-
1
-
-
13544249943
-
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
-
Ingelman-Sundberg M: Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 2005;5:6-13.
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 6-13
-
-
Ingelman-Sundberg, M.1
-
2
-
-
85006639536
-
Bioinformatics research on inter-racial difference in drug metabolism I. Analysis on frequencies of mutant alleles and poor metabolizers on CYP2D6 and CYP2C19
-
Shimizu T, Ochiai H, Asell F, Shimizu H, Saitoh R, Hama Y, Katada J, Hashimoto M, Matsui H, Taki K, Kaminuma T, Yamamoto M, Aida Y, Ohashi A, Ozawa N: Bioinformatics research on inter-racial difference in drug metabolism I. Analysis on frequencies of mutant alleles and poor metabolizers on CYP2D6 and CYP2C19. Drug Metab Pharmacokinet 2003;18:48-70.
-
(2003)
Drug Metab Pharmacokinet
, vol.18
, pp. 48-70
-
-
Shimizu, T.1
Ochiai, H.2
Asell, F.3
Shimizu, H.4
Saitoh, R.5
Hama, Y.6
Katada, J.7
Hashimoto, M.8
Matsui, H.9
Taki, K.10
Kaminuma, T.11
Yamamoto, M.12
Aida, Y.13
Ohashi, A.14
Ozawa, N.15
-
3
-
-
84992658158
-
Bioinformatics research on inter-racial difference in drug metabolism II. Analysis on relationship between enzyme activities of CYP2D6 and CYP2C19 and their relevant genotypes
-
Shimizu T, Ochiai H, Asell F, Yokono Y, Kikuchi Y, Nitta M, Hama Y, Yamaguchi S, Hashimoto M, Taki K, Nakata K, Aida Y, Ohashi A, Ozawa N: Bioinformatics research on inter-racial difference in drug metabolism II. Analysis on relationship between enzyme activities of CYP2D6 and CYP2C19 and their relevant genotypes. Drug Metab Pharmacokinet 2003;18:71-78.
-
(2003)
Drug Metab Pharmacokinet
, vol.18
, pp. 71-78
-
-
Shimizu, T.1
Ochiai, H.2
Asell, F.3
Yokono, Y.4
Kikuchi, Y.5
Nitta, M.6
Hama, Y.7
Yamaguchi, S.8
Hashimoto, M.9
Taki, K.10
Nakata, K.11
Aida, Y.12
Ohashi, A.13
Ozawa, N.14
-
4
-
-
16544363963
-
Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
-
Ozawa S, Soyama A, Saeki M, Fukushima-Uesaka H, Itoda M, Koyano S, Sai K, Ohno Y, Saito Y, Sawada J: Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab Pharmacokinet 2004;19:83-95.
-
(2004)
Drug Metab Pharmacokinet
, vol.19
, pp. 83-95
-
-
Ozawa, S.1
Soyama, A.2
Saeki, M.3
Fukushima-Uesaka, H.4
Itoda, M.5
Koyano, S.6
Sai, K.7
Ohno, Y.8
Saito, Y.9
Sawada, J.10
-
5
-
-
0029049844
-
Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia
-
Arthur H, Dahl ML, Siwers B, Sjoqvist F: Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia. J Clin Psychopharmacol 1995;15:211-216.
-
(1995)
J Clin Psychopharmacol
, vol.15
, pp. 211-216
-
-
Arthur, H.1
Dahl, M.L.2
Siwers, B.3
Sjoqvist, F.4
-
6
-
-
0031559639
-
CYP2D6 Hhal genotype and the neuroleptic malignant syndrome (NMS)
-
Iwahashi K, Nakamura K, Suwaki H, Tsuneoka Y, Ichikawa Y: CYP2D6 Hhal genotype and the neuroleptic malignant syndrome (NMS). Clin Chim Acta 1997;265:143-144.
-
(1997)
Clin Chim Acta
, vol.265
, pp. 143-144
-
-
Iwahashi, K.1
Nakamura, K.2
Suwaki, H.3
Tsuneoka, Y.4
Ichikawa, Y.5
-
7
-
-
0001697297
-
Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
-
Chou WH, Yan FX, de Leon J, Barnhill J, Rogers T, Cronin M, Pho M, Xiao V, Ryder TB, Liu WW, Teiling C, Wedlund PJ: Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol 2000;20:246-251.
-
(2000)
J Clin Psychopharmacol
, vol.20
, pp. 246-251
-
-
Chou, W.H.1
Yan, F.X.2
De Leon, J.3
Barnhill, J.4
Rogers, T.5
Cronin, M.6
Pho, M.7
Xiao, V.8
Ryder, T.B.9
Liu, W.W.10
Teiling, C.11
Wedlund, P.J.12
-
8
-
-
0034059585
-
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency
-
Sallee FR, DeVane CL, Ferrell RE: Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. J Child Adolesc Psychopharmacol 2000;10:27-34.
-
(2000)
J Child Adolesc Psychopharmacol
, vol.10
, pp. 27-34
-
-
Sallee, F.R.1
DeVane, C.L.2
Ferrell, R.E.3
-
9
-
-
0034467571
-
CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients
-
Scordo MG, Spina E, Romeo P, Dahl ML, Bertilsson L, Johansson I, Sjoqvist F: CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients. Eur J Clin Pharmacol 2000;56:679-683.
-
(2000)
Eur J Clin Pharmacol
, vol.56
, pp. 679-683
-
-
Scordo, M.G.1
Spina, E.2
Romeo, P.3
Dahl, M.L.4
Bertilsson, L.5
Johansson, I.6
Sjoqvist, F.7
-
11
-
-
0027534276
-
Molecular basis for rational megaprescribing in ultra-rapid hydroxylators of debrisoquine
-
Bertilsson L, Dahl ML, Sjoqvist F, Aberg-Wistedt A, Humble M, Johansson I, Lundqvist E, Ingelman-Sundberg M: Molecular basis for rational megaprescribing in ultra-rapid hydroxylators of debrisoquine. Lancet 1993;341:63.
-
(1993)
Lancet
, vol.341
, pp. 63
-
-
Bertilsson, L.1
Dahl, M.L.2
Sjoqvist, F.3
Aberg-Wistedt, A.4
Humble, M.5
Johansson, I.6
Lundqvist, E.7
Ingelman-Sundberg, M.8
-
12
-
-
0031949132
-
10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
-
Dalen P, Dahl ML, Ruiz ML, Nordin J, Bertilsson L: 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 1998;63:444-452.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 444-452
-
-
Dalen, P.1
Dahl, M.L.2
Ruiz, M.L.3
Nordin, J.4
Bertilsson, L.5
-
13
-
-
0036796048
-
The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
-
Brockmoller J, Kirchheiner J, Schmider J, Walter S, Sachse C, Muller-Oerlinghausen B, Roots I: The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther 2002;72:438-452.
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 438-452
-
-
Brockmoller, J.1
Kirchheiner, J.2
Schmider, J.3
Walter, S.4
Sachse, C.5
Muller-Oerlinghausen, B.6
Roots, I.7
-
14
-
-
0028207482
-
Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism
-
Mikus G, Bochner F, Eichelbaum M, Horak P, Somogyi AA, Spector S: Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism. J Pharmacol Exp Ther 1994;268:546-551.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 546-551
-
-
Mikus, G.1
Bochner, F.2
Eichelbaum, M.3
Horak, P.4
Somogyi, A.A.5
Spector, S.6
-
15
-
-
0030472254
-
Codeine and morphine in extensive and poor metabolizers of sparteine: Pharmacokinetics, analgesic effect and side effects
-
Poulsen L, Brosen K, Arendt-Nielsen L, Gram LF, Elbaek K, Sindrup SH: Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects. Eur J Clin Pharmacol 1996;51:289-295.
-
(1996)
Eur J Clin Pharmacol
, vol.51
, pp. 289-295
-
-
Poulsen, L.1
Brosen, K.2
Arendt-Nielsen, L.3
Gram, L.F.4
Elbaek, K.5
Sindrup, S.H.6
-
16
-
-
0036667952
-
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment
-
Rau T, Heide R, Bergmann K, Wuttke H, Werner U, Feifel N, Eschenhagen T: Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment. Pharmacogenetics 2002;12:465-472.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 465-472
-
-
Rau, T.1
Heide, R.2
Bergmann, K.3
Wuttke, H.4
Werner, U.5
Feifel, N.6
Eschenhagen, T.7
-
17
-
-
0142188770
-
Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status
-
Barclay ML, Sawyers SM, Begg EJ, Zhang M, Roberts RL, Kennedy MA, Elliott JM: Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics 2003;13:627-632.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 627-632
-
-
Barclay, M.L.1
Sawyers, S.M.2
Begg, E.J.3
Zhang, M.4
Roberts, R.L.5
Kennedy, M.A.6
Elliott, J.M.7
-
18
-
-
2442593964
-
Impact of CYP2D6 intermediate metabolizer alleles on single-dose desipramine pharmacokinetics
-
Furman KD, Grimm DR, Mueller T, Holley-Shanks RR, Bertz RJ, Williams LA, Spear BB, Katz DA: Impact of CYP2D6 intermediate metabolizer alleles on single-dose desipramine pharmacokinetics. Pharmacogenetics 2004;14:279-284.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 279-284
-
-
Furman, K.D.1
Grimm, D.R.2
Mueller, T.3
Holley-Shanks, R.R.4
Bertz, R.J.5
Williams, L.A.6
Spear, B.B.7
Katz, D.A.8
-
19
-
-
3543014421
-
A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
-
Raimundo S, Toscano C, Klein K, Fischer J, Griese EU, Eichelbaum M, Schwab M, Zanger UM: A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects. Clin Pharmacol Ther 2004;76:128-138.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 128-138
-
-
Raimundo, S.1
Toscano, C.2
Klein, K.3
Fischer, J.4
Griese, E.U.5
Eichelbaum, M.6
Schwab, M.7
Zanger, U.M.8
-
20
-
-
0032727992
-
Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers
-
Cai WM, Chen B, Zhou Y, Zhang YD : Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers. Clin Pharmacol Ther 1999;66:516-521.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 516-521
-
-
Cai, W.M.1
Chen, B.2
Zhou, Y.3
Zhang, Y.D.4
-
21
-
-
0032968696
-
Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major CYP2D6 genotypes
-
Huang J, Chuang SK, Cheng CL, Lai ML: Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major CYP2D6 genotypes. Clin Pharmacol Ther 1999;65:402-407.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 402-407
-
-
Huang, J.1
Chuang, S.K.2
Cheng, C.L.3
Lai, M.L.4
-
22
-
-
0035861049
-
Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review
-
Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W: Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA 2001;286:2270-2279.
-
(2001)
JAMA
, vol.286
, pp. 2270-2279
-
-
Phillips, K.A.1
Veenstra, D.L.2
Oren, E.3
Lee, J.K.4
Sadee, W.5
-
23
-
-
0030860004
-
Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
-
Marez D, Legrand M, Sabbagh N, Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 1997;7:193-202.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 193-202
-
-
Marez, D.1
Legrand, M.2
Sabbagh, N.3
Guidice, J.M.4
Spire, C.5
Lafitte, J.J.6
Meyer, U.A.7
Broly, F.8
-
24
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997;60:284-295.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
25
-
-
0031884233
-
Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
-
Griese EU, Zanger UM, Brudermanns U, Gaedigk A, Mikus G, Morike K, Stuven T, Eichelbaum M: Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 1998;8:15-26.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 15-26
-
-
Griese, E.U.1
Zanger, U.M.2
Brudermanns, U.3
Gaedigk, A.4
Mikus, G.5
Morike, K.6
Stuven, T.7
Eichelbaum, M.8
-
26
-
-
0032586732
-
Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population
-
Tateishi T, Chida M, Ariyoshi N, Mizorogi Y, Kamataki T, Kobayashi S: Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population. Clin Pharmacol Ther 1999;65:570-575.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 570-575
-
-
Tateishi, T.1
Chida, M.2
Ariyoshi, N.3
Mizorogi, Y.4
Kamataki, T.5
Kobayashi, S.6
-
27
-
-
18044401567
-
CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting
-
McElroy S, Sachse C, Brockmoller J, Richmond J, Lira M, Friedman D, Roots I, Silber BM, Milos PM: CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting. AAPS Pharm Sci 2000;2:E33.
-
(2000)
AAPS Pharm Sci
, vol.2
-
-
McElroy, S.1
Sachse, C.2
Brockmoller, J.3
Richmond, J.4
Lira, M.5
Friedman, D.6
Roots, I.7
Silber, B.M.8
Milos, P.M.9
-
28
-
-
0033461165
-
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
-
Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS: Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999;9:669-682.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 669-682
-
-
Gaedigk, A.1
Gotschall, R.R.2
Forbes, N.S.3
Simon, S.D.4
Kearns, G.L.5
Leeder, J.S.6
-
29
-
-
7744246753
-
Molecular diversity at the CYP2D6 locus in the Mediterranean region
-
Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G: Molecular diversity at the CYP2D6 locus in the Mediterranean region. Eur J Hum Genet 2004;12:916-924.
-
(2004)
Eur J Hum Genet
, vol.12
, pp. 916-924
-
-
Fuselli, S.1
Dupanloup, I.2
Frigato, E.3
Cruciani, F.4
Scozzari, R.5
Moral, P.6
Sistonen, J.7
Sajantila, A.8
Barbujani, G.9
-
30
-
-
18544386662
-
Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity
-
Hosking LK, Boyd PR, Xu CF, Nissum M, Cantone K, Purvis IJ, Khakhar R, Barnes MR, Liberwirth U, Hagen-Mann K, Ehm MG, Riley JH: Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity. Pharmacogenomics J 2002;2:165-175.
-
(2002)
Pharmacogenomics J
, vol.2
, pp. 165-175
-
-
Hosking, L.K.1
Boyd, P.R.2
Xu, C.F.3
Nissum, M.4
Cantone, K.5
Purvis, I.J.6
Khakhar, R.7
Barnes, M.R.8
Liberwirth, U.9
Hagen-Mann, K.10
Ehm, M.G.11
Riley, J.H.12
-
32
-
-
0042881041
-
Mathematical multi-locus approaches to localizing complex human trait genes
-
Hoh J, Ott J: Mathematical multi-locus approaches to localizing complex human trait genes. Nat Rev Genet 2003;4:701-709.
-
(2003)
Nat Rev Genet
, vol.4
, pp. 701-709
-
-
Hoh, J.1
Ott, J.2
-
33
-
-
33645392027
-
SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype
-
Sabbagh A, Darlu P: SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype. Genet Med 2006;8:76-85.
-
(2006)
Genet Med
, vol.8
, pp. 76-85
-
-
Sabbagh, A.1
Darlu, P.2
-
34
-
-
0035478854
-
Random forests
-
Breiman L: Random forests. Machine Learning 2001;45:5-32.
-
(2001)
Machine Learning
, vol.45
, pp. 5-32
-
-
Breiman, L.1
-
35
-
-
0034469337
-
Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
-
Isaza CA, Henao J, Lopez AM, Cacabelos R: Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population. Methods Find Exp Clin Pharmacol 2000;22:695-705.
-
(2000)
Methods Find Exp Clin Pharmacol
, vol.22
, pp. 695-705
-
-
Isaza, C.A.1
Henao, J.2
Lopez, A.M.3
Cacabelos, R.4
-
36
-
-
0036960924
-
Genetic polymorphisms of CYP2D6 in Chinese mainland
-
Ji L, Pan S, Wu J, Marti-Jaun J, Hersberger M: Genetic polymorphisms of CYP2D6 in Chinese mainland. Chin Med J. 2002;115:1780-1784.
-
(2002)
Chin Med J
, vol.115
, pp. 1780-1784
-
-
Ji, L.1
Pan, S.2
Wu, J.3
Marti-Jaun, J.4
Hersberger, M.5
-
37
-
-
0033965373
-
Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population
-
Garcia-Barcelo M, Chow LY, Chiu HF, Wing YK, Lee DT, Lam KL, Waye MM: Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population. Clin Chem 2000;46:18-23.
-
(2000)
Clin Chem
, vol.46
, pp. 18-23
-
-
Garcia-Barcelo, M.1
Chow, L.Y.2
Chiu, H.F.3
Wing, Y.K.4
Lee, D.T.5
Lam, K.L.6
Waye, M.M.7
-
38
-
-
0035133641
-
Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia
-
Griese EU, Ilett KF, Kitteringham NR, Eichelbaum M, Powell H, Spargo RM, Le-Souef PN, Musk AW, Minchin RF: Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia. Pharmacogenetics 2001;11:69-76.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 69-76
-
-
Griese, E.U.1
Ilett, K.F.2
Kitteringham, N.R.3
Eichelbaum, M.4
Powell, H.5
Spargo, R.M.6
Le-Souef, P.N.7
Musk, A.W.8
Minchin, R.F.9
-
39
-
-
0034743396
-
Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
-
Wennerholm A, Johansson I, Hidestrand M, Bertilsson L, Gustafsson LL, Ingelman-Sundberg M: Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity. Pharmacogenetics 2001;11:417-427.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 417-427
-
-
Wennerholm, A.1
Johansson, I.2
Hidestrand, M.3
Bertilsson, L.4
Gustafsson, L.L.5
Ingelman-Sundberg, M.6
-
40
-
-
0033429268
-
Decreased capacity for debrisoquine metabolism among black Tanzanians: Analyses of the CYP2D6 genotype and phenotype
-
Wennerholm A, Johansson I, Massele AY, Lande M, Alm C, Aden-Abdi Y, Dahl ML, Ingelman-Sundberg M, Bertilsson L, Gustafsson LL: Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype. Pharmacogenetics 1999;9:707-714.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 707-714
-
-
Wennerholm, A.1
Johansson, I.2
Massele, A.Y.3
Lande, M.4
Alm, C.5
Aden-Abdi, Y.6
Dahl, M.L.7
Ingelman-Sundberg, M.8
Bertilsson, L.9
Gustafsson, L.L.10
-
41
-
-
0033408498
-
Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population
-
Griese EU, Asante-Poku S, Ofori-Adjei D, Mikus G, Eichelbaum M: Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population. Pharmacogenetics 1999;9:715-723.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 715-723
-
-
Griese, E.U.1
Asante-Poku, S.2
Ofori-Adjei, D.3
Mikus, G.4
Eichelbaum, M.5
-
42
-
-
0036339071
-
Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
-
Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther 2002;72:76-89.
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 76-89
-
-
Gaedigk, A.1
Bradford, L.D.2
Marcucci, K.A.3
Leeder, J.S.4
-
43
-
-
0033680875
-
Use of classification trees for association studies
-
Zhang H, Bonney G: Use of classification trees for association studies. Genet Epidemiol 2000;19:323-332.
-
(2000)
Genet Epidemiol
, vol.19
, pp. 323-332
-
-
Zhang, H.1
Bonney, G.2
-
45
-
-
25444453244
-
Screening large-scale association study data: Exploiting interactions using random forests
-
Lunetta KL, Hayward LB, Segal J, Van Eerdewegh P: Screening large-scale association study data: exploiting interactions using random forests. BMC Genet 2004;5:32.
-
(2004)
BMC Genet
, vol.5
, pp. 32
-
-
Lunetta, K.L.1
Hayward, L.B.2
Segal, J.3
Van Eerdewegh, P.4
-
48
-
-
0034744364
-
Use of an artificial neural network to detect association between a disease and multiple marker genotypes
-
Curtis D, North BV, Sham PC: Use of an artificial neural network to detect association between a disease and multiple marker genotypes. Ann Hum Genet 2001;65:95-107.
-
(2001)
Ann Hum Genet
, vol.65
, pp. 95-107
-
-
Curtis, D.1
North, B.V.2
Sham, P.C.3
-
49
-
-
1542330229
-
Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes
-
North BV, Curtis D, Cassell PG, Hitman GA, Sham PC: Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes. Ann Hum Genet 2003;67:348-356.
-
(2003)
Ann Hum Genet
, vol.67
, pp. 348-356
-
-
North, B.V.1
Curtis, D.2
Cassell, P.G.3
Hitman, G.A.4
Sham, P.C.5
-
50
-
-
26444561943
-
Neural network analysis in pharmacogenetics of mood disorders
-
Serretti A, Smeraldi E: Neural network analysis in pharmacogenetics of mood disorders. BMC Med Genet 2004;5:27.
-
(2004)
BMC Med Genet
, vol.5
, pp. 27
-
-
Serretti, A.1
Smeraldi, E.2
-
51
-
-
11344282232
-
Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction model on childhood allergic asthma
-
Tomita Y, Tomida S, Hasegawa Y, Suzuki Y, Shirakawa T, Kobayashi T, Honda H: Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction model on childhood allergic asthma. BMC Bioinformatics 2004;5:120.
-
(2004)
BMC Bioinformatics
, vol.5
, pp. 120
-
-
Tomita, Y.1
Tomida, S.2
Hasegawa, Y.3
Suzuki, Y.4
Shirakawa, T.5
Kobayashi, T.6
Honda, H.7
-
52
-
-
27344457307
-
Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease
-
Di Luca M, Grossi E, Borroni B, Zimmermann M, Marcello E, Colciaghi F, Gardoni F, Intraligi M, Padovani A, Buscema M: Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease. J Transl Med 2005;3:30.
-
(2005)
J Transl Med
, vol.3
, pp. 30
-
-
Di Luca, M.1
Grossi, E.2
Borroni, B.3
Zimmermann, M.4
Marcello, E.5
Colciaghi, F.6
Gardoni, F.7
Intraligi, M.8
Padovani, A.9
Buscema, M.10
-
53
-
-
0034973569
-
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
-
Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH: Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001;69:138-147.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 138-147
-
-
Ritchie, M.D.1
Hahn, L.W.2
Roodi, N.3
Bailey, L.R.4
Dupont, W.D.5
Parl, F.F.6
Moore, J.H.7
-
54
-
-
0037310257
-
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity
-
Ritchie MD, Hahn LW, Moore JH: Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003;24:150-157.
-
(2003)
Genet Epidemiol
, vol.24
, pp. 150-157
-
-
Ritchie, M.D.1
Hahn, L.W.2
Moore, J.H.3
-
55
-
-
0037433052
-
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
-
Hahn LW, Ritchie MD, Moore JH: Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003;19:376-382.
-
(2003)
Bioinformatics
, vol.19
, pp. 376-382
-
-
Hahn, L.W.1
Ritchie, M.D.2
Moore, J.H.3
-
56
-
-
0002907949
-
The interaction of selection and linkage
-
Lewontin RC: The interaction of selection and linkage. Genetics 1964;49:49-67.
-
(1964)
Genetics
, vol.49
, pp. 49-67
-
-
Lewontin, R.C.1
-
57
-
-
0029150074
-
A comparison of linkage disequilibrium measures for fine scale mapping
-
Devlin B, Risch N: A comparison of linkage disequilibrium measures for fine scale mapping. Genomics 1995;29:311-322.
-
(1995)
Genomics
, vol.29
, pp. 311-322
-
-
Devlin, B.1
Risch, N.2
-
58
-
-
0034017850
-
GOLD-graphical overview of linkage disequilibrium
-
Abecasis GR, Cookson WO: GOLD-graphical overview of linkage disequilibrium. Bioinformatics 2000;16:182-183.
-
(2000)
Bioinformatics
, vol.16
, pp. 182-183
-
-
Abecasis, G.R.1
Cookson, W.O.2
-
59
-
-
1842539516
-
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
-
Nyholt DR: A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004;74:765-769.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 765-769
-
-
Nyholt, D.R.1
-
60
-
-
0034781050
-
A simple correction for multiple comparisons in interval mapping genome scans
-
Cheverud JM: A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001;87:52-58.
-
(2001)
Heredity
, vol.87
, pp. 52-58
-
-
Cheverud, J.M.1
-
61
-
-
0034891594
-
Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California
-
Wan YJ, Poland RE, Han G, Konishi T, Zheng YP, Berman N, Lin KM: Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in southern California. Pharmacogenetics 2001;11:489-499.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 489-499
-
-
Wan, Y.J.1
Poland, R.E.2
Han, G.3
Konishi, T.4
Zheng, Y.P.5
Berman, N.6
Lin, K.M.7
-
62
-
-
28844491802
-
Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenomic tests
-
Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K: Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clin Pharmacol Ther 2005;78:559-581.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 559-581
-
-
Andersson, T.1
Flockhart, D.A.2
Goldstein, D.B.3
Huang, S.M.4
Kroetz, D.L.5
Milos, P.M.6
Ratain, M.J.7
Thummel, K.8
-
63
-
-
0031028101
-
Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: A prospective study
-
Spina E, Gitto C, Avenoso A, Campo GM, Caputi AP, Perucca E: Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: A prospective study. Eur J Clin Pharmacol 1997;51:395-398.
-
(1997)
Eur J Clin Pharmacol
, vol.51
, pp. 395-398
-
-
Spina, E.1
Gitto, C.2
Avenoso, A.3
Campo, G.M.4
Caputi, A.P.5
Perucca, E.6
-
64
-
-
0034894010
-
CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: A first step towards subpopulation-specific dosages
-
Kirchheiner J, Brosen K, Dahl ML, Gram LF, Kasper S, Roots I, Sjoqvist F, Spina E, Brockmoller J: CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: A first step towards subpopulation-specific dosages. Acta Psychiatr Scand 2001;104:173-192.
-
(2001)
Acta Psychiatr Scand
, vol.104
, pp. 173-192
-
-
Kirchheiner, J.1
Brosen, K.2
Dahl, M.L.3
Gram, L.F.4
Kasper, S.5
Roots, I.6
Sjoqvist, F.7
Spina, E.8
Brockmoller, J.9
-
65
-
-
3142519666
-
Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
-
Kirchheiner J, Nickchen K, Bauer M, Wong ML, Licinio J, Roots I, Brockmoller J: Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response. Mol Psychiatry 2004;9:442-473.
-
(2004)
Mol Psychiatry
, vol.9
, pp. 442-473
-
-
Kirchheiner, J.1
Nickchen, K.2
Bauer, M.3
Wong, M.L.4
Licinio, J.5
Roots, I.6
Brockmoller, J.7
-
66
-
-
0346363770
-
CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR
-
Schaeffeler E, Schwab M, Eichelbaum M, Zanger UM: CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR. Hum Mutat 2003;22:476-485.
-
(2003)
Hum Mutat
, vol.22
, pp. 476-485
-
-
Schaeffeler, E.1
Schwab, M.2
Eichelbaum, M.3
Zanger, U.M.4
-
67
-
-
0029053644
-
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects
-
Dahl ML, Yue QY, Roh HK, Johansson I, Sawe J, Sjoqvist F, Bertilsson L: Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects. Pharmacogenetics 1995;5:159-164.
-
(1995)
Pharmacogenetics
, vol.5
, pp. 159-164
-
-
Dahl, M.L.1
Yue, Q.Y.2
Roh, H.K.3
Johansson, I.4
Sawe, J.5
Sjoqvist, F.6
Bertilsson, L.7
-
68
-
-
0034094251
-
Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes
-
Kubota T, Yamaura Y, Ohkawa N, Hara H, Chiba K: Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes. Br J Clin Pharmacol 2000;50:31-34.
-
(2000)
Br J Clin Pharmacol
, vol.50
, pp. 31-34
-
-
Kubota, T.1
Yamaura, Y.2
Ohkawa, N.3
Hara, H.4
Chiba, K.5
-
69
-
-
6344285930
-
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population
-
Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics 2004;5:895-931.
-
(2004)
Pharmacogenomics
, vol.5
, pp. 895-931
-
-
Solus, J.F.1
Arietta, B.J.2
Harris, J.R.3
Sexton, D.P.4
Steward, J.Q.5
McMunn, C.6
Ihrie, P.7
Mehall, J.M.8
Edwards, T.L.9
Dawson, E.P.10
-
70
-
-
15744379877
-
Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene
-
Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet 2004;19:313-319.
-
(2004)
Drug Metab Pharmacokinet
, vol.19
, pp. 313-319
-
-
Soyama, A.1
Kubo, T.2
Miyajima, A.3
Saito, Y.4
Shiseki, K.5
Komamura, K.6
Ueno, K.7
Kamakura, S.8
Kitakaze, M.9
Tomoike, H.10
Ozawa, S.11
Sawada, J.12
-
71
-
-
33745923150
-
Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals
-
Ebisawa A, Hiratsuka M, Sakuyama K, Konno Y, Sasaki T, Mizugaki M: Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals. Drug Metab Pharmacokinet 2005;20:294-299.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 294-299
-
-
Ebisawa, A.1
Hiratsuka, M.2
Sakuyama, K.3
Konno, Y.4
Sasaki, T.5
Mizugaki, M.6
-
72
-
-
20744455857
-
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
-
Gaedigk A, Bhathena A, Ndjountche L, Pearce RE, Abdel-Rahman SM, Alander SW, Bradford LD, Rogan PK, Leeder JS: Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J 2005;5:173-182.
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 173-182
-
-
Gaedigk, A.1
Bhathena, A.2
Ndjountche, L.3
Pearce, R.E.4
Abdel-Rahman, S.M.5
Alander, S.W.6
Bradford, L.D.7
Rogan, P.K.8
Leeder, J.S.9
-
74
-
-
19944420428
-
Optimal selection of SNP markers for disease association studies
-
Halldorsson BV, Istrail S, De La Vega FM: Optimal selection of SNP markers for disease association studies. Hum Hered 2004;58:190-202.
-
(2004)
Hum Hered
, vol.58
, pp. 190-202
-
-
Halldorsson, B.V.1
Istrail, S.2
De La Vega, F.M.3
-
75
-
-
0035775486
-
Pharmacogenomics: The inherited basis for interindividual differences in drug response
-
Evans WE, Johnson JA: Pharmacogenomics: The inherited basis for interindividual differences in drug response. Annu Rev Genomics Hum Genet 2001;2:9-39.
-
(2001)
Annu Rev Genomics Hum Genet
, vol.2
, pp. 9-39
-
-
Evans, W.E.1
Johnson, J.A.2
-
76
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 1989;45:889-904.
-
(1989)
Am J Hum Genet
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
|