Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers

Clinical Pharmacology and Therapeutics

Volumn 66, Issue 5, 1999, Pages 516-521

  Cai, Wei M ^a   Chen, Bing ^b   Zhou, Yan ^b   Zhang, Yin D ^b  

^a JINLING HOSPITAL   (China)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEBRISOQUINE 4 HYDROXYLASE; FLUOXETINE; PROPAFENONE;

ADULT; ARTICLE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0032727992     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(99)70015-9     Document Type: Article

References (17)

1. 1. Bertz RJ, Richard Cranneman G. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interaction. Clin Pharmacokinet 1997;32:210-57.
2. 2. Ereshefsky L, Riesenman C, Lam YW. Antidepressant drug interactions and the cytochrome P450 system: the role of cytochrome P450 2D6. Clin Pharmacokinet 1995; 29(suppl 1):10-8.
3. 3. Volz M, Mitrovic V, Schlepper M. Steady-state plasma concentrations of propafenone-chirality and metabolism, Int J Clin Pharmacol Ther 1994;32:370-5.
4. 4. Siddoway LA, Thompson KA, McAllister CB, Wang T, Wilkinson GR, Roden DM, et al. Polymorphism of propafenone metabolism and disposition in man: clinical pharmacokinetic consequences. Circulation 1987; 75:785-91.
5. 5. Cai WM, Chen B, Cai MH, Chen Y, Zhang YD, The influence of CYP2D6 activity on the kinetics of propafenone enantiomers in Chinese subjects. Br J Clin Pharmacol 1999;47:553-6.
6. 6. Cai WM, Chen B, Chu X. High performance liquid chromatographic determination of dextromethorphan and its metabolite in human urine. Acta Pharmaceutica Sinica 1997;32:861-4.
7. 7. Chen B, Cai WM, Wan W. Determination of propafenone enantiomeric concentrations in human plasma by stereoselective HPLC. Chin Pharm J 1998;33:546-9.
8. 8. Schmid B, Bricher J, Preisig R, Kupfer A. Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther 1985;38:618-24.
9. 9. Yang YC, Chen G, Yuan L. [A non-linear method and its program for calculating pharmacokinetic parameters.] Chung Kuo Yao Li Hsueh Pao 1983;4:217-20.
10. 10. Ozdemir V, Naranjo CA, Herrmann N, Reed K, Sellers EM, Kalow W. Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo. Clin Pharmacol Ther 1997;62:334-47.
11. 11. Vandel S, Bertschy G, Baumann P, Bouquet S, Bonin B, Francois F, et al. Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients. Pharmacol Res 1995; 31:347-53.
12. 12. Otton SV, Wu D, Joffe RT, Cheung SW, Sellers EM. Inhibition by fluoxetine of cytochrome P450 2D6 activity. Clin Pharmacol Ther 1993;53:401-9.
13. 13. Funck-Brentano C, Kroemer HK, Pavlou H, Woosley RL, Roden DM. Genetically determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect. Br J Clin Pharmacol 1989;27:435-44.
14. 14. Morike KE, Roden DM. Quinidine-enhanced β-blockade during treatment with propafenone in extensive metabolizer human subjects. Clin Pharmacol Ther 1994; 55:28-34.
15. 15. Bertilsson L, Lou YQ, Du YL, Liu Y, Kuang TY, Liao XM, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 1992;51:388-97.
16. 16. Zhou HH, Anthony LB, Roden DM, Wood AJJ. Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation. Clin Pharmacol Ther 1990;47:686-73.
17. 17. Birgersdotter UM, Wong W, Turgeon J, Roden DM. Stereoselective genetically determined interaction between chronic flecainide and quinidine in patients with arrhythmias. Br J Clin Pharmacol 1992;33:275-80.