Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 2, 2006, Pages 551-560

  Probin, Virginia ^a   Wang, Yong ^a   Bai, Aiping ^a   Zhou, Daohong ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKYLATING AGENT; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BUSULFAN; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PIFITHRIN ALPHA; PROTEIN P53; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL AGING; CELL KILLING; CELL PROLIFERATION; CONTROLLED STUDY; DIPLOIDY; DOSE RESPONSE; DOWN REGULATION; DRUG INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; TISSUE INJURY;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BUSULFAN; CELL AGING; CELLS, CULTURED; DNA DAMAGE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33751159641     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107771     Document Type: Article

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