Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines

Molecular and Cellular Biology

Volumn 17, Issue 11, 1997, Pages 6311-6320

  Chaya, Dina ^a   Fougère Deschatrette, Catherine ^a   Weiss, Mary C ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CYTOKERATIN 19 FRAGMENT; NUCLEAR FACTOR; NUCLEAR FACTOR 4; NUCLEAR FACTOR I; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; GENETIC TRANSCRIPTION; HEPATOMA CELL; IMMUNOFLUORESCENCE; KARYOTYPE; LIVER; LIVER FUNCTION; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; RAT;

EID: 1842411858     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.11.6311     Document Type: Article

References (83)

1. Amicone, L., F. M. Spagnoli, G. Späth, S. Giordano, C. Tommasini, S. Bernardini, V. Deluca, C. Dellarocca, M. C. Weiss, P. M. Comoglio, and M. Tripodi. 1997. Transgenic expression in the liver of truncated met blocks apoptosis and permits immortalization of hepatocytes. EMBO J. 16:495-503.
2. Bertolotti, R. 1977. A selective system for hepatoma cells producing gluconeogenic enzymes. Somatic Cell Genet. 3:365-380.
3. Besmond, C., J. C. Dreyfus, C. Gregori, M. Frain, M. M. Zakin, T. J. Sala, and A. Kahn. 1983. Nucleotide sequence of a cDNA clone for human aldolase B. Biochem. Biophys. Res. Commun. 117:601-609.
4. Block, G. D., J. Locker, W. C. Bowen, B. E. Petersen, S. Katyal, S. C. Strom, T. Riley, T. A. Howard, and G. K. Michalopoulos. 1996. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J. Cell Biol. 132:1133-1149.
5. Boshart, M., M. Kluppel, A. Schmidt, G. Schütz, and B. Luckow. 1992. Reporter constructs with low background activity utilizing the cat gene. Gene 110:129-130.
6. Boshart, M., D. Nitsch, and G. Schütz. 1993. Extinction of gene expression in somatic cell hybrids - a reflection of important regulatory mechanisms? Trends Genet. 9:240-245. (Review.)
7. Boshart, M., F. Weih, M. Nichols, and G. Schütz. 1991. The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell 66:849-859.
8. Bulla, G. A., V. DeSimone, R. Cortese, and R. E. Fournier. 1992. Extinction of alpha 1-antitrypsin gene expression in somatic cell hybrids: evidence for multiple controls. Genes Dev. 6:316-327.
9. Bulla, G. A., and R. E. Fournier. 1994. Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. Mol. Cell. Biol. 14:7086-7094.
10. Cassio, D. Personal communication.
11. Cassio, D., E. Rogier, G. Feldmann, and M. C. Weiss. 1986. Plasma-protein production by rat hepatoma cells in culture, their variants and revertants. Differentiation 30:220-228.
12. Cereghini, S. Personal communication.
13. Cereghini, S. 1996. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J. 10:267-282. (Review.)
14. Cereghini, S., M. Blumenfeld, and M. Yaniv. 1988. A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Dev. 2:957-974.
15. Cereghini, S., M. O. Ott, S. Power, and M. Maury. 1992. Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development 116:783-797.
16. Cereghini, S., M. Yaniv, and R. Cortese. 1990. Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J. 9:2257-2263.
17. Cerosaletti, K. M., and R. E. K. Fournier. 1996. Extinction of albumin gene expression in a panel of human chromosome 2 microcell hybrids. Genomics 31:348-358.
18. Chaya, D., C. Fougère-Deschatrette, and M. C. Weiss. 1996. Spontaneous apoptosis in a rat hepatoma cell line and its inhibition by dexamethasone. Cell Death Differ. 3:97-104.
19. Chouard, T., M. Blumenfeld, I. Bach, J. Vandekerckhove, S. Cereghini, and M. Yaniv. 1990. A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res. 18:5853-5863.
20. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
21. Clayton, D. F., M. Weiss, and J. J. Darnell. 1985. Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels. Mol. Cell. Biol. 5:2633-2641.
22. Coon, H. G., and M. C. Weiss. 1969. A quantitative comparison of formation of spontaneous and virus-produced viable hybrids. Proc. Natl. Acad. Sci. USA 62:852-859.
23. Corcos, L., and M. C. Weiss. 1988. Efficient one-step selection of hepatoma cell variants of a variety of phenotypes by use of aflatoxin B1. Differentiation 38:134-139.
24. Crabtree, G. R., and J. A. Kant. 1981. Molecular cloning of cDNA for the alpha, beta, and gamma chains of rat fibrinogen. A family of coordinately regulated genes. J. Biol. Chem. 256:9718-9723.
25. Derman, E., K. Krauter, L. Walling, C. Weinberger, M. Ray, and J. J. Darnell. 1981. Transcriptional control in the production of liver-specific mRNAs. Cell 23:731-739.
26. Deschatrette, J., E. E. Moore, M. Dubois, D. Cassio, and M. C. Weiss. 1979. Dedifferentiated variants of a rat hepatoma: analysis by cell hybridization. Somatic Cell Genet. 5:697-718.
27. Deschatrette, J., E. E. Moore, M. Dubois, and M. C. Weiss. 1980. Dedifferentiated variants of a rat hepatoma: reversion analysis. Cell 19:1043-1051.
28. Deschatrette, J., and M. C. Weiss. 1974. Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie 56:1603-1611.
29. Deschatrette, J., and M. C. Weiss. 1975. Extinction of liver-specific functions in hybrids between differentiated and dedifferentiated rat hepatoma cells. Somatic Cell Genet. 1:279-292.
30. de Simone, V., and R. Cortese. 1991. Transcriptional regulation of liver-specific gene expression. Curr. Opin. Cell Biol. 3:960-965.
31. de Wet, J., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
32. Edenberg, H. J., K. Zhang, K. Fong, W. F. Bosron, and T. K. Li. 1985. Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase. Proc. Natl. Acad. Sci. USA 82:2262-2266.
33. Evarts, R. P., P. Nagy, E. Marsden, and S. S. Thorgeirsson. 1987. In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver. Cancer Res. 47:5469-5475.
34. Evarts, R. P., P. Nagy, E. Marsden, and S. S. Thorgeirsson. 1987. A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 8:1737-1740.
35. Farber, E. 1956. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylaminofluorene and 3′-methyl-4-dimethyl amino azo benzene. Cancer Res. 16:142-155.
36. Faust, D. M., M. Boshart, S. T. Imaizumi, G. Schütz, and M. C. Weiss. 1994. Constancy of expression of the protein kinase A regulatory subunit R1 alpha in hepatoma cell lines of different phenotypes. Cell Growth Differ. 5:47-53.
37. Fausto, N. 1994. Liver stem cells, p. 1501-1518. In I. M. Arias, J. I. Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz (ed.), The liver: biology and pathology, 3rd ed. Raven Press, Ltd., New York, N.Y.
38. Fausto, N., J. M. Lemire, and N. Shiojiri. 1993. Cell lineages in hepatic development and the identification of progenitor cells in normal and injured liver. Proc. Soc. Exp. Biol. Med. 204:237-241. (Review.)
39. Favaloro, J., R. Treisman, and R. Kamen. 1980. Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping. Methods Enzymol. 65:718-749.
40. Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3:1314-1322.
41. Germain, L., R. Goyette, and N. Marceau. 1985. Differential cytokeratin and alpha-fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis. Cancer Res. 45:673-681.
42. Herbst, R. S., U. Nielsch, F. Sladek, E. Lai, L. E. Babiss, and J. J. Darnell. 1991. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. New Biol. 3:289-296.
43. Jagodzinski, L. L., T. D. Sargent, M. Yang, C. Glackin, and J. Bonner. 1981. Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin. Proc. Natl. Acad. Sci. USA 78:3521-3525.
44. Jiang, G., L. Nepomuceno, K. Hopkins, and F. M. Sladek. 1995. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol. Cell. Biol. 15:5131-5143.
45. Kelly, J. H., and G. J. Darlington. 1989. Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2. In Vitro Cell. Dev. Biol. 25:217-222.
46. Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10:905-920. (Review.)
47. Ktistaki, E., N. T. Ktistakis, E. Papadogeorgaki, and I. Talianidis. 1995. Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential. Proc. Natl. Acad. Sci. USA 92:9876-9880.
48. Kuo, C. J., P. B. Conley, L. Chen, F. M. Sladek, J. J. Darnell, and G. R. Crabtree. 1992. A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355:457-461.
49. Lai, E., V. R. Prezioso, E. Smith, O. Litvin, R. H. Costa, and J. J. Darnell. 1990. HNF-3A, a hepatocytc-enriched transcription factor of novel structure, is regulated transcriptionally. Genes Dev. 4:1427-1436.
50. Lehrach, H., D. Diamond, J. M. Wozney, and H. Boedtker. 1977. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16:4743-4751.
51. Lemire, J. M., N. Shiojiri, and N. Fausto. 1991. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am. J. Pathol. 139:535-552.
52. Levrat, F., V. Vallet, T. Berbar, L. Miquerol, A. Kahn, and B. Antoine. 1993. Influence of the content in transcription factors on the phenotype of mouse hepatocyte-like cell lines (mhAT). Exp. Cell Res. 209:307-316.
53. Littlefield, J. 1964. Selection of hybrids from mating of fibroblasts in vitro and their presumed recombinants. Science 145:709-710.
54. Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490.
55. Mendel, D. B., P. A. Khavari, P. B. Conley, M. K. Graves, L. P. Hansen, A. Admon, and G. R. Crabtree. 1991. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science 254: 1762-1767.
56. Mével-Ninio, M., and M. C. Weiss. 1981. Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids. J. Cell Biol. 90:339-350.
57. Mietus-Snyder, M., F. M. Sladek, G. S. Ginsburg, C. F. Kuo, J. A. Ladias, J. J. Darnell, and S. K. Karathanasis. 1992. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol. Cell. Biol. 12:1708-1718.
58. Miura, N., and K. Tanaka. 1993. Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins. Nucleic Acids Res. 21:3731-3736.
59. Moore, E. E., and M. C. Weiss. 1982. Selective isolation of stable and unstable dedifferentiated variants from a rat hepatoma cell line. J. Cell. Physiol. 111:1-8.
60. Nagy, P., H. C. Bisgaard, and S. S. Thorgeirsson. 1994. Expression of hepatic transcription factors during liver development and oval cell differentiation. J. Cell Biol. 126:223-233.
61. Ochoa, A., F. Brunel, D. Mendelzon, G. N. Cohen, and M. M. Zakin. 1989. Different liver nuclear proteins bind to similar DNA sequences in the 5′ flanking regions of three hepatic genes. Nucleic Acids Res. 17:119-133.
62. Orlando, V., and R. Paro. 1995. Chromatin multiprotein complexes involved in the maintenance of transcription patterns. Curr. Opin. Genet. Dev. 5:174-179.
63. Pitot, H. C., C. Peraino, P. A. Morse, and V. A. Potter. 1964. Hepatoma in tissue culture compared with adapting liver in vitro. Natl. Cancer Inst. Monogr. 13:229-242.
64. Power, S. C., and S. Cereghini. 1996. Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1. Mol. Cell. Biol. 16:778-791.
65. Reuber, M. D. 1961. A transplantable bile-secreting hepatocellular carcinoma in the rat. J. Natl. Cancer Inst. 26:891-899.
66. Rey Campos, J., T. Chouard, M. Yaniv, and S. Cereghini. 1991. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J. 10:1445-1457.
67. Rothfels, K. O., and L. Siminovitch. 1958. An air-drying technique for flattening chromosomes in mammalian cells grown in vitro. Stain Technol. 33:73-77.
68. Sargent, T. D., J. R. Wu, T. J. Sala, R. B. Wallace, A. A. Reyes, and J. Bonner. 1979. The rat serum albumin gene: analysis of cloned sequences. Proc. Natl. Acad. Sci. USA 76:3256-3260.
69. Seed, B., and J. Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene 67:271-277.
70. Sell, S., and H. L. Leffert. 1982. An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinoma. Hepatology 2:77-86.
71. Sirica, A. E. 1992. Biology of biliary epithelial cells. Prog. Liver Dis. 10:63-87. (Review.)
72. Sladek, F. M. 1994. Hepatocyte nuclear factor 4 (HNF4), p. 207-230. In F. Tronche and M. Yaniv (ed.), Liver gene expression. R. G. Landes Co., Austin, Tex.
73. Sladek, F. M., W. M. Zhong, E. Lai, and J. J. Darnell. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353-2365.
74. Späth, G. F., and M. C. Weiss. 1997. Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. Mol. Cell. Biol. 17:1913-1922.
75. Tee, L. B., Y. Kirilak, W. H. Huang, P. G. Smith, R. H. Morgan, and G. C. Yeoh. 1996. Dual phenotypic expression of hepatocytes and bile ductular markers in developing and preneoplastic rat liver. Carcinogenesis 17:251-259.
76. Tian, J. M., and U. Schibler. 1991. Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Dev. 5:2225-2234.
77. Tiemeier, D. C., S. M. Tilghman, and P. Leder. 1977. Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene 2:173-191.
78. Weiss, M. C., D. Cassio, and C. H. Sellem. 1988. Cell differentiation: contributions of somatic cell genetics. Cancer Surv. 7:295-302. (Review.)
79. Wolffe, A. P., and D. Pruss. 1996. Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84:817-819. (Review.)
80. Wu, J. C., G. Merlino, and N. Fausto. 1994. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc. Natl. Acad. Sci. USA 91:674-678.
81. Zakin, M. M., S. Bovard-Houppermans, and A. Ochoa. 1994. Liver-specific expression of plasma protein genes, p. 53-61. In F. Tronche and M. Yaniv (ed.), Liver gene expression. R. G. Landes Co., Austin, Tex.
82. Zaret, K. S. 1994. Genetic control of hepatocyte differentiation, p. 53-68. In I. M. Arias, J. I. Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz (ed.), The liver: biology and pathology, 3rd ed. Raven Press, Ltd., New York, N.Y.
83. Zhong, W., J. Mirkovitch, and J. J. Darnell. 1994. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol. Cell. Biol. 14:7276-7284.