-
5
-
-
0034699447
-
-
(c) Gura, T. Nature 2000, 407, 282-284.
-
(2000)
Nature
, vol.407
, pp. 282-284
-
-
Gura, T.1
-
6
-
-
0031922295
-
-
(d) Hinterding, K.; Alonso-Diaz, D.; Waldmann, H. Angew. Chem., Int. Ed. 1998, 37, 688-749.
-
(1998)
Angew. Chem., Int. Ed.
, vol.37
, pp. 688-749
-
-
Hinterding, K.1
Alonso-Diaz, D.2
Waldmann, H.3
-
7
-
-
0142147275
-
-
(a) Burke, M. D.; Berger, E. M.; Schreiber, S. L. Science 2003, 302, 613-618.
-
(2003)
Science
, vol.302
, pp. 613-618
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
8
-
-
7444242717
-
-
(b) Burke, M. D.; Berger, E. M.; Schreiber, S. L. J. Am. Chem. Soc. 2004, 126, 14095-14104.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 14095-14104
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
9
-
-
33744475697
-
-
For a recent example of building structurally complex and skeletally different architectures on a solid phase, see: Mitchell, J. T.; Shaw, J. T. Angew. Chem., Int. Ed. 2006, 45, 1722-1726.
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 1722-1726
-
-
Mitchell, J.T.1
Shaw, J.T.2
-
10
-
-
8444225024
-
-
(a) Austin, C. J.; Brady, L. S.; Insel, T. R.; Collins, F. S. Science 2004, 306, 1138-1139.
-
(2004)
Science
, vol.306
, pp. 1138-1139
-
-
Austin, C.J.1
Brady, L.S.2
Insel, T.R.3
Collins, F.S.4
-
12
-
-
3042799070
-
-
(a) Burke, M. D.; Schreiber, S. L. Angew. Chem., Int. Ed. 2004, 43, 46-58.
-
(2004)
Angew. Chem., Int. Ed.
, vol.43
, pp. 46-58
-
-
Burke, M.D.1
Schreiber, S.L.2
-
13
-
-
14144251136
-
-
(b) Arya, P.; Joseph, R.; Can, Z., Rakic, B. Chem. Biol. 2005, 12, 163-180.
-
(2005)
Chem. Biol.
, vol.12
, pp. 163-180
-
-
Arya, P.1
Joseph, R.2
Can, Z.3
Rakic, B.4
-
15
-
-
0141633672
-
-
For a few examples of bioactive natural products as inhibitors of protein-protein interactions, see: Boger, D. L.; Desharnais, J.; Capps, K. Angew. Chem., Int. Ed. 2003, 42, 4138-4176.
-
(2003)
Angew. Chem., Int. Ed.
, vol.42
, pp. 4138-4176
-
-
Boger, D.L.1
Desharnais, J.2
Capps, K.3
-
16
-
-
20444376940
-
-
For general review articles on protein-protein interactions, see: (a) Arkin, M. R. Curr. Opin. Chem. Biol. 2005, 9, 317-324.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 317-324
-
-
Arkin, M.R.1
-
19
-
-
0031872051
-
-
For a few examples of bioactive natural products as chemical dissectors of complex protein-protein interactions, see (a) Jordan, A.; Hadfield, J. A.; Lawrence, N. J.; McGown, A. T. Med. Res. Rev. 1998, 18, 259-296.
-
(1998)
Med. Res. Rev.
, vol.18
, pp. 259-296
-
-
Jordan, A.1
Hadfield, J.A.2
Lawrence, N.J.3
McGown, A.T.4
-
20
-
-
0000875480
-
-
(b) Nicolaou, K. C.; Hepworth, D.; King, N. P.; Finlay, M. R. V. Pure Appl. Chem. 1999, 71, 989-997.
-
(1999)
Pure Appl. Chem.
, vol.71
, pp. 989-997
-
-
Nicolaou, K.C.1
Hepworth, D.2
King, N.P.3
Finlay, M.R.V.4
-
21
-
-
1642401199
-
-
(c) Ravelli, R. B. G.; Gigant, B.; Curmi, P. A.; Jourdain, I.; Lachkar, S.; Sobel, A.; Knossow, M. Nature 2004, 428, 198-202.
-
(2004)
Nature
, vol.428
, pp. 198-202
-
-
Ravelli, R.B.G.1
Gigant, B.2
Curmi, P.A.3
Jourdain, I.4
Lachkar, S.5
Sobel, A.6
Knossow, M.7
-
22
-
-
3042686764
-
-
(d) Usui, T.; Watanabe, H.; Nakayama, H.; Tada, Y.; Kanoh, N.; Kondoh, M.; Asao, T.; Takio, K.; Watanabe, H.; Nishikawa, K.; Kitahara, T.; Osada, H. Chem. Biol. 2004, 11, 799-806.
-
(2004)
Chem. Biol.
, vol.11
, pp. 799-806
-
-
Usui, T.1
Watanabe, H.2
Nakayama, H.3
Tada, Y.4
Kanoh, N.5
Kondoh, M.6
Asao, T.7
Takio, K.8
Watanabe, H.9
Nishikawa, K.10
Kitahara, T.11
Osada, H.12
-
23
-
-
0942289842
-
-
Arya, P.; Durieux, P.; Chen, Z.-X.; Joseph, R.; Leek, D. M. J. Comb. Chem. 2004, 6, 54-64.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 54-64
-
-
Arya, P.1
Durieux, P.2
Chen, Z.-X.3
Joseph, R.4
Leek, D.M.5
-
24
-
-
0030602266
-
-
For a review on the synthesis of tetrahydroquinolines, see: Katritzky, A. R.; Rachwal, S.; Rachwal, B. Tetrahedron 1996, 52, 15031-15070.
-
(1996)
Tetrahedron
, vol.52
, pp. 15031-15070
-
-
Katritzky, A.R.1
Rachwal, S.2
Rachwal, B.3
-
25
-
-
9444226868
-
-
(a) Seebach, D.; Beck, A. K.; Bierbaum, D. J. Chem. Biodiversity 2004, 1, 1111-1239.
-
(2004)
Chem. Biodiversity
, vol.1
, pp. 1111-1239
-
-
Seebach, D.1
Beck, A.K.2
Bierbaum, D.J.3
-
27
-
-
0037154749
-
-
(a) Hoffman, R. V.; Maslouh, N.; Cervantes-Lee, F. J. Org. Chem. 2002, 67, 1045-1056.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 1045-1056
-
-
Hoffman, R.V.1
Maslouh, N.2
Cervantes-Lee, F.3
-
29
-
-
33750037828
-
-
note
-
Several bioactive natural products contain a 1,3-hydroxy carboxyl ester functional moiety.
-
-
-
-
30
-
-
0030484915
-
-
Li, G. G.; Angert, H. H.; Sharpless, K. B. Angew. Chem., Int. Ed. 1996, 35, 2813-2817.
-
(1996)
Angew. Chem., Int. Ed.
, vol.35
, pp. 2813-2817
-
-
Li, G.G.1
Angert, H.H.2
Sharpless, K.B.3
-
31
-
-
0035351150
-
-
(a) Tallarico, J. A.; Depew, K. M.; Pelish, H. E.; Westwood, N. J.; Lindsley, C. W.; Shair, M. D.; Schreiber, S. L.; Foley, M. A. J. Comb. Chem. 2001, 3, 312-318.
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 312-318
-
-
Tallarico, J.A.1
Depew, K.M.2
Pelish, H.E.3
Westwood, N.J.4
Lindsley, C.W.5
Shair, M.D.6
Schreiber, S.L.7
Foley, M.A.8
-
32
-
-
33750048373
-
-
Broad Institute of Harvard University and MIT, Boston, MA
-
(b) Mazitschek, R. Chemical Biology Program, Broad Institute of Harvard University and MIT, Boston, MA.
-
Chemical Biology Program
-
-
Mazitschek, R.1
-
33
-
-
13444302617
-
-
For a few examples on small molecule microarrays, see: (a) Uttamchandani, M.; Walsh, D. P.; Yao, S. Q.; Chang, Y.-T. Curr. Opin. Chem. Biol. 2005, 9, 4-13.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 4-13
-
-
Uttamchandani, M.1
Walsh, D.P.2
Yao, S.Q.3
Chang, Y.-T.4
-
34
-
-
0038682103
-
-
(b) Seeman, D. B.; Park, S. B.; Koehler, A. N.; Schreiber, S. L. Angew. Chem., Int. Ed. 2003, 42, 2376-2379.
-
(2003)
Angew. Chem., Int. Ed.
, vol.42
, pp. 2376-2379
-
-
Seeman, D.B.1
Park, S.B.2
Koehler, A.N.3
Schreiber, S.L.4
-
35
-
-
0038713943
-
-
(c) Koehler, A. N.; Shamji, A. F.; Schreiber, S. L. J. Am. Chem. Soc. 2003, 125, 8420-8421.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8420-8421
-
-
Koehler, A.N.1
Shamji, A.F.2
Schreiber, S.L.3
-
36
-
-
33646587681
-
-
(d) Bradner, J. E.; McPherson, O. M.; Mazitschek, R.; Barnes-Seeman, D.; Shen, J. P.; Dhaliwal, J.; Stevenson, K. E.; Duffner, J. L.; Park, S. B.; Neuberg, D. S.; Nghiem, P. T.; Schreiber, S. L.; Koehler, A. N. Chem. Biol. 2006, 13, 493-504.
-
(2006)
Chem. Biol.
, vol.13
, pp. 493-504
-
-
Bradner, J.E.1
McPherson, O.M.2
Mazitschek, R.3
Barnes-Seeman, D.4
Shen, J.P.5
Dhaliwal, J.6
Stevenson, K.E.7
Duffner, J.L.8
Park, S.B.9
Neuberg, D.S.10
Nghiem, P.T.11
Schreiber, S.L.12
Koehler, A.N.13
|