Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors

European Journal of Oral Sciences

Volumn 112, Issue 6, 2004, Pages 545-547

  Enlund, Fredrik ^a   Persson, Fredrik ^a   Stenman, Göran ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chromosome 6; Chromosome aberrations; PLAGL1; Salivary gland tumors; Tumor suppressor gene

Indexed keywords

TUMOR SUPPRESSOR PROTEIN;

ANALYTIC METHOD; ARTICLE; CHROMOSOME 6; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE EXPRESSION; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; NORTHERN BLOTTING; SALIVARY GLAND TUMOR; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BLOTTING, NORTHERN; CARCINOMA, ADENOID CYSTIC; CELL CYCLE PROTEINS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; SALIVARY GLAND NEOPLASMS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEINS; ZINC FINGERS;

EID: 10344243970     PISSN: 09098836     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0722.2004.00174.x     Document Type: Article

References (21)

1. MERTENS F, JOHANSSON B, HÖGLUND M, MITELMAN F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 1997; 57: 2765-2780.
2. MITELMAN F, JOHANSSON B, MERTENS F. Mitelman Database of Chromosome Aberrations in Cancer 2004 http://cgap.nci.nih.gov/Chromosomes/Mitelman
3. STENMAN G, SANDROS J, DAHLENFORS R, JUBERG-ODE M, MARK J. 6q- and loss of the Y chromosome - two common deviations in malignant human salivary gland tumors. Cancer Genet Cytogenet 1986; 22: 283-293.
4. STENMAN G, SANDROS J, MARK J, EDSTRÖM S. Partial 6q deletion in a human salivary gland adenocarcinoma. Cancer Genet Cytogenet 1989; 39: 153-156.
5. SANDROS J, STENMAN G, MARK J. Cytogenetic and molecular observations in human and experimental salivary gland tumors. Cancer Genet Cytogenet 1990; 44: 153-167.
6. JIN C, MARTINS C, JIN Y, WIEGANT J, WENNERBERG J, DICTOR M, GISSELSSON D, STROMBECK B, FONSECA I, MITELMAN F, TANKE HJ, HOGLUND M, MERTENS F. Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH. Genes Chromosomes Cancer 2001; 30: 161-167.
7. QUEIMADO L, REIS A, FONSECA I, MARTINS C, LOVETT M, SOARES J, PARREIRA L. A refined localization of two deleted regions in chromosome 6q associated with salivary gland carcinomas. Oncogene 1998; 16: 83-88.
8. STALLMACH I, ZENKLUSEN P, KOMMINOTH P, SCHMID S, PERREN A, Roos M, JIANMING Z, HEITZ PU, PFALTZ M. Loss of heterozygosity at chromosome 6q23-25 correlates with clinical and histologic parameters in salivary gland adenoid cystic carcinoma. Virchows Arch 2002; 440: 77-84.
9. KISHI M, NAKAMURA M, NISHIMINE M, ISHIDA E, SHIMADA K, KIRITA T, KONISHI N. Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas. Cancer Sci 2003; 94: 530-535.
10. ABDOLLAHI A, GODWIN AK, MILLER PD, GETTS LA, SCHULTZ DC, TAGUCHI T, TESTA JR, HAMILTON TC. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res 1997; 57: 2029-2034.
11. ABDOLLAHI A, ROBERTS D, GOODWIN AK, SCHULTZ DC, SONODA G, TESTA JR, HAMILTON TC. Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. Oncogene 1997; 14: 1973-1979.
12. SPENGLER D, VILLALBA M, HOFFMANN A, PANTALONI C, HOUSSAMI S, BOCKAERT J, JOURNOT L. Regulation of apoptosis and cell cycle arrest by Zacl, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J 1997; 16: 2814-2825.
13. VARRAULT A, CIANI E, APIOU F, BILANGES B, HOFFMANN A, PANTALONI C, BOCKAERT J, SPENGLER D, JOURNOT L. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci USA 1998; 95: 8835-8840.
14. KAS K, VOZ ML, RÖIJER E, ÅSTRÖM AK, MEYEN E, STENMAN G, VAN DE VEN WJ. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet 1997; 15: 170-174.
15. KAS K, Voz ML, HENSEN K, MEYEN E, VAN DE VEN WJ. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem 1998; 273: 23026-23032.
16. ÅSTRÖM A-K, VOZ ML, KAS K, RÖIJER E, WEDELL B, MANDAHL N, VAN DE VEN W, MARK J, STENMAN G. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities - identification of SII as a new fusion partner gene. Cancer Res 1999; 59: 918-923.
17. HENSEN K, VAN VALCKENBORGH IC, KAS K, VAN DE VEN WJ, VOZ ML. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Cancer Res 2002; 62: 1510-1517.
18. ABDOLLAHI A, BAO R, HAMILTON TC. LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein. Oncogene 1999; 18: 6477-6487.
19. ABDOLLAHI A, PISARCIK D, ROBERTS D, WEINSTEIN J, CAIRNS P, HAMILTON TC. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J Biol Chem 2003; 278: 6041-6049.
20. ENLUND F, BEHBOUDI A, ANDREN Y, OBERG C, LENDAHL U, MARK J, STENMAN G. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 2004; 292: 21-28.
21. NORDKVIST A, MARK J, GUSTAVSSON H, BANG G, STENMAN G. Nonrandom chromosome rearrangements in adenoid cystic carcinoma of the salivary glands. Genes Chromosomes Cancer 1994; 10: 115-121.