Cardioprotection by glucose-insulin-potassium: Dependence on K ATP channel opening and blood glucose concentration before ischemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 2 56-2, 2004, Pages

  LaDisa Jr , John F ^a,c   Krolikowski, John G ^a   Pagel, Paul S ^a,c   Warltier, David C ^a,b,c   Kersten, Judy R ^a,b  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c Medical College of Wisconsin and Marquette University   (United States)

Author keywords

Diabetes; Hyperglycemia; Myocardial infarction

Indexed keywords

ALLOXAN; GLIBENCLAMIDE; GLUCOSE; INSULIN; POTASSIUM; POTASSIUM CHANNEL; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CORONARY REPERFUSION; DOG; DRUG EFFICACY; DRUG MECHANISM; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; HYPERGLYCEMIA; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD GLUCOSE; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DOGS; DRUG ADMINISTRATION SCHEDULE; GLUCOSE; GLYBURIDE; HEMODYNAMIC PROCESSES; HYPOGLYCEMIC AGENTS; INSULIN; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; OSMOLAR CONCENTRATION; POTASSIUM; POTASSIUM CHANNELS;

EID: 3242716828     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00122.2004     Document Type: Article

References (30)

1. Akao M, Ohler A, O'Rourke B, and Marban E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res 88: 1267-1275, 2001.
2. Ashcroft FM, Harrison DE, and Ashcroft SJ. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature 312: 446-448, 1984.
3. Baines CP, Pass JM, and Ping P. Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning. Basic Res Cardiol 96: 207-218, 2001.
4. ATP channels in the isolated rabbit heart. Basic Res Cardiol 94: 188-198, 1999.
5. Depre C, Vanoverschelde JL, and Taegtmeyer H. Glucose for the heart. Circulation 99: 578-588, 1999.
6. Diaz R, Paolasso EA, Piegas LS, Tajer CD, Moreno MG, Corvalan R, Isea JE, and Romero G. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group. Circulation 98: 2227-2234, 1998.
7. Doenst T, Guthrie PH, Chemnitius JM, Zech R, and Taegtmeyer H. Fasting, lactate, and insulin improve ischemia tolerance in rat heart: a comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 270: H 1607-H1615, 1996.
8. Fath-Ordoubadi F and Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation 96: 1152-1156, 1997.
9. Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, Anversa P, and Kajstura J. Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 50: 2363-2375, 2001.
10. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, and Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of P13-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105: 1497-1502, 2002.
11. Gross GJ and Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 70: 223-233, 1992.
12. ATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol 285: H921-H930, 2003.
13. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, and Sowers JR. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100: 1134-1146, 1999.
14. Heng MK, Norris RM, Singh BN, and Barratt-Boyes C. Effects of glucose and glucose-insulin-potassium on haemodynamics and enzyme release after acute myocardial infarction. Br Heart J 39: 748-757, 1977.
15. Jonassen AK, Brar BK, Mjos OD, Sack MN, Latchman DS, and Yellon DM. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. J Mol Cell Cardiol 32: 757-764, 2000.
16. Jonassen AK, Sack MN, Mjos OD, and Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 89: 1191-1198, 2001.
17. ATP channels. Am J Physiol Heart Circ Physiol 280: H1744-H1750, 2001.
18. ATP) channels. Anesthesiology 85: 794-807, 1996.
19. Kersten JR, Schmeling TJ, Orth KG, Pagel PS, and Warltier DC. Acute hyperglycemia abolishes ischemic preconditioning in vivo. Am J Physiol Heart Circ Physiol 275: H721-H725, 1998.
20. ATP channels: reduction of myocardial infarct size with an acute memory phase. Anesthesiology 87: 361-370, 1997.
21. Kersten JR, Toller WG, Gross ER, Pagel PS, and Warltier DC. Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality. Am J Physiol Heart Circ Physiol 278: H1218-H1224, 2000.
22. Lell WA, Nielsen VG, McGiffin DC, Schmidt FE Jr, Kirklin JK, and Stanley AW Jr. Glucose-insulin-potassium infusion for myocardial protection during off-pump coronary artery surgery. Ann Thorac Surg 73: 1246-1251, 2002.
23. + channel in human pancreatic islet cells. Diabetes 38: 422-427, 1989.
24. Sack MN and Yellon DM. Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation. J Am Coll Cardiol 41: 1404-1407, 2003.
25. Soares PR, de Albuquerque CP, Chacko VP, Gerstenblith G, and Weiss RG. Role of preischemic glycogen depletion in the improvement of postischemic metabolic and contractile recovery of ischemia-preconditioned rat hearts. Circulation 96: 975-983, 1997.
26. Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, and De Micheli A. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 9: 166-181, 1962.
27. + channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3: 757-758, 2000.
28. + channel by insulin in rat skeletal muscle fibers. Biochem Biophys Res Commun 232: 536-539, 1997.
29. Warltier DC, Zyvoloski MG, Gross GJ, Hardman HF, and Brooks HL. Determination of experimental myocardial infarct size. J Pharmacol Methods 6: 199-210, 1981.
30. Xie LH, Takano M, Kakei M, Okamura M, and Noma A. Wortmannin, an inhibitor of phosphatidylinositol kinases, blocks the MgATP-dependent recovery of Kir6.2/SUR2A channels. J Physiol 514: 655-665, 1999.