A crucial role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells

Molecular Pharmacology

Volumn 54, Issue 1, 1998, Pages 59-69

  Tang, Kechun ^b   Wu, Hongjiang ^b   Mahata, Sushil K ^b   O'Connor, Daniel T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; CHROMOGRANIN A; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE TARGETING; GENETIC TRANSCRIPTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS;

EID: 0031819351     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.1.59     Document Type: Article

References (40)

1. Alessi DR, Cuenda A, Cohen P, Dudley DT, and Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
2. Boulton TG, Nye SH, Robbins DJ, Ip INJ, Radziejewska E, Morgenbesser SR, DePinho RA, Panayotatos N, Cobb MH, and Yancopoulos GD (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 7:248-254.
4. Brammar WJ (1996) Nicotinic acetylcholine-gated integral receptor-channels, in The Ion Channel FactsBook: Extracellular Ligand-Gated Channels (Conley EC, ed) pp 234-292, Academic Press, London.
5. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556.
6. Dewet JR, Wood KV, DeLuca M, Helinski D, and Subramani S (1986) Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 6:1663-1670.
7. Feig LA, Pan BT, Roberts TM, and Cooper GM (1986) Isolation of ras GTP-binding mutants using an in situ colony-binding assay. Proc Natl Acad Sci USA 83:4607-4611.
8. Feig LA and Cooper GM (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 8:3235-3243.
9. Ginty D, Bonni A, Greenberg ME (1994) Nerve growth factor activates a Rasdependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77:713-725.
10. Greene LA and Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-8.
11. Habener JF (1990) Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol Endocrinol 4:1087-1094.
12. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM, and Hammun YA (1995) Role for ceramide in cell cycle arrest. J Biol Chem 270:2047-2052.
13. Gorman CM, Moffat LF, and Howard BH (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051.
14. Honda Z, Takano T, Gotoh Y, Nishida E, Ito K, and Shimizu T (1994) Transfected platelet-activation factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J Biol Chem 269:2307-2315.
15. Johnson JA and Nathanson NM (1994) Differential requirements of p21 ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokinase. J Biol Chem 269:18856-18863.
16. Kuo ML and Yang NC (1995) Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem Biophys Res Commun 212:767-775.
17. Kyriakis JM and Avruch J (1996) Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271:24313-24316.
18. Marquardt B, Frith D, and Stabel S (1994) Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro. Oncogene 9:3213-3218.
19. Okada N and Koizumi S (1995) A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells. J Biol Chem 270:16464-16469.
20. Pang L, Sawada T, Decker SJ, and Saltiel AR (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC12 cells induced by nerve growth factor. J Biol Chem 270:13585-13588.
21. Parmer RJ, Xi X-P, Wu H, Helman LJ, and Petz LN (1993) Secretory protein traffic: chromogranin A contains a dominant targeting signal for the regulated pathway. J Clin Invest 92:1042-1054.
22. Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, and Cobb MH (1993) Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J Biol Chem 268:5097-5106.
23. Robinson MJ and Cobb MH (1997) Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9:180-186.
24. Roesler WJ, Vandenbark GR, and Hanson RW (1988) Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 263:9063-9070.
25. Rosen LB, Ginty DD, Weber MJ, and Greenberg ME (1994) Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12:1207-1221.
26. Rosen LB and Greenberg ME (1996) Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc Natl Acad Sci USA 93:1113-1118.
27. Sato F, Matsukawa Y, Nishino K, and Sakai T (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem Biophys Res Commun 204:578-584.
28. Sheng M, Dougan ST, McFadden G, and Greenberg ME (1988) Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. Mol Cell Biol 8:2787-2796.
29. Takiyyuddin MA, Cervenka JH, Hsiao RJ, Barbosa JA, Parmer RJ, and O'Connor DT (1990) Chromogranin A: storage and release in hypertension. Hypertension 15:237-246.
30. Tang K, Wu H, Mahata SK, Taupenot L, Rozansky DJ, Parmer RJ, and O'Connor DT (1996) Stimulus-transcription coupling in pheochromocytoma cells: promoter region-specific activation of chromogranin A biosynthesis. J Biol Chem 271:28382-28390.
31. Tang K, Wu H, Mahata SK, Mahata M, Gill BM, Parmer RJ, and O'Connor DT (1997) Stimulus coupling to transcription versus secretion in pheochromocytoma cells: convergent and divergent signal transduction pathways, and the crucial roles for route of cytosolic calcium entry and protein kinase C. J Clin Invest 100:1180-1192.
32. Thorburn J, McMahon M, and Thorburn A (1994) Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem 269:30580-30586.
33. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205-215.
34. Walton KM, Rehfuss RP, Chrivia JC, Lochner JE, and Goodman RH (1992) A dominant repressor of cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo. Mol Endocrinol 6:647-655.
35. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, and Brenner DA (1994) Oncogenic Ras activates c-jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci USA 91:6030-6034.
36. Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92-98.
37. Wu H, Rozansky DJ, Webster NJG, and O'Connor DT (1994) Cell type-specific gene expression in neuroendocrine system: a neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. J Clin Invest 94:118-129.
38. Wu H, Mahata SK, Mahata M, Webster NJG, Parmer RJ, and O'Connor DT (1995) A functional cyclic AMP response plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J Clin Invest 96:568-578.
39. Xia Z, Dudek H, Miranti CK, and Greenberg ME (1996) Calcium influx via the NMDA receptor induces immediate-early gene transcription by a MAP kinase ERK-dependent mechanism. J Neurosci 16:5425-5436.
40. Xing J, Ginty DD, and Greenberg ME (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (Washington DC) 273:959-963.