Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina

Journal of Neurochemistry

Volumn 99, Issue 2, 2006, Pages 524-536

  Valenciano, Ana I ^a,b   Corrochano, Silvia ^a   De Pablo, Flora ^a   De La Villa, Pedro ^c   De La Rosa, Enrique J ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Akt; Apoptosis; Insulin like growth factor I; Neurogenesis; Phosphatidylinositol 3 kinase; Programmed cell death

Indexed keywords

CASPASE; CASPASE INHIBITOR; CATHEPSIN; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROINSULIN; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOREACTIVITY; INSULIN SYNTHESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETINA; RETINA DEVELOPMENT; SURVIVAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASES; CATHEPSINS; CELL DIFFERENTIATION; ENZYME INHIBITORS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; NEURONS; ORGAN CULTURE TECHNIQUES; PEPTIDE HYDROLASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROINSULIN; PROTO-ONCOGENE PROTEINS C-AKT; RETINA; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 33749174297     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04043.x     Document Type: Article

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