Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding

Molecular and Cellular Biology

Volumn 23, Issue 3, 2003, Pages 988-1003

  Hoffmann, Anke ^a   Ciani, Elisabetta ^a   Boeckardt, Joel ^b   Holsboer, Florian ^a   Journot, Laurent ^b   Spengler, Dietmar ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b CNRS UPR 9023   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOKERATIN; HELIX LOOP HELIX PROTEIN; PALINDROMIC DNA; PROTEIN; PROTEIN P53; PROTEIN ZAC; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 6; ZINC FINGER PROTEIN 7;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL CYCLE; CONTROLLED STUDY; DIMERIZATION; DISSOCIATION CONSTANT; DNA BINDING; MOLECULAR RECOGNITION; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CELL LINE; DIMERIZATION; DNA; GENES, TUMOR SUPPRESSOR; HUMANS; KERATINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; ZINC FINGERS;

ANIMALIA;

EID: 0037306261     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.3.988-1003.2003     Document Type: Article

References (31)

1. Abdollahi, A., R. Bao, and T. C. Hamilton. 1999. LOT1 is a growth suppressor gene downregulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc finger protein. Oncogene 18:6477-6487.
2. Abdollahi, A., A. K. Godwin, P. D. Miller, L. A. Getts, D. C. Schultz, T. Taguchi, J. R. Testa, and T. C. Hamilton. 1997. Identification of a gene containing zinc finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res. 57:2029-2034.
3. Arima, T., R. A. Drewell, K. L. Arney, J. Inoue, Y. Makita, A. Hata, M. Oshimura, N. Wake, and M. A. Surani. 2001. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum. Mol. Genet. 10:1475-1483.
4. Bilanges, B., A. Varrault, E. Basyuk, C. Rodriguez, A. Mazumdar, C. Pantaloni, J. Bockaert, C. Theillet, D. Spengler, and L. Journot. 1999. Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors. Oncogene 18:3979-3988.
5. Bilanges, B., A. Varrault, A. Mazumdar, C. Pantaloni, A. Hoffmann, J. Bockaert, D. Spengler, and L. Journot. 2001. Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities. Oncogene 20:1246-1253.
6. Falls, J. G., D. J. Pulford, A. A. Wylie, and R. L. Jirtle. 1999. Genomic imprinting: implications for human disease. Am. J. Pathol. 154:635-647.
7. Gardner, R. J., D. J. Mackay, A. J. Mungall, C. Polychronakos, R. Siebert, J. P. Shield, I. K. Temple, and D. O. Robinson. 2000. An imprinted locus associated with transient neonatal diabetes mellitus. Hum. Mol. Genet. 9:589-596.
8. Gerber, H. P., K. Seipel, O. Georgiev, M. Hofferer, M. Hug, S. Rusconi, and W. Schaffner. 1994. Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263:808-811.
9. Hahn, S. 1993. Structure (?) and function of acidic transcription activators. Cell 72:481-483.
10. Hochschild, A., N. Irwin, and M. Ptashne. 1983. Repressor structure and the mechanism of positive control. Cell 32:319-325.
11. Huang, S. M., A. H. Schonthal, and M. R. Stallcup. 2001. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. Oncogene 20:2134-2143.
12. Huang, S. M., and M. R. Stallcup. 2000. Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors. Mol. Cell. Biol. 20:1855-1867.
13. Kamiya, M., H. Judson, Y. Okazaki, M. Kusakabe, M. Muramatsu, S. Takada, N. Takagi, T. Arima, N. Wake, K. Kamimura, K. Satomura, R. Hermann, D. T. Bonthron, and Y. Hayashizaki. 2000. The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes. Hum. Mol. Genet. 9:453-460.
14. Latchman, D. S. 2001. Transcription factors: bound to activate or repress. Trends Biochem. Sci. 26:211-213.
15. Lefstin, J. A., and K. R. Yamamoto. 1998. Allosteric effects of DNA on transcriptional regulators. Nature 392:885-888.
16. Mackay, G., A. M. Coupe, H. Shield, P. Storr, K. Temple, and O. Robinson. 2002. Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. Hum. Genet. 110:139-144.
17. Mackay, J. P., and M. Crossley. 1998. Zinc fingers are sticking together. Trends Biochem. Sci. 23:1-4.
18. Nelson, C. C., S. C. Hendy, R. J. Shukin, H. Cheng, N. Bruchovsky, B. F. Koop, and P. S. Rennie. 1999. Determinants of DNA sequence specificity of the androgen, progesterone, and glucocorticoid receptors: evidence for differential steroid receptor response elements. Mol. Endocrinol. 13:2090-2107.
19. Pagotto, U., T. Arzberger, E. Ciani, F. Lezoualc'h, C. Pilon, L. Journot, D. Spengler, and G. K. Stalla. 1999. Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation. Endocrinology 140:987-996.
20. Pagotto, U., T. Arzberger, M. Theodoropoulou, Y. Grubler, C. Pantaloni, W. Saeger, M. Losa, L. Journot, G. K. Stalla, and D. Spengler. 2000. The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas. Cancer Res. 60:6794-6799.
21. Piras, G., A. El Kharroubi, S. Kozlov, D. Escalante-Alcalde, L. Hernandez, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and C. L. Stewart. 2000. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines. Mol. Cell. Biol. 20:3308-3315.
22. Robyr, D., A. P. Wolffe, and W. Wahli. 2000. Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol. Endocrinol. 14:329-347.
23. Rozenfeld-Granot, G., J. Krishnamurthy, K. Kannan, A. Toren, N. Amariglio, D. Givol, and G. Rechavi. 2002. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1. Oncogene 21:1469-1476.
24. Spengler, D., M. Villalba, A. Hoffmann, C. Pantaloni, S. Houssami, J. Bockaert, and L. Journot. 1997. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 16:2814-2825.
25. Tomilin, A., A. Remenyi, K. Lins, H. Bak, S. Leidel, G. Vriend, M. Wilmanns, and H. R. Scholer. 2000. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 103:853-864.
26. Uesugi, M., O. Nyanguile, H. Lu, A. J. Levine, and G. L. Verdine. 1997. Induced alpha helix in the VP16 activation domain upon binding to a human TAF. Science 277:1310-1313.
27. Varrault, A., B. Bilanges, D. J. Mackay, E. Basyuk, B. Ahr, C. Fernandez, D. O. Robinson, J. Bockaert, and L. Journot. 2001. Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus. J. Biol. Chem. 276:18653-18656.
28. Varrault, A., E. Ciani, F. Apiou, B. Bilanges, A. Hoffmann, C. Pantaloni, J. Bockaert, D. Spengler, and L. Journot. 1998. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc. Natl. Acad. Sci. USA 95:8835-8840.
29. Wang, B. S., R. A. Grant, and C. O. Pabo. 2001. Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA. Nat. Struct. Biol. 8:589-593.
30. Wolfe, S. A., L. Nekludova, and C. O. Pabo. 2000. DNA recognition by Cys2His2 zinc finger proteins. Annu. Rev. Biophys. Biomol. Struct. 29:183-212.
31. Zhang, Z., A. Murphy, J. C. Hu, and T. Kodadek. 1999. Genetic selection of short peptides that support protein oligomerization in vivo. Curr. Biol. 9:417-420.