Caspase inhibitors block the retinal ganglion cell death following optic nerve transection

Molecular Brain Research

Volumn 67, Issue 1, 1999, Pages 36-45

  Chaudhary, P ^a   Ahmed, F ^a   Quebada, P ^a   Sharma, S C ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Axotomy; Caspase inhibitor; Microglia; Retinal ganglion cell

Indexed keywords

CASPASE INHIBITOR; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL X;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; FEMALE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROPHAGE; MICROGLIA; NERVE FIBER TRANSECTION; NERVE TRANSECTION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; AXOTOMY; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA PRIMERS; ENZYME PRECURSORS; FEMALE; GENE EXPRESSION; IN SITU HYBRIDIZATION; MICROGLIA; OLIGOPEPTIDES; OPTIC NERVE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0033528746     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00032-7     Document Type: Article

References (54)

1. J.M. Adams, S. Cory, The Bcl2 protein family: arbiters of cell survival, Science 281 (1998) 1322-1326.
2. R.C. Armstrong, T.J. Aja, K.D. Hoang, S. Gaur, X. bai, E.S. Alnemri, G. Litwack, D.S. Karanewsky, L.C. Fritz, K.J. Tomaselli, Activation of the CED3/ICE related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis, J. Neurosci. 17 (2) (1997) 553-562.
3. M. Bahr, Adult rat retinal glia in vitro: effects of in vivo crush-activation on glia proliferation and permissiveness for regenerating retinal ganglion cell axons, Exp. Neurol. 111 (1) (1991) 65-73.
4. K.D. Barron, M.P. Dentinger, G. Krohel, S.K. Easton, R. Mankes, Qualitative and quantitative ultrastructural observations on retinal ganglion cell layer of rat after intraorbital optic nerve crush, J. Neurocytol. 15 (3) (1986) 345-362.
5. M. Berkelaar, D.B. Clarke, Y.C. Wang, G.M. Bray, A.J. Aguayo, Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats, J. Neurosci. 14 (7) (1994) 4368-4374.
6. R.V. Bhat, R. DiRocco, V.R. Marcy, D.G. Flood, Y. Zhu, P. Dobrzanski, R. Siman, R. Scott, P.C. Contreras, M. Miller, Increased expression of IL-1beta converting enzyme in hippocampus after ischemia: selective localization in microglia, J. Neurosci. 16 (13) (1996) 4146-4154.
7. L. Bonfanti, E. Strettoi, S. Chierzi, M.C. Cenni, X.H. Liu, J.C. Martinou, L. Maffei, S.A. Rabacchi, Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2, J. Neurosci. 16 (13) (1996) 4186-4194.
8. D.E. Bredesen, Neural apoptosis, Ann. Neurol. 38 (6) (1995) 839-851.
9. A.M. Butt, S. Kirvell, Glial cells in transected optic nerves of immature rats: II. An immunohistochemical study, J. Neurocytol. 25 (6) (1996) 381-392.
10. M.C. Cenni, L. Bonfanti, J.C. Martinou, G.M. Ratto, E. Strettoi, L. Maffei, Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice, Eur. J. Neurosci. 8 (8) (1996) 1735-1745.
11. P. Chaudhary, F. Ahmed, S.C. Sharma, MK801 - a neuroprotectant in rat hypertensive eyes, Brain Res. 792 (1) (1998) 154-158.
12. D.W. Choi, Excitotoxic cell death, J. Neurobiol. 23 (9) (1992) 1261-1276.
13. Y. Cheng, M. Deshmukh, A. D'Costa, J.A. Demaro, J.M. Gidday, A. Shah, Y. Sun, M.F. Jacquin, E.M. Johnson Jr., D.M. Holtzman, Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ishemic brain injury, J. Clin. Invest. 101 (1998) 1992-1999.
14. G.M. Cohen, Caspases: the executioners of apoptosis, Biochem. J. 326 (1997) 1-16.
15. B.A. Eldadah, A.G. Yakovlev, A.I. Faden, The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells, J. Neurosci. 17 (16) (1997) 6105-6113.
16. M. Frank, H. Wolburg, Cellular reactions at the lesion site after crushing of the rat optic nerve, Glia 16 (3) (1996) 227-240.
17. E. Garcia-Valenzuela, W. Gorczyca, Z. Darzynkiewicz, S.C. Sharma, Apoptosis in adult retinal ganglion cells after axotomy, J. Neurobiol. 25 (4) (1994) 431-438.
18. D.R. Green, J.C. Reed, Mitochondria and apoptosis, Science 281 (1998) 1309-1312.
19. H. Hara, R.M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, M.A. Moskowitz, Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage, Proc. Natl. Acad. Sci. USA 94 (5) (1997) 2007-2012.
20. M.O. Hengartner, R.E. Ellis, H.R. Horvitz, Caenorhabditis elegans gene ced-9 protects cells from programmed cell death, Nature 356 (6369) (1992) 494-499.
21. M.O. Hengartner, H.R. Horvitz, C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2, Cell 76 (4) (1994) 665-676.
22. M.O. Hengartner, H.R. Horvitz, Programmed cell death in Caenorhabditis elegans, Curr. Opin. Genet. Dev. 4 (4) (1994) 581-586.
23. J. Honkaniemi, S.M. Massa, M. Breckinridge, F.R. Sharp, Global ischemia induces apoptosis-associated genes in hippocampus, Brain Res. Mol. Brain Res. 42 (1) (1996) 79-88.
24. S. Isenmann, C. Wahl, S. Krajewski, J.C. Reed, M. Bahr, Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in rat, Eur. J. Neurosci. 9 (1997) 1763-1772.
25. R.W. Keane, A. Srinivasan, L.M. Foster, M.P. Testa, T. Ord, D. Nonner, H.G. Wang, J.C. Reed, D.E. Bredesen, C. Kayalar, Activation of CPP32 during apoptosis of neurons and astrocytes, J. Neurosci. Res. 48 (2) (1997) 168-180.
26. P. Kermer, N. Klocker, M. Labes, M. Bahr, Inhibition of CPP32 like proteases rescues axotomized retinal ganglion cells from secondary cell death In Vivo, J. Neurosci. 18 (12) (1998) 4656-4662.
27. N. Klocker, F. Braunling, S. Isenmann, M. Bahr, In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells, NeuroReport 8 (16) (1997) 3439-3442.
28. N. Klocker, A. Cellerino, M. Bahr, Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo, J. Neurosci. 18 (3) (1998) 1038-1046.
29. L.A. Levin, C.L. Schlamp, R.L. Spieldoch, K.M. Geszvain, R.W. Nickells, Identification of the bcl-2 family of genes in the rat retina, Invest. Ophthalmol. Vis. Sci. 38 (12) (1997) 2545-2553.
30. R. Lucius, J. Sievers, YVAD protect post-natal retinal ganglion cells against axotomy-induced but not free radical-induced axonal degeneration in vitro, Brain Res. Mol. Brain Res. 48 (1) (1997) 181-184.
31. S. Mansour-Robaey, D.B. Clarke, Y.C. Wang, G.M. Bray, A.J. Aguayo, Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells, Proc. Natl. Acad. Sci. USA 91 (5) (1994) 1632-1636.
32. J. Mey, S. Thanos, Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo, Brain Res. 602 (2) (1993) 304-317.
33. D.W. Nicholson, N.A. Thornberry, Caspases: killer proteases, Trends Biochem. Sci. 22 (1997) 299-306.
34. Z.N. Oltvai, C.L. Milliman, S.J. Korsmeyer, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell 74 (4) (1993) 609-619.
35. P. Peinado-Ramon, M. Salvador, M.P. Villegas-Perez, M. Vidal-Sanz, Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study, Invest. Ophthalmol. Vis. Sci. 37 (4) (1996) 489-500.
36. V.H. Perry, M.C. Brown, S. Gordon, The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration, J. Exp. Med. 165 (4) (1987) 1218-1223.
37. H.A. Quigley, R.W. Nickells, D.J. Zack, L.A. Kerrigan, D.J. Thiboult, M.E. Pease, Ganglion cell death in experimental monkey glaucoma and axotomy occurs by apoptosis, Invest. Ophthalmol. Vis. Sci. 35 (1994) 2083.
38. H.A. Quigley, R.W. Nickells, L.A. Kerrigan, M.E. Pease, D.J. Thibault, D.J. Zack, Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis, Invest. Ophthalmol. Vis. Sci. 36 (5) (1995) 774-786.
39. S.A. Rabacchi, L. Bonfanti, X.H. Liu, L. Maffei, Apoptotic cell death induced by optic nerve lesion in the neonatal rat, J. Neurosci. 14 (9) (1994) 5292-5301.
40. M. Russelakis-Carneiro, L.C. Silveira, V.H. Perry, Factors affecting the survival of cat retinal ganglion cells after optic nerve injury, J. Neurocytol. 25 (6) (1996) 393-402.
41. L.M. Schwartz, C.E. Milligan, Cold thoughts of death: the role of ICE proteases in neuronal cell death, Trends Neurosci. 19 (1996) 555-562.
42. N.J. Sucher, S.A. Lipton, E.B. Dreyer, Molecular basis of glutamate toxicity in retinal ganglion cells, Vision Res. 37 (24) (1997) 3483-3493.
43. S. Thanos, J. Mey, M. Wild, Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro, J. Neurosci. 13 (2) (1993) 455-466.
44. S. Thanos, J. Kacza, J. Seeger, J. Mey, Old dyes for new scopes: the phagocytosis-dependent long-term fluorescence labelling of microglial cells in vivo, Trends Neurosci. 17 (5) (1994) 177-182.
45. C.B. Thompson, Apoptosis in the pathogenesis and treatment of disease, Science 267 (5203) (1995) 1456-1462.
46. N.A. Thornberry, Y. Lazebnik, Caspases: enemies within, Science 281 (1998) 1317-1322.
47. M. Vidal-Sanz, G.M. Bray, M.P. Villegas-Perez, S. Thanos, A.J. Aguayo, Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat, J. Neurosci. 7 (9) (1987) 2894-2909.
48. M.P. Villegas-Perez, M. Vidal-Sanz, M. Rasminsky, G.M. Bray, A.J. Aguayo, Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats, J. Neurobiol. 24 (1) (1993) 23-36.
49. D. Weibel, D. Cadelli, M.E. Schwab, Regeneration of lesioned rat optic nerve fibers is improved after neutralization of myelin-associated neurite growth inhibitors, Brain Res. 642 (1-2) (1994) 259-266.
50. D. Weibel, G.W. Kreutzberg, M.E. Schwab, Brain-derived neurotrophic factor (BDNF) prevents lesion-induced axonal die-back in young rat optic nerve, Brain Res. 679 (2) (1995) 249-254.
51. J. Xiang, D.T. Chao, S.J. Korsmeyer, BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases, Proc. Natl. Acad. Sci. USA 93 (25) (1996) 14559-14563.
52. A.G. Yakovlev, S.M. Knoblach, L. Fan, G.B. Fox, R. Goodnight, A.I. Faden, Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury, J. Neurosci. 17 (19) (1997) 7415-7424.
53. E. Yoles, M. Schwartz, Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve, Arch. Ophthalmol. 116 (7) (1998) 906-910.
54. J. Yuan, S. Shaham, S. Ledoux, H.M. Ellis, H.R. Horvitz, The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme, Cell 75 (4) (1993) 641-652.