Apoptosis and brain development

Mental Retardation and Developmental Disabilities Research Reviews

Volumn 7, Issue 4, 2001, Pages 261-266

  Roth, Kevin A ^a   D'Sa, Cleta ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Caspase; Neurodevelopment; Programmed cell death; Telencephalon

Indexed keywords

CASPASE 3; CASPASE 9; PROTEIN BAX; PROTEIN BCL X;

APOPTOSIS; BRAIN DEVELOPMENT; CELL ACTIVATION; CELL SUBPOPULATION; CELL SURVIVAL; EMBRYO; ENZYME ACTIVATION; GENE DISRUPTION; GENE MUTATION; HUMAN; MOUSE; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; PRIORITY JOURNAL; REVIEW; STEM CELL; SYNAPSE;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-X PROTEIN; BRAIN; CASPASES; GENES, BCL-2; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, MUTANT STRAINS; NEURAL PATHWAYS; NEURONS; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPINAL CORD; TELENCEPHALON;

EID: 0035187010     PISSN: 10804013     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrdd.1036     Document Type: Review

References (53)

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2. Defects in regulation of apoptosis in caspase-2-deficient mice
3. Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain
4. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex
5. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
6. Apaf1 (CED-4 Homolog) regulates programmed cell death in mammalian development
7. Molecular ordering of the cell death pathway
8. Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins
9. Regressive events in neurogenesis
10. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase-9 but neither Bax nor caspase-3
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12. Bax is required for neuronal death after trophic factor deprivation and during development
13. Cell birth, cell death, cell diversity and DNA breaks: How do they all fit together?
14. L is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
15. History of the discovery of neuronal death in embryos
16. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxiaischemia
17. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
18. The role of cell death in regulating the size and shape of the mammalian forebrain
19. Genetic control of programmed cell death in the nematode Caenorhabditis elegans
20. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
21. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
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25. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade
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27. Bcl-2 gene family in the nervous system
28. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development
29. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
30. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
31. Caspase structure, proteolytic substrates, and function during apoptotic cell death
32. Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain
33. Ethanol-induced apoptotic neurodegeneration in the developing brain
34. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
35. Cell death during development of the nervous system
36. Emerging roles of caspase-3 in apoptosis
37. L in the developing nervous system
38. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
39. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
40. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
41. Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice
42. Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro
43. Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis
44. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
45. Apoptosis and its relation to the cell cycle in the developing cerebral cortex
46. Caspases: Enemies within
47. Cell death in cortical development: How much? Why? So what?
48. Genetic malformations of the human cerebral cortex
49. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
50. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
51. L-Caspase-9 interactions in the developing nervous system: Evidence for multiple death pathways
52. Divinations and surprises: Genetic analysis of caspase function in mice
53. Apaf-1, a human protein homologous to C. Elegans CED-4, participates in cytochrome c-dependent activation of caspase-3