Murine γ-herpesvirus 68 limits naturally occurring CD4 +CD25+ T regulatory cell activity following infection

Journal of Immunology

Volumn 177, Issue 7, 2006, Pages 4670-4678

  Gasper Smith, Nancy ^a   Marriott, Ian ^a   Bost, Kenneth L ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HELPER CELL; HERPES VIRUS; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; LEUKOCYTOSIS; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MONONUCLEOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIRUS LATENCY;

EID: 33749142976     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.7.4670     Document Type: Article

References (68)

1. + suppressor T cells. J. Exp. Med. 193: F41-F46.
2. + regulatory T cells. Nat. Immunol. 4: 330-336.
3. + T regulatory cells. Nat. Immunol. 4: 337-342.
4. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
5. Schwartz, R. H. 2005. Natural regulatory T cells and self-tolerance. Nat. Immunol. 6: 327-330.
6. O'Garra, A., and P. Vieira. 2004. Regulatory T cells and mechanisms of immune system control. Nat. Med. 10: 801-805.
7. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101: 455-458.
8. Shevach, E. M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18: 423-449.
9. Paust, S., and H. Cantor. 2005. Regulatory T cells and autoimmune disease. Immunol. Rev. 204: 195-207.
10. + suppressor T cells. Immunol. Rev. 182: 58-67.
11. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193: 1295-1302.
12. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
13. + T cell responses. J. Exp. Med. 198: 889-901.
14. + immunoregulatory cells. J. Immunol. 167: 1137-1140.
15. + T cell activation. Eur. J. Immunol. 33: 3473-3483.
16. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
17. + regulatory T cells control the severity of viral immunoinflammatory lesions. J. Immunol. 172: 4123-4132.
18. Godfrey, V. L., B. T. Rouse, and J. E. Wilkinson. 1994. Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse. Am. J. Pathol. 145: 281-286.
19. Clark, L. B., M. W. Appleby, M. E. Brunkow, J. E. Wilkinson, S. F. Ziegler, and F. Ramsdell. 1999. Cellular and molecular characterization of the scurfy mouse mutant. J. Immunol. 162: 2546-2554.
20. Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6: 353-360.
21. Mills, K. H. 2004. Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 4: 841-855.
22. + regulatory T cells in viral infections. Vet. Immunol. Immunopathol. 108: 219-225.
23. + regulatory T cells. Nat. Med. 10: 29-30.
24. + T cells by regulatory T cells during persistent retroviral infection. Immunity 20: 293-303.
25. + T cells can prevent murine AIDS progression. J. Immunol. 172: 4917-4925.
26. Suvas, S., and B. T. Rouse. 2005. Regulation of microbial immunity: the suppressor cell renaissance. Viral Immunol. 18: 411-418.
27. Doherty, P. C., R. A. Tripp, A. M. Hamilton-Easton, R. D. Cardin, D. L. Woodland, and M. A. Blackman. 1997. Tuning into immunological dissonance: an experimental model for infectious mononucleosis. Curr. Opin. Immunol. 9: 477-483.
28. Mistrikova, J., H. Raslova, M. Mrmusova, and M. Kudelova. 2000. A murine γherpesvirus. Acta Virol. 44: 211-226.
29. Simas, J. P., and S. Efstathiou. 1998. Murine γherpesvirus 68: a model for the study of γherpesvirus pathogenesis. Trends Microbiol. 6: 276-282.
30. Flano, E., D. L. Woodland, and M. A. Blackman. 2002. A mouse model for infectious mononucleosis. Immunol. Res. 25: 201-217.
31. Nash, A. A., and N. P. Sunil-Chandra. 1994. Interactions of the murine γherpesvirus with the immune system. Curr. Opin. Immunol. 6: 560-563.
32. Gasper-Smith, N., and K. L. Bost. 2004. Initiation of the host response against murine γherpesvirus infection in immunocompetent mice. Viral Immunol. 17: 473-480.
33. Peacock, J. W., and K. L. Bost. 2000. Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine γherpesvirus-68. J. Gen. Virol. 81: 421-429.
34. Peacock, J. W., and K. L. Bost. 2001. Murine γherpesvirus-68- induced interleukin-10 increases viral burden, but limits virus-induced splenomegaly and leukocytosis. Immunology 104: 109-117.
35. Elsawa, S. F., and K. L. Bost. 2004. Murine γherpesvirus-68-induced IL-12 contributes to the control of latent viral burden, but also contributes to viral-mediated leukocytosis. J. Immunol. 172: 516-524.
36. Elsawa, S. F., W. Taylor, C. C. Petty, I. Marriott, J. V. Weinstock, and K. L. Bost. 2003. Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine γ-herpesvirus 68. J. Immunol. 170: 2605-2612.
37. Bost, K. L., S. C. Bieligk, and B. M. Jaffe. 1995. Lymphokine mRNA expression by transplantable murine B lymphocytic malignancies: tumor-derived IL-10 as a possible mechanism for modulating the anti-tumor response. J. Immunol. 154: 718-729.
38. Marriott, I., K. L. Bost, and M. J. Mason. 1998. Differential kinetics for induction of interleukin-6 mRNA expression in murine peritoneal macrophages: evidence for calcium-dependent and independent-signalling pathways. J. Cell. Physiol. 177: 232-240.
39. Nelson, D. A., and K. L. Bost. 2005. Quantification of hemokinin-1 peptide production and secretion from mouse B cells. Cell. Immunol. 237: 115-122.
40. Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: e45.
41. Nelson, D. A., I. Marriott, and K. L. Bost. 2004. Expression of hemokinin 1 mRNA by murine dendritic cells. J. Neuroimmunol. 155: 94-102.
42. Kubo, T., R. D. Hatton, J. Oliver, X. Liu, C. O. Elson, and C. T. Weaver. 2004. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J. Immunol. 173: 7249-7258.
43. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198: 235-247.
44. Penna, G., N. Giarratana, S. Amuchastegui, R. Mariani, K. C. Daniel, and L. Adorini. 2005. Manipulating dendritic cells to induce regulatory T cells. Microbes Infect. 7: 1033-1039.
45. Dutia, B. M., D. J. Allen, H. Dyson, and A. A. Nash. 1999. Type I interferons and IRF-1 play a critical role in the control of a γherpesvirus infection. Virology 261: 173-179.
46. Dutia, B. M., C. J. Clarke, D. J. Allen, and A. A. Nash. 1997. Pathological changes in the spleens of γ interferon receptor-deficient mice infected with murine γherpesvirus: a role for CD8 T cells. J. Virol. 71: 4278-4283.
47. Sunil-Chandra, N. P., J. Arno, J. Fazakerley, and A. A. Nash. 1994. Lymphoproliferative disease in mice infected with murine γherpesvirus 68. Am. J. Pathol. 145: 818-826.
48. Brown, H. J., M. J. Song, H. Deng, T. T. Wu, G. Cheng, and R. Sun. 2003. NF-κB inhibits γherpesvirus lytic replication. J. Virol. 77: 8532-8540.
49. Hong, Y., E. Holley-Guthrie, and S. Kenney. 1997. The bZip dimerization domain of the Epstein-Barr virus BZLF1 (Z) protein mediates lymphoid-specific negative regulation. Virology 229: 36-48.
50. Gutsch, D. E., E. A. Holley-Guthrie, Q. Zhang, B. Stein, M. A. Blanar, A. S. Baldwin, and S. C. Kenney. 1994. The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-κB. Mol. Cell. Biol. 14: 1939-1948.
51. Cahir-McFarland, E. D., K. Carter, A. Rosenwald, J. M. Giltnane, S. E. Henrickson, L. M. Staudt, and E. Kieff. 2004. Role of NF-κB in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J. Virol. 78: 4108-4119.
52. Usherwood, E. J., A. J. Ross, D. J. Allen, and A. A. Nash. 1996. Murine γherpesvirus-induced splenomegaly: a critical role for CD4 T cells. J. Gen. Virol. 77(Pt. 4): 627-630.
53. Sunil-Chandra, N. P., S. Efstathiou, and A. A. Nash. 1992. Murine γherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo. J. Gen. Virol. 73(Pt. 12): 3275-3279.
54. Sunil-Chandra, N. P., S. Efstathiou, and A. A. Nash. 1993. Interactions of murine γherpesvirus 68 with B and T cell lines. Virology 193: 825-833.
55. Flano, E., S. M. Husain, J. T. Sample, D. L. Woodland, and M. A. Blackman. 2000. Latent murine γ-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. J. Immunol. 165: 1074-1081.
56. Weck, K. E., S. S. Kim, H. I. Virgin, and S. H. Speck. 1999. Macrophages are the major reservoir of latent murine γherpesvirus 68 in peritoneal cells. J. Virol. 73: 3273-3283.
57. Dutia, B. M., J. P. Stewart, R. A. Clayton, H. Dyson, and A. A. Nash. 1999. Kinetic and phenotypic changes in murine lymphocytes infected with murine γherpesvirus-68 in vitro. J. Gen. Virol. 80(Pt. 10): 2729-2736.
58. James, J. A., and J. B. Barley. 1998. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice. J. Immunol. 160: 502-508.
59. Vaughan, J. H. 1995. The Epstein-Barr virus in autoimmunity. Springer Semin. Immunopathol. 17: 203-230.
60. Zandman-Goddard, G., and Y. Shoenfeld. 2005. Infections and SLE. Autoimmunity 38: 473-485.
61. Jun, H. S., and J. W. Yoon. 2003. A new look at viruses in type 1 diabetes. Diabetes Metab. Res. Rev. 19: 8-31.
62. Cook, S. D. 2004. Does Epstein-Barr virus cause multiple sclerosis? Rev. Neurol. Dis. 1: 115-123.
63. Haahr, S., A. M. Plesner, B. F. Vestergaard, and P. Hollsberg. 2004. A role of late Epstein-Barr virus infection in multiple sclerosis. Acta Neurol. Scand. 109: 270-275.
64. Pender, M. P. 2003. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases. Trends Immunol. 24: 584-588.
65. Hughes, R. A., R. D. Hadden, N. A. Gregson, and K. J. Smith. 1999. Pathogenesis of Guillain-Barre syndrome. J. Neuroimmunol. 100: 74-97.
66. Peacock, J. W., S. F. Elsawa, C. C. Petty, W. F. Hickey, and K. L. Bost. 2003. Exacerbation of experimental autoimmune encephalomyelitis in rodents infected with murine γherpesvirus-68. Eur. J. Immunol. 33: 1849-1858.
67. Yarilin, D. A., J. Valiando, and D. N. Posnett. 2004. A mouse herpesvirus induces relapse of experimental autoimmune arthritis by infection of the inflammatory target tissue. J. Immunol. 173: 5238-5246.
68. Stevenson, P. G., and S. Efstathiou. 2005. Immune mechanisms in murine γherpesvirus-68 infection. Viral Immunol. 18: 445-456.