUDY; INSULIN DEFICIENCY; INTRAUTERINE GROWTH RETARDATION; KARYOTYPE; MALE; MOUSE; NEWBORN DISEASE; NIDATION; NONHUMAN; OOCYTE; PANCREAS; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; REPORTER GENE; SEQUENCE HOMOLOGY; SPERM; SYNTENY; TUMOR SUPPRESSOR GENE; UNIPARENTAL DISOMY;

ANIMALIA;

EID: 0035394667     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.14.1475     Document Type: Article

References (26)

1. Completion of mouse embryogenesis requires both the maternal and paternal genomes
2. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
3. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
4. Imprinting and initiation of gene silencing in the germ cell
5. Genomic imprinting: Nature and clinical relevance
6. Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM) on chromosome 6q25-q27
7. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7
8. Further evidence for an imprinted gene for neonatal diabetes localised to chromosome 6q22-q23
9. Paternal uniparental disomy of chromosome 6 and transient neonatal diabetes mellitus
10. Localisation of a gene for transient neonatal diabetes mellitus to an 18.72 cR3000 (approximately 5.4 Mb) interval on chromosome 6q
11. The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes
12. Zac1 (Lot1), a potential tumour suppressor gene, and the gene for ε-sarcoglycan are maternally imprinted genes; identification by a subtraction screen of novel uniparental fibroblast lines
13. A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC
14. An imprinted locus associated with transient neonatal diabetes mellitus
15. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
16. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
17. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells
18. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins
19. Induction of PAC1-R (PACAP-type I receptor) gene by p53 and Zac
20. PACAP is an islet neuropeptide which contributes to glucose-stimulated insulin secretion
21. Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors
22. The pre-implantation ontogeny of H19 methylation imprint
23. Dynamics of DNA methylation during development
24. The imprinting box of the Prader-Willi/Angelman syndrome domain
25. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts
26. Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch