Transient in vivo activation of rat brain macrophages/microglial cells and astrocytes by immunostimulatory multiple CpG oligonucleotides

Journal of Neuroimmunology

Volumn 113, Issue 1, 2001, Pages 89-94

  Schluesener, Hermann J ^a   Seid, Karin ^a   Deininger, Martin ^a   Schwab, Jan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cytokine; Infection; Inflammation; Microglia; Nervous system

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; CYCLINE; CYTOKINE; ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; HEME OXYGENASE; IMMUNOSTIMULATING AGENT; OLIGONUCLEOTIDE; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DNA METHYLATION; DNA SEQUENCE; HUMAN; IMMUNOSTIMULATION; INFECTION; INFLAMMATION; MACROPHAGE ACTIVATION; MICROGLIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SIDE EFFECT;

EID: 0035255056     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00428-8     Document Type: Article

References (54)

1. Characterization and modulation of immune stimulation by modified oligonucleotides
2. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
3. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
4. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
5. Allograft inflammatory factor-1 defines a distinct subset of infiltrating macrophages/microglia in rat and human gliomas
6. Cyclooxygenase-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma
7. Intra-articularly localized bacterial DNA containing CpG motifs induce arthritis
8. Heme oxygenase-1 in tissue pathology. The Yin and Yang
9. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
10. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
11. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
12. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
13. Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II
14. CpG motifs as immune adjuvants
15. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
16. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
17. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
18. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury
19. Bacterial DNA as immune cell activator
20. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
21. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
22. Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis
23. The response of the cerebral hemisphere to the rat injury. I. The mature rat
24. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
25. Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: Evidence for blockade of apoptosis at a distal signalling step
26. The heme oxygenase system: A regulator of second messenger gases
27. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
28. CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines
29. Heme oxygenase: Protective gene or Trojan horse
30. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
31. Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis
32. Localization of endothelial-monocyte-activating polypeptide II (EMAP II), a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis: Expression by monocytes and activated microglial cells
33. Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis and uveitis: Expression by activated macrophages and microglial cells
34. Effects of autoantigen and dexamethasone treatement on expression of endothelial-monocyte-activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis
35. Centrally administered oligodeoxynucleotides in rats: Occurrence of non-specific effects
36. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract
37. Microbial products induce autoimmune disease by an IL-12 dependent process
38. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
39. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
40. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor alpha mediated shock
41. Macrophages ingest and are activated by bacterial DNA
42. Induction of heme oxygenase protein protects neurons in cortex and striatum, but not in hippocampus, against transient forebrain ischemia
43. Induction of haem oxygenase contributes to the synthesis of pro-inflammatory cytokines
44. Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell death and degeneration
45. Endothelial-monocyte-activating polypeptide II
46. Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA
47. Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: A negative feedback mechanism for the regulation of nitric oxide production
48. Cloning and characterization of allograft inflammatory factor-1: A novel macrophage factor identified in rat cardiac allografts with chronic rejection
49. Allograft inflammatory factor-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts
50. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
51. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
52. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel
53. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
54. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis