The molecular site of action of KATP channel inhibitors determines their ability to inhibit iNOS-mediated relaxation in rat aorta

Cardiovascular Research

Volumn 56, Issue 1, 2002, Pages 154-163

  Wilson, Andrew J ^a   Clapp, Lucie H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Endotoxins; K ATP channel; Nitric oxide; Smooth muscle

Indexed keywords

1 [1 (3 CHLOROPHENYL)CYCLOBUTYL] 2 CYANO 3 (3 PYRIDYL)GUANIDINE; 4 AMINOPYRIDINE; ARGININE; BARIUM ION; FORSKOLIN; GLIBENCLAMIDE; LEMAKALIM; N (1 ADAMANTYL) N' CYCLOHEXYL 4 MORPHOLINECARBOXAMIDINE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PNU 37883 A; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SULFONYLUREA DERIVATIVE; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

4-AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; AMINOPYRIDINES; ANALYSIS OF VARIANCE; ANIMALS; AORTA; ARGININE; BARIUM; ENDOTHELIUM, VASCULAR; GLYBURIDE; GUANIDINES; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; TOLBUTAMIDE; VASODILATOR AGENTS;

EID: 0036775363     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00504-7     Document Type: Article

References (36)

1. Landry D.W., Oliver J.A. The pathogenesis of vasodilatory shock. N Engl J Med. 345:2001;588-595.
2. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun. 172:1990;1132-1138.
3. Thiemermann C. Nitric oxide and septic shock. Gen Pharmacol. 29:1997;159-166.
4. Lincoln T.M., Dey N., Sellak H. cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol. 91:2001;1421-1430.
5. Bolotina V.M., Najibi S., Palacino J.J., Pagano P.J., Cohen R.A. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature (Lond). 368:1994;850-853.
6. Ca) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol. 124:1998;1131-1140.
7. Murphy M.E., Brayden J.E. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J Physiol (Lond). 486:1995;47-58.
8. Nelson M.T., Quayle J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 268:1995;C799-C822.
9. + channels. J Pharmacol Exp Ther. 279:1996;1514-1519.
10. +-channels in vascular hyporeactivity induced by endotoxin. Naunyn Schmiedebergs Arch Pharmacol. 359:1999;493-499.
11. + channels underlies relaxation to bacterial lipopolysaccharide in rat aorta. Biochem Biophys Res Commun. 224:1996;184-190.
12. Vanelli G., Hussain S.N.A., Aguggini G. Glibenclamide, a blocker of ATP-sensitive potassium channels, reverses endotoxin-induced hypotension in pig. Exp Physiol. 80:1995;167-170.
13. + channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog. J Clin Invest. 89:1992;2071-2074.
14. Sorrentino R., Bianca R., Lippolis L., et al. Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats. Br J Pharmacol. 127:1999;1447-1453.
15. + channels: Role of protein phosphatase-2B. Circ Res. 87:2000;1019-1025.
16. + channel of vascular smooth muscle cells. FEBS Lett. 345:1994;47-49.
17. ATP channels. Annu Rev Physiol. 60:1998;667-687.
18. Findlay I. Effects of glibenclamide upon ATP-sensitive-K channels during metabolic inhibition of isolated rat cardiac myocytes. Cardiovasc Drug Ther. 7:1993;495-497.
19. ATP channel blockers. J Pharmacol Exp Ther. 283:1997;1207-1213.
20. ATP channel inhibitor U37883A. Br J Pharmacol. 128:1999;667-672.
21. Garvey E.P., Oplinger J.A., Furfine E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric oxide synthase in vitro and in vivo. J Biol Chem. 272:1997;4959-4963.
22. Schmidt H.H.H.W., Kelm M. Determination of nitrite and nitrate by the Griess reaction. Feelisch M., Stamler J.S., Methods in nitric oxide research. 1996;491-497 Wiley, New York.
23. Feelisch M. The biochemical pathways of nitric oxide formation from nitrovasodilators: appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol. 17:1991;S25-S33.
24. ATP channels by U-37883A: a comparison with cardiac and skeletal muscle. Br J Pharmacol. 128:1999;909-916.
25. + channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence. Br J Pharmacol. 131:2000;213-222.
26. Delaey C., Van de Voorde J. Prostanoid-induced contractions are blocked by sulfonylureas. Eur J Pharmacol. 280:1995;179-184.
27. O'Brien A.J., Wilson A.J., Sibbald R., Singer M., Clapp L.H. Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model. Br J Pharmacol. 133:2001;351-360.
28. Wu C.C., Thiemermann C., Vane J.R. Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat. Br J Pharmacol. 114:1995;1273-1281.
29. ATP channels. Diabetes. 47:1998;1412-1418.
30. ATP channel significantly reverse endotoxin-induced vascular hyporeactivity. Br J Pharmacol. 135:2002;116P. abstract.
31. + channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide. J Pharmacol Exp Ther. 267:1993;1327-1335.
32. 3H-glibenclamide binding in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol. 357:1998;183-185.
33. Stefano G.B., Mugra J., Benson H., et al. Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta. Pharmacol Res. 43:2001;199-203.
34. ATP-channels. Life Sci. 64:1999;2471-2478.
35. + channel in cultured vascular smooth muscle cells. J Mol Cell Cardiol. 26:1994;1487-1495.
36. Bussolati O., Laris P.C., Nucci F.A., et al. Dependence of L-arginine accumulation on membrane potential in cultured human fibroblasts. Am J Physiol. 253:1987;C391-C397.