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Volumn 49, Issue 11, 2006, Pages 2659-2667

Phosphatidylinositol 3-kinase p85α regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population

Author keywords

Cytokines; Epidemiology; Genetics; Obesity; Weight regulation

Indexed keywords

LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 33749448847     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0388-z     Document Type: Article
Times cited : (19)

References (43)
  • 2
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
    • Niswender KD, Morrison CD, Clegg DJ et al (2003) Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231
    • (2003) Diabetes , vol.52 , pp. 227-231
    • Niswender, K.D.1    Morrison, C.D.2    Clegg, D.J.3
  • 4
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB (2000) In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141:2328-2339
    • (2000) Endocrinology , vol.141 , pp. 2328-2339
    • Kim, Y.B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 5
    • 0037228018 scopus 로고    scopus 로고
    • Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver
    • Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ (2003) Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 384:151-159
    • (2003) Biol Chem , vol.384 , pp. 151-159
    • Carvalheira, J.B.1    Ribeiro, E.B.2    Folli, F.3    Velloso, L.A.4    Saad, M.J.5
  • 6
    • 21744454840 scopus 로고    scopus 로고
    • Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line
    • Benomar Y, Roy AF, Aubourg A, Djiane J, Taouis M (2005) Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. Biochem J 388:929-939
    • (2005) Biochem J , vol.388 , pp. 929-939
    • Benomar, Y.1    Roy, A.F.2    Aubourg, A.3    Djiane, J.4    Taouis, M.5
  • 7
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal weight and obese humans
    • Considine RV, Sinha MK, Heiman ML et al (1996) Serum immunoreactive- leptin concentrations in normal weight and obese humans. N Engl J Med 334:292-295
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 8
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A (2002) A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 5:727-728
    • (2002) Nat Neurosci , vol.5 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 9
    • 2542444292 scopus 로고    scopus 로고
    • Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
    • Huang W, Dedousis N, Bhatt BA, O'Doherty RM (2004) Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem 279:21695-21700
    • (2004) J Biol Chem , vol.279 , pp. 21695-21700
    • Huang, W.1    Dedousis, N.2    Bhatt, B.A.3    O'Doherty, R.M.4
  • 10
    • 0030867766 scopus 로고    scopus 로고
    • From receptor to transporter: Insulin signalling to glucose transport
    • Holman GD, Kasuga M (1997) From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40:991-1003
    • (1997) Diabetologia , vol.40 , pp. 991-1003
    • Holman, G.D.1    Kasuga, M.2
  • 11
    • 0030271565 scopus 로고    scopus 로고
    • Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene
    • Fruman DA, Cantley LC, Carpenter CL (1996) Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics 37:113-121
    • (1996) Genomics , vol.37 , pp. 113-121
    • Fruman, D.A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 12
    • 0033780412 scopus 로고    scopus 로고
    • Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit
    • Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR (2000) Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit. Mol Cell Biol 20:8035-8046
    • (2000) Mol Cell Biol , vol.20 , pp. 8035-8046
    • Ueki, K.1    Algenstaedt, P.2    Mauvais-Jarvis, F.3    Kahn, C.R.4
  • 13
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    • Terauchi Y, Tsuji Y, Satoh S et al (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21:230-235
    • (1999) Nat Genet , vol.21 , pp. 230-235
    • Terauchi, Y.1    Tsuji, Y.2    Satoh, S.3
  • 14
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
    • Shepherd PR, Withers DJ, Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490
    • (1998) Biochem J , vol.333 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 15
    • 0030615068 scopus 로고    scopus 로고
    • p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin
    • Inukai K, Funaki M, Ogihara T et al (1997) p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 272:7873-7882
    • (1997) J Biol Chem , vol.272 , pp. 7873-7882
    • Inukai, K.1    Funaki, M.2    Ogihara, T.3
  • 16
    • 0031046812 scopus 로고    scopus 로고
    • Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: Effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index
    • Hansen T, Andersen CB, Echwald SM, Urhammer SA, Clausen JO, Vestergaard H et al (1997) Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes 46:494-501
    • (1997) Diabetes , vol.46 , pp. 494-501
    • Hansen, T.1    Andersen, C.B.2    Echwald, S.M.3    Urhammer, S.A.4    Clausen, J.O.5    Vestergaard, H.6
  • 17
    • 0008499455 scopus 로고    scopus 로고
    • Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: A novel variant with impaired insulin-stimulated lipid kinase activity
    • Baynes K, Beeton CA, Panayotou G et al (2000) Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity. Diabetologia 43:321-331
    • (2000) Diabetologia , vol.43 , pp. 321-331
    • Baynes, K.1    Beeton, C.A.2    Panayotou, G.3
  • 18
    • 0035095168 scopus 로고    scopus 로고
    • In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: Inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity
    • Hansen L, Zethelius B, Berglund L et al (2001) In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity. Diabetes 50:690-693
    • (2001) Diabetes , vol.50 , pp. 690-693
    • Hansen, L.1    Zethelius, B.2    Berglund, L.3
  • 19
    • 4243062602 scopus 로고    scopus 로고
    • Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
    • Barroso I, Luan J, Middelberg RP et al (2003) Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol 1:E20
    • (2003) PLoS Biol , vol.1
    • Barroso, I.1    Luan, J.2    Middelberg, R.P.3
  • 20
    • 4143134235 scopus 로고    scopus 로고
    • The future of association studies: Gene-based analysis and replication
    • Neale BM, Sham PC (2004) The future of association studies: gene-based analysis and replication. Am J Hum Genet 75:353-362
    • (2004) Am J Hum Genet , vol.75 , pp. 353-362
    • Neale, B.M.1    Sham, P.C.2
  • 21
    • 0344033602 scopus 로고    scopus 로고
    • Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power
    • Chapman JM, Cooper JD, Todd JA, Clayton DG (2003) Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered 56:18-31
    • (2003) Hum Hered , vol.56 , pp. 18-31
    • Chapman, J.M.1    Cooper, J.D.2    Todd, J.A.3    Clayton, D.G.4
  • 22
    • 0043175289 scopus 로고    scopus 로고
    • Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
    • Stram DO, Haiman CA, Hirschhorn JN et al (2003) Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Hum Hered 55:27-36
    • (2003) Hum Hered , vol.55 , pp. 27-36
    • Stram, D.O.1    Haiman, C.A.2    Hirschhorn, J.N.3
  • 23
    • 0036808034 scopus 로고    scopus 로고
    • The St. Thomas' UK Adult Twin Registry
    • Spector TD, MacGregor AJ (2002) The St. Thomas' UK Adult Twin Registry. Twin Res 5:440-443
    • (2002) Twin Res , vol.5 , pp. 440-443
    • Spector, T.D.1    MacGregor, A.J.2
  • 24
    • 0035670640 scopus 로고    scopus 로고
    • Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women
    • Andrew T, Hart D, Snieder H, de Lange M, Spector TD, MacGregor AJ (2001) Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4:464-477
    • (2001) Twin Res , vol.4 , pp. 464-477
    • Andrew, T.1    Hart, D.2    Snieder, H.3    De Lange, M.4    Spector, T.D.5    MacGregor, A.J.6
  • 25
    • 0344826588 scopus 로고    scopus 로고
    • Haplotype tagging single nucleotide polymorphisms and association studies
    • Thompson D, Stram D, Goldgar D, Witte JS (2003) Haplotype tagging single nucleotide polymorphisms and association studies. Hum Hered 56:48-55
    • (2003) Hum Hered , vol.56 , pp. 48-55
    • Thompson, D.1    Stram, D.2    Goldgar, D.3    Witte, J.S.4
  • 26
    • 0034017850 scopus 로고    scopus 로고
    • GOLD - Graphical overview of linkage disequilibrium
    • Abecasis GR, Cookson WO (2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics 16:182-183
    • (2000) Bioinformatics , vol.16 , pp. 182-183
    • Abecasis, G.R.1    Cookson, W.O.2
  • 27
    • 0030873884 scopus 로고    scopus 로고
    • Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations
    • Trégouët D-A, Ducimetère P, Tiret L (1997) Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations. Am J Hum Genet 61:189-199
    • (1997) Am J Hum Genet , vol.61 , pp. 189-199
    • Trégouët, D.-A.1    Ducimetère, P.2    Tiret, L.3
  • 28
    • 3242754160 scopus 로고    scopus 로고
    • Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: A study of female dizygotic twins
    • Dong Y, Zhu H, Wang X et al (2004) Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Pharmacogenetics 14:419-427
    • (2004) Pharmacogenetics , vol.14 , pp. 419-427
    • Dong, Y.1    Zhu, H.2    Wang, X.3
  • 29
    • 0036284203 scopus 로고    scopus 로고
    • Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    • Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG (2002) Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 53:79-91
    • (2002) Hum Hered , vol.53 , pp. 79-91
    • Zaykin, D.V.1    Westfall, P.H.2    Young, S.S.3    Karnoub, M.A.4    Wagner, M.J.5    Ehm, M.G.6
  • 30
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of bayesian methods for haplotype reconstruction from population genotype data
    • Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169
    • (2003) Am J Hum Genet , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 31
    • 0032940183 scopus 로고    scopus 로고
    • Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state
    • Avignon A, Boegner C, Mariano-Goulart D, Colette C, Monnier L (1999) Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state. Int J Obes Relat Metab Disord 23:512-517
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 512-517
    • Avignon, A.1    Boegner, C.2    Mariano-Goulart, D.3    Colette, C.4    Monnier, L.5
  • 32
    • 0037315294 scopus 로고    scopus 로고
    • Prediction of type 2 diabetes using simple measures of insulin resistance: Combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
    • Hanley AJ, Williams K, Gonzalez C et al (2003) Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes 52:463-469
    • (2003) Diabetes , vol.52 , pp. 463-469
    • Hanley, A.J.1    Williams, K.2    Gonzalez, C.3
  • 33
    • 12244264435 scopus 로고    scopus 로고
    • Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 34
    • 0041672374 scopus 로고    scopus 로고
    • Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    • Lake SL, Lyon H, Tantisira K et al (2003) Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered 55:56-65
    • (2003) Hum Hered , vol.55 , pp. 56-65
    • Lake, S.L.1    Lyon, H.2    Tantisira, K.3
  • 35
    • 0031803108 scopus 로고    scopus 로고
    • Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): Preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women
    • Baier LJ, Wiedrich C, Hanson RL, Bogardus C (1998) Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. Diabetes 47:973-975
    • (1998) Diabetes , vol.47 , pp. 973-975
    • Baier, L.J.1    Wiedrich, C.2    Hanson, R.L.3    Bogardus, C.4
  • 37
    • 13244252424 scopus 로고    scopus 로고
    • Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
    • Shepherd PR (2005) Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues. Acta Physiol Scand 183:3-12
    • (2005) Acta Physiol Scand , vol.183 , pp. 3-12
    • Shepherd, P.R.1
  • 38
    • 0037288941 scopus 로고    scopus 로고
    • Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
    • Niswender KD, Schwartz MW (2003) Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 24:1-10
    • (2003) Front Neuroendocrinol , vol.24 , pp. 1-10
    • Niswender, K.D.1    Schwartz, M.W.2
  • 39
    • 9644260562 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
    • Kubota N, Terauchi Y, Tobe K et al (2004) Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114:917-927
    • (2004) J Clin Invest , vol.114 , pp. 917-927
    • Kubota, N.1    Terauchi, Y.2    Tobe, K.3
  • 40
    • 0035013923 scopus 로고    scopus 로고
    • Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats
    • Yaspelkis BB 3rd, Davis JR, Saberi M et al (2001) Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats. Am J Physiol Endocrinol Metab 280:E130-E142
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Yaspelkis III, B.B.1    Davis, J.R.2    Saberi, M.3
  • 41
    • 0030828823 scopus 로고    scopus 로고
    • Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
    • Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring, HU (1997) Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40:1358-1362
    • (1997) Diabetologia , vol.40 , pp. 1358-1362
    • Kellerer, M.1    Koch, M.2    Metzinger, E.3    Mushack, J.4    Capp, E.5    Haring, H.U.6
  • 42
    • 0347624591 scopus 로고    scopus 로고
    • p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
    • Chen D, Mauvais-Jarvis F, Bluher M et al (2004) p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol 24:320-329
    • (2004) Mol Cell Biol , vol.24 , pp. 320-329
    • Chen, D.1    Mauvais-Jarvis, F.2    Bluher, M.3
  • 43
    • 2642683510 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
    • Kerouz, NJ, Horsch D, Pons S, Kahn CR (1997) Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest 100:3164-3172
    • (1997) J Clin Invest , vol.100 , pp. 3164-3172
    • Kerouz, N.J.1    Horsch, D.2    Pons, S.3    Kahn, C.R.4


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