Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro

Cell Biology International

Volumn 28, Issue 12, 2004, Pages 863-873

  Zhang, Chun ^a   Meng, Xianfang ^a   Zhu, Zhonghua ^a   Liu, Jianshe ^a   Deng, Anguo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Smooth muscle actin; Antisense oligodeoxynucleotide; Connective tissue growth factor; Human renal tubular epithelial cell; Transdifferentiation; Transforming growth factor

Indexed keywords

ALPHA ACTIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; TENASCIN; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN;

ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; CYTOPLASM; EXAMINATION; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INCUBATION TIME; KIDNEY CELL CULTURE; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; MYOFIBROBLAST; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETORY CELL; SMOOTH MUSCLE; UPREGULATION;

ACTINS; CELL DIFFERENTIATION; CELL LINE; COLLAGEN TYPE IV; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, PROXIMAL; OLIGONUCLEOTIDES, ANTISENSE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; VIMENTIN;

EID: 9644255578     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2004.09.003     Document Type: Article

References (39)

1. G.J. Becker, and T.D. Hewitson The role of tubulointerstitial injury in chronic renal failure Curr Opin Nephrol Hypertens 9 2000 133 138
2. I.E. Blom, R. Goldschmeding, and A. Leask Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 21 2002 473 482
3. E.P. Böttinger, and M. Bitzer TGF-β signaling in renal disease J Am Soc Nephrol 13 2002 2600 2610
4. J.J. Creely, S.J. DiMari, A.M. Howe, and M.A. Haralson Effects of transforming growth factor-beta on collagen synthesis by normal rat kidney epithelial cells Am J Pathol 140 1992 45 55
5. M.R. Duncan, K.S. Frazier, S. Abramson, S. Williams, H. Klapper, and X. Huang Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP FASEB J 13 1999 1774 1786
6. A.A. Eddy Molecular basis of renal fibrosis Pediatr Nephrol 15 2000 290 302
7. H.P. Erickson, and M.A. Bourdon Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors Annu Rev Cell Biol 5 1989 71 92
8. M. Essawy, O. Soylemezoglu, E.C. Muchaneta-Kubara, J. Shortland, C.B. Brown, and A.M. el Nahas Myofibroblasts and the progression of diabetic nephropathy Nephrol Dial Transplant 12 1997 43 50
9. J.M. Fan, Y.Y. Ng, P.A. Hill, D.J. Nikolic-Paterson, W. Mu, and R.C. Atkins Transforming growth factor-beta regulates tubular epithelial- myofibroblast transdifferentiation in vitro Kidney Int 56 1999 1455 1467
10. K.S. Frazier, A. Paredes, P. Dube, and E. Styer Connective tissue growth factor expression in the rat remnant kidney model and association with tubular epithelial cells undergoing transdifferentiation Vet Pathol 37 2000 328 335
11. K.S. Frazier, S. Williams, D. Kothapalli, H. Klapper, and G.R. Grotendorst Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor J Invest Dermatol 107 1996 404 411
12. E. Gore-Hyer, D. Shegogue, M. Markiewicz, S. Lo, D. Hazen-Martin, and E.L. Greene TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells Am J Physiol Renal Physiol 283 2002 F707 F716
13. E.D. Hay, and A. Zuk Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced Am J Kidney Dis 26 1995 678 690
14. C. Hill, A. Flyvbjerg, H. Gronbaek, J. Petrik, D.J. Hill, and C.R. Thomas The renal expression of transforming growth factor-beta isoforms and their receptors in acute and chronic experimental diabetes in rats Endocrinology 141 2000 1196 1208
15. B. Hogemann, A. Gillessen, W. Bocker, J. Rauterberg, and W. Domschke Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis Scand J Gastroenterol 28 1993 591 594
16. A. Igarashi, H. Okochi, D.M. Bradham, and G.R. Grotendorst Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair Mol Biol Cell 4 1993 637 645
17. Y. Ito, J. Aten, R.J. Bende, B.S. Oemar, T.J. Rabelink, and J.J. Weening Expression of connective tissue growth factor in human renal fibrosis Kidney Int 53 1998 853 861
18. H.A. Makhluf, J. Stepniakowska, S. Hoffman, E. Smith, E.C. LeRoy, and M. Trojanowska IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts J Invest Dermatol 107 1996 856 859
19. P.J. Miettinen, R. Ebner, A.R. Lopez, and R. Derynck TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors J Cell Biol 127 1994 2021 2036
20. E.C. Muchaneta-Kubara, and A.M. el Nahas Myofibroblast phenotypes expression in experimental renal scarring Nephrol Dial Transplant 12 1997 904 915
21. G.A. Muller, M. Zeisberg, and F. Strutz The importance of tubulointerstitial damage in progressive renal disease Nephrol Dial Transplant 15 2000 76 77
22. K.A. Nath Tubulointerstitial changes as a major determinant in the progression of renal damage Am J Kidney Dis 20 1992 1 17
23. Y.Y. Ng, T.P. Huang, W.C. Yang, Z.P. Chen, A.H. Yang, and W. Mu Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats Kidney Int 54 1998 864 876
24. H. Okada, S. Ban, S. Nagao, H. Takahashi, H. Suzuki, and E.G. Neilson Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation Kidney Int 58 2000 587 597
25. H. Okada, T. Inouem, H. Suzuki, F. Strutz, and E.G. Neilson Epithelial-mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo Nephrol Dial Transplant 15 2000 44 46
26. M. Okada, T. Takemura, K. Murakami, S. Hino, and K. Yoshioka Expression of tenascin in normal and diseased human kidneys Nippon Jinzo Gakkai Shi 38 1996 213 219
27. J.D. Potts, J.M. Dagle, J.A. Walder, D.L. Weeks, and R.B. Runyan Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3 Proc Natl Acad Sci U S A 88 1991 1516 1520
28. I.S. Roberts, C. Burrows, J.H. Shanks, M. Venning, and L.J. McWilliam Interstitial myofibroblasts: predictors of progression in membranous nephropathy J Clin Pathol 50 1997 123 127
29. S.J. Shankland, J. Pippin, R.H. Pichler, K.L. Gordon, S. Friedman, and L.I. Gold Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy Kidney Int 50 1996 116 124
30. F. Strutz, and G.A. Muller Interstitial pathomechanisms underlying progressive tubulointerstitial damage Kidney Blood Press Res 22 1999 71 80
31. F. Strutz, H. Okada, C.W. Lo, T. Danoff, R.L. Carone, and J.E. Tomaszewski Identification and characterization of a fibroblast marker: FSP1 J Cell Biol 130 1995 393 405
32. W.W. Tang, T.R. Ulich, D.L. Lacey, D.C. Hill, M. Qi, and S.A. Kaufman Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis Am J Pathol 148 1996 1169 1180
33. W.W. Tang, G.Y. Van, and M. Qi Myofibroblast and alpha 1 (III) collagen expression in experimental tubulointerstitial nephritis Kidney Int 51 1997 926 931
34. S. Wang, M. Denichilo, C. Brubaker, and R. Hirschberg Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy Kidney Int 60 2001 96 105
35. J. Yang, and Y. Liu Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis Am J Pathol 159 2001 1465 1475
36. H. Yokoi, M. Mukoyama, A. Sugawara, K. Mori, T. Nagae, and H. Makino Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis Am J Physiol Renal Physiol 282 2002 F933 F942
37. M. Zeisberg, G. Bonner, Y. Maeshima, P. Colorado, G.A. Muller, and F. Strutz Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation Am J Pathol 159 2001 1313 1321
38. G. Zhang, P.J. Moorhead, and A.M. el Nahas Myofibroblasts and the progression of experimental glomerulonephritis Exp Nephrol 3 1995 308 318
39. H.Y. Zhang, and S.H. Phan Inhibition of myofibroblast apoptosis by transforming growth factor beta(1) Am J Respir Cell Mol Biol 21 1999 658 665