메뉴 건너뛰기




Volumn 104, Issue 4, 2006, Pages

A critical look at growth factors and epithelial-to-mesenchymal transition in the adult kidney: Interrelationships between growth factors that regulate EMT in the adult kidney

Author keywords

Bone morphogenic protein 7; Connective tissue growth factor; Epithelial to mesenchymal transition; Hepatocyte growth factor; Transforming growth factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; GROWTH FACTOR; ION CHANNEL; OSTEOGENIC PROTEIN 1; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 33845350114     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094963     Document Type: Short Survey
Times cited : (46)

References (56)
  • 1
    • 0027296534 scopus 로고
    • Epithelium-mesenchyme interconversion as example of epithelial plasticity
    • Boyer B, Thiery JP: Epithelium-mesenchyme interconversion as example of epithelial plasticity. APMIS 1993;101:257-268.
    • (1993) APMIS , vol.101 , pp. 257-268
    • Boyer, B.1    Thiery, J.P.2
  • 2
    • 0032827029 scopus 로고    scopus 로고
    • Embryonic renal epithelia: Induction, nephrogenesis, and cell differentiation
    • Horster MF, Braun GS, Huber SM: Embryonic renal epithelia: induction, nephrogenesis, and cell differentiation. Physiol Rev 1999;79:1157-1191.
    • (1999) Physiol Rev , vol.79 , pp. 1157-1191
    • Horster, M.F.1    Braun, G.S.2    Huber, S.M.3
  • 3
    • 0031706340 scopus 로고    scopus 로고
    • The tubulointerstitium in progressive renal disease
    • Nath KA: The tubulointerstitium in progressive renal disease. Kidney Int 1998;54:992-994.
    • (1998) Kidney Int , vol.54 , pp. 992-994
    • Nath, K.A.1
  • 4
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y: Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004;15:1-12.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 5
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005;24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 6
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that fibroblasts derive from epithelium during tissue fibrosis
    • Iwano M, Plieth D, Danoff TM, et al: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002;110:341-350.
    • (2002) J Clin Invest , vol.110 , pp. 341-350
    • Iwano, M.1    Plieth, D.2    Danoff, T.M.3
  • 7
    • 0029091682 scopus 로고
    • Identification and characterization of a fibroblast marker: FSP1
    • Strutz F, Okada H, Lo CW, et al: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995;130:393-405.
    • (1995) J Cell Biol , vol.130 , pp. 393-405
    • Strutz, F.1    Okada, H.2    Lo, C.W.3
  • 8
    • 0036318317 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    • Rastaldi MP, Ferrario F, Giardino L, et al: Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 2002;62:137-146.
    • (2002) Kidney Int , vol.62 , pp. 137-146
    • Rastaldi, M.P.1    Ferrario, F.2    Giardino, L.3
  • 9
    • 0034811585 scopus 로고    scopus 로고
    • Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis
    • Jinde K, Nikolic-Paterson DJ, et al: Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis. Am J Kidney Dis 2001;38:761-769.
    • (2001) Am J Kidney Dis , vol.38 , pp. 761-769
    • Jinde, K.1    Nikolic-Paterson, D.J.2
  • 10
    • 20544462075 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis
    • Vongwiwatana A, Tasanarong A, Rayner DC, et al: Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant. 2005;5:1367-1374.
    • (2005) Am J Transplant , vol.5 , pp. 1367-1374
    • Vongwiwatana, A.1    Tasanarong, A.2    Rayner, D.C.3
  • 11
    • 0034785496 scopus 로고    scopus 로고
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    • Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001;159:1465-1475.
    • (2001) Am J Pathol , vol.159 , pp. 1465-1475
    • Yang, J.1    Liu, Y.2
  • 12
    • 0034799176 scopus 로고    scopus 로고
    • Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation
    • Zeisberg M, Bonner G, Maeshima Y, et al: Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am J Pathol 2001;159:1313-1321.
    • (2001) Am J Pathol , vol.159 , pp. 1313-1321
    • Zeisberg, M.1    Bonner, G.2    Maeshima, Y.3
  • 13
    • 0038582623 scopus 로고    scopus 로고
    • Gelatinase a (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation
    • Cheng S, Lovett DH: Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 2003;162:1937-1949.
    • (2003) Am J Pathol , vol.162 , pp. 1937-1949
    • Cheng, S.1    Lovett, D.H.2
  • 14
    • 0036132393 scopus 로고    scopus 로고
    • Role of Id family proteins in growth control
    • Yokota Y, Mori S: Role of Id family proteins in growth control. J Cell Physiol 2002;190:21-28.
    • (2002) J Cell Physiol , vol.190 , pp. 21-28
    • Yokota, Y.1    Mori, S.2
  • 15
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N: A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996;7:469-480.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 16
    • 4043089953 scopus 로고    scopus 로고
    • Connective tissue growth factor and renal diseases: Some answers, more questions
    • Wahab NA, Mason RM: Connective tissue growth factor and renal diseases: some answers, more questions. Curr Opin Nephrol Hypertens 2004;13:53-58.
    • (2004) Curr Opin Nephrol Hypertens , vol.13 , pp. 53-58
    • Wahab, N.A.1    Mason, R.M.2
  • 17
    • 20444399088 scopus 로고    scopus 로고
    • Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2
    • Wahab NA, Weston BS, Mason RM: Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2. Exp Cell Res 2005;307:305-314.
    • (2005) Exp Cell Res , vol.307 , pp. 305-314
    • Wahab, N.A.1    Weston, B.S.2    Mason, R.M.3
  • 18
    • 1542343906 scopus 로고    scopus 로고
    • Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation
    • Grotendorst GR, Rahmanie H, Duncan MR: Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. FASEB J 2004;18:469-479.
    • (2004) FASEB J , vol.18 , pp. 469-479
    • Grotendorst, G.R.1    Rahmanie, H.2    Duncan, M.R.3
  • 19
    • 30744478450 scopus 로고    scopus 로고
    • The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells
    • Phanish MK, Wahab NA, Colville-Nash P, et al: The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Biochem J 2006;393:601-607.
    • (2006) Biochem J , vol.393 , pp. 601-607
    • Phanish, M.K.1    Wahab, N.A.2    Colville-Nash, P.3
  • 20
    • 2542473312 scopus 로고    scopus 로고
    • Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis
    • Yokoi H, Mukoyama M, Nagae T, et al: Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol 2004;15:1430-1440.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1430-1440
    • Yokoi, H.1    Mukoyama, M.2    Nagae, T.3
  • 21
    • 10744221859 scopus 로고    scopus 로고
    • DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition
    • Higgins DF, Lappin DW, Kieran NE, et al: DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int 2003;64:2079-2091.
    • (2003) Kidney Int , vol.64 , pp. 2079-2091
    • Higgins, D.F.1    Lappin, D.W.2    Kieran, N.E.3
  • 22
    • 9644255578 scopus 로고    scopus 로고
    • Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro
    • Zhang C, Meng X, Zhu Z, et al: Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro. Cell Biol Int 2004;28:863-873.
    • (2004) Cell Biol Int , vol.28 , pp. 863-873
    • Zhang, C.1    Meng, X.2    Zhu, Z.3
  • 23
    • 21044454845 scopus 로고    scopus 로고
    • Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis
    • Okada H, Kikuta T, Kobayashi T, et al: Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. J Am Soc Nephrol 2005;16:133-143.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 133-143
    • Okada, H.1    Kikuta, T.2    Kobayashi, T.3
  • 24
    • 0033942485 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury
    • Terzi F, Burtin M, Hekmati M, et al: Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest 2000;106:225-234.
    • (2000) J Clin Invest , vol.106 , pp. 225-234
    • Terzi, F.1    Burtin, M.2    Hekmati, M.3
  • 25
    • 0036233040 scopus 로고    scopus 로고
    • Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    • Strutz F, Zeisberg M, Ziyadeh FN, et al: Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002;6:1714-1728.
    • (2002) Kidney Int , vol.6 , pp. 1714-1728
    • Strutz, F.1    Zeisberg, M.2    Ziyadeh, F.N.3
  • 26
    • 27344459731 scopus 로고    scopus 로고
    • Differential immunoexpressions of cytoskeletons in renal epithelial and interstitial cells in rat and canine fibrotic kidneys, and in kidney-related cell lines under fibrogenic stimuli
    • Yamate J, Kuribayashi M, Kuwamura M, et al: Differential immunoexpressions of cytoskeletons in renal epithelial and interstitial cells in rat and canine fibrotic kidneys, and in kidney-related cell lines under fibrogenic stimuli. Exp Toxicol Pathol 2005;57:135-147.
    • (2005) Exp Toxicol Pathol , vol.57 , pp. 135-147
    • Yamate, J.1    Kuribayashi, M.2    Kuwamura, M.3
  • 27
    • 0034112481 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    • Strutz F, Zeisberg M, Hemmerlein B, et al: Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 2000;57:1521-1538.
    • (2000) Kidney Int , vol.57 , pp. 1521-1538
    • Strutz, F.1    Zeisberg, M.2    Hemmerlein, B.3
  • 28
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • Bates RC, Mercurio AM: Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 2003;14:1790-1800.
    • (2003) Mol Biol Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 29
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism
    • Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, et al: Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005;111:2509-2517.
    • (2005) Circulation , vol.111 , pp. 2509-2517
    • Rodriguez-Vita, J.1    Sanchez-Lopez, E.2    Esteban, V.3
  • 30
    • 0036785218 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
    • Yang J, Dai C, Liu Y: Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol 2002;13:2464-2477.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2464-2477
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 31
    • 0035061819 scopus 로고    scopus 로고
    • Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro
    • Fan JM, Huang XR, Ng YY, et al: Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro. Am J Kidney Dis 2001;37:820-831.
    • (2001) Am J Kidney Dis , vol.37 , pp. 820-831
    • Fan, J.M.1    Huang, X.R.2    Ng, Y.Y.3
  • 32
    • 9144254680 scopus 로고    scopus 로고
    • Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cellmyofibroblast transdifferentiation via Jak/Stat pathway activation
    • Nightingale J, Patel S, Suzuki N, et al: Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cellmyofibroblast transdifferentiation via Jak/Stat pathway activation. J Am Soc Nephrol 2004;15:21-32.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 21-32
    • Nightingale, J.1    Patel, S.2    Suzuki, N.3
  • 33
    • 1642336325 scopus 로고    scopus 로고
    • Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway
    • Li JH, Wang W, Huang XR, et al: Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. Am J Pathol 2004;164:1389-1397.
    • (2004) Am J Pathol , vol.164 , pp. 1389-1397
    • Li, J.H.1    Wang, W.2    Huang, X.R.3
  • 34
    • 16844371760 scopus 로고    scopus 로고
    • A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition
    • Yang J, Dai C, Liu Y: A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol 2005;16:68-78.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 68-78
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 35
    • 0037315742 scopus 로고    scopus 로고
    • Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice
    • Inoue T, Okada H, Kobayashi T, et al: Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice. FASEB J 2003;17:268-270.
    • (2003) FASEB J , vol.17 , pp. 268-270
    • Inoue, T.1    Okada, H.2    Kobayashi, T.3
  • 36
    • 2542433088 scopus 로고    scopus 로고
    • Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF
    • Dai C, Liu Y: Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol 2004;15:1402-1412.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1402-1412
    • Dai, C.1    Liu, Y.2
  • 37
    • 0029810973 scopus 로고    scopus 로고
    • Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7)
    • Vukicevic S, Kopp JB, Luyten FP, et al: Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci USA 1996;93:9021-9026.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9021-9026
    • Vukicevic, S.1    Kopp, J.B.2    Luyten, F.P.3
  • 38
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelialto-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, et al: BMP-7 counteracts TGF-beta1-induced epithelialto-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-968.
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3
  • 39
    • 0242582117 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
    • Zeisberg M, Bottiglio C, Kumar N, et al: Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Renal Physiol 2003;285:F1060-F1067.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Zeisberg, M.1    Bottiglio, C.2    Kumar, N.3
  • 40
    • 2942536704 scopus 로고    scopus 로고
    • Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein
    • Kowanetz M, Valcourt U, Bergstrom R: Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol 2004;24:4241-4254.
    • (2004) Mol Cell Biol , vol.24 , pp. 4241-4254
    • Kowanetz, M.1    Valcourt, U.2    Bergstrom, R.3
  • 41
    • 2542441495 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells
    • Wang S, Hirschberg R: Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J Biol Chem 2004;279:23200-23206.
    • (2004) J Biol Chem , vol.279 , pp. 23200-23206
    • Wang, S.1    Hirschberg, R.2
  • 42
    • 0028912590 scopus 로고
    • Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction
    • Naldini L, Vigna E, Bardelli A, et al: Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem 1995;270:603-611.
    • (1995) J Biol Chem , vol.270 , pp. 603-611
    • Naldini, L.1    Vigna, E.2    Bardelli, A.3
  • 43
    • 14844290237 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    • Zeisberg M, Shah AA, Kalluri R: Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem 2005;280:8094-8100.
    • (2005) J Biol Chem , vol.280 , pp. 8094-8100
    • Zeisberg, M.1    Shah, A.A.2    Kalluri, R.3
  • 44
    • 0043192745 scopus 로고    scopus 로고
    • GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations
    • Benchabane H, Wrana JL: GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol Cell Biol 2003;23:6646-6661.
    • (2003) Mol Cell Biol , vol.23 , pp. 6646-6661
    • Benchabane, H.1    Wrana, J.L.2
  • 45
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
    • Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 2001;276:12477-12480.
    • (2001) J Biol Chem , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 46
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway
    • Ulloa L, Doody J, Massague J: Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 1999;397:710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 47
    • 2942535966 scopus 로고    scopus 로고
    • Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    • Fukasawa H, Yamamoto T, Togawa A, et al: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci USA. 2004;101:8687-8692.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8687-8692
    • Fukasawa, H.1    Yamamoto, T.2    Togawa, A.3
  • 48
    • 0036014928 scopus 로고    scopus 로고
    • Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation
    • Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY: Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 2002;13:1464-1472.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1464-1472
    • Li, J.H.1    Zhu, H.J.2    Huang, X.R.3    Lai, K.N.4    Johnson, R.J.5    Lan, H.Y.6
  • 49
    • 1242339699 scopus 로고    scopus 로고
    • CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter
    • Ionescu AM, Drissi H, Schwarz Em, et al: CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol 2004;198:428-440.
    • (2004) J Cell Physiol , vol.198 , pp. 428-440
    • Ionescu, A.M.1    Drissi, H.2    Schwarz, Em.3
  • 50
    • 0034708801 scopus 로고    scopus 로고
    • Smad6 as a transcriptional corepressor
    • Bai S, Shi X, Yang X, et al: Smad6 as a transcriptional corepressor. J Biol Chem 2000;275:8267-8270.
    • (2000) J Biol Chem , vol.275 , pp. 8267-8270
    • Bai, S.1    Shi, X.2    Yang, X.3
  • 51
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata A, Lagna G, Massague J, et al: Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 1998;12:186-197.
    • (1998) Genes Dev , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massague, J.3
  • 52
    • 0344629431 scopus 로고    scopus 로고
    • Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    • Lin X, Liang YY, Sun B, et al: Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol 2003;23:9081-9093.
    • (2003) Mol Cell Biol , vol.23 , pp. 9081-9093
    • Lin, X.1    Liang, Y.Y.2    Sun, B.3
  • 53
    • 20444384532 scopus 로고    scopus 로고
    • Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA
    • Wahab NA, Weston BS, Mason RM: Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 2005;16:340-351.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 340-351
    • Wahab, N.A.1    Weston, B.S.2    Mason, R.M.3
  • 54
    • 0035798710 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor
    • Segarini PR, Nesbitt JE, Li D, Hays LG, Yates JR 3rd, Carmichael DF: The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J Biol Chem 2001;276:40659-40667.
    • (2001) J Biol Chem , vol.276 , pp. 40659-40667
    • Segarini, P.R.1    Nesbitt, J.E.2    Li, D.3    Hays, L.G.4    Yates III, J.R.5    Carmichael, D.F.6
  • 55
    • 0032913069 scopus 로고    scopus 로고
    • Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo
    • Babic AM, Chen CC, Lau LF: Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 1999;19:2958-2966.
    • (1999) Mol Cell Biol , vol.19 , pp. 2958-2966
    • Babic, A.M.1    Chen, C.C.2    Lau, L.F.3
  • 56
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, et al: Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002;4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.