CTLA-4Ig suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPase mediator of oxidative stress in rheumatoid arthritis T cells

Arthritis and Rheumatism

Volumn 54, Issue 10, 2006, Pages 3135-3143

  Remans, P H J ^a   Wijbrandts, C A ^a   Sanders, M E ^a   Toes, R E ^b   Breedveld, F C ^b   Tak, P P ^a   Van Laar, J M ^b   Reedquist, K A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY; CD28 ANTIGEN; CYTOKINE; DICHLORODIHYDROFLUORESCEIN DIACETATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYBRID PROTEIN; RAP1 PROTEIN; REACTIVE OXYGEN METABOLITE; REACTIVE SULFUR SPECIES; THYMIDINE;

ADULT; ARTICLE; CELL ADHESION; CELL CONTACT; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MALE; MITOGENESIS; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN FAMILY; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVIOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELL COMMUNICATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOCONJUGATES; MALE; OXIDATIVE STRESS; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 33750343810     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22139     Document Type: Article

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