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Volumn 24, Issue 8, 2006, Pages 2327-2334

Altered subcellular location of phosphorylated Smads in Alzheimer's disease

Author keywords

Alzheimer's disease; Cytoplasmic granules; Human hippocampus; Neurofibrillary tangles; Smad2; Smad3

Indexed keywords

AMYLOID; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 33750320547     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05109.x     Document Type: Article
Times cited : (80)

References (63)
  • 1
    • 0030613249 scopus 로고    scopus 로고
    • TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    • Abdollah, S., Macias-Silva, M., Tsukazaki, T., Hayashi, H., Attisano, L. & Wrana, J.L. (1997) TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem., 272, 27678-27685.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27678-27685
    • Abdollah, S.1    Macias-Silva, M.2    Tsukazaki, T.3    Hayashi, H.4    Attisano, L.5    Wrana, J.L.6
  • 2
    • 0348108123 scopus 로고    scopus 로고
    • Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: The 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
    • Arendt, T. (2003) Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity. Prog. Neurobiol., 71, 83-248.
    • (2003) Prog. Neurobiol. , vol.71 , pp. 83-248
    • Arendt, T.1
  • 3
    • 0029066704 scopus 로고
    • Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease
    • Arendt, T., Holzer, M., Grossmann, A., Zedlick, D. & Bruckner, M.K. (1995) Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. Neuroscience, 68, 5-18.
    • (1995) Neuroscience , vol.68 , pp. 5-18
    • Arendt, T.1    Holzer, M.2    Grossmann, A.3    Zedlick, D.4    Bruckner, M.K.5
  • 4
    • 0030477755 scopus 로고    scopus 로고
    • Expression of TGF-beta type II receptor mRNA in the CNS
    • Bottner, M., Unsicker, K. & Suter-Crazzolara, C. (1996) Expression of TGF-beta type II receptor mRNA in the CNS. Neuroreport, 7, 2903-2907.
    • (1996) Neuroreport , vol.7 , pp. 2903-2907
    • Bottner, M.1    Unsicker, K.2    Suter-Crazzolara, C.3
  • 5
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H. & Braak, E. (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.), 82, 239-259.
    • (1991) Acta Neuropathol. (Berl.) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 6
    • 0036311159 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads
    • Burton, T., Liang, B., Dibrov, A. & Amara, F. (2002) Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads. Biochem. Biophys. Res. Commun., 295, 713-723.
    • (2002) Biochem. Biophys. Res. Commun. , vol.295 , pp. 713-723
    • Burton, T.1    Liang, B.2    Dibrov, A.3    Amara, F.4
  • 9
    • 0033602186 scopus 로고    scopus 로고
    • A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
    • Dennler, S., Huet, S. & Gauthier, J.M. (1999) A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene, 18, 1643-1648.
    • (1999) Oncogene , vol.18 , pp. 1643-1648
    • Dennler, S.1    Huet, S.2    Gauthier, J.M.3
  • 10
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck, R., Akhurst, R.J. & Balmain, A. (2001) TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet., 29, 117-129.
    • (2001) Nat. Genet. , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 12
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • ten Dijke, P. & Hill, C.S. (2004) New insights into TGF-beta-Smad signalling. Trends Biochem. Sci., 29, 265-273.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 13
    • 7444257309 scopus 로고    scopus 로고
    • Sp1 and Smad transcription factors cooperate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription
    • Docagne, F., Gabriel, C., Lebeurrier, N., Lesne, S., Hommet, Y., Plawinski, L., MacKenzie, E.T. & Vivien, D. (2004) Sp1 and Smad transcription factors cooperate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription. Biochem. J., 383, 393-399.
    • (2004) Biochem. J. , vol.383 , pp. 393-399
    • Docagne, F.1    Gabriel, C.2    Lebeurrier, N.3    Lesne, S.4    Hommet, Y.5    Plawinski, L.6    MacKenzie, E.T.7    Vivien, D.8
  • 15
    • 14044271131 scopus 로고    scopus 로고
    • The human protein disulphide isomerase family: Substrate interactions and functional properties
    • Ellgaard, L. & Ruddock, L.W. (2005) The human protein disulphide isomerase family: substrate interactions and functional properties. EMBO Report, 6, 28-32.
    • (2005) EMBO Report , vol.6 , pp. 28-32
    • Ellgaard, L.1    Ruddock, L.W.2
  • 16
    • 0035140069 scopus 로고    scopus 로고
    • Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: Signaling by BMPs and TGF-betas
    • Flanders, K.C., Kim, E.S. & Roberts, A.B. (2001) Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas. Dev. Dyn., 220, 141-154.
    • (2001) Dev. Dyn. , vol.220 , pp. 141-154
    • Flanders, K.C.1    Kim, E.S.2    Roberts, A.B.3
  • 17
    • 0034767430 scopus 로고    scopus 로고
    • Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
    • Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K. & Miyazono, K. (2001) Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell, 12, 1431-1443.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1431-1443
    • Fukuchi, M.1    Imamura, T.2    Chiba, T.3    Ebisawa, T.4    Kawabata, M.5    Tanaka, K.6    Miyazono, K.7
  • 19
    • 0028981791 scopus 로고
    • Induction of p21ras in Alzheimer pathology
    • Gartner, U., Holzer, M., Heumann, R. & Arendt, T. (1995) Induction of p21ras in Alzheimer pathology. Neuroreport, 6, 1441-1444.
    • (1995) Neuroreport , vol.6 , pp. 1441-1444
    • Gartner, U.1    Holzer, M.2    Heumann, R.3    Arendt, T.4
  • 20
    • 0033625416 scopus 로고    scopus 로고
    • Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
    • Goumans, M.J. & Mummery, C. (2000) Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol., 44, 253-265.
    • (2000) Int. J. Dev. Biol. , vol.44 , pp. 253-265
    • Goumans, M.J.1    Mummery, C.2
  • 21
    • 0026501888 scopus 로고
    • Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
    • Greenberg, S.G., Davies, P., Schein, J.D. & Binder, L.I. (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J. Biol. Chem., 267, 564-569.
    • (1992) J. Biol. Chem. , vol.267 , pp. 564-569
    • Greenberg, S.G.1    Davies, P.2    Schein, J.D.3    Binder, L.I.4
  • 22
    • 0021921539 scopus 로고
    • The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue
    • Hardy, J.A., Wester, P., Winblad, B., Gezelius, C., Bring, G. & Eriksson, A. (1985) The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue. J. Neural Transm., 61, 253-264.
    • (1985) J. Neural Transm. , vol.61 , pp. 253-264
    • Hardy, J.A.1    Wester, P.2    Winblad, B.3    Gezelius, C.4    Bring, G.5    Eriksson, A.6
  • 23
    • 0037144841 scopus 로고    scopus 로고
    • TGF beta receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
    • Hayes, S., Chawla, A. & Corvera, S. (2002) TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J. Cell Biol., 158, 1239-1249.
    • (2002) J. Cell Biol. , vol.158 , pp. 1239-1249
    • Hayes, S.1    Chawla, A.2    Corvera, S.3
  • 24
    • 24644476507 scopus 로고    scopus 로고
    • Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: Implications for carcinogenesis
    • Javelaud, D. & Mauviel, A. (2005) Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene, 24, 5742-5750.
    • (2005) Oncogene , vol.24 , pp. 5742-5750
    • Javelaud, D.1    Mauviel, A.2
  • 25
    • 24344491428 scopus 로고    scopus 로고
    • Pathway- and expression level-dependent effects of oncogenic N-Ras: p27 (Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
    • Kfir, S., Ehrlich, M., Goldshmid, A., Liu, X., Kloog, Y. & Henis, Y.I. (2005) Pathway- and expression level-dependent effects of oncogenic N-Ras: p27 (Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling. Mol. Cell Biol., 25, 8239-8250.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 8239-8250
    • Kfir, S.1    Ehrlich, M.2    Goldshmid, A.3    Liu, X.4    Kloog, Y.5    Henis, Y.I.6
  • 26
    • 16844381310 scopus 로고    scopus 로고
    • TGF-{beta}1 activates two distinct type I receptors in neurons: Implications for neuronal NF-{kappa}B signaling
    • Konig, H.G., Kogel, D., Rami, A. & Prehn, J.H. (2005) TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell Biol., 168, 1077-1086.
    • (2005) J. Cell Biol. , vol.168 , pp. 1077-1086
    • Konig, H.G.1    Kogel, D.2    Rami, A.3    Prehn, J.H.4
  • 27
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
    • Kretzschmar, M., Doody, J., Timokhina, I. & Massague, J. (1999) A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev., 13, 804-816.
    • (1999) Genes Dev. , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 28
    • 0035167095 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
    • Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C.H. & Moustakas, A. (2001) Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol. Biol. Cell, 12, 1079-1091.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1079-1091
    • Kurisaki, A.1    Kose, S.2    Yoneda, Y.3    Heldin, C.H.4    Moustakas, A.5
  • 29
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    • Labbe, E., Silvestri, C., Hoodless, P.A., Wrana, J.L. & Attisano, L. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell, 2, 109-120.
    • (1998) Mol. Cell , vol.2 , pp. 109-120
    • Labbe, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 32
    • 21244447539 scopus 로고    scopus 로고
    • Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury
    • Lin, A.H., Luo, J., Mondshein, L.H., ten Dijke, P., Vivien, D., Contag, C.H. & Wyss-Coray, T. (2005) Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J. Immunol., 175, 547-554.
    • (2005) J. Immunol. , vol.175 , pp. 547-554
    • Lin, A.H.1    Luo, J.2    Mondshein, L.H.3    Ten Dijke, P.4    Vivien, D.5    Contag, C.H.6    Wyss-Coray, T.7
  • 33
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X., Sun, Y., Constantinescu, S.N., Karam, E., Weinberg, R.A. & Lodish, H.F. (1997) Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl Acad. Sci. USA, 94, 10669-10674.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 34
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-beta-activated smad2
    • Lo, R.S. & Massague, J. (1999) Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat. Cell Biol., 1, 472-478.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massague, J.2
  • 35
    • 23844514359 scopus 로고    scopus 로고
    • SMAD pathway mediation of BDNF and TGFbeta2 regulation of proliferation and differentiation of hippocampal granule neurons
    • Lu, J., Wu, Y., Sousa, N. & Almeida, O.F. (2005) SMAD pathway mediation of BDNF and TGFbeta2 regulation of proliferation and differentiation of hippocampal granule neurons. Development, 132, 3231-3242.
    • (2005) Development , vol.132 , pp. 3231-3242
    • Lu, J.1    Wu, Y.2    Sousa, N.3    Almeida, O.F.4
  • 36
    • 33746319163 scopus 로고    scopus 로고
    • Endogenous TGF-beta receptor-mediated smad signaling complexes analyzed by mass spectrometry
    • Luo, Q., Nieves, E., Kzhyshkowska, J. & Angeletti, R.H. (2006) Endogenous TGF-beta receptor-mediated smad signaling complexes analyzed by mass spectrometry. Mol. Cell Proteomics, 5, 1245-1260.
    • (2006) Mol. Cell Proteomics , vol.5 , pp. 1245-1260
    • Luo, Q.1    Nieves, E.2    Kzhyshkowska, J.3    Angeletti, R.H.4
  • 37
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague, J., Blain, S.W. & Lo, R.S. (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell, 103, 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 38
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura, I., Denissova, N.G., Wang, G., He, D., Long, J. & Liu, F. (2004) Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature, 430, 226-231.
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 39
    • 0024227225 scopus 로고
    • Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease
    • Metuzals, J., Robitaille, Y., Houghton, S., Gauthier, S. & Leblanc, R. (1988) Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease. J. Neurocytol., 17, 827-833.
    • (1988) J. Neurocytol. , vol.17 , pp. 827-833
    • Metuzals, J.1    Robitaille, Y.2    Houghton, S.3    Gauthier, S.4    Leblanc, R.5
  • 40
    • 0021821862 scopus 로고
    • Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity index
    • Monfort, J.C., Javoy-Agid, F., Hauw, J.J., Dubois, B. & Agid, Y. (1985) Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity index. Brain, 108, 301-313.
    • (1985) Brain , vol.108 , pp. 301-313
    • Monfort, J.C.1    Javoy-Agid, F.2    Hauw, J.J.3    Dubois, B.4    Agid, Y.5
  • 41
    • 0036272313 scopus 로고    scopus 로고
    • Internalization-dependent and - independent requirements for transforming growth factor beta receptor signaling via the Smad pathway
    • Penheiter, S.G., Mitchell, H., Garamszegi, N., Edens, M., Dore, J.J. Jr & Leof, E.B. (2002) Internalization-dependent and - independent requirements for transforming growth factor beta receptor signaling via the Smad pathway. Mol. Cell Biol., 22, 4750-4759.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 4750-4759
    • Penheiter, S.G.1    Mitchell, H.2    Garamszegi, N.3    Edens, M.4    Dore Jr., J.J.5    Leof, E.B.6
  • 43
    • 0141957335 scopus 로고    scopus 로고
    • Quantifying mRNA in postmortem human brain: Influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance
    • Preece, P. & Cairns, N.J. (2003) Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Res. Mol. Brain Res., 118, 60-71.
    • (2003) Brain Res. Mol. Brain Res. , vol.118 , pp. 60-71
    • Preece, P.1    Cairns, N.J.2
  • 44
    • 14844307044 scopus 로고    scopus 로고
    • The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells
    • Runyan, C.E., Schnaper, H.W. & Poncelet, A.C. (2005) The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells. J. Biol. Chem., 280, 8300-8308.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8300-8308
    • Runyan, C.E.1    Schnaper, H.W.2    Poncelet, A.C.3
  • 45
    • 0035947593 scopus 로고    scopus 로고
    • Filamin associates with Smads and regulates transforming growth factor-beta signaling
    • Sasaki, A., Masuda, Y., Ohta, Y., Ikeda, K. & Watanabe, K. (2001) Filamin associates with Smads and regulates transforming growth factor-beta signaling. J. Biol. Chem., 276, 17871-17877.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17871-17877
    • Sasaki, A.1    Masuda, Y.2    Ohta, Y.3    Ikeda, K.4    Watanabe, K.5
  • 47
    • 0034052842 scopus 로고    scopus 로고
    • Identification and characterization of a PDZ. Protein that interacts with activin type II receptors
    • Shoji, H., Tsuchida, K., Kishi, H., Yamakawa, N., Matsuzaki, T., Liu, Z., Nakamura, T. & Sugino, H. (2000) Identification and characterization of a PDZ. protein that interacts with activin type II receptors. J. Biol. Chem., 275, 5485-5492.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5485-5492
    • Shoji, H.1    Tsuchida, K.2    Kishi, H.3    Yamakawa, N.4    Matsuzaki, T.5    Liu, Z.6    Nakamura, T.7    Sugino, H.8
  • 48
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
    • Souchelnytskyi, S., Tamaki, K., Engstrom, U., Wernstedt, C., ten Dijke, P. & Heldin, C.H. (1997) Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem., 272, 28107-28115.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6
  • 50
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    • Tarkowski, E., Issa, R., Sjogren, M., Wallin, A., Blennow, K., Tarkowski, A. & Kumar, P. (2002) Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol. Aging, 23, 237-243.
    • (2002) Neurobiol. Aging , vol.23 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjogren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski, A.6    Kumar, P.7
  • 51
    • 19344373889 scopus 로고    scopus 로고
    • The nature of the phagosomal membrane: Endoplasmic reticulum versus plasmalemma
    • Touret, N., Paroutis, P. & Grinstein, S. (2005) The nature of the phagosomal membrane: endoplasmic reticulum versus plasmalemma. J. Leukoc. Biol., 77, 878-885.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 878-885
    • Touret, N.1    Paroutis, P.2    Grinstein, S.3
  • 52
    • 0346665754 scopus 로고    scopus 로고
    • Connective tissue growth factor in Alzheimer's disease
    • Ueberham, U., Ueberham, E., Gruschka, H. & Arendt, T. (2003) Connective tissue growth factor in Alzheimer's disease. Neuroscience, 116, 1-6.
    • (2003) Neuroscience , vol.116 , pp. 1-6
    • Ueberham, U.1    Ueberham, E.2    Gruschka, H.3    Arendt, T.4
  • 53
    • 0030471162 scopus 로고    scopus 로고
    • TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid
    • Vawter, M.P., Dillon-Carter, O., Tourtellotte, W.W., Carvey, P. & Freed, W.J. (1996) TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid. Exp. Neurol., 142, 313-322.
    • (1996) Exp. Neurol. , vol.142 , pp. 313-322
    • Vawter, M.P.1    Dillon-Carter, O.2    Tourtellotte, W.W.3    Carvey, P.4    Freed, W.J.5
  • 54
    • 0642286567 scopus 로고    scopus 로고
    • The cell cycle and human neurodegenerative disease
    • Vincent, I., Pae, C.I. & Hallows, J.L. (2003) The cell cycle and human neurodegenerative disease. Prog. Cell Cycle Res., 5, 31-41.
    • (2003) Prog. Cell Cycle Res. , vol.5 , pp. 31-41
    • Vincent, I.1    Pae, C.I.2    Hallows, J.L.3
  • 55
    • 0027450057 scopus 로고
    • Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies
    • van der Wal, E.A., Gomez-Pinilla, F. & Cotman, C.W. (1993) Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport, 4, 69-72.
    • (1993) Neuroreport , vol.4 , pp. 69-72
    • Van Der Wal, E.A.1    Gomez-Pinilla, F.2    Cotman, C.W.3
  • 57
    • 33746942748 scopus 로고    scopus 로고
    • Inner nuclear membrane and regulation of Smad-mediated signaling
    • Worman, H.J. (2006) Inner nuclear membrane and regulation of Smad-mediated signaling. Biochim. Biophys. Acta, 1761, 626-631.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 626-631
    • Worman, H.J.1
  • 58
    • 0035827668 scopus 로고    scopus 로고
    • Formation of a stable heterodimer between Smad2 and Smad4
    • Wu, J.W., Fairman, R., Penry, J. & Shi, Y. (2001) Formation of a stable heterodimer between Smad2 and Smad4. J. Biol. Chem., 276, 20688-20694.
    • (2001) J. Biol. Chem. , vol.276 , pp. 20688-20694
    • Wu, J.W.1    Fairman, R.2    Penry, J.3    Shi, Y.4
  • 59
  • 60
    • 0034604343 scopus 로고    scopus 로고
    • Importin beta mediates nuclear translocation of Smad 3
    • Xiao, Z., Liu, X. & Lodish, H.F. (2000) Importin beta mediates nuclear translocation of Smad 3. J. Biol. Chem., 275, 23425-23428.
    • (2000) J. Biol. Chem. , vol.275 , pp. 23425-23428
    • Xiao, Z.1    Liu, X.2    Lodish, H.F.3
  • 61
    • 0142211206 scopus 로고    scopus 로고
    • Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    • Xu, L., Alarcon, C., Col, S. & Massague, J. (2003) Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J. Biol. Chem., 278, 42569-42577.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42569-42577
    • Xu, L.1    Alarcon, C.2    Col, S.3    Massague, J.4
  • 62
    • 0036670359 scopus 로고    scopus 로고
    • Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
    • Xu, L., Kang, Y., Col, S. & Massague, J. (2002) Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol. Cell, 10, 271-282.
    • (2002) Mol. Cell , vol.10 , pp. 271-282
    • Xu, L.1    Kang, Y.2    Col, S.3    Massague, J.4
  • 63
    • 4344713918 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease
    • Zetterberg, H., Andreasen, N. & Blennow, K. (2004) Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease. Neurosci. Lett., 367, 194-196.
    • (2004) Neurosci. Lett. , vol.367 , pp. 194-196
    • Zetterberg, H.1    Andreasen, N.2    Blennow, K.3


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