Underexpressed coactivators PGC1α and SRC1 impair hepatocyte nuclear factor 4α function and promote dedifferentiation in human hepatoma cells

Journal of Biological Chemistry

Volumn 281, Issue 40, 2006, Pages 29840-29849

  Martínez Jiménez, Celia P ^a   Gómez Lechón, M José ^a   Castell, José V ^a,b   Jover, Ramiro ^a,b  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEOSTASIS; HUMAN HEPATOMA CELLS; UREOGENIC RATE;

BIOLOGICAL ORGANS; GENES; INSULIN; METABOLISM;

CELL CULTURE;

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HISTONE ACETYLTRANSFERASE PCAF; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STEROID RECEPTOR COACTIVATOR 1; HEAT SHOCK PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASE; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ALDOB GENE; APOAV GENE; APOC3 GENE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYP7A1 GENE; GENE; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; OTC GENE; PEPCK GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ADULT; AGED; COMPARATIVE STUDY; DOWN REGULATION; DRUG ANTAGONISM; FEMALE; GENETICS; HOMEOSTASIS; LIVER; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; HEAT-SHOCK PROTEINS; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASES; HOMEOSTASIS; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; TRANSCRIPTION FACTORS;

EID: 33749551429     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604046200     Document Type: Article

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