-
1
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte, D.3
Seeley, R.J.4
Baskin, D.G.5
-
2
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ et al (2003) Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231
-
(2003)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
-
3
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW (2001) Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413:794-795
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers, M.G.5
Schwartz, M.W.6
-
4
-
-
0034457883
-
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
-
Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB (2000) In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141:2328-2339
-
(2000)
Endocrinology
, vol.141
, pp. 2328-2339
-
-
Kim, Y.B.1
Uotani, S.2
Pierroz, D.D.3
Flier, J.S.4
Kahn, B.B.5
-
5
-
-
0037228018
-
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver
-
Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ (2003) Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 384:151-159
-
(2003)
Biol Chem
, vol.384
, pp. 151-159
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Folli, F.3
Velloso, L.A.4
Saad, M.J.5
-
6
-
-
21744454840
-
Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line
-
Benomar Y, Roy AF, Aubourg A, Djiane J, Taouis M (2005) Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. Biochem J 388:929-939
-
(2005)
Biochem J
, vol.388
, pp. 929-939
-
-
Benomar, Y.1
Roy, A.F.2
Aubourg, A.3
Djiane, J.4
Taouis, M.5
-
7
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal weight and obese humans
-
Considine RV, Sinha MK, Heiman ML et al (1996) Serum immunoreactive- leptin concentrations in normal weight and obese humans. N Engl J Med 334:292-295
-
(1996)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
8
-
-
0036321620
-
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
-
Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A (2002) A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 5:727-728
-
(2002)
Nat Neurosci
, vol.5
, pp. 727-728
-
-
Zhao, A.Z.1
Huan, J.N.2
Gupta, S.3
Pal, R.4
Sahu, A.5
-
9
-
-
2542444292
-
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
-
Huang W, Dedousis N, Bhatt BA, O'Doherty RM (2004) Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem 279:21695-21700
-
(2004)
J Biol Chem
, vol.279
, pp. 21695-21700
-
-
Huang, W.1
Dedousis, N.2
Bhatt, B.A.3
O'Doherty, R.M.4
-
10
-
-
0030867766
-
From receptor to transporter: Insulin signalling to glucose transport
-
Holman GD, Kasuga M (1997) From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40:991-1003
-
(1997)
Diabetologia
, vol.40
, pp. 991-1003
-
-
Holman, G.D.1
Kasuga, M.2
-
11
-
-
0030271565
-
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene
-
Fruman DA, Cantley LC, Carpenter CL (1996) Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics 37:113-121
-
(1996)
Genomics
, vol.37
, pp. 113-121
-
-
Fruman, D.A.1
Cantley, L.C.2
Carpenter, C.L.3
-
12
-
-
0033780412
-
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit
-
Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR (2000) Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit. Mol Cell Biol 20:8035-8046
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8035-8046
-
-
Ueki, K.1
Algenstaedt, P.2
Mauvais-Jarvis, F.3
Kahn, C.R.4
-
13
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
-
Terauchi Y, Tsuji Y, Satoh S et al (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21:230-235
-
(1999)
Nat Genet
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
Tsuji, Y.2
Satoh, S.3
-
14
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
Shepherd PR, Withers DJ, Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490
-
(1998)
Biochem J
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
15
-
-
0030615068
-
p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin
-
Inukai K, Funaki M, Ogihara T et al (1997) p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 272:7873-7882
-
(1997)
J Biol Chem
, vol.272
, pp. 7873-7882
-
-
Inukai, K.1
Funaki, M.2
Ogihara, T.3
-
16
-
-
0031046812
-
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: Effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index
-
Hansen T, Andersen CB, Echwald SM, Urhammer SA, Clausen JO, Vestergaard H et al (1997) Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes 46:494-501
-
(1997)
Diabetes
, vol.46
, pp. 494-501
-
-
Hansen, T.1
Andersen, C.B.2
Echwald, S.M.3
Urhammer, S.A.4
Clausen, J.O.5
Vestergaard, H.6
-
17
-
-
0008499455
-
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: A novel variant with impaired insulin-stimulated lipid kinase activity
-
Baynes K, Beeton CA, Panayotou G et al (2000) Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity. Diabetologia 43:321-331
-
(2000)
Diabetologia
, vol.43
, pp. 321-331
-
-
Baynes, K.1
Beeton, C.A.2
Panayotou, G.3
-
18
-
-
0035095168
-
In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: Inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity
-
Hansen L, Zethelius B, Berglund L et al (2001) In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity. Diabetes 50:690-693
-
(2001)
Diabetes
, vol.50
, pp. 690-693
-
-
Hansen, L.1
Zethelius, B.2
Berglund, L.3
-
19
-
-
4243062602
-
Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
-
Barroso I, Luan J, Middelberg RP et al (2003) Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol 1:E20
-
(2003)
PLoS Biol
, vol.1
-
-
Barroso, I.1
Luan, J.2
Middelberg, R.P.3
-
20
-
-
4143134235
-
The future of association studies: Gene-based analysis and replication
-
Neale BM, Sham PC (2004) The future of association studies: gene-based analysis and replication. Am J Hum Genet 75:353-362
-
(2004)
Am J Hum Genet
, vol.75
, pp. 353-362
-
-
Neale, B.M.1
Sham, P.C.2
-
21
-
-
0344033602
-
Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power
-
Chapman JM, Cooper JD, Todd JA, Clayton DG (2003) Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered 56:18-31
-
(2003)
Hum Hered
, vol.56
, pp. 18-31
-
-
Chapman, J.M.1
Cooper, J.D.2
Todd, J.A.3
Clayton, D.G.4
-
22
-
-
0043175289
-
Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
-
Stram DO, Haiman CA, Hirschhorn JN et al (2003) Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Hum Hered 55:27-36
-
(2003)
Hum Hered
, vol.55
, pp. 27-36
-
-
Stram, D.O.1
Haiman, C.A.2
Hirschhorn, J.N.3
-
23
-
-
0036808034
-
The St. Thomas' UK Adult Twin Registry
-
Spector TD, MacGregor AJ (2002) The St. Thomas' UK Adult Twin Registry. Twin Res 5:440-443
-
(2002)
Twin Res
, vol.5
, pp. 440-443
-
-
Spector, T.D.1
MacGregor, A.J.2
-
24
-
-
0035670640
-
Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women
-
Andrew T, Hart D, Snieder H, de Lange M, Spector TD, MacGregor AJ (2001) Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4:464-477
-
(2001)
Twin Res
, vol.4
, pp. 464-477
-
-
Andrew, T.1
Hart, D.2
Snieder, H.3
De Lange, M.4
Spector, T.D.5
MacGregor, A.J.6
-
25
-
-
0344826588
-
Haplotype tagging single nucleotide polymorphisms and association studies
-
Thompson D, Stram D, Goldgar D, Witte JS (2003) Haplotype tagging single nucleotide polymorphisms and association studies. Hum Hered 56:48-55
-
(2003)
Hum Hered
, vol.56
, pp. 48-55
-
-
Thompson, D.1
Stram, D.2
Goldgar, D.3
Witte, J.S.4
-
26
-
-
0034017850
-
GOLD - Graphical overview of linkage disequilibrium
-
Abecasis GR, Cookson WO (2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics 16:182-183
-
(2000)
Bioinformatics
, vol.16
, pp. 182-183
-
-
Abecasis, G.R.1
Cookson, W.O.2
-
27
-
-
0030873884
-
Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations
-
Trégouët D-A, Ducimetère P, Tiret L (1997) Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations. Am J Hum Genet 61:189-199
-
(1997)
Am J Hum Genet
, vol.61
, pp. 189-199
-
-
Trégouët, D.-A.1
Ducimetère, P.2
Tiret, L.3
-
28
-
-
3242754160
-
Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: A study of female dizygotic twins
-
Dong Y, Zhu H, Wang X et al (2004) Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Pharmacogenetics 14:419-427
-
(2004)
Pharmacogenetics
, vol.14
, pp. 419-427
-
-
Dong, Y.1
Zhu, H.2
Wang, X.3
-
29
-
-
0036284203
-
Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
-
Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG (2002) Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 53:79-91
-
(2002)
Hum Hered
, vol.53
, pp. 79-91
-
-
Zaykin, D.V.1
Westfall, P.H.2
Young, S.S.3
Karnoub, M.A.4
Wagner, M.J.5
Ehm, M.G.6
-
30
-
-
0242691208
-
A comparison of bayesian methods for haplotype reconstruction from population genotype data
-
Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169
-
(2003)
Am J Hum Genet
, vol.73
, pp. 1162-1169
-
-
Stephens, M.1
Donnelly, P.2
-
31
-
-
0032940183
-
Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state
-
Avignon A, Boegner C, Mariano-Goulart D, Colette C, Monnier L (1999) Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state. Int J Obes Relat Metab Disord 23:512-517
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
, pp. 512-517
-
-
Avignon, A.1
Boegner, C.2
Mariano-Goulart, D.3
Colette, C.4
Monnier, L.5
-
32
-
-
0037315294
-
Prediction of type 2 diabetes using simple measures of insulin resistance: Combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
-
Hanley AJ, Williams K, Gonzalez C et al (2003) Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes 52:463-469
-
(2003)
Diabetes
, vol.52
, pp. 463-469
-
-
Hanley, A.J.1
Williams, K.2
Gonzalez, C.3
-
33
-
-
12244264435
-
Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits
-
Purcell S, Cherny SS, Sham PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150
-
(2003)
Bioinformatics
, vol.19
, pp. 149-150
-
-
Purcell, S.1
Cherny, S.S.2
Sham, P.C.3
-
34
-
-
0041672374
-
Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
-
Lake SL, Lyon H, Tantisira K et al (2003) Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered 55:56-65
-
(2003)
Hum Hered
, vol.55
, pp. 56-65
-
-
Lake, S.L.1
Lyon, H.2
Tantisira, K.3
-
35
-
-
0031803108
-
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): Preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women
-
Baier LJ, Wiedrich C, Hanson RL, Bogardus C (1998) Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. Diabetes 47:973-975
-
(1998)
Diabetes
, vol.47
, pp. 973-975
-
-
Baier, L.J.1
Wiedrich, C.2
Hanson, R.L.3
Bogardus, C.4
-
36
-
-
0037133050
-
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha
-
Almind K, Delahaye L, Hansen T, Van Obberghen E, Pedersen O, Kahn CR (2002) Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha. Proc Natl Acad Sci USA 99:2124-2148
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2124-2148
-
-
Almind, K.1
Delahaye, L.2
Hansen, T.3
Van Obberghen, E.4
Pedersen, O.5
Kahn, C.R.6
-
37
-
-
13244252424
-
Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
-
Shepherd PR (2005) Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues. Acta Physiol Scand 183:3-12
-
(2005)
Acta Physiol Scand
, vol.183
, pp. 3-12
-
-
Shepherd, P.R.1
-
38
-
-
0037288941
-
Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
-
Niswender KD, Schwartz MW (2003) Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 24:1-10
-
(2003)
Front Neuroendocrinol
, vol.24
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
39
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
-
Kubota N, Terauchi Y, Tobe K et al (2004) Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114:917-927
-
(2004)
J Clin Invest
, vol.114
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
-
40
-
-
0035013923
-
Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats
-
Yaspelkis BB 3rd, Davis JR, Saberi M et al (2001) Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats. Am J Physiol Endocrinol Metab 280:E130-E142
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Yaspelkis III, B.B.1
Davis, J.R.2
Saberi, M.3
-
41
-
-
0030828823
-
Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring, HU (1997) Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40:1358-1362
-
(1997)
Diabetologia
, vol.40
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
42
-
-
0347624591
-
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
-
Chen D, Mauvais-Jarvis F, Bluher M et al (2004) p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol 24:320-329
-
(2004)
Mol Cell Biol
, vol.24
, pp. 320-329
-
-
Chen, D.1
Mauvais-Jarvis, F.2
Bluher, M.3
-
43
-
-
2642683510
-
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
-
Kerouz, NJ, Horsch D, Pons S, Kahn CR (1997) Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest 100:3164-3172
-
(1997)
J Clin Invest
, vol.100
, pp. 3164-3172
-
-
Kerouz, N.J.1
Horsch, D.2
Pons, S.3
Kahn, C.R.4
|