Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias

Acta Neuropathologica

Volumn 112, Issue 6, 2006, Pages 715-725

  Schick, Volker ^a   Majores, Michael ^a   Engels, Gudrun ^a   Spitoni, Sylvia ^a   Koch, Arend ^a   Elger, Christian E ^b   Simon, Matthias ^b   Knobbe, Christiane ^c   Blümcke, Ingmar ^d   Becker, Albert J ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Akt; CTMP; FCD; Glioneuronal lesion; PI3K pathway; PTEN

Indexed keywords

CARBOXYL TERMINAL MODULATOR PROTEIN; LEUCINE; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CORTICAL DYSPLASIA; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; EPILEPSY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; BRAIN DISEASES; DNA MUTATIONAL ANALYSIS; EPILEPSY; HUMANS; IMMUNOHISTOCHEMISTRY; LASERS; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MICRODISSECTION; MUTATION; NERVOUS SYSTEM MALFORMATIONS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 33750307229     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-006-0128-y     Document Type: Article

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