Tumor necrosis factor-α- and hyperglycemia-induced insulin resistance: Evidence for different mechanisms and different effects on insulin signaling

Journal of Clinical Investigation

Volumn 97, Issue 6, 1996, Pages 1471-1477

  Kroder, Gerhild ^a   Bossenmaier, Birgit ^a   Kellerer, Monika ^a   Capp, Edison ^a   Stoyanov, Borislav ^a   Mühlhöfer, Andreas ^a   Berti, Lucia ^a   Horikoshi, Hiroyoshi ^b   Ullrich, Axel ^c   Häring, Hans ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DAIICHI SANKYO CO   (Japan)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Insulin receptor; Non insulin dependent diabetes mellitus; Obesity; Phosphotyrosine phosphatase; Protein kinase C

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ARSENOSOBENZENE; ENZYME INHIBITOR; GLUCOSE; INSULIN RECEPTOR; IODINE 125; ORTHOVANADIC ACID; PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

3T3 CELLS; ANIMALS; DRUG RESISTANCE; GENE TRANSFER TECHNIQUES; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN; MICE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029997466     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118569     Document Type: Article

References (33)

1. DeFronzo, R.A., R.C Bonnadonna, and E. Ferrannini 1992. Pathogenesis of NIDDM:a balanced overview Diabetes Care. 15:318-368.
2. Beck-Nielsen, H., and L.C Groop 1994 Metabolic and genetic characterization of prediabetic state. J. Clin. Invest. 94:1714-1721.
3. Maegawa, H , Y. Shigeta, K. Egawa, and M. Kobayashi. 1991. Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in non-obese subjects with NIDDM. Diabetes 40.815-819.
4. Bulangu, L., B L Nyomba, V.M Ossowski, C. Bogardus, and D.M. Mott 1990. Insulin-sensitive tyrosine kinase:relationship with in vivo insulin action in humans. Am J Physiol. 258:E964-974.
5. Arner, P., T. Pollare, H. Lithell, and J.N. Livingston. 1987. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 30:437-440.
6. Häring, H.U , B. Obermaier Kusser, B. Ermel, Z. Su, J. Mushack, E. Rattenhuber, J Hölzl, D. Kirsch, F. Machicao, and L. Herberg. 1987. Insulin receptor kinase defects as a possible cause of cellular insulin resistance. Diabete & Metab. 13:284-293.
7. Obermaier-Kusser, B , M.F. White, D. Pongratz, Z. Su, B. Ermel, C Mühlbacher, and H.U Häring. 1989 A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus and obesity J. Biol Chem 264.9497-9503.
8. Nolan, J.J., G. Freidenberg, R. Henry, D. Reichart, and J.M. Olefsky 1994. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of non-insulin-dependent diabetes mellitus and obesity J. Clin Endocrinol. & Metab 78.471-477.
9. Caro, J.F , M.K Sinha, S.J. Raju, O. Ittop, W.J. Pories, E.G., Flickingcr D. Meelheim, and G.L Dohm. 1987. Insulin receptor kinase in human skeletal muscle from obese subjects with and without non-insulin-dependent diabetes. J. Clin Invest. 79:1330-1337.
10. Cox, N., P.A. Epstein, and R.S. Spielman. 1989. Linkage studies on NIDDM and the insulin and insulin-receptor genes. Diabetes 38:653-658.
11. Haring, H.U., and II. Mehnert. 1993 Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for signal transmitter defect causing insulin resistance of the skeletal muscle Diabetologia. 36:176-182.
12. Kellerer, M , B Obermaier-Kusser, A. Profrock, E. Schleicher, E. Setter, J Mushack, B. Ermel, and H.U. Häring. 1991. Insulin activates GTP binding to a 40 kDa protein in fat cells. Biochem. J. 274:103-108.
13. Maddux, B A., P. Sbraccia, S. Kumakura, S. Sasson, J. Youngren, A. Fisher, S. Spencer, A. Grupe, W Henzel, T A. Stewart. et al. 1995. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature (Lond.). 373:448-451
14. Müller, H.K., M Kellerer, B. Ermel, A. Mühlhöfer, B Obermaier-Kusser, B. Vogt, and H.U. Haring. 1991. Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells. Diabetes 40.1440-1447.
15. Berti, L., L. Mosthaf, G. Kroder, M. Kellerer, S Tippmer, J. Mushack, E Seffer, K. Seedorf, and H.U. Häring. 1994. Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. J. Biol. Chem. 269:3381-3386.
16. Ide, R., H. Maegawa, R. Kikkawa, Y Shigeta, and A. Kashiwagi. 1994. High glucose condition activates protein tyrosine phosphatase (PTPase) and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts. Biochem Biophys. Res. Commun. 201:71-77.
17. Pillay, T.S. 1994. Mechanism of glucose-induced inhibition of insulin receptor phosphorylation and kinase activity. Diabetes. 43:(Suppl. 1):A240
18. Hotamisligil, G S., N.S. Shargill, and B.M. Spicgelman. 1993. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science (Wash. DC). 259:87-91
19. Hotamisligil, O.S., A. Budavari, D.L. Murray, and B.M. Spiegelman, 1994. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. J Clin. Invest. 94:1543-1549.
20. Hotamisligil, G S., D.L. Murray, L.N. Choy, and B.M. Spiegelman. 1994 Tumor necrosis factor α inhibits signaling from the insulin receptor. Proc. Natl. Acad Sci. USA. 91:4854-4858
21. Feinstein, R., H. Kanety, M.Z. Papa, B. Lunenfeld, and A. Karasik 1993. Tumor necrosis factor-α supresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol. Chem. 268:26055-26058.
22. McClain, D.A., H. Maegawa, J. Levy, T. Huecksteadt, T.J. Dull, J. Lee, A. Ullrich, and J.M. Olefsky. 1988. Properties of a HIR with a COOH-terminal truncation. J Biol Chem. 263:8904-8911.
23. Kellerer, M , G. Kroder, S. Tippmer, L. Berti, R. Kiehn, L. Mosthaf, and H.U. Haring, 1994. Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts. Diabetes. 43:447-453
24. Carpenter, C., K R. Auger, B.C. Duckworth, W. Hou, B. Schaffhausen, and L.C. Cabtley. 1993. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity Mol. Cell. Biol. 13:1657-1665.
25. Dhand, R., J Hiles, S.R. Panayotou, M J. Fry, I. Gout, N.F. Totty, O. Truang, P. Vincenlo, O. Truong, K. Yonezawa, and M. Kasuga, 1994. PI3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO (Eur. Mol. Biol. Organ.) J 13:522-533.
26. Lam, K., C.L. Carpenter, N.B. Ruderman, J.C. Friel, and K.L. Kelly, 1994. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1.J. Biol. Chem. 269.20648-20652.
27. Pillay, T.S., T. Sasaoka, and J.M. Olefsky. 1995. Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase. J. Biol. Chem. 270: 991-994.
28. Calalb, M.B., T.R Polte, and S.K. Hanks. 1995. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15:954-963.
29. Schlaepfer, D.D., S.K. Hanks, T. Hunter, and P. van-der-Geer 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (Lond.). 372:786-791
30. Gates, R.E , L E. King, Jr , S.K. Hanks, and L.B. Nanney. 1994. Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture. Cell. Growth & Differ. 5:891-899.
31. Chen, H.C., and J.L. Guan. 1994. Association of focal adhesion kinase with its potantial substrate phosphatidyhnositol 3-kinase. Proc Natl Acad. Sci. USA. 91:1014-10152.
32. Polte, T.R , A.J. Naftilan, and S.K. Hanks. 1994. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J. Cell. Biochem. 55:106-119.
33. FAK) tyrosine phosphorylation, and rearrangement of actin stress fibers. J. Biol. Chem. 270:10199-10203.