Immunohistochemical expression of smads 1-6 in the 15-day gestation mouse embryo: Signaling by BMPs and TGF-βs

Developmental Dynamics

Volumn 220, Issue 2, 2001, Pages 141-154

  Flanders, Kathleen C ^a   Kim, Edward S ^a   Roberts, Anita B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Activin; Bone morphogenetic proteins; Immunohistochemistry; Mouse embryo; Organogenesis; Smad proteins; Transforming growth factor

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; EMBRYO; GESTATIONAL AGE; GROWTH PLATE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; ORGAN SPECIFICITY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0035140069     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1096>3.0.CO;2-4     Document Type: Article

References (81)

1. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
2. Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
3. Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas
4. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
5. Recombinant bone morphogenetic protein-2 stimulates differentiation in primary cultures of fetal rat calvarial osteoblasts
6. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
7. The role of TGF-β signaling in cancer
8. TGF-beta receptor signaling
9. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
10. Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development
11. Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures
12. Osteoblastic responses to TGF-β during bone remodeling
13. Localization and actions of transforming growth factor-beta s in the embryonic nervous system
14. Transforming growth factor-betas in neurodegenerative disease
15. Transforming growth factor-beta. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by Buffalo rat liver cells
16. TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells
17. Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily
18. Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells
19. Altered transforming growth factor signaling in epithelial cells when ras activation is blocked
20. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the smad4 tumor suppressor
21. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
22. Role of transforming growth factor-beta in the development of the mouse embryo
23. Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis
24. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
25. Characterization of the mouse Smad 1 gene and its expression pattern in adult mouse tissues
26. Cloning of rat type I receptor cDNA for bone morphogenetic protein-2 and bone morphogenetic protein-4, and the localization compared with that of the ligands
27. Smad6 inhibits signalling by the TGF-beta superfamily
28. Localization of transforming growth factor-beta type I and type II receptors in mouse development
29. Transforming growth factor beta1 induces nuclear export of inhibitory smad7
30. Expression of TGF-beta-related genes during mouse embryo whisker morphogenesis
31. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur
32. Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activities
33. Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: Analysis of mesoderm inducing activity
34. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
35. Regulation of immune responses by TGF-beta
36. A human Mad protein acting as a BMP-regulated transcriptional activator
37. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
38. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
39. Concurrent and distinct transcription and translation of transforming growth factor-beta type I and type II receptors in rodent embryogenesis
40. TGF-beta signal transduction
41. Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo
42. TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2
43. Regulation of differentiation by TGF-beta
44. Transforming growth factor-beta 1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells
45. Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP)
46. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
47. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
48. Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis
49. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
50. Effect of transforming growth factor-β on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum
51. Localization and binding of transforming growth factor-beta isoforms in mouse pre-implantation embryos and in delayed and activated blastocysts
52. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
53. Specificity, diversity, and regulation in TGF-beta superfamily signaling
54. Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta
55. The transforming growth factors-β
56. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
57. TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro
58. Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis
59. Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta
60. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
61. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
62. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor- Beta receptors
63. Peptide growth factors are multifunctional
64. Smad5 induces ventral fates in Xenopus embryo
65. Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
66. Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction
67. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
68. TGF-beta related genes in development
69. Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning
70. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
71. Smads and early developmental signaling by the TGFbeta superfamily
72. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
73. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
74. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
75. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
76. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
77. Immunohistochemical localization of bone morphogenetic proteins and their receptors in epiphyseal growth plate
78. Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression
79. Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture
80. Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture
81. Smad3 mutant mice develop metastatic colorectal cancer