Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells

Environmental Toxicology and Pharmacology

Volumn 22, Issue 3, 2006, Pages 283-291

  Chen, Zhi Bo ^a,b   Liu, Chang ^a   Chen, Feng Qing ^c   Li, Shan Yu ^a   Liang, Qiao ^d   Liu, Lan Ying ^a  

^a JILIN UNIVERSITY   (China)

^b QIQIHAR UNIVERSITY   (China)

^c BaiCheng Education Normal College   (China)

^d Zhanjiang Central People's Hospital   (China)

Author keywords

Adrenergic receptor; Antagonist; Breast cancer; ERK1 2; HMEC; MAP kinase; nAchR; NNK; Proliferation; Tobacco carcinogen

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ALPHA BUNGAROTOXIN; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CARCINOGEN; MECAMYLAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; UO 126;

ARTICLE; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOBACCO;

NICOTIANA TABACUM;

EID: 33749125009     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2006.04.001     Document Type: Article

References (45)

1. Andreyev H.J., Norman A.R., Cunningham D., Oates J.R., and Clarke P.A. Kirsten ras mutations in patients with colorectal cancer: The multicenter "RASCAL" study. J. Natl. Cancer Inst. 90 (1998) 675-684
2. Arredondo J., Hall L.L., Ndoye A., Nguyen V.T., Chemyavsky A.I., Bercovich D., et al. Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Lab. Invest. 83 (2003) 207-225
3. Askari M.D., Tsao M.S., and Schuller H.M. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. J. Cancer Res. Clin. Oncol. 131 (2005) 639-648
4. Barbacid M. Ras genes. Annu. Rev. Biochem. 56 (1987) 779-827
5. Bartsch H., and Spiegelhalder B. Environmental exposure to N-nitroso compounds (NNOC) and precursors: an overview. Eur. J. Cancer Prev. 5 (1996) 11-17
6. Belinsky S.A., Devereux T.R., Maronpot R.R., Stoner G.D., and Anderson M.W. Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res. 49 (1989) 5305-5311
7. Bos, J.L., 1989. Ras oncogenes in human cancer: a review [published erratum appears in Cancer Res. 1990 15;50(4):1352]. Cancer Res. 49, 4682-4689.
8. Bose C., Zhang H., Udupa K.B., and Chowdhory P. Activation of p-ERK1/2 by nicotine in pancreatic tumor cell line AR42J: effects on proliferation and secretion. Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2005) G926-G934
9. Cakir Y., Plummer III H.K., Tithof P.K., and Schuller H.M. Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. Int. J. Oncol. 21 (2002) 153-157
10. Cattaneo M.G., Codignola A., Vicentini L.M., Clementi F., and Sher E. Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma. Cancer Res. 53 (1993) 5566-5568
11. Dunn K.L., Espino P.S., Drobic B., He S., and Davie J.R. The Ras-MAPK signal transduction pathway, cancer and chromatin Remodeling. Biochem. Cell Biol. 83 (2005) 1-14
12. Fang J.Y., and Richardson B.C. The MAPK signalling pathways and colorectal cancer. Lancet Oncol. 6 (2005) 322-327
13. Hamajima N., Hirose K., Tajima K., Rohan T., Calle E.E., and Heath Jr. C.W. Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br. J. Cancer 87 (2002) 1234-1245
14. Hecht S.S. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol. 11 (1998) 559-603
15. Hecht S.S. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol. 3 (2002) 461-469
16. Hecht S.S., and Hoffmann D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv. 8 (1989) 273-279
17. Heusch W.L., and Maneckjee R. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 19 (1998) 551-556
18. Ho Y.S., Chen C.H., Wang Y.J., Pestell R.G., Albanese C., Chen R.J., et al. Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicol. Appl. Pharmacol. 205 (2005) 133-148
19. Hoffmann D., Hoffmann I., and El-Bayoumy K. The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chel 14 (2001) 767-790
20. Johnson K.C. Accumulating evidence on passive and active smoking and breast cancer risk. Int. J. Cancer 117 (2005) 619-628
21. Jull B.A., Plummer III H.K., and Schuller H.M. Nicotine receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. J. Cancer Res. Clin. Oncol. 127 (2001) 707-717
22. Kelsey J.L. Breast cancer epidemiology: Summary and future directions. Epidemiol. Rev. 15 (1993) 256-263
23. MAPK in Interleukin-1β- and tumor necrosis factor-∞-induced low density lipoprotein receptor expression in HepG2 Cells. J. Biol. Chem. 273 (1998) 15742-15748
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
25. Magee P.N. Nitrosamines and human cancer: introduction and overview. Eur. J. Cancer Prev. 5 (1996) 7-10
26. Mueller H., Flury N., Eppenberger-Castori S., Kueng W., David F., and Eppenberger U. Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients. Int. J. Cancer 89 (2000) 384-388
27. Nakayama H., Numakawa T., Ikeuchi T., and Hatanaka H. Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells. J. Neurochem. 79 (2001) 489-498
28. Nakayama H., Numakawa T., and Ikeuchi T. Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells. J. Neurochem. 83 (2002) 1372-1379
29. Salh B., Marotta A., Matthewson C., Ahluwalia M., Flint J., Owen D., et al. Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. Anticancer Res. 19 (1999) 731-740
30. Santen R.J., Song R.X., McPherson R., Kumar R., Adam L., Jeng M.H., et al. The role of mitogen-activated protein (MAP) kinase in breast cancer. J. Steroid. Biochem. Mol. Biol. 80 (2002) 239-256
31. Schuller H.M., and Orloff M. Tobacco-specific carcinogenic nitrosamines, ligands for nicotine acetylcholine receptors in humn lung cancer cells. Biochem. Pharmacol. 55 (1998) 1377-1384
32. Schuller H.M., Tithof P.K., Williams M., and Plummer III H. The tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Is a ß-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via ß-adrenergic receptor-mediated release of arachidonic acid. Cancer Res. 59 (1999) 4510-4515
33. Schuller H.M., Porter B., Riechert A., Walker K., and Schmoyer R. Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. Lung Cancer 45 (2004) 11-18
34. Sivaraman V.S., Wang H., Nuovo G.J., and Malbon C.C. Hyperexpression of mitogen activated protein kinase in human breast cancer. J. Clin. Invest. 99 (1997) 1478-1483
35. Slattery M.L., Edwards S., Curtin K., Schaffer D., and Neuhausen S. Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. Cancer Epidemiol. Biomar. Prev. 12 (2003) 882-889
36. Tang K., Wu H., Mahata S.K., and O'Connor D.T. A crucial role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells. Mol. Pharmacol. 54 (1998) 59-69
37. Ulrich C.M., Bigler J., Whitton J.A., Bostick R., Fofdick L., and Porter J.D. Epoxide Hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. Cancer Epidemiol. Biomar. Prev. 10 (2001) 875-882
38. Upadhyaya P., Kenney P.M.J., Hochalter B., Wang M., and Hecht S.S. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse. Carcinogenesis 20 (1999) 1577-1582
39. Vainio H., Kaaks R., and Bianchini F. Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur. J. Cancer Prev. 11 (2002) S94-S100
40. Wang J., Chen Y.B., Zhu X.N., and Chen R.Z. Activation of p42/44 mitogen-activated protein kinase pathway in long-term potentiation induced by nicotine in hippocampal CA1 region in rats. Acta Pharmacol. Sin. 22 (2001) 685-690
41. Wang X., Wang Q., Hu W., and Evers B.M. Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. Oncogene 23 (2004) 1885-1895
42. Weddle D.L., Tithoff P., Williams M., and Schuller H.M. ß-Adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis 22 (2001) 473-479
43. West K.A., Brognard J., Clark A.S., Linnoila I.R., Yang X., Swain S.M., Harris C., Belinsky S., and Dennis P.A. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway eoithelial cells. J. Clin. Invest. 111 (2003) 81-90
44. Yang Y., Zhang Z., Mukherjee A.B., and Linnoila R.L. Increased susceptibility of mice lacking Clara cell 10-kDa protein to lungtumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. J. Biol. Chem. 279 (2004) 29336-29340
45. Zhang H., and Cai B. The impact of tobacco on lung health in China. Respirology 8 (2003) 17-21