Role of KATP channels in sepsis

Cardiovascular Research

Volumn 72, Issue 2, 2006, Pages 220-230

  Buckley, James F ^a,b   Singer, Mervyn ^b   Clapp, Lucie H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Insulin; K ATP channel; Mitochondria; Multi organ failure; Sepsis; Septic shock; Vascular hyporeactivity

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANGIOTENSIN II; BMS 191095; CALCITONIN GENE RELATED PEPTIDE; CATECHOLAMINE; CLAMIKALANT; CYCLIC GMP; CYTOKINE; ENDOTHELIN; GLIBENCLAMIDE; GLICLAZIDE; GLUCOSE; INSULIN; N (1 ADAMANTYL) N' CYCLOHEXYL 4 MORPHOLINECARBOXAMIDINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; TOLBUTAMIDE; UNCLASSIFIED DRUG; VASOPRESSIN; POTASSIUM CHANNEL;

ACTIN POLYMERIZATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CELL DAMAGE; CELL PROTECTION; CHANNEL GATING; CYTOSKELETON; DEPOLYMERIZATION; DRUG EFFECT; ENERGY; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HUMAN; HYPERGLYCEMIA; HYPOTENSION; IMMUNE RESPONSE; INSULIN RESISTANCE; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOPHYSIOLOGY; POTASSIUM TRANSPORT; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; STRESS; ISCHEMIC PRECONDITIONING; METABOLISM; VASODILATATION;

ADENOSINE TRIPHOSPHATE; HUMANS; ISCHEMIC PRECONDITIONING; MULTIPLE ORGAN FAILURE; POTASSIUM CHANNELS; SEPSIS; VASODILATION;

EID: 33749431988     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.07.011     Document Type: Review

References (109)

1. Annane D., Bellissant E., and Cavaillon J.M. Septic shock. Lancet 365 (2005) 63-78
2. Tsiotou A.G., Sakorafas G.H., Anagnostopoulos G., and Bramis J. Septic shock; current pathogenetic concepts from a clinical perspective. Med Sci Monit 11 (2005) RA76-RA85
3. Das U.N. Current advances in sepsis and septic shock with particular emphasis on the role of insulin. Med Sci Monit 9 (2003) RA181-RA192
4. Boveris A., Alvarez S., and Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic Biol Med 33 (2002) 1186-1193
5. Thiemermann C. Nitric oxide and septic shock. Gen Pharmacol 29 (1997) 159-166
6. Clapp L.H., and Tinker A. Potassium channels in the vasculature. Curr Opin Nephrol Hypertens 7 (1998) 91-98
7. Landry D.W., and Oliver J.A. The pathogenesis of vasodilatory shock. N Engl J Med 345 (2001) 588-594
8. Lopez A., Lorente J.A., Steingrub J., Bakker J., McLuckie A., Willatts S., et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32 (2004) 21-30
9. O'Brien A.J., Clapp L.H., and Singer M. Terlipressin therapy for norepinephrine-resistant septic shock. Lancet 359 (2002) 1209-1210
10. Shieh C.C., Coghlan M., Sullivan J.P., and Gopalakrishnan M. Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52 (2000) 557-594
11. + channels. Biochim Biophys Acta 1461 (1999) 285-305
12. + channels. Prog Biophys Mol Biol 81 (2003) 133-176
13. Rodrigo G.C., and Standen N.B. ATP-sensitive potassium channels. Curr Pharm Des 11 (2005) 1915-1940
14. + channels: role of protein phosphatase-2B. Circ Res 87 (2000) 1019-1025
15. Orie N.N., Perrino B.A., Tinker A., and Clapp L.H. Calcineurin Aα regulates Kir6.1/SUR2B in HEK293 cells through an interaction with protein kinase A. J Physiol 567P (2005) C24
16. Singer M., Coluzzi F., O'Brien A.J., and Clapp L.H. Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide. Lancet 365 (2005) 1873-1875
17. ATP channel subunit essential for cell protection against ischemia. EMBO J 21 (2002) 3936-3948
18. ATP channel macromolecular complex and regulate its function. J Biol Chem 280 (2005) 38464-38470
19. ATP channels as metabolic sensors in acute metabolic changes. J Mol Cell Cardiol 38 (2005) 917-925
20. Quayle J.M., Nelson M.T., and Standen N.B. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev 77 (1997) 1166-1232
21. + channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog. J Clin Invest 89 (1992) 2071-2074
22. Vanelli G., Hussain S.N., Dimori M., and Aguggini G. Cardiovascular responses to glibenclamide during endotoxaemia in the pig. Vet Res Commun 21 (1997) 187-200
23. Sorrentino R., Bianca R., Lippolis L., Sorrentino L., Autore G., and Pinto A. Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats. Br J Pharmacol 127 (1999) 1447-1453
24. Humphrey S.J. Pharmacology of the K-ATP channel blocking morpholinoguanidine PNU-37883A. Cardiovasc Drug Rev 17 (1999) 295-328
25. ATP channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro. Br J Pharmacol 144 (2005) 367-375
26. Sato N., Nakayama T., Asai S., and Soma M. A haplotype in the human Sur2 gene is associated with essential hypertension. J Hum Hypertens 20 (2006) 87-90
27. Shi N.Q., Ye B., and Makielski J.C. Function and distribution of the SUR isoforms and splice variants. J Mol Cell Cardiol 39 (2005) 51-60
28. Sakai K., Saito K., and Akima M. Synergistic effect of calcitonin gene-related peptide on adenosine-induced vasodepression in rats. Eur J Pharmacol 344 (1998) 153-159
29. + channel. Circ Res 94 (2004) 1359-1366
30. + channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes. Am J Physiol 283 (2002) H1545-H1554
31. Lin Y.F., Raab-Graham K., Jan Y.N., and Jan L.Y. NO stimulation of ATP-sensitive potassium channels: involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci U S A 101 (2004) 7799-7804
32. ATP channel inhibitors to reverse iNOS-mediated vasorelaxation. Cardiovasc Res 56 (2002) 154-163
33. + channel activities of cultured smooth muscle cells from porcine coronary artery. Am J Physiol 263 (1992) H491-H496
34. + channels. Circulation 96 (1997) 3129-3135
35. + channels via V1 receptors activation in the guinea pig heart. Circ J 66 (2002) 277-282
36. ATP channels and an overview of alternative mechanisms. J Mol Cell Cardiol 39 (2005) 17-50
37. ATP channel gene expression in rat hearts. J Clin Invest 100 (1997) 3053-3059
38. ATP channel genes by hypoxia. Mol Cell Biochem 225 (2001) 145-150
39. Meng X., Brown J.M., Ao L., Rowland R.T., Nordeen S.K., Banerjee A., et al. Myocardial gene reprogramming associated with a cardiac cross-resistant state induced by LPS preconditioning. Am J Physiol 275 (1998) C475-C483
40. Wang Y.P., Sato C., Mizoguchi K., Yamashita Y., Oe M., and Maeta H. Lipopolysaccharide triggers late preconditioning against myocardial infarction via inducible nitric oxide synthase. Cardiovasc Res 56 (2002) 33-42
41. Wu C.C., Thiemermann C., and Vane J.R. Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat. Br J Pharmacol 114 (1995) 1273-1281
42. Vanelli G., Hussain S.N.A., and Aguggini G. Glibenclamide, a blocker of ATP-sensitive potassium channels, reverses endotoxin-induced hypotension in pig. Exp Physiol 80 (1995) 167-170
43. d'Emmanuele d. V., Lippolis L., Autore G., Popolo A., Marzocco S., Sorrentino L., et al. Dexamethasone improves vascular hyporeactivity induced by LPS in vivo by modulating ATP-sensitive potassium channels activity. Br J Pharmacol 140 (2003) 91-96
44. ATP-1) channel by endotoxemia. Muscle Nerve 23 (2000) 967-969
45. + channels in experimental colitis. Am J Physiol 287 (2004) G274-G285
46. Annane D. Glucocorticoids in the treatment of severe sepsis and septic shock. Curr Opin Crit Care 11 (2005) 449-453
47. Warrillow S., Egi M., and Bellomo R. Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock. Crit Care Med 34 (2006) 980-985
48. O'Brien A.J., Wilson A.J., Sibbald R., Singer M., and Clapp L.H. Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model. Br J Pharmacol 133 (2001) 351-360
49. Vallance P., and Chan N. Endothelial function and nitric oxide: clinical relevance. Heart 85 (2001) 342-350
50. O'Brien A.J., Stidwill R., Clapp L.H., and Singer M. LPS induces iNOS in all layers of rat meseneteric artery in both in vitro and in vivo models. Intensive Care Med 29 (2003) S508
51. + channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence. Br J Pharmacol 131 (2000) 213-222
52. Chen S.J., Wu C.C., Yang S.N., Lin C.I., and Yen M.H. Hyperpolarization contributes to vascular hyporeactivity in rats with lipopolysaccharide-induced endotoxic shock. Life Sci 68 (2000) 659-668
53. ATP channels underlie endotoxin-induced smooth muscle hyperpolarization in rat mesenteric resistance arteries. Br J Pharmacol 142 (2004) 479-484
54. ATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol 139 (2003) 122-128
55. Preiser J.C., Zhang H., Debelle F., Fesler P., Kafi S.A., Naeije R., et al. Hemodynamic effects of glibenclamide during endotoxemia: contrasting findings in vitro versus in vivo. Shock 19 (2003) 223-228
56. Annane D., Sanquer S., Sebille V., Faye A., Djuranovic D., Raphael J.C., et al. Compartmentalised inducible nitric-oxide synthase activity in septic shock. Lancet 355 (2000) 1143-1148
57. Wheeler M.A., Smith S.D., Garcia-Cardena G., Nathan C.F., Weiss R.M., and Sessa W.C. Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest 99 (1997) 110-116
58. + channel of vascular smooth muscle cells. FEBS Lett 345 (1994) 47-49
59. + channels. Am J Physiol 289 (2005) H2244-H2250
60. Wei E.P., Kontos H.A., and Beckman J.S. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am J Physiol 40 (1996) H1262-H1266
61. Sommer D., Coleman S., Swanson S.A., and Stemmer P.M. Differential susceptibilities of serine/threonine phosphatases to oxidative and nitrosative stress. Arch Biochem Biophys 404 (2002) 271-278
62. Griffin E.C., Aiyar N., Slivjak M.J., and Smith III E.F. Effect of endotoxicosis on plasma and tissue levels of calcitonin gene-related peptide. Circ Shock 38 (1992) 50-54
63. Arnalich F., Sanchez J.F., Martinez M., Jimenez M., Lopez J., Vazquez J.J., et al. Changes in plasma concentrations of vasoactive neuropeptides in patients with sepsis and septic shock. Life Sci 56 (1995) 75-81
64. Huttemeier P.C., Ritter E.F., and Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. Am J Physiol 265 (1993) H767-H769
65. Witthaut R., Busch C., Fraunberger P., Walli A., Seidel D., Pilz G., et al. Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dysfunction. Intensive Care Med 29 (2003) 1696-1702
66. Martin C., Leone M., Viviand X., Ayem M.L., and Guieu R. High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock. Crit Care Med 28 (2000) 3198-3202
67. Amann K.J., and Pollard T.D. Cellular regulation of actin network assembly. Curr Biol 10 (2000) R728-R730
68. Cipolla M.J., Gokina N.I., and Osol G. Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior. FASEB J 16 (2002) 72-76
69. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 275 (2000) 21722-21729
70. Brady P.A., Alekseev A.E., Aleksandrova L.A., Gomez L.A., and Terzic A. A disrupter of actin microfilaments impairs sulfonylurea-inhibitory gating of cardiac K-ATP channels. Am J Physiol 40 (1996) H2710-H2716
71. + channels. Pflugers Arch Eur J Physiol 434 (1997) 203-205
72. Loffler C., and Quast U. Pharmacological characterization of the sulphonylurea receptor in rat isolated aorta. Br J Pharmacol 120 (1997) 476-480
73. 3H-glibenclamide binding in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol 357 (1998) 183-185
74. ATP channel inhibition in an in vivo model of sepsis. Intensive Care Med 28 Suppl.1 (2002) S234
75. Banan A., Smith G.S., Kokoska E.R., and Miller T.A. Role of actin cytoskeleton in prostaglandin-induced protection against ethanol in an intestinal epithelial cell line. J Surg Res 88 (2000) 104-113
76. Chakravortty D., and Nanda Kumar K.S. Bacterial lipopolysaccharide induces cytoskeletal rearrangement in small intestinal lamina propria fibroblasts: actin assembly is essential for lipopolysaccharide signaling. Biochim Biophys Acta 1500 (2000) 125-136
77. Aslan M., Ryan T.M., Townes T.M., Coward L., Kirk M.C., Barnes S., et al. Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. J Biol Chem 278 (2003) 4194-4204
78. Dalle-Donne I., Milzani A., Giustarini D., Di Simplicio P., Colombo R., and Rossi R. S-NO-actin: S-nitrosylation kinetics and the effect on isolated vascular smooth muscle. J Muscle Res Cell Motil 21 (2000) 171-181
79. Goldblum S.E., Ding X., Brann T.W., and Campbell-Washington J. Bacterial lipopolysaccharide induces actin reorganization, intercellular gap formation, and endothelial barrier dysfunction in pulmonary vascular endothelial cells: concurrent F-actin depolymerization and new actin synthesis. J Cell Physiol 157 (1993) 13-23
80. Chakravortty D., Koide N., Kato Y., Sugiyama T., Kawai M., Fukada M., et al. Cytoskeletal alterations in lipopolysaccharide-induced bovine vascular endothelial cell injury and its prevention by sodium arsenite. Clin Diagn Lab Immunol 7 (2000) 218-225
81. Levy B., Gibot S., Franck P., Cravoisy A., and Bollaert P.E. Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 365 (2005) 871-875
82. Boekstegers P., Weidenhofer S., Pilz G., and Werdan K. Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock. Infection 19 (1991) 317-323
83. VanderMeer T.J., Wang H., and Fink M.P. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23 (1995) 1217-1226
84. Brealey D., and Singer M. Mitochondrial Dysfunction in Sepsis. Curr Infect Dis Rep 5 (2003) 365-371
85. Brealey D., Bland M., Hargreaves I., Heales S., Land J., Smolenski R., et al. Mitochondrial dysfunction in human septic shock. Lancet 360 (2002) 219-223
86. Brealey D., Karyampudi S., Jacques T.S., Novelli M., Stidwill R., Taylor V., et al. Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol 286 (2004) R491-R497
87. Hart D.W., Gore D.C., Rinehart A.J., Asimakis G.K., and Chinkes D.L. Sepsis-induced failure of hepatic energy metabolism. J Surg Res 115 (2003) 139-147
88. Simonson S.G., Welty-Wolf K., Huang Y.T., Griebel J.A., Caplan M.S., Fracica P.J., et al. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock 43 (1994) 34-43
89. Kantrow S.P., Taylor D.E., Carraway M.S., and Piantadosi C.A. Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. Arch Biochem Biophys 345 (1997) 278-288
90. Vanhorebeek I., De Vos R., Mesotten D., Wouters P.J., Wolf-Peeters C., and Van den Berghe G. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365 (2005) 53-59
91. + cycle. Biochim Biophys Acta 1606 (2003) 23-41
92. ATP channels in cell survival and death. J Mol Cell Cardiol 39 (2005) 7-16
93. ATP opening on heart mitochondria. Am J Physiol 290 (2006) H406-H415
94. Akao M., Ohler A., O'Rourke B., and Marban E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res 88 (2001) 1267-1275
95. Huang L., Li W., Li B., and Zou F. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neurosci Lett 398 (2006) 34-38
96. Sharshar T., Blanchard A., Paillard M., Raphael J.C., Gajdos P., and Annane D. Circulating vasopressin levels in septic shock. Crit Care Med 31 (2003) 1752-1758
97. Van den Berghe G., Wouters P., Weekers F., Verwaest C., Bruyninckx F., Schetz M., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 345 (2001) 1359-1367
98. Van den Berghe G., Wilmer A., Hermans G., Meersseman W., Wouters P.J., Milants I., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
99. Devos P., Chiolero R., Van den Berghe G., and Preiser J.C. Glucose, insulin and myocardial ischaemia. Curr Opin Clin Nutr Metab Care 9 (2006) 131-139
100. + currents depends on the integrity of the cytoskeleton. J Physiol 514 (1999) 735-745
101. ATP channel opening and blood glucose concentration before ischemia. Am J Physiol 287 (2004) H601-H607
102. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. J Clin Invest 114 (2004) 1187-1195
103. + channel is essential for innate immunity. Nature 427 (2004) 853-858
104. Haslberger A., Romanin C., and Koerber R. Membrane potential modulates release of tumor necrosis factor in lipopolysaccharide-stimulated mouse macrophages. Mol Biol Cell 3 (1992) 451-460
105. + channel in transmembrane signaling. J Immunol 166 (2001) 1009-1015
106. Muller M., Scheel O., Lindner B., Gutsmann T., and Seydel U. The role of membrane-bound LBP, endotoxin aggregates, and the MaxiK channel in LPS-induced cell activation. J Endotoxin Res 9 (2003) 181-186
107. Lowry M.A., Goldberg J.I., and Belosevic M. Induction of nitric oxide (NO) synthesis in murine macrophages requires potassium channel activity. Clin Exp Immunol 111 (1998) 597-603
108. + channels by the aminoguanidine carboxylate BVT.12777. J Neuroendocrinol 17 (2005) 246-254
109. + channel by insulin in rat skeletal muscle fibers. Biochem Biophys Res Commun 232 (1997) 536-539