Nitric oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium (MPP +) but not release of MPP + in rat C6 glioma cells expressing human dopamine transporter

British Journal of Pharmacology

Volumn 137, Issue 8, 2002, Pages 1155-1162

  Cao, Bo Jin ^a,b   Reith, Maarten E A ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Dopamine; Dopamine transporter; N methyl 4 phenylpyridinium (MPP +); Nitric oxide; Peroxynitrite

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 3 MORPHOSYNODIOMINE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CATALASE; DIETHYLAMINE; DIETHYLENETRIAMINE; DIPROPYLENETRIAMINE; DOPAMINE; DOPAMINE TRANSPORTER; HYDROGEN PEROXIDE; HYDROXOCOBALAMIN; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE DONOR; PEROXYNITRITE; SPERMINE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG EFFECT; DRUG HALF LIFE; GLIOMA CELL; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS; TUMOR CELLS, CULTURED;

EID: 0036954964     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704974     Document Type: Article

References (44)

1. Babich, H. & Zuckerbraun, H.L. (2001). In vitro cytotoxicity of glyco-S-nitrosothiols, a novel class of nitric oxide donors. Toxicology in Vitro, 15, 181-190.
2. Black, M.D., Matthews, E.K. & Humphrey, P.P.A. (1994). the effects of a photosensitive nitric oxide donor on basal and electrically-stimulated dopamine efflux from the rat striatum in vitro. Neuropharmacology, 33, 1357-1365.
3. Bönisch, H. (1998). Transport and drug binding kinetics in membrane vesicle preparation. Methods Enzymol., 296, 259-278.
4. Büyükuysal, R.L. (1997a). Effect of nitric oxide donors on endogenous dopamine release from striatal slices. I: Requirements to antioxidants in the medium. Fundam. Clin. Pharmacol., 11, 519-527.
5. Büyükuysal, R.L. (1997b). Effect of nitric oxide donors on endogenous dopamine release from striatal slices. II: The role of voltage-dependent sodium channels, calcium channel activation, reverse transport mechanism, guanylate cyclase and endogenous glutamate. Fundam. Clin. Pharmacol., 11, 528-536.
6. Canals, S., Casarejos, M.J., Rodriguez-Martin, E., de Bernardo, S. & Mena, M.A. (2001). Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures. J. Neurochem., 76, 56-68.
7. Chen, N.-H. & Reith, M.E.A. (2002). Structure-function relationships for biogenic amine neurotransmitter transporters. In Neurotransmitter Transporters, Structure, Function, and Regulation, 2nd Edn. ed. Reith, M.E.A. pp. 53-109. Totowa, NJ: Humana Press.
8. Cook, J.A., Wink, DA., Blount, V., Krishna, M.C. & Hanbauer, I. (1996). Role of antioxidants in the nitric oxide-elicited inhibition of dopamine uptake in cultured mesencephalic neurons. Insights into potential mechanisms of nitric oxide-mediated neurotoxicity. Neurochem. Int., 28, 609-617.
9. Dawson, V.L., Dawson, T.M., Bartley, D.A., Uhl, G.R. & Snyder, S.H. (1993). Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci., 13, 2651-2661.
10. Eshleman, A.J., Henningsen, R.A., Neve, K.A. & Janowsky, A. (1994). Release of dopamine via the human transporter. Mol. Pharmacol., 45, 312-316.
11. Eshleman, A.J., Stewart, E., Evenson, A.K., Mason, J.N., Blakely, R.D., Janowsky, A. & Neve, K.A. (1997). Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. J. Neurochem., 69, 1459-1466.
12. Falkenburger, B.H., Barstow, K.L. & Mintz, I.M. (2001). Dendrodendritic inhibition through reversal of dopamine transport. Science, 293, 2465-2467.
13. Feelisch, M. (1998). The use of nitric oxide donors in pharmacological studies. Naunyn-Schmiedebergs Arch. Pharmacol., 358, 113-122.
14. Ferrero, R., Rodriguez-Pascual, F., Miras-Portugal, M.T. & Torres, M. (1999). Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: Correlation with nitric oxide production. Br. J. Pharmacol., 127, 779-787.
15. Fitzhugh, A.L. & Keefer, L.K. (2000). Diazeniumdiolates: Pro- and antioxidant applications of the 'NONOates'. Free Radic. Biol. Med., 28, 1463-1469.
16. Gomeza, J., Zafra, F., Olivares, L., Gimenez, C. & Aragon, C. (1995). Regulation by phorbol esters of the glycine transporter (GLYT1) in glioblastoma cells. Biochim. Biophys. Acta, 1233, 41-46.
17. Guevara-Guzman, R., Emson, P.C. & Kendrick, K.M. (1994). Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP. J. Neurochem., 62, 807-810.
18. Janowsky, A., Neve, K. & Eshleman, A.J. (1998). Uptake and release of neurotransmitters. In Current Protocols in Neuroscience, Suppl. 2, unit 7.9. eds. Crawley, J.N., Gerfen, C.R., Rogawski, M.A., Sibley, D.R. & Skolnick, P. pp. 1-22. New York: John Wiley & Sons, Inc.
19. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M. & Snyder, S.H. (1985). Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U.S.A., 82, 2173-2177.
20. 3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux. Synapse, 30, 97-106.
21. Kaye, D.M., Gruskin, S., Smith, A.I. & Esler, M.D. (2000). Nitric oxide mediated modulation of norepinephrine transport: Identification of a potential target for S-nitrosylation. Br. J. Pharmacol., 130, 1060-1064.
22. Kiss, J.P. & Vizi, E.S. (2001). Nitric oxide: A novel link between synaptic and nonsynaptic transmission. Trends Neurosci., 24, 211-215.
23. Leviel, V. (2001). The reverse trasnport of DA, what physiological significance? Neurochem. Int., 38, 83-106.
24. Lonart, G., Cassels, K.L. & Johnson, K.M. (1993). Nitric oxide induces calcium-dependent [3H]dopamine release from striatal slices. J. Neurosci. Res., 35, 192-198.
25. 3H]glutamate by striatal synaptosomes. J. Neurochem., 63, 2108-2117.
26. Lonart, G., Wang, J. & Johnson, K.M. (1992). Nitric oxide induces neurotransmitter release from hippocampal slices. Eur. J. Pharmacol., 220, 271-272.
27. Lonart, G. & Zigmond, M.J. (1991). High glutamate concentrations evoke Ca(++)-independent dopamine release from striatal slices: A possible role of reverse dopamine transport. J. Pharmacol. Exp. Ther., 256, 1132-1138.
28. Maciver, C.R., Bednar, D.L. & Karbon, E.W. (1991). Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Neurosci. Lett., 132, 146-150.
29. Mayfield, R.D. & Zahniser, N.R. (2001). Dopamine D(2) receptor regulation of the dopamine transporter expressed in xenopus laevis oocytes is voltage-independent. Mol. Pharmacol., 59, 113-121.
30. Nicholls, J.G., Martin, A.R & Wallace, B.C. (1992). From Neuron to Brain. pp. 159-160. Sunderland, MA: Sinauer Associates, Inc.
31. Park, S.U., Ferrer, J.V., Javitch, J.A. & Kuhn, D.M. (2002). Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: Potential mechanism of neurotoxicity in dopamine neurons. J. Neurosci., 22, 4399-4405.
32. 3H]dopamine uptake. Brain Res., 641, 83-91.
33. Reith, M.E.A., Xu, C., Zhang, L. & Coffey, L.L. (1996). Translocation of dopamine and binding of WIN 35,428 measured under identical conditions in cells expressing the cloned human dopamine transporter. Naunyn Schmiedebergs Arch. Pharmacol., 354, 295-304.
34. Ritz, M.C., Mantione, C.R. & London, ED. (1994). Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology (Berl), 114, 47-52.
35. Rodriguez-Martin, E, Casarejos, M.J., Bazan, E., Canals, S., Herranz, A.S. & Mena, M.A. (2000). Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line. Neuropharmacology, 39, 2090-2100.
36. Roy, B., du Moulinet D'Hardemare, A. & Fontecave, M. (1994). New thionitrites: Synthesis, stability, and nitric oxide generation. J. Org. Chem., 59, 7019-7026.
37. Sitte, H.H., Huck, S. Reither, H., Boehm, S., Singer, E.A. & Pifl, C. (1998). Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter. J. Neurochem., 71, 1289-1297.
38. Verkhratsky, A. & Steinhäuser, C. (2000). Ion channels in glial cells. Brain Res. Rev., 32, 380-412.
39. West, A.R. & Galloway, M.P. (1998). Nitric oxide and potassium chloride-facilitated striatal dopamine efflux in vivo: Role of calcium-dependent release mechanisms. Neurochem. Int., 33, 493-501.
40. West, A.R., Galloway, M.P. & Grace, A.A. (2002). Regulation of striatal dopamine neurotransmission by nitric oxide: Effector pathways and signaling mechanisms. Synapse. 44, 227-245.
41. Whitehead, R.E., Ferrer, J.V., Javitch, J.A. & Justice, J.B. (2001). Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter. J. Neurochem., 76, 1242-1251.
42. Williams, K., Hanna, J.L. & Molinoff, P.B. (1991). Developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines. Mol. Pharmacol., 40, 774-782.
43. Wu, Q., Reith, M.EA., Walker, Q.D., Carrol, F.I. & Garris, P.A. (2002). Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: An in vivo voltammetric study. J. Neurosci., 22, 6272-6281.
44. Zamora, R., Matthys, K.E. & Herman, A.G. (1997). The protective role of thiols against nitric oxide-mediated cytotoxicity in murine macrophage J774 cells. Eur. J. Pharmacol., 321, 87-96.