Acrylamide axonopathy revisited

Toxicology and Applied Pharmacology

Volumn 188, Issue 3, 2003, Pages 135-153

  LoPachin, R M ^a,d   Balaban, C D ^b   Ross, J F ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b University of Pittsburgh School of Medicine   (United States)

^c The Health and Environmental Safety Alliance   (United States)

^d MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Axon degeneration; Distal axonopathy; Nerve terminal; Neurotoxicity; Toxic neuropathy

Indexed keywords

ACRYLAMIDE;

ARGYROPHILIA; BRAIN; BRAIN NUCLEUS; BRAIN STEM; CELL DAMAGE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; FOREBRAIN; GAIT; GRAY MATTER; GRIP STRENGTH; INTOXICATION; LOCOMOTION; LOW DRUG DOSE; MEDICAL ASSESSMENT; MESENCEPHALON; NERVE DEGENERATION; NERVE ENDING; NERVE FIBER DEGENERATION; NERVE TRACT; NEUROFILAMENT; NEUROPATHY; NEUROTOXICITY; NONHUMAN; OBSERVATION; OPEN FIELD BEHAVIOR; PATHOPHYSIOLOGY; PURKINJE CELL; REVIEW; RISK FACTOR; SILVER STAINING; SPINAL CORD; WHITE MATTER;

EID: 0037406475     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(02)00072-8     Document Type: Review

References (152)

1. Abou-Donia M.B., Ibrahim S.M., Corcoran J.J., Lack L., Friedman M.A., Lapadula D.M. Neurotoxicity of glycidamide, an acrylamide metabolite, following intraperitoneal injections in rats. J. Toxicol. Environ. Health. 39:1993;447-464.
2. Agrawal A.K., Seth P.K., Squibb R.E., Tilson H.A., Uphouse L.L., Bondy S.C. Neurotransmitter receptors in brain regions of acrylamide-treated rats. I. Effects of a single exposure to acrylamide. Pharmacol. Biochem. Behav. 14:1981;527-531.
3. Agrawal A.K., Squibb R.E., Bondy S.C. Effects of acrylamide treatment upon the dopamine receptor. Toxicol. Appl. Pharmacol. 58:1981;89-99.
4. Alderson B.H., Volpe P. Distribution of endoplasmic reticulum and calciosome markers in membrane fractions isolated from different regions of the canine brain. Arch. Biochem. Biophys. 272:1989;162-174.
5. Angner R.T., Kelly R.M., Wiley R.G., Walsh T.J., Reuhl K.R. Preferential destruction of cerebellar Purkinje cells by OX7-saporin. NeuroToxicology. 21:2000;395-404.
6. Antal M., Sholomenko G.N., Moschovakis A.K., Storm-Mathisen J., Heizmann C.W., Hunziker W. The termination pattern and postsynaptic targets of rubrospinal fibers in the rat spinal cord a light and electron microscopic study . J. Comp. Neurol. 325:1992;22-37.
7. Balaban C.D. Ovlivo-vestibular and cerebello-vestibular connections in albino rabbits. Neuroscience. 12:1984;129-149.
8. Balaban C.D. Central neruotoxic effects of intraperitoneally administered 3-acetylpyridine, harmaline and niacinamide in Sprague-Dawley and Long-Evans rats a critical review of central 3-aceylpyridine neurotoxicity . Brain Res. Rev. 9:1985;21-42.
9. Balaban C.D. The use of selective silver degeneration stains in neurotoxicology. Isaacson R.L., Jensen K.F. The Vulnerable Brain and Environmental Risks Volume 1: Malnutrition and Hazard Assessment. 1992;223-238 Plenum Press, New York.
10. Balaban C.D., O'Callaghan J.P., Billingsley M.L. Trimethyltin-induced neuronal damage in the rat brain comparative studies suing silver degeneration stains, immunocytochemistry and immunoassay for neurontypic and gliotypic proteins . Neuroscience. 26:1988;337-361.
11. Balice-Gordon R.J., Lichtman J.W. Long-term synapse loss induced by focal blockade of postsynaptic receptors. Nature. 372:1994;519-524.
12. Barber D., Hunt J.R., Ehrich M., Lehning E.J., LoPachin R.M. Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing. NeuroToxicology. 22:2001;341-353.
13. Bergmark E., Calleman C.J., Costa L.G. Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat. Toxicol. Appl. Pharmacol. 111:1991;352-363.
14. Bergmark E., Calleman C.J., He F., Costa L.G. Determination of hemoglobin adducts in humans occupationally exposed to acrylamide. Toxicol. Appl. Pharmacol. 120:1993;45-54.
15. Bisby M.A., Redshaw J.D. Acrylamide neuropathy changes in composition of proteins of fast axonal transport resemble those observed in regenerating axons . J. Neurochem. 48:1987;924-928.
16. Bondy S.C., Tilson H.A., Agrawal A.K. Neurotransmitter receptors in brain regions of acrylamide-treated rats. II. Effects of extended exposure to acrylamide. Pharmacol. Biochem. Behav. 14:1981;533-537.
17. Brat D.J., Brimijoin S. Acrylamide and glycidamide impair outgrowth in differentiating NIE.115 neuroblastoma without disturbing rapid bi-directional transport of organelles observed by video microscopy. J. Neurochem. 60:1993;2145-2152.
18. Burek J.D., Albee R.R., Beyer J.E., Bell T.J., Carreon R.M., Morden D.C., Wade C.E., Hermann E.A., Gorzinski S.J. Subchronic toxicity of acrylamide administered to rats in drinking water followed by up to 144 days of recovery. J. Environ. Pathol. Toxicol. 4:1980;157-182.
19. Burgess D.L., Kohrman D.C., Galt J., Plummer N.W., Jones J.M., Spear B., Meisler M.H. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant "motor endplate disease." Nat. Gen. 10:1995;461-465.
20. Calleman C.J. The metabolism and pharmacokinetics of acrylamide implications for mechanisms of toxicity and human risk estimation . Drug Metab. Rev. 28:1996;527-590.
21. Campbell S.K., Parker T.D., Welker W. Somatotopic organization of the external cuneate nucleus in albino rats. Brain Res. 77:1974;1-23.
22. Carlsen J., de Olmos J.S. A modified cupric-silver technique for the impregnation of degenerating neurons and their processes. Brain Res. 208:1981;426-431.
23. Cavanagh J.B. The significance of the "dying-back" process in experimental and human neurological disease. Int. Rev. Exp. Pathol. 3:1964;219-267.
24. Cavanagh J.B. The dying back process. Arch. Pathol. Lab. Med. 103:1979;659-664.
25. Cavanagh J.B. The pathokinetics of acrylamide intoxication a reassessment of the problem . Neuropathol. Appl. Neurobiol. 8:1982;315-336.
26. Cavanagh J.B. Mechanisms of axon degeneration in three toxic neuropathies organophosphorus, acrylamide and hexacarbon compared . Smith W.T., Cavanagh J.B. Recent Advances in Neuropathology. 1982;213-242 Churchill Livingstone, New York.
27. Cavanagh J.B., Gysbers M.F. Ultrastructural features of the Purkinje cell damage caused by acrylamide in the rat a new phenomenon in cellular neurophysiology . J. Neurocytol. 12:1983;413-437.
28. Cavanagh J.B., Nolan C.C. Selective loss of Purkinje cells from the rat cerebellum caused by acrylamide and the responses of β-glucuronidase and β-galactosidase. Acta Neuropathol. 58:1982;210-214.
29. Crepel F., Jaillard D. Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro. J. Physiol. 432:1991;123-141.
30. Crofton K.M., Padilla S., Tilson H.A., Anthony D.C., Raymer J.H., MacPhail R.C. The impact of dose rate on the neurotoxicity of acrylamide the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects . Toxicol. Appl. Pharmacol. 139:1996;163-176.
31. DeGrandchamp R.L., Lowndes H.E. Early degeneration and sprouting at the rat neuromuscular junction following acrylamide administration. Neuropathol. Appl. Neurobiol. 16:1990;239-254.
32. DeGrandchamp R.L., Reuhl K.R., Lowndes H.E. Synaptic terminal degeneration and remodeling at the rat neuromuscular junction resulting from a single exposure to acrylamide. Toxicol. Appl. Pharmacol. 105:1990;422-433.
33. de Olmos J.D., Beltramino C.A., de Olmos-de Lorenzo S. Use of an amino-cupric silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia and physical trauma. Neurotoxicol. Teratol. 16:1994;545-561.
34. de Olmos J.D., Ingram W.R. An improved cupric-silver method for impregnation of axonal and terminal degeneration. Brain Res. 33:1972;523-529.
35. De Rojas T.C., Goldstein B.D. Primary afferent terminal function following acrylamide alterations in the dorsal root potential and reflex . Toxicol. Appl. Pharmacol. 88:1987;175-182.
36. Dick D.J., Boakes R.J., Harris J.B. A cerebellar abnormality in the mouse with motor end-late disease. Neuropathol. Appl. Neurobiol. 11:1985;141-147.
37. Droz B., Koenig H.L., Di Giamberardino L., Courand J.Y., Chretien M., Souyri F. The importance of axonal transport and endoplasmic reticulum in the function of cholinergic synapse in normal and pathological conditions. Tucek S. Progress in Brain Research. 1979;23-44 Elsevier, Amsterdam.
38. Duc C., Catsicas S. Ultrastructural localization of SNAP-25 within the rat spinal cord and peripheral nervous system. J. Comp. Neurol. 356:1995;152-163.
39. Fink R.P., Heimer L. Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 4:1967;369-374.
40. Fix A.S., Ross J.F., Stitzel S.R., Switzer R.C. Integrated evaluation of central nervous system lesions stains for neurons, astrocytes and microglia reveal the spatial and temporal features of MK-801-induced neuronal necrosis in the rat cerebral cortex . Toxicol. Pathol. 24:1996;291-304.
41. Friedman M.A., Tyl R.W., Marr M.C., Myers C.B., Gerling F.S., Ross W.P. Effects of lactational administration of acrylamide on rat dams and offspring. Reprod. Toxicol. 13:1999;511-520.
42. Garcia E.P., McPherson P.S., Chilcote T.J., Takei K., DeCamilli P. rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. J. Cell Biol. 129:1995;105-120.
43. Ghetti B., Wisneiwski H.M., Cook R.D., Schaumburg H.H. Changes in the CNS after acute and chronic acrylamide intoxication. Am. J. Pathol. 70:1973;78A.
44. Ghez C., Thach W.T. The cerebellum. Kandel E.R., Schwartz J.H., Jessell T.M. Principles of Neural Science. 4th ed. 2000;832-852 McGraw-Hill, New York.
45. Gipon L., Schotman P., Jennekens F.G.I., Gispen W.H. Polyneuropathies and CNS protein metabolism. I. Description of the acrylamide syndrome in rats. Neuropathol. Appl. Neurobiol. 3:1977;115-123.
46. Gold B.G., Austin D.R., Griffin J.W. Regulation of aberrant neurofilament phosphorylation in neuronal perikarya. II. Correlation with continued axonal elongation following axotomy. J. Neuropathol. Exp. Neurol. 50:1991;627-648.
47. Gold B.G., Griffin J.W., Pestronk A., Hoffman P.N., Stanley E.F., Price D.L. Somatofugal axonal atrophy produced by botulinum toxin. Neurosci. Abst. 12:1986;1108.
48. Gold B.G., Schaumburg H.H. Acrylamide. Spencer P.S., Schaumburg H.H., Ludolph A.C. Experimental and Clinical Neurotoxicology. 2nd ed. 2000;124-132 Oxford University Press, New York.
49. Goldstein B.D. Acrylamide neurotoxicity altered spinal monosynaptic response to quipazine, a serotonin agonist in cats . Toxicol. Appl. Pharmacol. 78:1985;436-444.
50. Goldstein B.D., Lowndes H.E. Spinal cord defect in the peripheral neuropathy resulting from acrylamide. NeuroToxicology. 1:1979;75-87.
51. Goldstein B.D., Lowndes H.E. Group Ia primary afferent terminal defect in cats with acrylamide neuropathy. NeuroToxicology. 2:1981;297-312.
52. Griffin J.W., Price D.L., Drachman D.B. Impaired axonal regeneration in acrylamide intoxication. J. Neurobiol. 8:1977;355-370.
53. Harry G.J. Acrylamide-induced alterations in axonal transport. Mol. Neurobiol. 6:1992;203-216.
54. Harry G.J., Goodrum J.F., Bouldin T.W., Toews A.D., Morell P. Acrylamide-induced increases in deposition of axonally transported glycoproteins in rat sciatic nerve. J. Neurochem. 52:1989;1240-1247.
55. Harry G.J., Morell P., Bouldin T.W. Acrylamide exposure preferentially impairs axonal transport of glycoproteins in myelinated axons. J. Neurosci. Res. 31:1992;554-560.
56. Hegstrom C.D., Truman J.W. Synapse loss and axon retraction in response to local muscle degeneration. J. Neurobiol. 31:1994;175-188.
57. Hoffman P.N., Koo E.H., Muma N.A., Griffin J.W., Price D.L. Role of neurofilaments in control of axonal caliber in myleinated nerve fibers. Lasek R.J., Black M.M. Intrinsic Determinants of Neuronal Form and Function. 1988;389-402 Alan Liss, New York.
58. Hopkins A. The effect of acrylamide on the peripheral nervous system of the baboon. J. Neurol. Neurosurg. Psychiat. 33:1970;805-816.
59. Ito M. The Cerebellum and Neural Control. 1984;Raven Press, New York.
60. Jahn R., Sudhof T.C. Membrane fusion and exocytosis. Ann. Rev. Biochem. 68:1999;863-911.
61. Jansen A.S.P., Van Nguyen X., Karpitskiy V., Mettenleiter T.C., Loewy A.D. Central command neurons of the sympathetic nervous system basis of the fight or flight response . Science. 270:1995;644-646.
62. Kelly R.B., Grote E. Protein targeting in the neuron. Annu. Rev. Neurosci. 16:1993;95-127.
63. Kemp D.S., Vellaccio F. Organic Chemistry. Worth Publishers. 1980;839-874 New York.
64. Kemplay S., Cavanagh J.B. Effects of acrylamide and other sulfhydryl compound in vivo and in vitro on staining of motor nerve terminals by the zinc iodide-osmium technique. Muscle Nerve. 7:1984;94-100.
65. Kemplay S., Cavanagh J.B. Effects of acrylamide and some other sulfhydryl reagents on spontaneous and pathologically induced terminal sprouting from motor end-plates. Muscle Nerve. 7:1984;101-109.
66. Khanin R., Segel L., Futerman A.H. The diffusion of molecules in axonal plasma membranes the sites of insertion of new membrane molecules and their distribution along the axon surface . J. Ther. Biol. 193:1998;371-382.
67. Konnerth A., Dreessen J., Augustine G.J. Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells. Proc. Natl. Acad Sci. USA. 89:1992;7051-7055.
68. Kopp D.M., Perkel D.J., Balice-Gordon R.J. Disparity in neurotransmitter release probability among competing inputs during neuromuscular synapse elimination. J. Neurosci. 20:2000;8771-8779.
69. Kuperman A.S. Effects of acrylamide on the central nervous system of the cat. J. Pharmacol. Exp. Ther. 123:1958;180-192.
70. Kuwajima G., Futatsugi A., Niinobe M., Nakanishi S., Mikoshiba K. Two types of ryanodine receptors in mouse brain skeletal muscle type exclusively in Purkinje cells and cardiac muscle type in various neurons . Neuron. 9:1992;1133-1142.
71. Lehning E.J., Balaban C.D., Ross J.F., Reid M.L., LoPachin R.M. Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum. NeuroToxicology. 23:2002;397-414.
72. Lehning E.J., Balaban C.D., Ross J.F., LoPachin R.M. Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in rat brainstem and spinal cord. NeuroToxicology. 23:2002;415-429.
73. Lehning E.J., Balaban C.D., Ross J.F., LoPachin R.M. Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in rat forebrain. NeuroToxicology. 24:2003;125-136.
74. Lehning E.J., Doshi R., Isaksson N., Stys P.K., LoPachin R.M. Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons role of reverse sodium-calcium exchange . J. Neurochem. 66:1996;493-500.
75. Lehning E.J., Dyer K.S., Jortner B.S., LoPachin R.M. Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy. Toxicol. Appl. Pharmacol. 135:1995;58-66.
76. Lehning E.J., Gaughan C.L., LoPachin R.M. Acrylamide intoxication modifies in vitro responses of peripheral nerve axons to anoxia. J. Periph. Nervous Sys. 2:1997;165-174.
77. Lehning E.J., LoPachin R.M., Matthew J., Eichberg J. Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats. J. Toxicol. Environ. Health. 42:1994;331-342.
78. Lehning E.J., Persaud A., Dyer K.R., Jortner B.S., LoPachin R.M. Biochemical and morphologic characterization of acrylamide peripheral neuropathy. Toxicol. Appl. Pharmacol. 151:1998;211-221.
79. LeQuesne P.M. Acrylamide. Spencer P.S., Schaumburg H.H. Experimental and Clinical Neurotoxicology. 1st ed. 1980;309-325 Williams and Wilkins, Baltimore, MD.
80. LeQuesne P.M. Clinical and morphological findings in acrylamide toxicity. NeuroToxicology. 6:1985;17-24.
81. Li J.-Y., Jahn R., Dahlstrom A. Axonal transport and targeting of the t-SNAREs SNAP-25 and syntaxin 1 in the peripheral nervous system. Eur. J. Cell Biol. 70:1996;12-22.
82. Lin R.C., Scheller R.H. Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol. 16:2000;19-49.
83. Lipton S.A., Kater S.B. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. TINS. 12:1989;265-270.
84. Llano I., DiPalo R., Marty A. Calcium-induced calcium release in cerebellar Purkinje cells. Neuron. 12:1994;663-673.
85. LoPachin R.M. The role of fast axonal transport in acrylamide pathophysiology mechanism or epiphenomenon? Neurotoxicology. 23:2002;253-257.
86. LoPachin R.M., Lehning E.J. Acrylamide-induced distal axon degeneration a proposed mechanism of action . NeuroToxicology. 15:1994;247-260.
87. LoPachin R.M., Lehning E.J. Mechanism of calcium entry during axon injury and degeneration. Toxicol. Appl. Pharmacol. 143:1997;233-244.
88. LoPachin R.M., Lehning E.J., Opanashuk L.A., Jortner B.S. Rate of neurotoxicant exposure determines morphologic manifestations of distal axonopathy. Toxicol. Appl. Pharmacol. 167:2000;75-86.
89. LoPachin R.M., Ross J.F., Lehning E.J. Nerve terminals as the primary site of acrylamide action a hypothesis . NeuroToxicology. 23:2002;43-60.
90. LoPachin R.M., Ross J.F., Reid M.L., Dasgupta S., Mansukhani S., Lehning E.J. Neurological evaluation of toxic axonopathies in rats acrylamide and 2,5-hexanedione . NeuroToxicology. 23:2002;95-110.
91. LoPachin, R.M., Schwarcz, A.I., Gaughan, C.L., Mansukhani, S., Das, S., 2002c. In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release. Toxicol. Appl. Pharmacol., submitted.
92. Martenson C.H., Odom A., Sheetz M.P., Graham D.G. In vitro acrylamide exposure alters growth cone morphology. Toxicol. Appl. Pharmacol. 131:1995;119-129.
93. Meffert M.K., Calakòs N.C., Scheller R.H., Schulamn H. Nitric oxide modulates synaptic vesicle docking/fusion reactions. Neuron. 16:1996;1229-1236.
94. Morgan A. Exocytosis. Essays Biochem. 30:1995;77-95.
95. Morris S.A., Schmid S.L. The Ferrari of endocytosis? Curr. Biol. 5:1995;113-115.
96. Nakata T., Terada S., Hirokawa N. Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons. J. Cell Biol. 140:1998;659-674.
97. Nauta W.J.H., Gygax P.A. Silver impregnation of degenerating axon terminals in the central nervous system. 1. Technique, 2. Chemical notes. Stain Technol. 26:1951;5-11.
98. Nauta W.J.H., Gygax P.A. Silver impregnation of degenerating axons in the central nervous system. Stain Technol. 29:1954;91-93.
99. 14C]GABA release from brain synaptosomes the role of SH-groups . Biochemistry. 65:2000;1215-1224.
100. Nichols B.J., Pelham H.R.B. SNAREs and membrane fusion in the Golgi apparatus. Biochem. Biophys. Acta. 1404:1998;9-31.
101. O'Shaughnessy D.J., Losos G.J. Comparison of central and peripheral nervous system lesions caused by high-dose short-term and low-dose subchronic acrylamide treatment in rats. Toxicol. Pathol. 14:1986;389-394.
102. Palay S., Chan-Palay V. Cerebellar Cortex Cytology and Organization . 1974;Springer Publishing, New York.
103. Pan Z.H., Segal M.M., Lipton S.A. Nitric oxide-related species inhibit evoked neurotransmition but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proc. Natl. Acad. Sci. USA. 93:1996;15423-15428.
104. Perkel D.J., Hestrin S., Sah P., Nicoll R.A. Excitatory synaptic currents in Purkinje cells. Proc. R. Soc. Lond. B. 241:1990;116-121.
105. Pinter, M.J., Vanden Noven, S., Muccio, D., Wallace, N. 1991. Axotomy-like changes in cat motoneuron electrical properties elicited by botulinum toxin depend on the complete elimination of neuromuscular transmission. J. Neurosci. 11, 657-666.
106. Pinter M.J., Waldeck R.F., Wallace N., Cork L.C. Motor unit behavior in canine motor neuron disease. J. Neurosci. 15:1969;3447-3457.
107. Prineas J. The pathogenesis of dying-back polyneuropathies. Part II. An ultrastructural study of experimental acrylamide intoxication in the cat. J. Neuropathol. Exp. Neurol. 28:1969;598-621.
108. Raff M.C., Whitmore A.V., Finn J.T. Axonal self-destruction and neurodegeneration. Science. 296:2002;868-871.
109. Ralevic V., Aberdeen J.A., Burnstock G. Acrylamide-induced autonomic neuropathy of rat mesenteric vessels histological and pharmacological studies . J. Auto. Nervous Sys. 34:1991;77-88.
110. Rich M., Lichtman J.W. Motor nerve terminal loss from degenerating muscle fibers. Neuron. 3:1989;677-688.
111. Ross C.A., Meldolesi J., Milner T.A., Satoh T., Supattapone S., Synder S.H. Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature. 339:1989;468-470.
112. Rossi F., Jankovski A., Sotelo C. Target neuron controls the integrity of afferent axon phenotype a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice . J. Neurosci. 15:1995;2040-2056.
113. Rothman J.E., Wieland F.T. Protein sorting by transport vesicles. Science. 272:1996;227-234.
114. Satchell P.M. Baroreceptor dysfunction in acrylamide axonal neuropathy. Brain. 113:1990;167-176.
115. Schaumburg H.H., Wisniewski H.M., Spencer P.S. Ultrastructural studies of the dying-back process. I. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication. J. Neuropathol. Exp. Neurol. 33:1974;260-284.
116. 2+ release channels in rat brain. J. Neurosci. 13:1993;3051-3063.
117. Sickles D.W., Brady S.T., Testino A., Friedman M.A., Wrenn R.W. Direct effect of the neurotoxicant acrylamide on kinesin-based microtubule motility. J. Neurosci. Res. 46:1996;7-17.
118. Sickles D.W., Stone D., Friedman M.A. Fast axonal transport a site of acrylamide neurotoxicity? NeuroToxicology. 23:2002;223-251.
119. Sidenius P., Jakobsen J. Anterograde axonal transport in rats during intoxication with acrylamide. J. Neurochem. 40:1983;697-704.
120. Sotelo C. Axonal abnormalities in cerebellar Purkinje cells of the "hyperspiny Purkinje cell" mutant mouse. J. Neurocytol. 19:1990;737-755.
121. Spencer P.S., Schaumburg H.H. A review of acrylamide neurotoxicity. Part I. Properties, uses and human exposure. Can. J. Neurol. Sci. 1:1974;151-169.
122. Spencer P.S., Schaumburg H.H. A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms. Can. J. Neurol. Sci. 1:1974;170-192.
123. Spencer P.S., Schaumburg H.H. Central-peripheral distal axonopathy - the pathology of dying-back polyneuropathies. Zimmerman H. Progress in Neuropathology. 1976;253-276 Grune & Stratton, New York.
124. Spencer P.S., Schaumburg H.H. Ultrastructural studies of the dying-back process. III. The evolution of experimental peripheral giant axonal degeneration. J. Neuropathol. Exp. Neurol. 36:1977;276-299.
125. Spencer P.S., Schaumburg H.H. Ultrastructural studies of the dying-back process. IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathy. J. Neuropathol. Exp. Neurol. 36:1977;300-320.
126. Spencer P.S., Schaumburg H.H. Classification of neurotoxic disease a morphological approach . Spencer P.S., Schaumburg H.H. Experimental and Clinical Neurotoxicology. 1980;92-99 Williams and Wilkins, Baltimore, MD.
127. Sterman A.B. Acrylamide induces early morphologic reorganization of the neuronal cell body. Neurology. 32:1982;1023-1026.
128. Sterman A.B. Altered sensory ganglia in acrylamide neuropathy; quantitative evidence of neuronal reorganization. J. Neuropathol. Exp. Neurol. 42:1983;166-176.
129. Sterman A.B. Acrylamide-induced remodeling of perikarya in rat superior cervical ganglia. Neuropathol. Appl. Neurobiol. 10:1984;221-234.
130. Sterman A.B., Sposito N. 2,5-Hexanedione and acrylamide produce reorganization of motoneuron perikarya. Neuropathol. Appl. Neurobiol. 11:1985;201-212.
131. Stone J.D., Peterson A.P., Eyer J., Oblak T.G., Sickles D.W. Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport video-enhanced differential interference microscopy in peripheral nervous system axons . Toxicol. Appl. Pharmacol. 161:1999;50-58.
132. Stone J.D., Peterson A.P., Eyer J., Sickles D.W. Neurofilaments are non-essential elements of toxicant-induced reductions in fast axonal transport pulse labeling in CNS neurons . NeuroToxicology. 21:2000;447-458.
133. Stys P.K., LoPachin R.M. Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons. Neuroscience. 82:1998;21-32.
134. Sudhof T.C. The synaptic vesicle cycle a cascade of protein-protein interactions . Nature. 375:1995;645-653.
135. Sudhof T.C. The synaptic vesicle cycle revisited. Neuron. 28:2000;317-320.
136. Switzer R.C. Application of silver degeneration stains for neurotoxicity testing. Toxicol. Pathol. 28:2000;70-83.
137. Tanaka D., Bursian S.J., Lehning E.J. Silver impregnation of organophosphorous-induced delayed neuropathy in the central nervous system. Isaacson R.L., Jensen K.F. The Vulnerable Brain and Environmental Risks, Vol. 2 Toxins in Food . 1992;223-238 Plenum Press, New York.
138. Tareke E., Rydberg P., Karlsson P., Eriksson S., Tornqvist M. Acrylamide a cooking carcinogen? Chem. Res. Toxicol. 13:2000;517-522.
139. Thomas P.K. The peripheral nervous system as a target for toxic substances. Spencer P.S., Schaumburg H.H. Experimental and Clinical Neurotoxicology. 1980;35-47 Williams & Wilkins, Baltimore, MD.
140. Tracey D.J. Ascending and descending pathways in the spinal cord. Paxinos G. The Rat Nervous System. 1995;689-704 Academic Press, New York.
141. Triarhou L.C. Rate of neuronal fallout in a transsynaptic cerebellar model. Brain Res. Bull. 47:1998;219-222.
142. Tsujihata M., Engel A.G., Lambert E.H. Motor end-plate fine structure in acrylamide dying-back neuropathy a sequential morphometric study . Neurology. 24:1974;849-856.
143. Tyl R.W., Marr M.C., Myers C.B., Ross W.P., Friedman M.A. Relationship between acrylamide reproductive and neurotoxicity in male rats. Repro. Toxicol. 14:2000;147-157.
144. Ueyama T., Houtani T., Ikeda M., Sato K., Sugimoto T., Mizuno N. Distribution of primary afferent fibers projecting from hindlimb cutaneous nerves to the medulla oblongata in the cat and rat. J. Comp. Neurol. 341:1994;145-158.
145. U.S. Environmental Protection Agency, 1985. Toxic Substance Control Act Testing Guidelines. Federal Register, Vol. 50, 40 CFR, Part 798, Subpart G. No. 188.
146. Preliminary assessment of health risks from exposure to acrylamide. Office of Toxic Substances. 1988;U.S. Environmental Protection Agency, Washington, D.C.
147. Walton P.D., Airey J.A., Sutko J.L., Beck C.F., Mignery G.A., Sudhop T.C., Deernick T.J., Ellisman M.H. Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons. J. Cell Biol. 113:1991;1145-1157.
148. Worley P.F., Baraban J.M., Snyder S.H. Inositol 1,4,5-trisphosphate receptor binding autoradiographic localization in rat brain . J. Neurosci. 9:1989;339-346.
149. Yoshimura S., Imai K., Saitoh Y., Yamaguchi H., Ohtaki S. The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs. Mol. Chem. Neuropathol. 16:1992;59-84.
150. Zakharenko S., Popov S. Dynamics of axonal microtubules regulate the topology of new membrane insertion into the growing neurites. J. Cell Biol. 143:1998;1077-1086.
151. Zemlan F.P., Kow L.M., Morrell J.I., Pfaff D.W. Descending tracts of the lateral columns of the rat spinal cord a study using the horseradish peroxidase and silver impregnation techniques . J. Anat. 128:1979;489-512.
152. Zhao H.M., Wenthold R.J., Wang Y.X., Petralia R.S. γ-Glutamate receptors are differentially distributed at parallel and climbing fiber synapses on Purkinje cells. J. Neurochem. 68:1997;104-1052.